This is the analysis script to prepare the data to run analyses for the project “Anxiety, depression and trauma symptom change during the COVID-19 pandemic: retrospective versus objective assessment” - Young et al (2020)

Script written by K L Purves, K N Thompson, C Huebel and M Davies. Email: kirstin.purves@kcl.ac.uk, katie.thompson@kcl.ac.uk, christopher.1.huebel@kcl.ac.uk, molly.davies@kcl.ac.uk

Set up

Clear global environment

Retrieve the current date to use it for file endings to not overwrite files when one exports files

Packages

Install packages (if they are not available in your version of R)

Load packages

Registered S3 method overwritten by 'pryr':
  method      from
  print.bytes Rcpp
For best results, restart R session and update pander using devtools:: or remotes::install_github('rapporter/pander')

Attaching package: 'polycor'
The following object is masked from 'package:psych':

    polyserial
corrplot 0.84 loaded
── Attaching packages ─────────────────────────────────────── tidyverse 1.3.0 ──
✓ ggplot2 3.3.2     ✓ purrr   0.3.4
✓ tibble  3.0.4     ✓ dplyr   1.0.2
✓ tidyr   1.0.0     ✓ stringr 1.4.0
✓ readr   1.4.0     ✓ forcats 0.4.0
── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
x ggplot2::%+%()   masks psych::%+%()
x ggplot2::alpha() masks psych::alpha()
x dplyr::filter()  masks stats::filter()
x dplyr::lag()     masks stats::lag()
x tibble::view()   masks summarytools::view()

R functions

Half-violin plot

Colour palettes

Define colours for plotting this are the standard coping colours

Choose in this chunk which palette to use 04.07.2020 - Default to 2 colour COPING palette

ggplot theme

Set up ggplot theme for the plots

Function for split violin plot

Data import

Source data file paths

Read in data

[1] 31884   609
  [1] "Sample"                                                          
  [2] "ID"                                                              
  [3] "startDate.prepandemic"                                           
  [4] "Age_uncleaned"                                                   
  [5] "Gender_unc"                                                      
  [6] "Sex"                                                             
  [7] "EduYrs"                                                          
  [8] "demographics.college_or_university_degree"                       
  [9] "demographics.a_levelsas_levels_or_equivalent"                    
 [10] "demographics.o_levelsgcses_or_equivalent"                        
 [11] "demographics.cses_or_equivalent"                                 
 [12] "demographics.nvq_or_hnd_or_hnc_or_equivalent"                    
 [13] "Ethnicity_unc"                                                   
 [14] "Gender_numeric"                                                  
 [15] "Sex_numeric"                                                     
 [16] "demographics.college_or_university_degree_numeric"               
 [17] "demographics.a_levelsas_levels_or_equivalent_numeric"            
 [18] "demographics.o_levelsgcses_or_equivalent_numeric"                
 [19] "demographics.cses_or_equivalent_numeric"                         
 [20] "demographics.nvq_or_hnd_or_hnc_or_equivalent_numeric"            
 [21] "Ethnicity_numeric"                                               
 [22] "Gender"                                                          
 [23] "Ethnicity"                                                       
 [24] "Age"                                                             
 [25] "age_category_numeric"                                            
 [26] "age_category"                                                    
 [27] "highest_education_prepan_numeric"                                
 [28] "highest_education_prepan"                                        
 [29] "employment.phd"                                                  
 [30] "employment.masters_degree_or_equivalent"                         
 [31] "employment.postgraduate_degree_or_equivalent"                    
 [32] "employment.bachelors_degree_or_equivalent"                       
 [33] "employment.a_levelsas_levels_or_equivalent"                      
 [34] "employment.o_levelsgcses_or_equivalent"                          
 [35] "employment.cses_or_equivalent"                                   
 [36] "employment.nvq_or_hnd_or_hnc_or_equivalent"                      
 [37] "employment.government_work_key_workers"                          
 [38] "employment.unemployed"                                           
 [39] "employment.zerohours_contract"                                   
 [40] "employment.stayathome_parent_or_carer"                           
 [41] "employment.retired"                                              
 [42] "employment.student_gcse_or_a_level"                              
 [43] "employment.student_university"                                   
 [44] "employment.became_unemployed"                                    
 [45] "employment.furloughed_or_paid_leave_government_funded"           
 [46] "employment.furloughed_or_paid_leave_company_funded"              
 [47] "employment.paid_leave_furloughed"                                
 [48] "employment.phd_numeric"                                          
 [49] "employment.masters_degree_or_equivalent_numeric"                 
 [50] "employment.postgraduate_degree_or_equivalent_numeric"            
 [51] "employment.bachelors_degree_or_equivalent_numeric"               
 [52] "employment.a_levelsas_levels_or_equivalent_numeric"              
 [53] "employment.o_levelsgcses_or_equivalent_numeric"                  
 [54] "employment.cses_or_equivalent_numeric"                           
 [55] "employment.nvq_or_hnd_or_hnc_or_equivalent_numeric"              
 [56] "employment.government_work_key_workers_numeric"                  
 [57] "employment.unemployed_numeric"                                   
 [58] "employment.zerohours_contract_numeric"                           
 [59] "employment.stayathome_parent_or_carer_numeric"                   
 [60] "employment.retired_numeric"                                      
 [61] "employment.student_gcse_or_a_level_numeric"                      
 [62] "employment.student_university_numeric"                           
 [63] "employment.became_unemployed_numeric"                            
 [64] "employment.furloughed_or_paid_leave_government_funded_numeric"   
 [65] "employment.furloughed_or_paid_leave_company_funded_numeric"      
 [66] "employment.paid_leave_furloughed_numeric"                        
 [67] "highest_education_numeric"                                       
 [68] "highest_education"                                               
 [69] "key_worker_numeric"                                              
 [70] "key_worker"                                                      
 [71] "anxiety_disorders_numeric"                                       
 [72] "anxiety_disorders"                                               
 [73] "mhd.specific_phobia_e.g._phobia_of_flying_numeric"               
 [74] "mhd.specific_phobia_e.g._phobia_of_flying"                       
 [75] "mhd.social_anxiety_or_social_phobia_numeric"                     
 [76] "mhd.social_anxiety_or_social_phobia"                             
 [77] "agoraphobia_panic_disorder_numeric"                              
 [78] "agoraphobia_panic_disorder"                                      
 [79] "depressive_disorders_numeric"                                    
 [80] "depressive_disorders"                                            
 [81] "eating_disorders_numeric"                                        
 [82] "eating_disorders"                                                
 [83] "obsessive_compulsive_disorders_numeric"                          
 [84] "obsessive_compulsive_disorders"                                  
 [85] "psychotic_disorders_numeric"                                     
 [86] "psychotic_disorders"                                             
 [87] "mhd.mania_hypomania_bipolar_or_manicdepression_numeric"          
 [88] "mhd.mania_hypomania_bipolar_or_manicdepression"                  
 [89] "mhd.posttraumatic_stress_disorder_ptsd_numeric"                  
 [90] "mhd.posttraumatic_stress_disorder_ptsd"                          
 [91] "autism_spectrum_disorder_numeric"                                
 [92] "autism_spectrum_disorder"                                        
 [93] "mhd.attention_deficit_hyperactivity_disorder_numeric"            
 [94] "mhd.attention_deficit_hyperactivity_disorder"                    
 [95] "mhd.personality_disorder_numeric"                                
 [96] "mhd.personality_disorder"                                        
 [97] "personality_cluster_a_numeric"                                   
 [98] "personality_cluster_a"                                           
 [99] "personality_cluster_b_numeric"                                   
[100] "personality_cluster_b"                                           
[101] "personality_cluster_c_numeric"                                   
[102] "personality_cluster_c"                                           
[103] "depression_and_anxiety_numeric"                                  
[104] "depression_and_anxiety"                                          
[105] "restricting_vs_binge_eating_eating_disorders_numeric"            
[106] "restricting_vs_binge_eating_eating_disorders"                    
[107] "bipolar_and_schizophrenia_numeric"                               
[108] "bipolar_and_schizophrenia"                                       
[109] "control_numeric"                                                 
[110] "control"                                                         
[111] "disorders_total_count"                                           
[112] "comorbidity_total_count_numeric"                                 
[113] "comorbidity_total_count_factor_numeric"                          
[114] "comorbidity_total_count_factor"                                  
[115] "mhd.none_of_the_above"                                           
[116] "mhd.none_of_the_above.1"                                         
[117] "gad.feeling_nervous_anxious_or_on_edge_prepan"                   
[118] "gad.control_worrying_stop_prepan"                                
[119] "gad.worrying_too_much_about_different_things_prepan"             
[120] "gad.trouble_relaxing_prepan"                                     
[121] "gad.sit_restless_hard_prepan"                                    
[122] "gad.becoming_easily_annoyed_or_irritable_prepan"                 
[123] "gad.awful_feeling_afraid_happen_prepan"                          
[124] "gad.feeling_nervous_anxious_or_on_edge_prepan_numeric"           
[125] "gad.control_worrying_stop_prepan_numeric"                        
[126] "gad.worrying_too_much_about_different_things_prepan_numeric"     
[127] "gad.trouble_relaxing_prepan_numeric"                             
[128] "gad.sit_restless_hard_prepan_numeric"                            
[129] "gad.becoming_easily_annoyed_or_irritable_prepan_numeric"         
[130] "gad.awful_feeling_afraid_happen_prepan_numeric"                  
[131] "gad.sum_score_prepan_raw"                                        
[132] "na_per_person_gad_prepan"                                        
[133] "gad.sum_score_prepan"                                            
[134] "pcl.stressful_experience_repeated_images_prepan"                 
[135] "pcl.stressful_experience_upset_reminded_prepan"                  
[136] "pcl.stressful_situation_avoiding_activities_prepan"              
[137] "pcl.cut_people_feeling_distant_prepan"                           
[138] "pcl.feeling_irritable_or_having_angry_outbursts_prepan"          
[139] "pcl.difficulty_concentrating_prepan"                             
[140] "pcl.stressful_experience_repeated_images_prepan_numeric"         
[141] "pcl.stressful_experience_upset_reminded_prepan_numeric"          
[142] "pcl.stressful_situation_avoiding_activities_prepan_numeric"      
[143] "pcl.cut_people_feeling_distant_prepan_numeric"                   
[144] "pcl.feeling_irritable_or_having_angry_outbursts_prepan_numeric"  
[145] "pcl.difficulty_concentrating_prepan_numeric"                     
[146] "pcl.sum_score_prepan_raw"                                        
[147] "na_per_person_pcl_prepan"                                        
[148] "pcl.sum_score_prepan"                                            
[149] "phq.little_interest_or_pleasure_in_doing_things_prepan"          
[150] "phq.feeling_down_depressed_or_hopeless_prepan"                   
[151] "phq.staying_asleep_sleeping_trouble_prepan"                      
[152] "phq.feeling_tired_or_having_little_energy_prepan"                
[153] "phq.poor_appetite_or_overeating_prepan"                          
[154] "phq.feeling_bad_failure_family_prepan"                           
[155] "phq.trouble_concentrating_reading_newspaper_prepan"              
[156] "phq.moving_fidgety_noticed_opposite_prepan"                      
[157] "phq.dead_hurting_thoughts_prepan"                                
[158] "phq.little_interest_or_pleasure_in_doing_things_prepan_numeric"  
[159] "phq.feeling_down_depressed_or_hopeless_prepan_numeric"           
[160] "phq.staying_asleep_sleeping_trouble_prepan_numeric"              
[161] "phq.feeling_tired_or_having_little_energy_prepan_numeric"        
[162] "phq.poor_appetite_or_overeating_prepan_numeric"                  
[163] "phq.feeling_bad_failure_family_prepan_numeric"                   
[164] "phq.trouble_concentrating_reading_newspaper_prepan_numeric"      
[165] "phq.moving_fidgety_noticed_opposite_prepan_numeric"              
[166] "phq.dead_hurting_thoughts_prepan_numeric"                        
[167] "phq.sum_score_prepan_raw"                                        
[168] "na_per_person_phq_prepan"                                        
[169] "phq.missing_only_suicide_item_prepan"                            
[170] "phq.sum_score_prepan"                                            
[171] "phq.sum_score_8items_prepan"                                     
[172] "ocir.i_repeatedly_check_doors_windows_drawers_etc_prepan"        
[173] "ocir.arranged_things_change_upset_prepan"                        
[174] "ocir.repeat_feel_numbers_prepan"                                 
[175] "ocir.clean_simply_wash_feel_prepan"                              
[176] "ocir.mind_upset_unpleasant_thoughts_prepan"                      
[177] "ocir.afraid_avoid_throwing_things_prepan"                        
[178] "ocir.light_switches_water_taps_prepan"                           
[179] "ocir.arranged_things_prepan"                                     
[180] "ocir.good_feel_bad_numbers_prepan"                               
[181] "ocir.hands_longer_wash_prepan"                                   
[182] "ocir.saved_things_prepan"                                        
[183] "ocir.frequently_difficulty_rid_nasty_prepan"                     
[184] "ocir.i_check_things_more_often_than_necessary_prepan"            
[185] "ocir.arranged_properly_objects_upset_prepan"                     
[186] "ocir.feel_compelled_count_things_prepan"                         
[187] "ocir.strangers_touch_touched_difficult_prepan"                   
[188] "ocir.control_difficult_find_thoughts_prepan"                     
[189] "ocir.i_collect_things_i_dont_need_prepan"                        
[190] "ocir.i_repeatedly_check_doors_windows_drawers_etc_prepan_numeric"
[191] "ocir.arranged_things_change_upset_prepan_numeric"                
[192] "ocir.repeat_feel_numbers_prepan_numeric"                         
[193] "ocir.clean_simply_wash_feel_prepan_numeric"                      
[194] "ocir.mind_upset_unpleasant_thoughts_prepan_numeric"              
[195] "ocir.afraid_avoid_throwing_things_prepan_numeric"                
[196] "ocir.light_switches_water_taps_prepan_numeric"                   
[197] "ocir.arranged_things_prepan_numeric"                             
[198] "ocir.good_feel_bad_numbers_prepan_numeric"                       
[199] "ocir.hands_longer_wash_prepan_numeric"                           
[200] "ocir.saved_things_prepan_numeric"                                
[201] "ocir.frequently_difficulty_rid_nasty_prepan_numeric"             
[202] "ocir.i_check_things_more_often_than_necessary_prepan_numeric"    
[203] "ocir.arranged_properly_objects_upset_prepan_numeric"             
[204] "ocir.feel_compelled_count_things_prepan_numeric"                 
[205] "ocir.strangers_touch_touched_difficult_prepan_numeric"           
[206] "ocir.control_difficult_find_thoughts_prepan_numeric"             
[207] "ocir.i_collect_things_i_dont_need_prepan_numeric"                
[208] "ocir.sum_score_prepan_raw"                                       
[209] "na_per_person_ocir_prepan"                                       
[210] "ocir.sum_score_prepan"                                           
[211] "startDate.coping"                                                
[212] "gad.problems_made_difficult_care"                                
[213] "gad.pandemic_felt_feelings"                                      
[214] "gad.feeling_nervous_anxious_or_on_edge_retro"                    
[215] "gad.control_worrying_stop_retro"                                 
[216] "gad.worrying_too_much_about_different_things_retro"              
[217] "gad.trouble_relaxing_retro"                                      
[218] "gad.sit_restless_hard_retro"                                     
[219] "gad.becoming_easily_annoyed_or_irritable_retro"                  
[220] "gad.awful_feeling_afraid_happen_retro"                           
[221] "gad.feeling_nervous_anxious_or_on_edge_base"                     
[222] "gad.control_worrying_stop_base"                                  
[223] "gad.worrying_too_much_about_different_things_base"               
[224] "gad.trouble_relaxing_base"                                       
[225] "gad.sit_restless_hard_base"                                      
[226] "gad.becoming_easily_annoyed_or_irritable_base"                   
[227] "gad.awful_feeling_afraid_happen_base"                            
[228] "gad.problems_made_difficult_care_numeric"                        
[229] "gad.pandemic_felt_feelings_numeric"                              
[230] "gad.feeling_nervous_anxious_or_on_edge_retro_numeric"            
[231] "gad.control_worrying_stop_retro_numeric"                         
[232] "gad.worrying_too_much_about_different_things_retro_numeric"      
[233] "gad.trouble_relaxing_retro_numeric"                              
[234] "gad.sit_restless_hard_retro_numeric"                             
[235] "gad.becoming_easily_annoyed_or_irritable_retro_numeric"          
[236] "gad.awful_feeling_afraid_happen_retro_numeric"                   
[237] "gad.feeling_nervous_anxious_or_on_edge_base_numeric"             
[238] "gad.control_worrying_stop_base_numeric"                          
[239] "gad.worrying_too_much_about_different_things_base_numeric"       
[240] "gad.trouble_relaxing_base_numeric"                               
[241] "gad.sit_restless_hard_base_numeric"                              
[242] "gad.becoming_easily_annoyed_or_irritable_base_numeric"           
[243] "gad.awful_feeling_afraid_happen_base_numeric"                    
[244] "gad.sum_score_retro_raw"                                         
[245] "gad.sum_score_base_raw"                                          
[246] "na_per_person_gad_base"                                          
[247] "na_per_person_gad_retro"                                         
[248] "gad.sum_score_base"                                              
[249] "gad.sum_score_retro"                                             
[250] "pcl.stressful_experience_repeated_images_base"                   
[251] "pcl.stressful_experience_upset_reminded_base"                    
[252] "pcl.stressful_situation_avoiding_activities_base"                
[253] "pcl.cut_people_feeling_distant_base"                             
[254] "pcl.feeling_irritable_or_having_angry_outbursts_base"            
[255] "pcl.difficulty_concentrating_base"                               
[256] "pcl.stressful_experience_repeated_images_retro"                  
[257] "pcl.stressful_experience_upset_reminded_retro"                   
[258] "pcl.stressful_situation_avoiding_activities_retro"               
[259] "pcl.cut_people_feeling_distant_retro"                            
[260] "pcl.feeling_irritable_or_having_angry_outbursts_retro"           
[261] "pcl.difficulty_concentrating_retro"                              
[262] "pcl.stressful_experience_repeated_images_base_numeric"           
[263] "pcl.stressful_experience_upset_reminded_base_numeric"            
[264] "pcl.stressful_situation_avoiding_activities_base_numeric"        
[265] "pcl.cut_people_feeling_distant_base_numeric"                     
[266] "pcl.feeling_irritable_or_having_angry_outbursts_base_numeric"    
[267] "pcl.difficulty_concentrating_base_numeric"                       
[268] "pcl.stressful_experience_repeated_images_retro_numeric"          
[269] "pcl.stressful_experience_upset_reminded_retro_numeric"           
[270] "pcl.stressful_situation_avoiding_activities_retro_numeric"       
[271] "pcl.cut_people_feeling_distant_retro_numeric"                    
[272] "pcl.feeling_irritable_or_having_angry_outbursts_retro_numeric"   
[273] "pcl.difficulty_concentrating_retro_numeric"                      
[274] "pcl.sum_score_retro_raw"                                         
[275] "pcl.sum_score_base_raw"                                          
[276] "na_per_person_pcl_base"                                          
[277] "na_per_person_pcl_retro"                                         
[278] "pcl.sum_score_base"                                              
[279] "pcl.sum_score_retro"                                             
[280] "phq.problems_made_difficult_care"                                
[281] "phq.pandemic_felt_feelings"                                      
[282] "phq.little_interest_or_pleasure_in_doing_things_retro"           
[283] "phq.feeling_down_depressed_or_hopeless_retro"                    
[284] "phq.staying_asleep_sleeping_trouble_retro"                       
[285] "phq.feeling_tired_or_having_little_energy_retro"                 
[286] "phq.poor_appetite_or_overeating_retro"                           
[287] "phq.feeling_bad_failure_family_retro"                            
[288] "phq.trouble_concentrating_reading_newspaper_retro"               
[289] "phq.moving_fidgety_noticed_opposite_retro"                       
[290] "phq.dead_hurting_thoughts_retro"                                 
[291] "phq.little_interest_or_pleasure_in_doing_things_base"            
[292] "phq.feeling_down_depressed_or_hopeless_base"                     
[293] "phq.staying_asleep_sleeping_trouble_base"                        
[294] "phq.feeling_tired_or_having_little_energy_base"                  
[295] "phq.poor_appetite_or_overeating_base"                            
[296] "phq.feeling_bad_failure_family_base"                             
[297] "phq.trouble_concentrating_reading_newspaper_base"                
[298] "phq.moving_fidgety_noticed_opposite_base"                        
[299] "phq.dead_hurting_thoughts_base"                                  
[300] "phq.problems_made_difficult_care_numeric"                        
[301] "phq.pandemic_felt_feelings_numeric"                              
[302] "phq.little_interest_or_pleasure_in_doing_things_retro_numeric"   
[303] "phq.feeling_down_depressed_or_hopeless_retro_numeric"            
[304] "phq.staying_asleep_sleeping_trouble_retro_numeric"               
[305] "phq.feeling_tired_or_having_little_energy_retro_numeric"         
[306] "phq.poor_appetite_or_overeating_retro_numeric"                   
[307] "phq.feeling_bad_failure_family_retro_numeric"                    
[308] "phq.trouble_concentrating_reading_newspaper_retro_numeric"       
[309] "phq.moving_fidgety_noticed_opposite_retro_numeric"               
[310] "phq.dead_hurting_thoughts_retro_numeric"                         
[311] "phq.little_interest_or_pleasure_in_doing_things_base_numeric"    
[312] "phq.feeling_down_depressed_or_hopeless_base_numeric"             
[313] "phq.staying_asleep_sleeping_trouble_base_numeric"                
[314] "phq.feeling_tired_or_having_little_energy_base_numeric"          
[315] "phq.poor_appetite_or_overeating_base_numeric"                    
[316] "phq.feeling_bad_failure_family_base_numeric"                     
[317] "phq.trouble_concentrating_reading_newspaper_base_numeric"        
[318] "phq.moving_fidgety_noticed_opposite_base_numeric"                
[319] "phq.dead_hurting_thoughts_base_numeric"                          
[320] "phq.sum_score_retro_raw"                                         
[321] "phq.sum_score_base_raw"                                          
[322] "na_per_person_phq_retro"                                         
[323] "phq.missing_only_suicide_item_retro"                             
[324] "na_per_person_phq_base"                                          
[325] "phq.missing_only_suicide_item_base"                              
[326] "phq.sum_score_base"                                              
[327] "phq.sum_score_8items_base"                                       
[328] "phq.sum_score_retro"                                             
[329] "phq.sum_score_8items_retro"                                      
[330] "ocir.felt_pandemic_feelings"                                     
[331] "ocir.i_repeatedly_check_doors_windows_drawers_etc_retro"         
[332] "ocir.arranged_things_change_upset_retro"                         
[333] "ocir.repeat_feel_numbers_retro"                                  
[334] "ocir.clean_simply_wash_feel_retro"                               
[335] "ocir.mind_upset_unpleasant_thoughts_retro"                       
[336] "ocir.afraid_avoid_throwing_things_retro"                         
[337] "ocir.light_switches_water_taps_retro"                            
[338] "ocir.arranged_things_retro"                                      
[339] "ocir.good_feel_bad_numbers_retro"                                
[340] "ocir.hands_longer_wash_retro"                                    
[341] "ocir.saved_things_retro"                                         
[342] "ocir.frequently_difficulty_rid_nasty_retro"                      
[343] "ocir.i_check_things_more_often_than_necessary_retro"             
[344] "ocir.arranged_properly_objects_upset_retro"                      
[345] "ocir.feel_compelled_count_things_retro"                          
[346] "ocir.strangers_touch_touched_difficult_retro"                    
[347] "ocir.control_difficult_find_thoughts_retro"                      
[348] "ocir.i_collect_things_i_dont_need_retro"                         
[349] "ocir.i_repeatedly_check_doors_windows_drawers_etc_base"          
[350] "ocir.arranged_things_change_upset_base"                          
[351] "ocir.repeat_feel_numbers_base"                                   
[352] "ocir.clean_simply_wash_feel_base"                                
[353] "ocir.mind_upset_unpleasant_thoughts_base"                        
[354] "ocir.afraid_avoid_throwing_things_base"                          
[355] "ocir.light_switches_water_taps_base"                             
[356] "ocir.arranged_things_base"                                       
[357] "ocir.good_feel_bad_numbers_base"                                 
[358] "ocir.hands_longer_wash_base"                                     
[359] "ocir.saved_things_base"                                          
[360] "ocir.frequently_difficulty_rid_nasty_base"                       
[361] "ocir.i_check_things_more_often_than_necessary_base"              
[362] "ocir.arranged_properly_objects_upset_base"                       
[363] "ocir.feel_compelled_count_things_base"                           
[364] "ocir.strangers_touch_touched_difficult_base"                     
[365] "ocir.control_difficult_find_thoughts_base"                       
[366] "ocir.i_collect_things_i_dont_need_base"                          
[367] "ocir.felt_pandemic_feelings_numeric"                             
[368] "ocir.i_repeatedly_check_doors_windows_drawers_etc_retro_numeric" 
[369] "ocir.arranged_things_change_upset_retro_numeric"                 
[370] "ocir.repeat_feel_numbers_retro_numeric"                          
[371] "ocir.clean_simply_wash_feel_retro_numeric"                       
[372] "ocir.mind_upset_unpleasant_thoughts_retro_numeric"               
[373] "ocir.afraid_avoid_throwing_things_retro_numeric"                 
[374] "ocir.light_switches_water_taps_retro_numeric"                    
[375] "ocir.arranged_things_retro_numeric"                              
[376] "ocir.good_feel_bad_numbers_retro_numeric"                        
[377] "ocir.hands_longer_wash_retro_numeric"                            
[378] "ocir.saved_things_retro_numeric"                                 
[379] "ocir.frequently_difficulty_rid_nasty_retro_numeric"              
[380] "ocir.i_check_things_more_often_than_necessary_retro_numeric"     
[381] "ocir.arranged_properly_objects_upset_retro_numeric"              
[382] "ocir.feel_compelled_count_things_retro_numeric"                  
[383] "ocir.strangers_touch_touched_difficult_retro_numeric"            
[384] "ocir.control_difficult_find_thoughts_retro_numeric"              
[385] "ocir.i_collect_things_i_dont_need_retro_numeric"                 
[386] "ocir.i_repeatedly_check_doors_windows_drawers_etc_base_numeric"  
[387] "ocir.arranged_things_change_upset_base_numeric"                  
[388] "ocir.repeat_feel_numbers_base_numeric"                           
[389] "ocir.clean_simply_wash_feel_base_numeric"                        
[390] "ocir.mind_upset_unpleasant_thoughts_base_numeric"                
[391] "ocir.afraid_avoid_throwing_things_base_numeric"                  
[392] "ocir.light_switches_water_taps_base_numeric"                     
[393] "ocir.arranged_things_base_numeric"                               
[394] "ocir.good_feel_bad_numbers_base_numeric"                         
[395] "ocir.hands_longer_wash_base_numeric"                             
[396] "ocir.saved_things_base_numeric"                                  
[397] "ocir.frequently_difficulty_rid_nasty_base_numeric"               
[398] "ocir.i_check_things_more_often_than_necessary_base_numeric"      
[399] "ocir.arranged_properly_objects_upset_base_numeric"               
[400] "ocir.feel_compelled_count_things_base_numeric"                   
[401] "ocir.strangers_touch_touched_difficult_base_numeric"             
[402] "ocir.control_difficult_find_thoughts_base_numeric"               
[403] "ocir.i_collect_things_i_dont_need_base_numeric"                  
[404] "ocir.sum_score_retro_raw"                                        
[405] "ocir.sum_score_base_raw"                                         
[406] "na_per_person_ocir_retro"                                        
[407] "na_per_person_ocir_base"                                         
[408] "ocir.sum_score_base"                                             
[409] "ocir.sum_score_retro"                                            
[410] "alsfrs.limb_weakness_noticed_past"                               
[411] "alsfrs.normal"                                                   
[412] "alsfrs.slow_or_sloppy_all_words_are_legible"                     
[413] "alsfrs.not_all_words_are_legible"                                
[414] "alsfrs.able_to_grip_pen"                                         
[415] "alsfrs.unable_to_grip_pen"                                       
[416] "alsfrs.have_you_noticed_any_difficulty_walking"                  
[417] "alsfrs.do_you_have_any_difficulty_climbing_stairs"               
[418] "alsfrs.limb_weakness_noticed_past_numeric"                       
[419] "alsfrs.normal_numeric"                                           
[420] "alsfrs.slow_or_sloppy_all_words_are_legible_numeric"             
[421] "alsfrs.not_all_words_are_legible_numeric"                        
[422] "alsfrs.able_to_grip_pen_numeric"                                 
[423] "alsfrs.unable_to_grip_pen_numeric"                               
[424] "alsfrs.have_you_noticed_any_difficulty_walking_numeric"          
[425] "alsfrs.do_you_have_any_difficulty_climbing_stairs_numeric"       
[426] "ess.felt_excessively_sleepy_past"                                
[427] "ess.sitting_and_reading"                                         
[428] "ess.watching_tv"                                                 
[429] "ess.sitting_inactive_in_a_public_place"                          
[430] "ess.break_passenger_car_hour"                                    
[431] "ess.afternoon_rest_circumstances_lying"                          
[432] "ess.sitting_and_talking_to_someone"                              
[433] "ess.sitting_quietly_after_a_lunch_without_alcohol"               
[434] "ess.car_minutes_stopped_traffic"                                 
[435] "ess.insomnia"                                                    
[436] "ess.narcolepsy"                                                  
[437] "ess.rem_sleep_behaviour_disorder"                                
[438] "ess.restless_legs_syndrome"                                      
[439] "ess.sleep_apnea"                                                 
[440] "ess.sleep_terrors"                                               
[441] "ess.sleepwalking"                                                
[442] "ess.other"                                                       
[443] "ess.none"                                                        
[444] "ess.felt_excessively_sleepy_past_numeric"                        
[445] "ess.sitting_and_reading_numeric"                                 
[446] "ess.watching_tv_numeric"                                         
[447] "ess.sitting_inactive_in_a_public_place_numeric"                  
[448] "ess.break_passenger_car_hour_numeric"                            
[449] "ess.afternoon_rest_circumstances_lying_numeric"                  
[450] "ess.sitting_and_talking_to_someone_numeric"                      
[451] "ess.sitting_quietly_after_a_lunch_without_alcohol_numeric"       
[452] "ess.car_minutes_stopped_traffic_numeric"                         
[453] "ess.insomnia_numeric"                                            
[454] "ess.narcolepsy_numeric"                                          
[455] "ess.rem_sleep_behaviour_disorder_numeric"                        
[456] "ess.restless_legs_syndrome_numeric"                              
[457] "ess.sleep_apnea_numeric"                                         
[458] "ess.sleep_terrors_numeric"                                       
[459] "ess.sleepwalking_numeric"                                        
[460] "ess.other_numeric"                                               
[461] "ess.none_numeric"                                                
[462] "midas.headaches_suffered_past_month"                             
[463] "midas.days_past_month_miss_work_school"                          
[464] "midas.days_past_month_work_school_half_productivity"             
[465] "midas.days_past_month_miss_housework"                            
[466] "midas.days_past_month_housework_half_productivity"               
[467] "midas.days_past_month_miss_social_activities"                    
[468] "midas.headaches_suffered_past_month_numeric"                     
[469] "midas.days_past_month_miss_work_school_numeric"                  
[470] "midas.days_past_month_work_school_half_productivity_numeric"     
[471] "midas.days_past_month_miss_housework_numeric"                    
[472] "midas.days_past_month_housework_half_productivity_numeric"       
[473] "midas.days_past_month_miss_social_activities_numeric"            
[474] "nmss.ability_taste_food_smell"                                   
[475] "nmss.severe_taste_smell_loss"                                    
[476] "nmss.ability_taste_food_smell_numeric"                           
[477] "nmss.severe_taste_smell_loss_numeric"                            
[478] "nmsw.drink_problems_choking_difficulty"                          
[479] "nmsw.regularly_night_pass_urine"                                 
[480] "nmsw.sex_difficult_finding"                                      
[481] "nmsw.weak_standing_feeling_light"                                
[482] "nmsw.acting_moving_sleep_talking"                                
[483] "nmsw.double_vision"                                              
[484] "nmsw.drink_problems_choking_difficulty_numeric"                  
[485] "nmsw.regularly_night_pass_urine_numeric"                         
[486] "nmsw.sex_difficult_finding_numeric"                              
[487] "nmsw.weak_standing_feeling_light_numeric"                        
[488] "nmsw.acting_moving_sleep_talking_numeric"                        
[489] "nmsw.double_vision_numeric"                                      
[490] "tinnitus.ears_noises_minutes_head"                               
[491] "tinnitus.ears_noises_minutes_head_frequency"                     
[492] "tinnitus.noises_worry_worst_upset"                               
[493] "tinnitus.ears_noises_minutes_head_numeric"                       
[494] "tinnitus.ears_noises_minutes_head_frequency_numeric"             
[495] "tinnitus.noises_worry_worst_upset_numeric"                       
[496] "ID.dup"                                                          
[497] "prepandemic_january_31_numeric"                                  
[498] "prepandemic_january_31"                                          
[499] "prepandemic_march_1_numeric"                                     
[500] "prepandemic_march_1"                                             
[501] "prepandemic_march_23_numeric"                                    
[502] "prepandemic_march_23"                                            
[503] "time_diff_coping_lockdown_march_23"                              
[504] "time_diff_coping_awareness_march_1"                              
[505] "time_diff_coping_first_case_uk_jan_31"                           
[506] "time_diff_signup_lockdown_march_23"                              
[507] "time_diff_signup_awareness_march_1"                              
[508] "time_diff_signup_first_case_uk_jan_31"                           
[509] "time_diff_sign_up_coping"                                        
[510] "phq.diff_score_retro_prepan"                                     
[511] "phq.diff_score_base_prepan"                                      
[512] "phq.diff_score_base_retro"                                       
[513] "gad.diff_score_retro_prepan"                                     
[514] "gad.diff_score_base_prepan"                                      
[515] "gad.diff_score_base_retro"                                       
[516] "pcl.diff_score_base_prepan"                                      
[517] "ocir.diff_score_retro_prepan"                                    
[518] "ocir.diff_score_base_prepan"                                     
[519] "ocir.diff_score_base_retro"                                      
[520] "data_group_phq_numeric"                                          
[521] "data_group_phq"                                                  
[522] "data_group_gad_numeric"                                          
[523] "data_group_gad"                                                  
[524] "data_group_pcl_numeric"                                          
[525] "data_group_pcl"                                                  
[526] "data_group_ocir_numeric"                                         
[527] "data_group_ocir"                                                 
[528] "respiratory.breath_diarrhoea_fatigue_fever"                      
[529] "respiratory.worst_ill_feel"                                      
[530] "respiratory.persistent_cough"                                    
[531] "respiratory.skipping_meals_because_you_felt_unwell"              
[532] "respiratory.was_your_sense_of_smell_impaired"                    
[533] "respiratory.was_your_sense_of_taste_impaired"                    
[534] "respiratory.feeling_tiredfatigued"                               
[535] "respiratory.throat_swab_coronavirus_nose"                        
[536] "respiratory.throat_swab_test_nose"                               
[537] "respiratory.coronavirus_antibody_test"                           
[538] "respiratory.results_antibody_test"                               
[539] "respiratory.breath_diarrhoea_fatigue_fever_numeric"              
[540] "respiratory.worst_ill_feel_numeric"                              
[541] "respiratory.persistent_cough_numeric"                            
[542] "respiratory.skipping_meals_because_you_felt_unwell_numeric"      
[543] "respiratory.was_your_sense_of_smell_impaired_numeric"            
[544] "respiratory.was_your_sense_of_taste_impaired_numeric"            
[545] "respiratory.feeling_tiredfatigued_numeric"                       
[546] "respiratory.throat_swab_coronavirus_nose_numeric"                
[547] "respiratory.throat_swab_test_nose_numeric"                       
[548] "respiratory.coronavirus_antibody_test_numeric"                   
[549] "respiratory.results_antibody_test_numeric"                       
[550] "respiratory.anosmia_binary"                                      
[551] "respiratory.pcough_binary"                                       
[552] "respiratory.fatigue_binary"                                      
[553] "respiratory.skipped_meals_binary"                                
[554] "Sex_respiratory"                                                 
[555] "Age_respiratory"                                                 
[556] "covid_symptoms"                                                  
[557] "covid_probability"                                               
[558] "covid_odds_ratio"                                                
[559] "covid_odds_ratio_50_numeric"                                     
[560] "covid_odds_ratio_50"                                             
[561] "covid_probable_case_incl_screening_numeric"                      
[562] "covid_probable_case_incl_screening"                              
[563] "COPING_ID"                                                       
[564] "Birthyear_unc"                                                   
[565] "Birthmonth"                                                      
[566] "Birthday"                                                        
[567] "Birthyear_unc_numeric"                                           
[568] "Birthmonth_numeric"                                              
[569] "Birthday_numeric"                                                
[570] "Birthyear_numeric"                                               
[571] "Birthdate"                                                       
[572] "Cohort"                                                          
[573] "Ethnicity.unc"                                                   
[574] "Cohort_numeric"                                                  
[575] "Ethnicity.unc_numeric"                                           
[576] "Ethnicity_full"                                                  
[577] "Transgender_uncleaned"                                           
[578] "Transgender_uncleaned_numeric"                                   
[579] "employment.what_is_your_highest_level_of_education"              
[580] "employment.what_is_your_highest_level_of_education_numeric"      
[581] "respiratory.coronavirus_week_antibody_test"                      
[582] "respiratory.coronavirus_week_antibody_test_numeric"              
[583] "covid_test_positive_double_numeric"                              
[584] "covid_test_positive_double"                                      
[585] "gad.covid_test_positive_numeric"                                 
[586] "covid_test_positive"                                             
[587] "age_category_collapsed_numeric"                                  
[588] "age_category_collapsed"                                          
[589] "age_category_collapsed_reordered"                                
[590] "Gender_collapsed_numeric"                                        
[591] "Gender_collapsed"                                                
[592] "Ethnicity_collapsed_numeric"                                     
[593] "Ethnicity_collapsed"                                             
[594] "Disorder_hierarchical_psychosis_numeric"                         
[595] "Disorder_hierarchical_psychosis"                                 
[596] "Disorder_hierarchical_numeric"                                   
[597] "Disorder_hierarchical"                                           
[598] "gad.change_binary_numeric"                                       
[599] "gad.change_binary"                                               
[600] "phq.change_binary_numeric"                                       
[601] "phq.change_binary"                                               
[602] "ocir.change_binary_numeric"                                      
[603] "ocir.change_binary"                                              
[604] "prepandemic_3_months_numeric"                                    
[605] "prepandemic_3_months"                                            
[606] "prepandemic_6_months_numeric"                                    
[607] "prepandemic_6_months"                                            
[608] "prepandemic_9_months_numeric"                                    
[609] "prepandemic_9_months"

Important vectors with collections of columns

Vectors for sum_score

 [1] "gad.sum_score_prepan"        "pcl.sum_score_prepan"       
 [3] "phq.sum_score_prepan"        "phq.sum_score_8items_prepan"
 [5] "ocir.sum_score_prepan"       "gad.sum_score_base"         
 [7] "gad.sum_score_retro"         "pcl.sum_score_base"         
 [9] "pcl.sum_score_retro"         "phq.sum_score_base"         
[11] "phq.sum_score_8items_base"   "phq.sum_score_retro"        
[13] "phq.sum_score_8items_retro"  "ocir.sum_score_base"        
[15] "ocir.sum_score_retro"       
[1] "phq.sum_score_prepan" "phq.sum_score_base"   "phq.sum_score_retro" 
[1] "gad.sum_score_prepan" "gad.sum_score_base"   "gad.sum_score_retro" 
[1] "ocir.sum_score_prepan" "ocir.sum_score_base"   "ocir.sum_score_retro" 
[1] "pcl.sum_score_prepan" "pcl.sum_score_base"   "pcl.sum_score_retro"

Vectors for diff_score

 [1] "phq.diff_score_retro_prepan"  "phq.diff_score_base_prepan"  
 [3] "phq.diff_score_base_retro"    "gad.diff_score_retro_prepan" 
 [5] "gad.diff_score_base_prepan"   "gad.diff_score_base_retro"   
 [7] "pcl.diff_score_base_prepan"   "ocir.diff_score_retro_prepan"
 [9] "ocir.diff_score_base_prepan"  "ocir.diff_score_base_retro"  
[1] "phq.diff_score_retro_prepan" "phq.diff_score_base_prepan" 
[3] "phq.diff_score_base_retro"  
[1] "gad.diff_score_retro_prepan" "gad.diff_score_base_prepan" 
[3] "gad.diff_score_base_retro"  
[1] "ocir.diff_score_retro_prepan" "ocir.diff_score_base_prepan" 
[3] "ocir.diff_score_base_retro"

ANALYSIS PLAN

  1. Calculate mean change per disorder group
    1. Disorders (9)
    1. Rank the disorders by the size of the change
    1. Sex
    2. Age (13; RAMP; potentially collapse above 65 depending on group sizes)
    3. Ethnicity groups (5; White European, Black (British), Asian, Arab, Mixed)

1. Questionnaire comparions: Calculate mean change per group

gad

Summary scores

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf
Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Table for knitting gad sum score summary table

Change Variable Min Max Mean Median SD Skew Kurtosis
No change Base 0 21 2.665863 0.0 4.451322 2.1775181 4.4518534
No change Prepan 0 21 8.254932 7.0 6.202852 0.4754996 -0.9032129
No change Retro Inf -Inf NaN NA NA NA NA
Worsening Base 0 21 8.695957 7.0 5.696058 0.5245479 -0.8011604
Worsening Prepan 0 21 9.403875 8.0 5.859497 0.3389671 -0.9329372
Worsening Retro 0 21 4.638103 4.0 4.279377 1.3752419 1.9313176
Improvement Base 0 21 4.771279 3.0 4.830869 1.3672217 1.5731623
Improvement Prepan 0 21 9.228041 8.0 5.817921 0.3295928 -0.9032305
Improvement Retro 0 21 8.362857 7.0 5.468934 0.5124932 -0.5869968
NA Base 0 21 5.700000 4.5 5.994045 1.0357477 0.1012029
NA Prepan 0 21 10.000000 13.0 8.563488 -0.0313927 -1.9895986
NA Retro Inf -Inf NaN NA NA NA NA

Differences scores

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf
Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Table for knitting gad diff summary table

Change Variable Min Max Mean Median SD Skew Kurtosis
No change Base - prepan -21 20 -2.0498783 -1 4.730325 -0.4870231 1.5079948
No change Base - retro Inf -Inf NaN NA NA NA NA
No change Prepan - retro Inf -Inf NaN NA NA NA NA
Worsening Base - prepan -18 21 0.9694803 1 5.309832 -0.0145504 0.6007935
Worsening Base - retro -21 21 4.0587466 3 4.286868 0.7700269 0.8792915
Worsening Prepan - retro -21 18 -3.5772884 -3 5.108094 -0.2892807 0.4412892
Improvement Base - prepan -21 12 -4.0760778 -3 5.490428 -0.2970813 0.1264514
Improvement Base - retro -21 21 -3.5866667 -3 5.322797 0.4752668 2.1484694
Improvement Prepan - retro -21 20 0.3536379 1 5.692678 -0.1576467 0.8754152
NA Base - prepan -9 6 -1.5000000 -2 5.431390 0.0468089 -1.6798094
NA Base - retro Inf -Inf NaN NA NA NA NA
NA Prepan - retro Inf -Inf NaN NA NA NA NA

Long format

Plots diff

makes this into percentages

Warning: Removed 56536 rows containing non-finite values (stat_count).

Warning: Removed 33099 rows containing non-finite values (stat_bin).

Warning: Removed 33099 rows containing non-finite values (stat_bin).

Warning: Removed 23437 rows containing non-finite values (stat_bin).

Plots sum

Warning: Removed 33099 rows containing non-finite values (stat_bin).

Warning: Removed 33099 rows containing non-finite values (stat_bin).

Violin plots

Warning: `fun.y` is deprecated. Use `fun` instead.
Warning: `fun.ymin` is deprecated. Use `fun.min` instead.
Warning: `fun.ymax` is deprecated. Use `fun.max` instead.
Warning: Removed 33099 rows containing non-finite values (stat_ydensity).
Warning: Removed 33099 rows containing non-finite values (stat_summary).
Warning: Removed 33099 rows containing missing values (geom_point).

Warning: `fun.y` is deprecated. Use `fun` instead.
Warning: `fun.ymin` is deprecated. Use `fun.min` instead.
Warning: `fun.ymax` is deprecated. Use `fun.max` instead.
Warning: Removed 33099 rows containing non-finite values (stat_ydensity).
Warning: Removed 33099 rows containing non-finite values (stat_summary).
Warning: Removed 33099 rows containing missing values (geom_point).

Warning: `fun.y` is deprecated. Use `fun` instead.
Warning: `fun.ymin` is deprecated. Use `fun.min` instead.
Warning: `fun.ymax` is deprecated. Use `fun.max` instead.
Warning: Removed 33099 rows containing non-finite values (stat_ydensity).
Warning: Removed 33099 rows containing non-finite values (stat_summary).
Warning: Removed 33099 rows containing missing values (geom_point).

phq

Summary scores

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf
Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Table for knitting phq sum score summary table

Phq.change_binary Variable Min Max Mean Median SD Skew Kurtosis
No change Base 0 27 3.779763 2 5.481075 2.0240159 3.8206843
No change Prepan 0 27 10.489318 9 7.211689 0.4737527 -0.7484781
No change Retro Inf -Inf NaN NA NA NA NA
Worsening Base 0 27 10.318865 9 6.601230 0.5934998 -0.5407978
Worsening Prepan 0 27 11.731892 11 6.742218 0.3025175 -0.7730617
Worsening Retro 0 27 5.713298 4 5.275219 1.4212461 1.9501353
Improvement Base 0 27 6.759112 5 5.758644 1.0575115 0.7067317
Improvement Prepan 0 27 11.511645 11 6.718528 0.3046296 -0.8118759
Improvement Retro 0 27 9.813261 9 6.780903 0.5958911 -0.4615114
NA Base 0 27 5.884892 3 6.885270 1.1461385 0.3684788
NA Prepan 0 25 11.424242 9 7.583000 0.3851207 -1.1446285
NA Retro Inf -Inf NaN NA NA NA NA

Differences score

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Table for knitting phq diff summary table

Phq.change_binary Variable Min Max Mean Median SD Skew Kurtosis
No change Base - prepan -25 23 -1.9826472 -1 5.133551 -0.3168253 1.6880781
No change Base - retro Inf -Inf NaN NA NA NA NA
No change Prepan - retro Inf -Inf NaN NA NA NA NA
Worsening Base - prepan -23 24 0.7995943 1 5.546920 -0.0685706 0.8779614
Worsening Base - retro -18 27 4.6013154 4 4.537987 0.9270470 1.3367436
Worsening Prepan - retro -27 21 -4.2498646 -4 5.496923 -0.3766182 0.6037092
Improvement Base - prepan -22 14 -4.0313183 -3 5.595035 -0.4118415 0.2308405
Improvement Base - retro -24 23 -3.0461797 -3 5.576957 0.0339898 1.8480119
Improvement Prepan - retro -27 22 -0.1211679 0 6.134474 -0.0254236 0.7299648
NA Base - prepan -21 8 -0.5312500 0 6.111778 -1.1041870 1.8755762
NA Base - retro Inf -Inf NaN NA NA NA NA
NA Prepan - retro Inf -Inf NaN NA NA NA NA

Long format

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Violin plots

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ocir

Summary scores

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Table for knitting ocir sum score summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base 0 72 17.80762 15 12.88086 1.1272426 1.1744348
Prepan 1 71 27.48730 26 14.13691 0.6265723 -0.0286904
Retro 0 71 16.99466 14 12.83344 1.0979581 0.9647110

Differences scores

Table for knitting ocir diff summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base - prepan -40 34 -8.0439560 -7 10.749154 -0.1101172 0.6746143
Base - retro -44 72 0.9100517 0 9.658776 0.2846682 2.4704171
Prepan - retro -30 27 -3.5058005 -3 9.301472 -0.0619316 0.3779813

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++CH: Rank the disorders by the size of the change

PCL: Calculate the total GLAD, COPING, RAMP baseline ## PCL

Table for knitting pcl sum score summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base - prepan -23 24 0.2068164 0 5.666463 -0.0743275 0.6542706

Table for knitting pcl diff summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base 6 30 12.33784 11 6.051631 0.9357645 -0.0152704
Prepan 6 30 15.63577 15 6.120978 0.3799305 -0.7386952

For each item present percentages of how say that this is due to the pandemic

PCL Item Binary_score n prop n_prop
pcl.cut_people_feeling_distant_retro_numeric 0 5970 18.7 5970 (18.7%)
pcl.cut_people_feeling_distant_retro_numeric 1 15402 48.3 15402 (48.3%)
pcl.cut_people_feeling_distant_retro_numeric Missing 10512 33.0 10512 (33%)
pcl.difficulty_concentrating_retro_numeric 0 9916 31.1 9916 (31.1%)
pcl.difficulty_concentrating_retro_numeric 1 10289 32.3 10289 (32.3%)
pcl.difficulty_concentrating_retro_numeric Missing 11679 36.6 11679 (36.6%)
pcl.feeling_irritable_or_having_angry_outbursts_retro_numeric 0 8756 27.5 8756 (27.5%)
pcl.feeling_irritable_or_having_angry_outbursts_retro_numeric 1 9870 31.0 9870 (31%)
pcl.feeling_irritable_or_having_angry_outbursts_retro_numeric Missing 13258 41.6 13258 (41.6%)
pcl.stressful_experience_repeated_images_retro_numeric 0 13112 41.1 13112 (41.1%)
pcl.stressful_experience_repeated_images_retro_numeric 1 2902 9.1 2902 (9.1%)
pcl.stressful_experience_repeated_images_retro_numeric Missing 15870 49.8 15870 (49.8%)
pcl.stressful_experience_upset_reminded_retro_numeric 0 13848 43.4 13848 (43.4%)
pcl.stressful_experience_upset_reminded_retro_numeric 1 3742 11.7 3742 (11.7%)
pcl.stressful_experience_upset_reminded_retro_numeric Missing 14294 44.8 14294 (44.8%)
pcl.stressful_situation_avoiding_activities_retro_numeric 0 9158 28.7 9158 (28.7%)
pcl.stressful_situation_avoiding_activities_retro_numeric 1 2465 7.7 2465 (7.7%)
pcl.stressful_situation_avoiding_activities_retro_numeric Missing 20261 63.5 20261 (63.5%)

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Create subsets of data for analyses

Filter data frame to create 2 additional datasets. Additional exclusion criteria (beyond those listed above) are specified below:

  1. Retrospective - baseline change anlyses i. Exclude individuals missing retrospective and/or baseline data
  2. Prepandemic - baseline change analyses i. Exclude individuals missing pandemic and/or baseline data ii. Exclude individuals with prepandemic data collected after 1st March.

Retro-baseline analyses

[1] 23539   609

Prepan-baseline analyses Exclude individuals with NA for MHD, age, gender; exclude if prepan data collected after 1 March

[1] 11230   609

Prepan-baseline analyses Exclude individuals with NA for MHD, age, gender; exclude if prepan data collected after 1 March (to ensure comparability with prepan analyses)

[1] 11230   609
  1. Regression models (Regress covariates out of the change? Which?)
    1. Model 0: Disorders
    2. Model 1: Model 0 + Sex + Age + Ethnicity + Time registration and baseline

  2. Re-calculate change

  3. Re-rank the change again

  4. PCL:
    1. Calculate the total GLAD, COPING, RAMP baseline
    2. For each item:
      1. present percentages of how say that this is due to the pandemic
      2. Calculate a variable PCL pandemic score
      3. If one item is highly endorsed due to pandemic -> exclude in sensitivity analysis

2. Regression

Regress covariates out of the change? Which?

Model naming conventions: 0 - unadjusted 1 - adjusted a - hierarchical disorders b - overlapping disorder categories

++MD: We may want to exclude disorders from Model b that aren’t including in the hierarchy (e.g. ADHD, ASD)

Functions

GAD baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.48 2.38 2.57 0.05 0.00e+00
Anxiety disorders 4.13 3.88 4.39 0.13 5.84e-217
Eating disorders 3.76 2.94 4.58 0.42 3.03e-19
OCDs 6.52 5.85 7.19 0.34 1.26e-80
PTSD 4.97 4.31 5.64 0.34 3.36e-48
Depressive disorders 5.76 5.63 5.88 0.06 0.00e+00
Bipolar disorders 7.40 7.08 7.72 0.16 0.00e+00
n R2 adjust. R2 F p value df
31331 0.22 0.22 1503.62 0.00e+00 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.67 2.59 2.76 0.04 0.00e+00
Depressive and anxiety disorder 5.63 5.50 5.77 0.07 0.00e+00
Only depressive disorder 2.08 1.90 2.25 0.09 4.32e-117
Only anxiety disorder 4.03 3.81 4.26 0.11 1.97e-264
Eating disorders 1.46 1.22 1.69 0.12 1.10e-33
OCDs 1.94 1.71 2.17 0.12 8.53e-63
Psychotic and bipolar disorder 0.38 -0.26 1.02 0.33 0.24
Only psychotic disorder 0.35 -0.20 0.90 0.28 0.21
Only bipolar disorder 0.46 0.11 0.80 0.18 0.009
PTSD 1.56 1.35 1.77 0.11 2.35e-48
ASD 2.18 1.77 2.59 0.21 1.80e-25
ADHD 1.17 0.63 1.71 0.28 2.36e-05
Personality disorder 2.19 1.89 2.49 0.15 5.79e-46
n R2 adjust. R2 F p value df
31331 0.22 0.22 1503.62 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.89 8.47 9.31 0.21 0.00e+00
Anxiety disorders 2.97 2.71 3.23 0.13 4.70e-110
Eating disorders 2.11 1.30 2.92 0.41 3.11e-07
OCDs 4.01 3.35 4.67 0.34 1.32e-32
PTSD 3.97 3.31 4.64 0.34 1.77e-31
Depressive disorders 4.53 4.39 4.67 0.07 0.00e+00
Bipolar disorders 6.08 5.77 6.40 0.16 2.59e-300
Female 1.00 0.86 1.14 0.07 2.36e-44
Non-binary/Self-defined 1.60 1.04 2.17 0.29 2.48e-08
19-25 years -1.49 -1.90 -1.09 0.21 3.23e-13
26-35 years -3.23 -3.60 -2.85 0.19 1.59e-63
36-45 years -4.07 -4.45 -3.70 0.19 3.21e-98
46-55 years -4.80 -5.17 -4.43 0.19 8.04e-142
56-65 years -5.83 -6.20 -5.46 0.19 4.66e-209
66-70 years -6.80 -7.20 -6.40 0.20 1.32e-240
71-75 years -6.99 -7.42 -6.57 0.22 8.69e-225
76+ years -6.92 -7.46 -6.38 0.28 3.43e-137
Mixed or multiple ethnic origins 0.05 -0.40 0.50 0.23 0.84
Asian or Asian British -0.32 -0.86 0.23 0.28 0.26
African or African British -0.25 -1.18 0.68 0.47 0.60
Other ethnicity 0.98 0.15 1.81 0.42 0.02
Time difference: Lockdown to baseline -0.24 -0.27 -0.21 0.02 1.30e-55
n R2 adjust. R2 F p value df
31331 0.22 0.22 1503.62 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.89 8.50 9.29 0.20 0.00e+00
Depressive and anxiety disorder 4.61 4.46 4.75 0.07 0.00e+00
Only depressive disorder 1.81 1.63 2.00 0.09 1.19e-83
Only anxiety disorder 3.06 2.82 3.29 0.12 2.30e-145
Eating disorders 0.90 0.67 1.13 0.12 3.32e-14
OCDs 1.45 1.23 1.67 0.11 5.32e-37
Psychotic and bipolar disorder 0.74 0.12 1.37 0.32 0.02
Only psychotic disorder 0.51 -0.02 1.05 0.27 0.06
Only bipolar disorder 0.65 0.31 0.99 0.17 1.75e-04
PTSD 1.58 1.38 1.79 0.11 9.15e-51
ASD 1.31 0.90 1.72 0.21 2.74e-10
ADHD 0.46 -0.08 0.99 0.27 0.10
Personality disorder 1.82 1.52 2.11 0.15 2.43e-33
Female 0.94 0.81 1.08 0.07 1.03e-42
Non-binary/Self-defined 0.69 0.15 1.23 0.28 0.01
19-25 years -1.73 -2.10 -1.35 0.19 2.84e-19
26-35 years -3.33 -3.69 -2.98 0.18 7.22e-76
36-45 years -3.98 -4.34 -3.62 0.18 4.45e-105
46-55 years -4.49 -4.84 -4.14 0.18 4.33e-139
56-65 years -5.36 -5.70 -5.01 0.18 1.23e-200
66-70 years -6.30 -6.68 -5.93 0.19 1.11e-234
71-75 years -6.51 -6.91 -6.11 0.20 3.55e-220
76+ years -6.40 -6.91 -5.89 0.26 1.01e-131
Mixed or multiple ethnic origins 0.10 -0.33 0.53 0.22 0.65
Asian or Asian British 0.15 -0.36 0.67 0.26 0.56
African or African British -0.16 -1.05 0.72 0.45 0.72
Other ethnicity 0.74 -0.04 1.53 0.40 0.06
Key worker -0.34 -0.47 -0.22 0.06 5.46e-08
Time difference: Lockdown to baseline -0.25 -0.28 -0.22 0.01 1.19e-65
n R2 adjust. R2 F p value df
31331 0.22 0.22 1503.62 0.00e+00 6

GAD prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.16 -2.09 -0.22 0.48 0.02
Anxiety disorders 0.19 -0.84 1.22 0.53 0.72
Eating disorders -0.57 -2.60 1.47 1.04 0.59
OCDs -0.14 -1.55 1.26 0.72 0.84
PTSD -0.06 -1.68 1.57 0.83 0.95
Depressive disorders 0.85 -0.09 1.79 0.48 0.08
Bipolar disorders 0.80 -0.21 1.81 0.52 0.12
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.83 -1.51 -0.16 0.34 0.02
Depressive and anxiety disorder 0.45 -0.24 1.13 0.35 0.20
Only depressive disorder 0.98 0.24 1.72 0.38 0.009
Only anxiety disorder -0.24 -1.01 0.53 0.40 0.54
Eating disorders 0.18 -0.15 0.51 0.17 0.29
OCDs -0.26 -0.57 0.05 0.16 0.11
Psychotic and bipolar disorder -0.51 -1.42 0.39 0.46 0.27
Only psychotic disorder 0.76 0.00 1.52 0.39 0.05
Only bipolar disorder 0.20 -0.26 0.65 0.23 0.40
PTSD 0.14 -0.16 0.43 0.15 0.36
ASD 0.16 -0.44 0.76 0.31 0.61
ADHD -0.74 -1.56 0.09 0.42 0.08
Personality disorder -0.16 -0.57 0.24 0.21 0.43
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.96 -3.19 -0.72 0.63 0.002
Anxiety disorders 0.13 -0.91 1.16 0.53 0.81
Eating disorders -0.72 -2.75 1.32 1.04 0.49
OCDs -0.24 -1.65 1.16 0.72 0.74
PTSD -0.21 -1.85 1.43 0.84 0.80
Depressive disorders 0.75 -0.19 1.69 0.48 0.12
Bipolar disorders 0.76 -0.26 1.77 0.52 0.14
Female 0.49 0.21 0.77 0.14 5.29e-04
Non-binary/Self-defined 0.42 -0.37 1.22 0.40 0.29
19-25 years 0.53 -0.16 1.23 0.35 0.13
26-35 years 0.50 -0.17 1.16 0.34 0.14
36-45 years 0.65 -0.02 1.33 0.34 0.06
46-55 years 0.47 -0.20 1.14 0.34 0.17
56-65 years 0.65 -0.03 1.34 0.35 0.06
66-70 years 0.25 -0.59 1.10 0.43 0.56
71-75 years 0.18 -0.82 1.18 0.51 0.72
76+ years 0.93 -0.75 2.60 0.85 0.28
Mixed or multiple ethnic origins 0.30 -0.42 1.01 0.37 0.42
Asian or Asian British -0.25 -1.41 0.92 0.60 0.68
African or African British -1.25 -3.01 0.51 0.90 0.16
Other ethnicity 0.04 -1.08 1.17 0.57 0.94
Time difference: Lockdown to baseline 0.00 -0.07 0.06 0.03 0.89
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.67 -2.71 -0.63 0.53 0.002
Depressive and anxiety disorder 0.38 -0.31 1.08 0.35 0.27
Only depressive disorder 0.92 0.18 1.67 0.38 0.02
Only anxiety disorder -0.29 -1.07 0.49 0.40 0.47
Eating disorders 0.14 -0.20 0.47 0.17 0.42
OCDs -0.26 -0.58 0.05 0.16 0.10
Psychotic and bipolar disorder -0.40 -1.31 0.52 0.47 0.39
Only psychotic disorder 0.79 0.02 1.55 0.39 0.04
Only bipolar disorder 0.29 -0.17 0.74 0.23 0.22
PTSD 0.11 -0.18 0.41 0.15 0.46
ASD 0.25 -0.36 0.87 0.31 0.42
ADHD -0.72 -1.55 0.11 0.42 0.09
Personality disorder -0.19 -0.60 0.22 0.21 0.36
Female 0.46 0.18 0.74 0.14 0.001
Non-binary/Self-defined 0.46 -0.33 1.25 0.40 0.26
19-25 years 0.53 -0.15 1.22 0.35 0.13
26-35 years 0.49 -0.17 1.15 0.34 0.15
36-45 years 0.61 -0.06 1.28 0.34 0.08
46-55 years 0.40 -0.27 1.06 0.34 0.24
56-65 years 0.58 -0.10 1.26 0.35 0.10
66-70 years 0.16 -0.68 1.00 0.43 0.71
71-75 years 0.19 -0.80 1.18 0.51 0.71
76+ years 0.87 -0.80 2.54 0.85 0.31
Mixed or multiple ethnic origins 0.32 -0.40 1.04 0.37 0.39
Asian or Asian British -0.18 -1.35 0.98 0.60 0.76
African or African British -1.18 -2.94 0.58 0.90 0.19
Other ethnicity -0.06 -1.17 1.04 0.56 0.91
Key worker 0.17 -0.05 0.39 0.11 0.12
Time difference: Lockdown to baseline -0.01 -0.07 0.06 0.03 0.85
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.25 1.42 3.07 0.42 9.22e-08
gad.sum_score_prepan 0.55 0.53 0.56 0.01 0.00e+00
Anxiety disorders 0.59 -0.31 1.49 0.46 0.20
Eating disorders 0.79 -0.98 2.57 0.91 0.38
OCDs 1.42 0.19 2.65 0.63 0.02
PTSD 1.15 -0.27 2.57 0.73 0.11
Depressive disorders 1.51 0.68 2.33 0.42 3.39e-04
Bipolar disorders 1.86 0.98 2.75 0.45 3.80e-05
n R2 adjust. R2 F p value df
11144 0.32 0.32 743.84 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.98 2.38 3.58 0.30 1.34e-22
gad.sum_score_prepan 0.52 0.50 0.53 0.01 0.00e+00
Depressive and anxiety disorder 0.83 0.23 1.42 0.30 0.006
Only depressive disorder -0.24 -0.88 0.40 0.33 0.47
Only anxiety disorder 0.11 -0.56 0.78 0.34 0.76
Eating disorders 0.73 0.44 1.02 0.15 6.17e-07
OCDs 0.61 0.34 0.88 0.14 1.08e-05
Psychotic and bipolar disorder -0.53 -1.31 0.26 0.40 0.19
Only psychotic disorder 0.39 -0.27 1.05 0.34 0.24
Only bipolar disorder 0.17 -0.23 0.56 0.20 0.41
PTSD 0.75 0.50 1.01 0.13 5.96e-09
ASD 0.90 0.38 1.42 0.27 7.08e-04
ADHD -0.13 -0.84 0.59 0.36 0.73
Personality disorder 0.92 0.56 1.27 0.18 3.95e-07
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.40 2.31 4.48 0.56 9.83e-10
gad.sum_score_prepan 0.52 0.50 0.53 0.01 0.00e+00
Anxiety disorders 0.56 -0.34 1.46 0.46 0.22
Eating disorders 0.67 -1.09 2.44 0.90 0.45
OCDs 1.21 -0.01 2.43 0.62 0.05
PTSD 1.42 0.00 2.84 0.73 0.05
Depressive disorders 1.61 0.79 2.43 0.42 1.29e-04
Bipolar disorders 2.08 1.20 2.97 0.45 4.22e-06
Female 0.52 0.28 0.76 0.12 2.04e-05
Non-binary/Self-defined 0.81 0.13 1.50 0.35 0.02
19-25 years -0.23 -0.83 0.38 0.31 0.46
26-35 years -0.95 -1.54 -0.37 0.30 0.001
36-45 years -1.13 -1.72 -0.54 0.30 1.67e-04
46-55 years -1.46 -2.05 -0.87 0.30 1.08e-06
56-65 years -1.95 -2.55 -1.35 0.31 2.03e-10
66-70 years -3.00 -3.74 -2.26 0.38 2.31e-15
71-75 years -3.31 -4.18 -2.43 0.45 1.22e-13
76+ years -2.72 -4.17 -1.26 0.74 2.47e-04
Mixed or multiple ethnic origins 0.08 -0.55 0.71 0.32 0.80
Asian or Asian British -0.16 -1.18 0.85 0.52 0.75
African or African British -0.47 -1.99 1.05 0.78 0.55
Other ethnicity 0.50 -0.48 1.47 0.50 0.32
Key worker -0.33 -0.52 -0.15 0.10 5.01e-04
Time difference: Lockdown to baseline 0.00 -0.06 0.05 0.03 0.92
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.11 3.20 5.02 0.46 8.29e-19
gad.sum_score_prepan 0.49 0.48 0.51 0.01 0.00e+00
Depressive and anxiety disorder 0.92 0.33 1.52 0.30 0.002
Only depressive disorder 0.01 -0.63 0.66 0.33 0.96
Only anxiety disorder 0.07 -0.60 0.74 0.34 0.83
Eating disorders 0.61 0.32 0.89 0.15 3.79e-05
OCDs 0.53 0.26 0.80 0.14 1.22e-04
Psychotic and bipolar disorder -0.26 -1.05 0.52 0.40 0.51
Only psychotic disorder 0.45 -0.20 1.10 0.33 0.18
Only bipolar disorder 0.32 -0.07 0.71 0.20 0.11
PTSD 0.82 0.56 1.07 0.13 2.73e-10
ASD 0.70 0.18 1.23 0.27 0.009
ADHD -0.21 -0.92 0.50 0.36 0.55
Personality disorder 0.80 0.44 1.15 0.18 1.06e-05
Female 0.40 0.16 0.64 0.12 9.85e-04
Non-binary/Self-defined 0.41 -0.27 1.09 0.35 0.23
19-25 years -0.29 -0.88 0.30 0.30 0.34
26-35 years -1.04 -1.61 -0.47 0.29 3.54e-04
36-45 years -1.19 -1.76 -0.61 0.29 5.70e-05
46-55 years -1.47 -2.05 -0.90 0.29 5.40e-07
56-65 years -1.90 -2.49 -1.31 0.30 2.61e-10
66-70 years -2.88 -3.61 -2.15 0.37 1.06e-14
71-75 years -3.07 -3.93 -2.21 0.44 2.42e-12
76+ years -2.57 -4.00 -1.13 0.73 4.67e-04
Mixed or multiple ethnic origins 0.06 -0.56 0.68 0.32 0.86
Asian or Asian British -0.03 -1.03 0.97 0.51 0.96
African or African British -0.39 -1.90 1.12 0.77 0.62
Other ethnicity 0.40 -0.55 1.34 0.48 0.41
Key worker -0.22 -0.41 -0.04 0.09 0.02
Time difference: Lockdown to baseline 0.00 -0.05 0.06 0.03 0.89
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

GAD retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.58 2.44 2.72 0.07 9.69e-272
Anxiety disorders 0.82 0.51 1.13 0.16 1.80e-07
Eating disorders 0.41 -0.51 1.33 0.47 0.38
OCDs 1.10 0.32 1.88 0.40 0.006
PTSD 1.01 0.24 1.78 0.39 0.01
Depressive disorders 0.87 0.71 1.04 0.09 4.00e-24
Bipolar disorders 0.86 0.49 1.24 0.19 5.71e-06
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.58 2.45 2.71 0.07 2.17e-303
Depressive and anxiety disorder 0.85 0.68 1.03 0.09 4.94e-21
Only depressive disorder 0.25 0.01 0.48 0.12 0.04
Only anxiety disorder 0.86 0.58 1.15 0.14 2.26e-09
Eating disorders 0.49 0.22 0.76 0.14 4.28e-04
OCDs 0.05 -0.21 0.31 0.13 0.72
Psychotic and bipolar disorder -0.20 -0.96 0.56 0.39 0.61
Only psychotic disorder -0.28 -0.94 0.38 0.34 0.41
Only bipolar disorder -0.21 -0.62 0.19 0.21 0.30
PTSD 0.41 0.17 0.66 0.12 8.72e-04
ASD 0.36 -0.12 0.83 0.24 0.14
ADHD 0.01 -0.63 0.64 0.32 0.99
Personality disorder 0.29 -0.06 0.64 0.18 0.11
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.84 3.34 4.34 0.25 4.80e-51
Anxiety disorders 0.57 0.25 0.90 0.17 5.42e-04
Eating disorders 0.03 -0.91 0.96 0.48 0.96
OCDs 0.54 -0.25 1.34 0.41 0.18
PTSD 0.78 -0.01 1.58 0.41 0.05
Depressive disorders 0.64 0.45 0.82 0.10 2.71e-11
Bipolar disorders 0.65 0.27 1.03 0.20 9.33e-04
Female 0.77 0.57 0.97 0.10 2.12e-14
Non-binary/Self-defined -0.24 -0.90 0.43 0.34 0.48
19-25 years 1.02 0.56 1.47 0.23 1.13e-05
26-35 years 0.31 -0.12 0.74 0.22 0.15
36-45 years -0.18 -0.61 0.25 0.22 0.41
46-55 years -0.37 -0.79 0.05 0.22 0.09
56-65 years -0.53 -0.96 -0.11 0.22 0.01
66-70 years -0.83 -1.33 -0.34 0.25 0.001
71-75 years -1.20 -1.76 -0.65 0.28 2.41e-05
76+ years -1.53 -2.36 -0.69 0.43 3.31e-04
Mixed or multiple ethnic origins -0.65 -1.19 -0.11 0.28 0.02
Asian or Asian British -0.45 -1.16 0.26 0.36 0.22
African or African British -0.55 -1.73 0.62 0.60 0.35
Other ethnicity -0.03 -0.99 0.93 0.49 0.95
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 5.62e-34
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.74 3.26 4.23 0.25 2.13e-51
Depressive and anxiety disorder 0.65 0.46 0.85 0.10 4.27e-11
Only depressive disorder 0.25 0.00 0.51 0.13 0.05
Only anxiety disorder 0.64 0.34 0.93 0.15 2.89e-05
Eating disorders 0.29 0.01 0.56 0.14 0.04
OCDs -0.09 -0.36 0.17 0.14 0.49
Psychotic and bipolar disorder 0.09 -0.67 0.86 0.39 0.81
Only psychotic disorder -0.05 -0.71 0.62 0.34 0.89
Only bipolar disorder -0.11 -0.52 0.30 0.21 0.60
PTSD 0.43 0.18 0.68 0.13 6.90e-04
ASD 0.36 -0.13 0.85 0.25 0.15
ADHD -0.06 -0.70 0.58 0.33 0.85
Personality disorder 0.18 -0.18 0.54 0.18 0.32
Female 0.73 0.53 0.93 0.10 4.08e-13
Non-binary/Self-defined -0.32 -0.98 0.34 0.34 0.35
19-25 years 0.94 0.50 1.38 0.23 3.14e-05
26-35 years 0.19 -0.22 0.61 0.21 0.36
36-45 years -0.30 -0.72 0.12 0.22 0.17
46-55 years -0.47 -0.88 -0.05 0.21 0.03
56-65 years -0.52 -0.93 -0.10 0.21 0.01
66-70 years -0.68 -1.16 -0.19 0.25 0.006
71-75 years -1.06 -1.60 -0.51 0.28 1.56e-04
76+ years -1.37 -2.18 -0.55 0.42 0.001
Mixed or multiple ethnic origins -0.57 -1.10 -0.03 0.27 0.04
Asian or Asian British -0.22 -0.90 0.47 0.35 0.53
African or African British -0.63 -1.80 0.53 0.59 0.29
Other ethnicity -0.10 -1.04 0.83 0.48 0.83
Key worker 0.31 0.15 0.48 0.08 1.19e-04
Time difference: Lockdown to baseline -0.22 -0.26 -0.19 0.02 4.81e-34
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.53 3.40 3.67 0.07 0.00e+00
gad.sum_score_retro 0.61 0.59 0.62 0.01 0.00e+00
Anxiety disorders 1.81 1.52 2.11 0.15 1.59e-33
Eating disorders 1.26 0.40 2.13 0.44 0.004
OCDs 2.70 1.97 3.44 0.38 5.91e-13
PTSD 2.16 1.43 2.88 0.37 5.60e-09
Depressive disorders 2.28 2.11 2.45 0.09 1.24e-151
Bipolar disorders 2.94 2.57 3.30 0.18 7.53e-57
n R2 adjust. R2 F p value df
18588 0.32 0.32 1276.84 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.75 3.62 3.88 0.07 0.00e+00
gad.sum_score_retro 0.55 0.54 0.57 0.01 0.00e+00
Depressive and anxiety disorder 2.31 2.14 2.49 0.09 3.78e-148
Only depressive disorder 0.67 0.45 0.89 0.11 2.55e-09
Only anxiety disorder 1.89 1.63 2.16 0.14 4.35e-44
Eating disorders 0.78 0.53 1.03 0.13 1.83e-09
OCDs 0.75 0.50 0.99 0.12 2.15e-09
Psychotic and bipolar disorder 0.10 -0.60 0.81 0.36 0.77
Only psychotic disorder 0.03 -0.58 0.65 0.31 0.92
Only bipolar disorder 0.16 -0.21 0.54 0.19 0.40
PTSD 0.84 0.61 1.07 0.12 3.49e-13
ASD 1.02 0.58 1.46 0.22 6.19e-06
ADHD 0.44 -0.15 1.03 0.30 0.14
Personality disorder 1.09 0.76 1.42 0.17 6.62e-11
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.60 6.13 7.08 0.24 3.52e-160
gad.sum_score_retro 0.56 0.54 0.57 0.01 0.00e+00
Anxiety disorders 1.48 1.18 1.79 0.15 1.21e-21
Eating disorders 0.78 -0.09 1.65 0.44 0.08
OCDs 1.90 1.16 2.64 0.38 4.84e-07
PTSD 1.98 1.24 2.73 0.38 1.79e-07
Depressive disorders 2.07 1.89 2.26 0.09 1.34e-109
Bipolar disorders 2.77 2.41 3.14 0.19 2.09e-49
Female 0.76 0.57 0.94 0.09 6.80e-16
Non-binary/Self-defined 0.28 -0.33 0.90 0.31 0.37
19-25 years -0.05 -0.48 0.37 0.22 0.81
26-35 years -1.04 -1.45 -0.64 0.21 3.56e-07
36-45 years -1.64 -2.05 -1.23 0.21 4.23e-15
46-55 years -1.97 -2.37 -1.56 0.20 9.93e-22
56-65 years -2.42 -2.82 -2.02 0.20 4.11e-32
66-70 years -2.95 -3.42 -2.48 0.24 6.06e-35
71-75 years -3.36 -3.88 -2.83 0.27 6.44e-36
76+ years -3.41 -4.19 -2.64 0.40 7.58e-18
Mixed or multiple ethnic origins -0.40 -0.90 0.10 0.26 0.12
Asian or Asian British -0.28 -0.94 0.38 0.34 0.40
African or African British -0.20 -1.29 0.89 0.56 0.72
Other ethnicity 0.27 -0.62 1.16 0.46 0.55
Key worker -0.04 -0.19 0.11 0.08 0.58
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 3.47e-39
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.83 6.37 7.29 0.23 1.01e-183
gad.sum_score_retro 0.51 0.50 0.53 0.01 0.00e+00
Depressive and anxiety disorder 2.15 1.96 2.33 0.09 1.30e-112
Only depressive disorder 0.79 0.56 1.02 0.12 3.26e-11
Only anxiety disorder 1.61 1.34 1.89 0.14 2.29e-30
Eating disorders 0.52 0.26 0.77 0.13 6.90e-05
OCDs 0.57 0.33 0.82 0.13 5.17e-06
Psychotic and bipolar disorder 0.42 -0.28 1.12 0.36 0.24
Only psychotic disorder 0.26 -0.36 0.87 0.31 0.41
Only bipolar disorder 0.30 -0.08 0.67 0.19 0.13
PTSD 0.92 0.69 1.15 0.12 3.14e-15
ASD 0.78 0.33 1.23 0.23 6.56e-04
ADHD 0.24 -0.35 0.83 0.30 0.42
Personality disorder 1.00 0.67 1.33 0.17 2.51e-09
Female 0.70 0.52 0.88 0.09 2.67e-14
Non-binary/Self-defined -0.11 -0.71 0.50 0.31 0.73
19-25 years -0.27 -0.68 0.14 0.21 0.19
26-35 years -1.27 -1.66 -0.89 0.20 1.12e-10
36-45 years -1.81 -2.20 -1.41 0.20 2.26e-19
46-55 years -2.04 -2.42 -1.65 0.20 6.20e-25
56-65 years -2.38 -2.76 -1.99 0.20 2.22e-33
66-70 years -2.80 -3.25 -2.35 0.23 7.82e-34
71-75 years -3.17 -3.68 -2.66 0.26 3.08e-34
76+ years -3.24 -3.99 -2.49 0.38 3.39e-17
Mixed or multiple ethnic origins -0.30 -0.79 0.19 0.25 0.23
Asian or Asian British 0.08 -0.55 0.71 0.32 0.81
African or African British -0.17 -1.24 0.90 0.55 0.76
Other ethnicity 0.19 -0.68 1.05 0.44 0.67
Key worker 0.05 -0.10 0.19 0.08 0.53
Time difference: Lockdown to baseline -0.23 -0.27 -0.20 0.02 2.12e-42
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

GAD retro: sensitivity

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.16 1.00 3.32 0.59 2.65e-04
Anxiety disorders 1.11 -0.16 2.38 0.65 0.09
Eating disorders 1.99 -0.40 4.38 1.22 0.10
OCDs 1.16 -0.57 2.88 0.88 0.19
PTSD 1.80 -0.09 3.70 0.97 0.06
Depressive disorders 1.19 0.03 2.36 0.60 0.05
Bipolar disorders 1.05 -0.20 2.30 0.64 0.10
n R2 adjust. R2 F p value df
8058 0.00 0.00 0.94 0.47 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.55 1.72 3.38 0.42 1.97e-09
Depressive and anxiety disorder 0.73 -0.11 1.57 0.43 0.09
Only depressive disorder 0.15 -0.76 1.07 0.47 0.74
Only anxiety disorder 0.84 -0.11 1.78 0.48 0.08
Eating disorders 0.55 0.16 0.93 0.20 0.006
OCDs -0.21 -0.57 0.15 0.18 0.25
Psychotic and bipolar disorder -0.30 -1.39 0.79 0.56 0.59
Only psychotic disorder -0.16 -1.07 0.74 0.46 0.73
Only bipolar disorder -0.29 -0.83 0.24 0.27 0.28
PTSD 0.39 0.06 0.73 0.17 0.02
ASD 0.22 -0.49 0.92 0.36 0.55
ADHD 0.12 -0.86 1.09 0.50 0.81
Personality disorder 0.42 -0.06 0.90 0.24 0.09
n R2 adjust. R2 F p value df
8058 0.00 0.00 0.94 0.47 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.30 0.82 3.79 0.76 0.002
Anxiety disorders 0.99 -0.27 2.25 0.64 0.12
Eating disorders 1.69 -0.69 4.06 1.21 0.16
OCDs 0.90 -0.81 2.61 0.87 0.30
PTSD 1.94 0.06 3.82 0.96 0.04
Depressive disorders 1.23 0.06 2.39 0.59 0.04
Bipolar disorders 1.17 -0.08 2.41 0.63 0.07
Female 0.67 0.33 1.01 0.17 1.22e-04
Non-binary/Self-defined -0.64 -1.56 0.28 0.47 0.17
19-25 years 0.94 0.14 1.73 0.41 0.02
26-35 years 0.22 -0.54 0.99 0.39 0.57
36-45 years -0.24 -1.01 0.54 0.40 0.55
46-55 years -0.44 -1.21 0.33 0.39 0.26
56-65 years -0.94 -1.74 -0.15 0.41 0.02
66-70 years -1.20 -2.24 -0.17 0.53 0.02
71-75 years -1.84 -3.08 -0.59 0.64 0.004
76+ years -2.69 -5.01 -0.37 1.19 0.02
Mixed or multiple ethnic origins -0.80 -1.63 0.03 0.42 0.06
Asian or Asian British 0.11 -1.24 1.47 0.69 0.87
African or African British -1.27 -3.25 0.71 1.01 0.21
Other ethnicity 0.05 -1.26 1.36 0.67 0.94
Time difference: Lockdown to baseline -0.07 -0.15 0.00 0.04 0.05
n R2 adjust. R2 F p value df
8058 0.00 0.00 0.94 0.47 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.71 1.48 3.95 0.63 1.74e-05
Depressive and anxiety disorder 0.71 -0.14 1.55 0.43 0.10
Only depressive disorder 0.37 -0.54 1.29 0.47 0.43
Only anxiety disorder 0.67 -0.27 1.62 0.48 0.16
Eating disorders 0.37 -0.02 0.76 0.20 0.06
OCDs -0.27 -0.63 0.09 0.18 0.15
Psychotic and bipolar disorder 0.03 -1.05 1.12 0.55 0.95
Only psychotic disorder 0.11 -0.80 1.02 0.46 0.81
Only bipolar disorder -0.17 -0.70 0.37 0.27 0.54
PTSD 0.46 0.12 0.80 0.17 0.008
ASD 0.25 -0.46 0.96 0.36 0.50
ADHD 0.21 -0.76 1.18 0.50 0.67
Personality disorder 0.29 -0.19 0.77 0.24 0.23
Female 0.59 0.25 0.93 0.17 7.07e-04
Non-binary/Self-defined -0.76 -1.68 0.16 0.47 0.10
19-25 years 0.84 0.05 1.63 0.40 0.04
26-35 years 0.09 -0.67 0.86 0.39 0.81
36-45 years -0.35 -1.12 0.43 0.39 0.38
46-55 years -0.56 -1.33 0.22 0.39 0.16
56-65 years -0.96 -1.75 -0.16 0.41 0.02
66-70 years -1.13 -2.16 -0.10 0.53 0.03
71-75 years -1.60 -2.84 -0.36 0.63 0.01
76+ years -2.51 -4.83 -0.20 1.18 0.03
Mixed or multiple ethnic origins -0.74 -1.57 0.09 0.42 0.08
Asian or Asian British 0.14 -1.20 1.49 0.69 0.83
African or African British -1.24 -3.21 0.74 1.01 0.22
Other ethnicity -0.14 -1.42 1.14 0.65 0.83
Key worker 0.36 0.11 0.61 0.13 0.005
Time difference: Lockdown to baseline -0.07 -0.15 0.00 0.04 0.06
n R2 adjust. R2 F p value df
8058 0.00 0.00 0.94 0.47 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.62 3.56 5.69 0.54 2.04e-17
gad.sum_score_retro 0.52 0.50 0.55 0.01 0.00e+00
Anxiety disorders 1.15 0.00 2.31 0.59 0.05
Eating disorders 2.74 0.56 4.93 1.11 0.01
OCDs 2.21 0.64 3.78 0.80 0.006
PTSD 2.11 0.39 3.84 0.88 0.02
Depressive disorders 1.73 0.66 2.79 0.54 0.001
Bipolar disorders 2.17 1.03 3.31 0.58 1.86e-04
n R2 adjust. R2 F p value df
8058 0.20 0.20 290.49 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.45 4.69 6.21 0.39 2.82e-44
gad.sum_score_retro 0.48 0.46 0.51 0.01 0.00e+00
Depressive and anxiety disorder 0.89 0.13 1.65 0.39 0.02
Only depressive disorder -0.64 -1.46 0.18 0.42 0.13
Only anxiety disorder 0.67 -0.18 1.52 0.43 0.12
Eating disorders 0.88 0.53 1.23 0.18 8.46e-07
OCDs 0.51 0.19 0.84 0.17 0.002
Psychotic and bipolar disorder -0.33 -1.31 0.65 0.50 0.51
Only psychotic disorder 0.14 -0.68 0.95 0.42 0.74
Only bipolar disorder 0.07 -0.41 0.55 0.25 0.77
PTSD 0.84 0.54 1.15 0.16 6.51e-08
ASD 0.86 0.23 1.49 0.32 0.008
ADHD 0.52 -0.36 1.39 0.45 0.25
Personality disorder 1.26 0.83 1.69 0.22 1.31e-08
n R2 adjust. R2 F p value df
9688 0.01 0.01 11.18 1.82e-12 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.89 4.53 7.26 0.70 2.81e-17
gad.sum_score_retro 0.50 0.48 0.53 0.01 0.00e+00
Anxiety disorders 1.16 0.02 2.31 0.58 0.05
Eating disorders 2.59 0.43 4.74 1.10 0.02
OCDs 2.00 0.44 3.55 0.79 0.01
PTSD 2.51 0.80 4.22 0.87 0.004
Depressive disorders 1.99 0.93 3.05 0.54 2.34e-04
Bipolar disorders 2.54 1.40 3.67 0.58 1.17e-05
Female 0.53 0.22 0.84 0.16 7.40e-04
Non-binary/Self-defined 0.01 -0.82 0.84 0.42 0.99
19-25 years -0.12 -0.85 0.60 0.37 0.74
26-35 years -1.11 -1.81 -0.41 0.36 0.002
36-45 years -1.56 -2.27 -0.85 0.36 1.60e-05
46-55 years -1.87 -2.57 -1.16 0.36 2.50e-07
56-65 years -2.58 -3.31 -1.86 0.37 3.91e-12
66-70 years -3.19 -4.14 -2.25 0.48 3.37e-11
71-75 years -4.04 -5.18 -2.91 0.58 3.22e-12
76+ years -3.80 -5.91 -1.70 1.07 3.98e-04
Mixed or multiple ethnic origins -0.60 -1.35 0.15 0.38 0.12
Asian or Asian British 0.20 -1.03 1.43 0.63 0.75
African or African British -0.42 -2.21 1.37 0.91 0.64
Other ethnicity 0.37 -0.81 1.56 0.60 0.53
Key worker -0.16 -0.39 0.07 0.12 0.18
Time difference: Lockdown to baseline -0.04 -0.11 0.03 0.03 0.30
n R2 adjust. R2 F p value df
9688 0.01 0.01 11.18 1.82e-12 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.80 5.68 7.92 0.57 3.94e-32
gad.sum_score_retro 0.47 0.45 0.49 0.01 2.49e-310
Depressive and anxiety disorder 1.03 0.27 1.79 0.39 0.008
Only depressive disorder -0.21 -1.03 0.61 0.42 0.61
Only anxiety disorder 0.58 -0.27 1.43 0.43 0.18
Eating disorders 0.69 0.34 1.04 0.18 1.04e-04
OCDs 0.42 0.10 0.75 0.17 0.01
Psychotic and bipolar disorder -0.02 -0.99 0.95 0.50 0.97
Only psychotic disorder 0.34 -0.47 1.16 0.41 0.41
Only bipolar disorder 0.21 -0.27 0.69 0.24 0.39
PTSD 0.94 0.63 1.24 0.16 1.62e-09
ASD 0.65 0.01 1.29 0.32 0.05
ADHD 0.53 -0.35 1.40 0.44 0.24
Personality disorder 1.12 0.69 1.55 0.22 3.69e-07
Female 0.39 0.09 0.70 0.16 0.01
Non-binary/Self-defined -0.43 -1.26 0.39 0.42 0.30
19-25 years -0.21 -0.92 0.50 0.36 0.56
26-35 years -1.20 -1.88 -0.51 0.35 6.43e-04
36-45 years -1.60 -2.29 -0.90 0.36 7.04e-06
46-55 years -1.83 -2.52 -1.13 0.36 2.79e-07
56-65 years -2.43 -3.15 -1.72 0.37 2.89e-11
66-70 years -3.00 -3.93 -2.07 0.47 2.51e-10
71-75 years -3.59 -4.71 -2.48 0.57 2.72e-10
76+ years -3.46 -5.54 -1.39 1.06 0.001
Mixed or multiple ethnic origins -0.56 -1.30 0.18 0.38 0.14
Asian or Asian British 0.30 -0.91 1.51 0.62 0.63
African or African British -0.32 -2.10 1.45 0.90 0.72
Other ethnicity 0.23 -0.91 1.38 0.58 0.69
Key worker -0.03 -0.25 0.20 0.12 0.82
Time difference: Lockdown to baseline -0.03 -0.10 0.04 0.03 0.39
n R2 adjust. R2 F p value df
9688 0.01 0.01 11.18 1.82e-12 6

PHQ baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.31 3.20 3.42 0.05 0.00e+00
Anxiety disorders 3.48 3.20 3.77 0.15 1.82e-122
Eating disorders 4.06 3.14 4.99 0.47 8.24e-18
OCDs 6.00 5.24 6.76 0.39 3.57e-54
PTSD 5.18 4.42 5.93 0.39 5.41e-41
Depressive disorders 7.19 7.05 7.33 0.07 0.00e+00
Bipolar disorders 9.75 9.39 10.12 0.19 0.00e+00
n R2 adjust. R2 F p value df
31315 0.26 0.26 1846.76 0.00e+00 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.56 3.46 3.66 0.05 0.00e+00
Depressive and anxiety disorder 6.64 6.49 6.79 0.08 0.00e+00
Only depressive disorder 3.53 3.33 3.73 0.10 7.11e-257
Only anxiety disorder 3.22 2.97 3.48 0.13 5.24e-133
Eating disorders 2.18 1.92 2.45 0.14 4.24e-57
OCDs 2.04 1.78 2.30 0.13 4.62e-54
Psychotic and bipolar disorder 0.27 -0.46 1.00 0.37 0.47
Only psychotic disorder 0.80 0.17 1.42 0.32 0.01
Only bipolar disorder 1.31 0.91 1.70 0.20 6.16e-11
PTSD 2.05 1.81 2.29 0.12 1.16e-63
ASD 2.80 2.34 3.27 0.24 4.82e-32
ADHD 1.90 1.28 2.51 0.31 1.73e-09
Personality disorder 3.40 3.06 3.74 0.17 6.36e-84
n R2 adjust. R2 F p value df
31315 0.26 0.26 1846.76 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.06 11.59 12.54 0.24 0.00e+00
Anxiety disorders 2.12 1.82 2.41 0.15 2.72e-45
Eating disorders 2.22 1.31 3.13 0.46 1.85e-06
OCDs 3.15 2.41 3.90 0.38 1.21e-16
PTSD 4.05 3.29 4.80 0.38 7.75e-26
Depressive disorders 5.92 5.76 6.07 0.08 0.00e+00
Bipolar disorders 8.34 7.98 8.70 0.18 0.00e+00
Female 0.92 0.76 1.08 0.08 3.84e-30
Non-binary/Self-defined 2.57 1.93 3.21 0.32 2.66e-15
19-25 years -3.52 -3.97 -3.06 0.23 6.32e-52
26-35 years -5.86 -6.28 -5.43 0.22 6.84e-160
36-45 years -6.63 -7.06 -6.21 0.22 2.00e-200
46-55 years -7.10 -7.52 -6.69 0.21 2.19e-240
56-65 years -8.28 -8.70 -7.87 0.21 0.00e+00
66-70 years -9.46 -9.91 -9.01 0.23 0.00e+00
71-75 years -9.59 -10.07 -9.11 0.24 0.00e+00
76+ years -9.46 -10.07 -8.84 0.31 2.59e-198
Mixed or multiple ethnic origins 0.39 -0.12 0.90 0.26 0.14
Asian or Asian British -0.13 -0.75 0.49 0.31 0.69
African or African British 0.00 -1.05 1.05 0.53 1.00
Other ethnicity 1.15 0.21 2.09 0.48 0.02
Time difference: Lockdown to baseline -0.21 -0.25 -0.18 0.02 7.66e-36
n R2 adjust. R2 F p value df
31315 0.26 0.26 1846.76 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.29 11.84 12.73 0.23 0.00e+00
Depressive and anxiety disorder 5.56 5.40 5.73 0.08 0.00e+00
Only depressive disorder 3.38 3.17 3.58 0.11 6.14e-221
Only anxiety disorder 2.05 1.79 2.31 0.13 9.24e-53
Eating disorders 1.56 1.30 1.82 0.13 3.95e-31
OCDs 1.44 1.19 1.69 0.13 6.72e-29
Psychotic and bipolar disorder 0.55 -0.16 1.26 0.36 0.13
Only psychotic disorder 0.87 0.26 1.48 0.31 0.005
Only bipolar disorder 1.48 1.10 1.86 0.20 3.55e-14
PTSD 2.08 1.84 2.31 0.12 1.64e-67
ASD 1.48 1.02 1.94 0.23 3.28e-10
ADHD 1.10 0.49 1.70 0.31 3.73e-04
Personality disorder 3.05 2.72 3.39 0.17 4.68e-71
Female 0.84 0.69 0.99 0.08 2.58e-27
Non-binary/Self-defined 1.38 0.77 1.99 0.31 9.36e-06
19-25 years -3.79 -4.22 -3.37 0.22 8.38e-68
26-35 years -5.95 -6.35 -5.55 0.20 1.54e-184
36-45 years -6.54 -6.95 -6.14 0.21 1.31e-217
46-55 years -6.79 -7.19 -6.40 0.20 3.97e-245
56-65 years -7.87 -8.26 -7.48 0.20 0.00e+00
66-70 years -9.10 -9.52 -8.68 0.22 0.00e+00
71-75 years -9.27 -9.72 -8.82 0.23 0.00e+00
76+ years -9.11 -9.69 -8.54 0.30 5.70e-206
Mixed or multiple ethnic origins 0.38 -0.11 0.86 0.25 0.13
Asian or Asian British 0.29 -0.29 0.87 0.30 0.33
African or African British 0.19 -0.81 1.18 0.51 0.71
Other ethnicity 0.80 -0.09 1.69 0.45 0.08
Key worker -0.67 -0.81 -0.53 0.07 1.27e-20
Time difference: Lockdown to baseline -0.22 -0.25 -0.19 0.02 7.11e-42
n R2 adjust. R2 F p value df
31315 0.26 0.26 1846.76 0.00e+00 6

PHQ prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.65 -2.63 -0.67 0.50 9.81e-04
Anxiety disorders 1.89 0.81 2.97 0.55 5.93e-04
Eating disorders 0.02 -2.07 2.12 1.07 0.98
OCDs 1.82 0.36 3.29 0.75 0.01
PTSD 1.28 -0.43 2.99 0.87 0.14
Depressive disorders 1.19 0.20 2.17 0.50 0.02
Bipolar disorders 0.79 -0.27 1.85 0.54 0.15
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.55 -2.26 -0.84 0.36 1.69e-05
Depressive and anxiety disorder 1.08 0.36 1.79 0.37 0.003
Only depressive disorder 0.94 0.16 1.71 0.39 0.02
Only anxiety disorder 1.75 0.94 2.56 0.41 2.28e-05
Eating disorders 0.37 0.02 0.72 0.18 0.04
OCDs 0.01 -0.32 0.33 0.17 0.96
Psychotic and bipolar disorder -0.79 -1.75 0.17 0.49 0.11
Only psychotic disorder 0.13 -0.66 0.92 0.40 0.75
Only bipolar disorder -0.32 -0.80 0.15 0.24 0.18
PTSD -0.17 -0.48 0.13 0.16 0.26
ASD 0.35 -0.28 0.98 0.32 0.28
ADHD 0.07 -0.79 0.93 0.44 0.87
Personality disorder -0.02 -0.44 0.41 0.22 0.93
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.08 -3.37 -0.79 0.66 0.002
Anxiety disorders 1.82 0.74 2.90 0.55 9.92e-04
Eating disorders -0.14 -2.24 1.96 1.07 0.90
OCDs 1.65 0.18 3.11 0.75 0.03
PTSD 1.03 -0.69 2.75 0.88 0.24
Depressive disorders 1.13 0.14 2.12 0.50 0.02
Bipolar disorders 0.79 -0.28 1.85 0.54 0.15
Female 0.29 0.00 0.58 0.15 0.05
Non-binary/Self-defined -0.11 -0.93 0.72 0.42 0.80
19-25 years 0.03 -0.69 0.75 0.37 0.93
26-35 years -0.03 -0.72 0.66 0.35 0.93
36-45 years -0.07 -0.77 0.64 0.36 0.85
46-55 years -0.37 -1.06 0.33 0.36 0.30
56-65 years -0.39 -1.11 0.32 0.37 0.28
66-70 years -0.34 -1.22 0.54 0.45 0.45
71-75 years -0.70 -1.74 0.35 0.53 0.19
76+ years 0.16 -1.60 1.92 0.90 0.86
Mixed or multiple ethnic origins -0.01 -0.76 0.74 0.38 0.97
Asian or Asian British -1.33 -2.55 -0.11 0.62 0.03
African or African British -1.12 -2.96 0.71 0.94 0.23
Other ethnicity -0.05 -1.22 1.11 0.60 0.93
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.07
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.10 -3.18 -1.01 0.55 1.51e-04
Depressive and anxiety disorder 1.09 0.37 1.81 0.37 0.003
Only depressive disorder 0.99 0.21 1.77 0.40 0.01
Only anxiety disorder 1.72 0.91 2.54 0.42 3.42e-05
Eating disorders 0.32 -0.03 0.67 0.18 0.07
OCDs -0.02 -0.34 0.31 0.17 0.92
Psychotic and bipolar disorder -0.69 -1.65 0.27 0.49 0.16
Only psychotic disorder 0.15 -0.65 0.94 0.41 0.72
Only bipolar disorder -0.22 -0.70 0.25 0.24 0.36
PTSD -0.17 -0.48 0.14 0.16 0.27
ASD 0.35 -0.29 0.99 0.33 0.29
ADHD 0.05 -0.81 0.91 0.44 0.91
Personality disorder -0.05 -0.48 0.37 0.22 0.80
Female 0.26 -0.04 0.55 0.15 0.09
Non-binary/Self-defined -0.11 -0.94 0.72 0.42 0.79
19-25 years -0.01 -0.72 0.71 0.37 0.98
26-35 years -0.05 -0.74 0.64 0.35 0.89
36-45 years -0.07 -0.76 0.63 0.36 0.85
46-55 years -0.37 -1.06 0.33 0.36 0.30
56-65 years -0.38 -1.09 0.34 0.36 0.30
66-70 years -0.25 -1.12 0.63 0.45 0.58
71-75 years -0.58 -1.62 0.46 0.53 0.27
76+ years 0.24 -1.52 2.00 0.90 0.79
Mixed or multiple ethnic origins 0.02 -0.73 0.77 0.38 0.96
Asian or Asian British -1.19 -2.41 0.03 0.62 0.06
African or African British -1.09 -2.93 0.75 0.94 0.25
Other ethnicity -0.27 -1.43 0.89 0.59 0.64
Key worker 0.12 -0.10 0.35 0.12 0.29
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.15 1.27 3.04 0.45 1.76e-06
phq.sum_score_prepan 0.61 0.60 0.63 0.01 0.00e+00
Anxiety disorders 0.84 -0.13 1.80 0.49 0.09
Eating disorders 0.25 -1.62 2.12 0.95 0.79
OCDs 1.91 0.61 3.21 0.66 0.004
PTSD 1.14 -0.38 2.66 0.78 0.14
Depressive disorders 1.83 0.95 2.71 0.45 4.61e-05
Bipolar disorders 2.21 1.26 3.16 0.48 4.76e-06
n R2 adjust. R2 F p value df
11134 0.41 0.41 1107.68 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.76 2.12 3.40 0.33 3.18e-17
phq.sum_score_prepan 0.59 0.57 0.60 0.01 0.00e+00
Depressive and anxiety disorder 1.18 0.55 1.81 0.32 2.47e-04
Only depressive disorder 0.52 -0.16 1.20 0.35 0.13
Only anxiety disorder 0.40 -0.32 1.11 0.37 0.28
Eating disorders 1.02 0.72 1.33 0.16 6.68e-11
OCDs 0.68 0.39 0.96 0.15 4.12e-06
Psychotic and bipolar disorder -0.69 -1.53 0.16 0.43 0.11
Only psychotic disorder 0.19 -0.50 0.89 0.36 0.58
Only bipolar disorder 0.15 -0.27 0.56 0.21 0.49
PTSD 0.58 0.31 0.85 0.14 2.86e-05
ASD 1.04 0.48 1.59 0.28 2.62e-04
ADHD 0.46 -0.30 1.22 0.39 0.23
Personality disorder 1.28 0.90 1.66 0.19 3.03e-11
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.88 2.72 5.04 0.59 6.34e-11
phq.sum_score_prepan 0.58 0.57 0.60 0.01 0.00e+00
Anxiety disorders 0.74 -0.22 1.70 0.49 0.13
Eating disorders 0.16 -1.69 2.02 0.95 0.86
OCDs 1.60 0.31 2.90 0.66 0.02
PTSD 1.26 -0.26 2.78 0.78 0.10
Depressive disorders 2.01 1.13 2.89 0.45 7.48e-06
Bipolar disorders 2.51 1.56 3.46 0.48 2.07e-07
Female 0.29 0.03 0.54 0.13 0.03
Non-binary/Self-defined 0.69 -0.04 1.42 0.37 0.06
19-25 years -0.93 -1.57 -0.29 0.33 0.004
26-35 years -1.75 -2.37 -1.14 0.32 2.79e-08
36-45 years -1.97 -2.60 -1.34 0.32 7.37e-10
46-55 years -2.20 -2.82 -1.58 0.32 4.87e-12
56-65 years -2.79 -3.43 -2.15 0.33 1.14e-17
66-70 years -3.81 -4.60 -3.02 0.40 3.28e-21
71-75 years -4.34 -5.28 -3.41 0.48 6.96e-20
76+ years -3.69 -5.24 -2.13 0.79 3.47e-06
Mixed or multiple ethnic origins 0.10 -0.56 0.77 0.34 0.76
Asian or Asian British -0.91 -1.99 0.17 0.55 0.10
African or African British -0.47 -2.09 1.15 0.83 0.57
Other ethnicity 0.32 -0.72 1.36 0.53 0.55
Key worker -0.55 -0.75 -0.35 0.10 6.75e-08
Time difference: Lockdown to baseline 0.06 0.00 0.12 0.03 0.04
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.59 3.61 5.56 0.50 3.04e-20
phq.sum_score_prepan 0.56 0.55 0.58 0.01 0.00e+00
Depressive and anxiety disorder 1.35 0.72 1.98 0.32 2.87e-05
Only depressive disorder 0.90 0.22 1.58 0.35 0.010
Only anxiety disorder 0.30 -0.41 1.02 0.36 0.40
Eating disorders 0.92 0.62 1.23 0.16 3.80e-09
OCDs 0.57 0.28 0.86 0.15 9.41e-05
Psychotic and bipolar disorder -0.50 -1.34 0.34 0.43 0.24
Only psychotic disorder 0.24 -0.45 0.94 0.35 0.50
Only bipolar disorder 0.31 -0.10 0.73 0.21 0.14
PTSD 0.66 0.39 0.93 0.14 1.94e-06
ASD 0.68 0.12 1.24 0.29 0.02
ADHD 0.32 -0.43 1.08 0.39 0.40
Personality disorder 1.19 0.82 1.57 0.19 5.78e-10
Female 0.12 -0.14 0.37 0.13 0.38
Non-binary/Self-defined 0.28 -0.44 1.01 0.37 0.44
19-25 years -1.06 -1.68 -0.43 0.32 9.55e-04
26-35 years -1.89 -2.50 -1.28 0.31 1.06e-09
36-45 years -2.07 -2.68 -1.45 0.31 4.65e-11
46-55 years -2.24 -2.85 -1.63 0.31 7.86e-13
56-65 years -2.78 -3.41 -2.16 0.32 3.69e-18
66-70 years -3.69 -4.47 -2.92 0.40 1.24e-20
71-75 years -4.18 -5.10 -3.26 0.47 5.05e-19
76+ years -3.57 -5.11 -2.02 0.79 5.89e-06
Mixed or multiple ethnic origins 0.07 -0.58 0.73 0.34 0.83
Asian or Asian British -0.67 -1.74 0.39 0.54 0.21
African or African British -0.31 -1.92 1.29 0.82 0.70
Other ethnicity 0.13 -0.88 1.15 0.52 0.79
Key worker -0.45 -0.65 -0.25 0.10 8.99e-06
Time difference: Lockdown to baseline 0.07 0.01 0.13 0.03 0.02
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

PHQ retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.04 2.90 3.18 0.07 0.00e+00
Anxiety disorders 0.61 0.28 0.93 0.17 2.45e-04
Eating disorders 0.57 -0.40 1.54 0.50 0.25
OCDs 1.07 0.29 1.85 0.40 0.007
PTSD 1.06 0.26 1.86 0.41 0.010
Depressive disorders 0.92 0.74 1.09 0.09 1.60e-25
Bipolar disorders 0.89 0.50 1.27 0.20 7.07e-06
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.08 2.95 3.22 0.07 0.00e+00
Depressive and anxiety disorder 0.74 0.56 0.92 0.09 1.08e-15
Only depressive disorder 0.41 0.17 0.65 0.12 8.67e-04
Only anxiety disorder 0.59 0.29 0.88 0.15 9.74e-05
Eating disorders 0.66 0.37 0.94 0.14 5.62e-06
OCDs 0.19 -0.08 0.47 0.14 0.16
Psychotic and bipolar disorder -0.92 -1.71 -0.14 0.40 0.02
Only psychotic disorder -0.55 -1.23 0.13 0.35 0.11
Only bipolar disorder -0.09 -0.51 0.34 0.22 0.69
PTSD 0.56 0.30 0.81 0.13 1.57e-05
ASD 0.51 0.02 1.00 0.25 0.04
ADHD 0.08 -0.57 0.73 0.33 0.80
Personality disorder 0.29 -0.07 0.65 0.18 0.11
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.88 5.37 6.38 0.26 1.82e-113
Anxiety disorders 0.24 -0.10 0.58 0.17 0.17
Eating disorders 0.04 -0.97 1.04 0.51 0.94
OCDs 0.35 -0.45 1.15 0.41 0.39
PTSD 0.75 -0.09 1.58 0.43 0.08
Depressive disorders 0.69 0.50 0.88 0.10 1.39e-12
Bipolar disorders 0.70 0.30 1.10 0.20 5.97e-04
Female 0.75 0.55 0.95 0.10 2.42e-13
Non-binary/Self-defined 0.16 -0.51 0.84 0.35 0.64
19-25 years -0.59 -1.05 -0.13 0.23 0.01
26-35 years -1.41 -1.85 -0.98 0.22 1.30e-10
36-45 years -1.83 -2.27 -1.39 0.22 3.28e-16
46-55 years -1.83 -2.26 -1.40 0.22 6.32e-17
56-65 years -2.00 -2.43 -1.57 0.22 1.27e-19
66-70 years -2.37 -2.88 -1.87 0.26 2.93e-20
71-75 years -2.43 -3.00 -1.86 0.29 1.00e-16
76+ years -2.68 -3.53 -1.83 0.43 6.31e-10
Mixed or multiple ethnic origins -0.21 -0.76 0.34 0.28 0.46
Asian or Asian British -0.19 -0.90 0.52 0.36 0.60
African or African British -0.28 -1.46 0.91 0.60 0.65
Other ethnicity -0.40 -1.39 0.58 0.50 0.42
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 9.23e-36
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.94 5.45 6.43 0.25 3.37e-123
Depressive and anxiety disorder 0.59 0.39 0.79 0.10 7.25e-09
Only depressive disorder 0.46 0.20 0.71 0.13 5.07e-04
Only anxiety disorder 0.26 -0.05 0.57 0.16 0.10
Eating disorders 0.43 0.15 0.72 0.15 0.003
OCDs 0.04 -0.23 0.32 0.14 0.75
Psychotic and bipolar disorder -0.69 -1.48 0.10 0.40 0.09
Only psychotic disorder -0.42 -1.10 0.27 0.35 0.24
Only bipolar disorder 0.05 -0.38 0.48 0.22 0.83
PTSD 0.57 0.31 0.83 0.13 1.50e-05
ASD 0.20 -0.30 0.70 0.26 0.44
ADHD 0.00 -0.67 0.66 0.34 1.00
Personality disorder 0.26 -0.11 0.63 0.19 0.17
Female 0.68 0.48 0.88 0.10 1.94e-11
Non-binary/Self-defined 0.03 -0.64 0.71 0.34 0.92
19-25 years -0.74 -1.19 -0.30 0.23 0.001
26-35 years -1.60 -2.02 -1.18 0.22 1.17e-13
36-45 years -2.01 -2.45 -1.58 0.22 4.99e-20
46-55 years -2.00 -2.43 -1.58 0.22 1.60e-20
56-65 years -2.09 -2.51 -1.67 0.21 2.27e-22
66-70 years -2.34 -2.83 -1.84 0.25 1.52e-20
71-75 years -2.44 -3.00 -1.88 0.29 1.81e-17
76+ years -2.71 -3.54 -1.88 0.42 1.72e-10
Mixed or multiple ethnic origins -0.11 -0.65 0.44 0.28 0.70
Asian or Asian British 0.00 -0.69 0.69 0.35 1.00
African or African British -0.20 -1.36 0.96 0.59 0.73
Other ethnicity -0.53 -1.49 0.44 0.49 0.28
Key worker 0.26 0.09 0.42 0.08 0.002
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 9.68e-37
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.98 3.84 4.12 0.07 0.00e+00
phq.sum_score_retro 0.67 0.65 0.68 0.01 0.00e+00
Anxiety disorders 1.27 0.96 1.58 0.16 5.42e-16
Eating disorders 1.44 0.52 2.36 0.47 0.002
OCDs 2.27 1.53 3.01 0.38 1.97e-09
PTSD 2.06 1.30 2.83 0.39 1.05e-07
Depressive disorders 2.53 2.35 2.70 0.09 4.76e-173
Bipolar disorders 3.32 2.94 3.70 0.19 7.81e-66
n R2 adjust. R2 F p value df
19512 0.43 0.43 2104.41 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.22 4.09 4.36 0.07 0.00e+00
phq.sum_score_retro 0.63 0.61 0.64 0.01 0.00e+00
Depressive and anxiety disorder 2.33 2.15 2.51 0.09 1.27e-140
Only depressive disorder 1.19 0.96 1.42 0.12 1.20e-24
Only anxiety disorder 1.22 0.94 1.49 0.14 9.57e-18
Eating disorders 1.08 0.81 1.34 0.14 1.85e-15
OCDs 0.78 0.52 1.03 0.13 2.12e-09
Psychotic and bipolar disorder -0.59 -1.32 0.14 0.37 0.12
Only psychotic disorder -0.16 -0.80 0.48 0.32 0.62
Only bipolar disorder 0.45 0.05 0.84 0.20 0.03
PTSD 1.01 0.77 1.25 0.12 8.41e-17
ASD 1.31 0.85 1.76 0.23 1.83e-08
ADHD 0.74 0.13 1.35 0.31 0.02
Personality disorder 1.39 1.05 1.73 0.17 1.23e-15
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.55 8.07 9.03 0.24 1.01e-258
phq.sum_score_retro 0.62 0.60 0.63 0.01 0.00e+00
Anxiety disorders 0.78 0.46 1.10 0.16 1.62e-06
Eating disorders 0.80 -0.13 1.73 0.48 0.09
OCDs 1.22 0.47 1.97 0.38 0.001
PTSD 1.72 0.94 2.50 0.40 1.51e-05
Depressive disorders 2.37 2.19 2.56 0.10 1.36e-132
Bipolar disorders 3.26 2.88 3.65 0.20 9.94e-62
Female 0.76 0.58 0.95 0.10 1.13e-15
Non-binary/Self-defined 0.96 0.33 1.59 0.32 0.003
19-25 years -1.53 -1.96 -1.10 0.22 3.15e-12
26-35 years -2.80 -3.21 -2.39 0.21 3.65e-41
36-45 years -3.28 -3.70 -2.86 0.21 9.85e-54
46-55 years -3.35 -3.76 -2.94 0.21 7.37e-58
56-65 years -3.81 -4.21 -3.40 0.21 4.81e-74
66-70 years -4.51 -4.98 -4.03 0.24 2.91e-76
71-75 years -4.56 -5.10 -4.02 0.27 1.65e-61
76+ years -4.64 -5.44 -3.85 0.41 2.77e-30
Mixed or multiple ethnic origins -0.02 -0.54 0.49 0.26 0.93
Asian or Asian British -0.10 -0.76 0.56 0.34 0.77
African or African British -0.15 -1.25 0.94 0.56 0.78
Other ethnicity 0.06 -0.87 0.98 0.47 0.90
Key worker -0.17 -0.33 -0.02 0.08 0.03
Time difference: Lockdown to baseline -0.22 -0.26 -0.19 0.02 3.31e-37
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.94 8.48 9.40 0.24 2.14e-302
phq.sum_score_retro 0.58 0.57 0.60 0.01 0.00e+00
Depressive and anxiety disorder 2.25 2.05 2.44 0.10 1.23e-114
Only depressive disorder 1.39 1.15 1.63 0.12 3.90e-30
Only anxiety disorder 0.79 0.50 1.08 0.15 7.82e-08
Eating disorders 0.81 0.54 1.08 0.14 2.62e-09
OCDs 0.58 0.32 0.84 0.13 8.63e-06
Psychotic and bipolar disorder -0.30 -1.02 0.43 0.37 0.42
Only psychotic disorder 0.00 -0.64 0.63 0.32 0.99
Only bipolar disorder 0.65 0.26 1.05 0.20 0.001
PTSD 1.10 0.86 1.34 0.12 2.66e-19
ASD 0.74 0.28 1.20 0.24 0.002
ADHD 0.53 -0.08 1.14 0.31 0.09
Personality disorder 1.41 1.06 1.75 0.17 7.42e-16
Female 0.66 0.47 0.84 0.09 2.44e-12
Non-binary/Self-defined 0.48 -0.14 1.10 0.32 0.13
19-25 years -1.85 -2.26 -1.43 0.21 2.14e-18
26-35 years -3.13 -3.52 -2.73 0.20 1.13e-54
36-45 years -3.57 -3.97 -3.17 0.20 7.02e-68
46-55 years -3.55 -3.95 -3.16 0.20 8.84e-70
56-65 years -3.91 -4.31 -3.52 0.20 4.43e-84
66-70 years -4.51 -4.97 -4.05 0.23 1.63e-81
71-75 years -4.55 -5.07 -4.03 0.27 5.06e-65
76+ years -4.67 -5.44 -3.90 0.39 1.35e-32
Mixed or multiple ethnic origins 0.07 -0.44 0.57 0.26 0.79
Asian or Asian British 0.18 -0.45 0.82 0.32 0.57
African or African British -0.01 -1.08 1.06 0.54 0.98
Other ethnicity -0.13 -1.02 0.76 0.45 0.77
Key worker -0.08 -0.23 0.07 0.08 0.30
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 6.23e-39
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

PHQ retro: Sensitivity

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.75 1.61 3.89 0.58 2.21e-06
Anxiety disorders 0.64 -0.62 1.90 0.64 0.32
Eating disorders 0.84 -1.60 3.28 1.25 0.50
OCDs 0.73 -0.96 2.42 0.86 0.40
PTSD 1.07 -0.87 3.01 0.99 0.28
Depressive disorders 0.99 -0.15 2.14 0.59 0.09
Bipolar disorders 0.79 -0.44 2.02 0.63 0.21
n R2 adjust. R2 F p value df
8319 0.00 0.00 0.83 0.55 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.95 2.13 3.77 0.42 1.94e-12
Depressive and anxiety disorder 0.68 -0.16 1.51 0.42 0.11
Only depressive disorder 0.48 -0.42 1.38 0.46 0.30
Only anxiety disorder 0.50 -0.44 1.44 0.48 0.30
Eating disorders 0.55 0.16 0.95 0.20 0.006
OCDs -0.12 -0.49 0.24 0.19 0.51
Psychotic and bipolar disorder -0.74 -1.85 0.38 0.57 0.19
Only psychotic disorder -0.46 -1.38 0.47 0.47 0.33
Only bipolar disorder -0.27 -0.81 0.27 0.28 0.33
PTSD 0.43 0.09 0.78 0.18 0.01
ASD 0.01 -0.70 0.71 0.36 0.99
ADHD 0.27 -0.72 1.26 0.50 0.59
Personality disorder 0.38 -0.10 0.86 0.25 0.12
n R2 adjust. R2 F p value df
8319 0.00 0.00 0.83 0.55 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.70 2.25 5.16 0.74 6.60e-07
Anxiety disorders 0.51 -0.75 1.76 0.64 0.43
Eating disorders 0.54 -1.89 2.97 1.24 0.66
OCDs 0.41 -1.28 2.09 0.86 0.64
PTSD 1.08 -0.87 3.03 0.99 0.28
Depressive disorders 1.02 -0.13 2.17 0.58 0.08
Bipolar disorders 0.93 -0.30 2.16 0.63 0.14
Female 0.57 0.22 0.91 0.17 0.001
Non-binary/Self-defined -0.47 -1.39 0.45 0.47 0.32
19-25 years -0.06 -0.84 0.71 0.39 0.87
26-35 years -0.70 -1.44 0.05 0.38 0.07
36-45 years -1.06 -1.82 -0.31 0.39 0.006
46-55 years -1.10 -1.85 -0.34 0.38 0.004
56-65 years -1.83 -2.61 -1.05 0.40 4.48e-06
66-70 years -1.87 -2.90 -0.84 0.53 3.81e-04
71-75 years -2.66 -3.97 -1.34 0.67 7.26e-05
76+ years -2.65 -4.99 -0.31 1.19 0.03
Mixed or multiple ethnic origins -0.57 -1.40 0.26 0.42 0.18
Asian or Asian British -0.86 -2.18 0.47 0.68 0.21
African or African British -0.29 -2.33 1.76 1.04 0.78
Other ethnicity -0.29 -1.60 1.02 0.67 0.66
Time difference: Lockdown to baseline -0.06 -0.14 0.01 0.04 0.10
n R2 adjust. R2 F p value df
8319 0.00 0.00 0.83 0.55 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.88 2.67 5.09 0.62 3.92e-10
Depressive and anxiety disorder 0.77 -0.07 1.60 0.43 0.07
Only depressive disorder 0.80 -0.11 1.71 0.46 0.08
Only anxiety disorder 0.42 -0.52 1.37 0.48 0.38
Eating disorders 0.40 0.01 0.80 0.20 0.05
OCDs -0.17 -0.54 0.19 0.19 0.36
Psychotic and bipolar disorder -0.49 -1.61 0.62 0.57 0.38
Only psychotic disorder -0.23 -1.15 0.70 0.47 0.63
Only bipolar disorder -0.10 -0.65 0.44 0.28 0.71
PTSD 0.48 0.13 0.83 0.18 0.007
ASD -0.09 -0.80 0.63 0.36 0.81
ADHD 0.28 -0.70 1.27 0.50 0.57
Personality disorder 0.32 -0.16 0.80 0.25 0.19
Female 0.49 0.14 0.83 0.18 0.005
Non-binary/Self-defined -0.55 -1.47 0.37 0.47 0.24
19-25 years -0.16 -0.93 0.60 0.39 0.67
26-35 years -0.80 -1.54 -0.06 0.38 0.03
36-45 years -1.17 -1.92 -0.42 0.38 0.002
46-55 years -1.21 -1.96 -0.46 0.38 0.002
56-65 years -1.88 -2.66 -1.11 0.40 1.95e-06
66-70 years -1.82 -2.84 -0.79 0.52 5.07e-04
71-75 years -2.51 -3.81 -1.21 0.66 1.50e-04
76+ years -2.55 -4.88 -0.21 1.19 0.03
Mixed or multiple ethnic origins -0.58 -1.41 0.25 0.42 0.17
Asian or Asian British -0.75 -2.07 0.56 0.67 0.26
African or African British -0.20 -2.24 1.84 1.04 0.85
Other ethnicity -0.44 -1.73 0.85 0.66 0.50
Key worker 0.24 -0.01 0.50 0.13 0.06
Time difference: Lockdown to baseline -0.06 -0.14 0.01 0.04 0.10
n R2 adjust. R2 F p value df
8319 0.00 0.00 0.83 0.55 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.30 4.25 6.35 0.54 8.28e-23
phq.sum_score_retro 0.61 0.60 0.63 0.01 0.00e+00
Anxiety disorders 0.02 -1.14 1.17 0.59 0.98
Eating disorders 1.40 -0.84 3.65 1.14 0.22
OCDs 1.16 -0.39 2.71 0.79 0.14
PTSD 1.08 -0.70 2.86 0.91 0.24
Depressive disorders 1.56 0.51 2.62 0.54 0.004
Bipolar disorders 2.10 0.97 3.24 0.58 2.74e-04
n R2 adjust. R2 F p value df
8319 0.34 0.34 602.29 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.91 5.15 6.67 0.39 7.36e-52
phq.sum_score_retro 0.59 0.57 0.61 0.01 0.00e+00
Depressive and anxiety disorder 0.80 0.04 1.56 0.39 0.04
Only depressive disorder 0.18 -0.64 1.00 0.42 0.67
Only anxiety disorder -0.35 -1.20 0.51 0.44 0.43
Eating disorders 1.04 0.69 1.40 0.18 1.14e-08
OCDs 0.51 0.17 0.84 0.17 0.003
Psychotic and bipolar disorder -0.75 -1.77 0.26 0.52 0.15
Only psychotic disorder -0.14 -0.98 0.70 0.43 0.74
Only bipolar disorder 0.25 -0.24 0.75 0.25 0.31
PTSD 0.84 0.52 1.15 0.16 1.90e-07
ASD 0.72 0.07 1.36 0.33 0.03
ADHD 0.73 -0.17 1.62 0.46 0.11
Personality disorder 1.50 1.06 1.94 0.22 3.07e-11
n R2 adjust. R2 F p value df
9687 0.02 0.02 39.82 3.86e-48 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.40 6.05 8.75 0.69 1.21e-26
phq.sum_score_retro 0.59 0.57 0.61 0.01 0.00e+00
Anxiety disorders 0.01 -1.14 1.17 0.59 0.98
Eating disorders 1.28 -0.94 3.50 1.13 0.26
OCDs 0.89 -0.65 2.43 0.79 0.26
PTSD 1.38 -0.40 3.16 0.91 0.13
Depressive disorders 1.87 0.81 2.93 0.54 5.19e-04
Bipolar disorders 2.56 1.42 3.70 0.58 1.02e-05
Female 0.45 0.14 0.76 0.16 0.005
Non-binary/Self-defined 0.50 -0.34 1.34 0.43 0.25
19-25 years -0.99 -1.70 -0.29 0.36 0.006
26-35 years -2.02 -2.71 -1.34 0.35 7.28e-09
36-45 years -2.39 -3.09 -1.69 0.36 1.83e-11
46-55 years -2.39 -3.09 -1.70 0.35 1.54e-11
56-65 years -3.30 -4.01 -2.58 0.37 2.51e-19
66-70 years -4.09 -5.04 -3.14 0.48 3.00e-17
71-75 years -4.79 -5.99 -3.59 0.61 5.69e-15
76+ years -4.42 -6.55 -2.28 1.09 5.07e-05
Mixed or multiple ethnic origins -0.33 -1.10 0.43 0.39 0.39
Asian or Asian British -0.56 -1.77 0.64 0.62 0.36
African or African British -0.30 -2.16 1.56 0.95 0.75
Other ethnicity 0.03 -1.17 1.24 0.61 0.96
Key worker -0.35 -0.58 -0.11 0.12 0.004
Time difference: Lockdown to baseline -0.03 -0.10 0.04 0.04 0.39
n R2 adjust. R2 F p value df
9687 0.02 0.02 39.82 3.86e-48 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.19 7.07 9.30 0.57 1.98e-46
phq.sum_score_retro 0.57 0.55 0.59 0.01 0.00e+00
Depressive and anxiety disorder 1.05 0.30 1.81 0.39 0.006
Only depressive disorder 0.71 -0.10 1.53 0.42 0.09
Only anxiety disorder -0.39 -1.24 0.47 0.44 0.37
Eating disorders 0.88 0.52 1.24 0.18 1.37e-06
OCDs 0.43 0.09 0.76 0.17 0.01
Psychotic and bipolar disorder -0.49 -1.49 0.52 0.51 0.34
Only psychotic disorder 0.05 -0.79 0.88 0.43 0.91
Only bipolar disorder 0.45 -0.04 0.94 0.25 0.07
PTSD 0.93 0.61 1.24 0.16 7.73e-09
ASD 0.33 -0.31 0.98 0.33 0.31
ADHD 0.64 -0.26 1.53 0.45 0.16
Personality disorder 1.40 0.97 1.84 0.22 3.86e-10
Female 0.26 -0.05 0.57 0.16 0.10
Non-binary/Self-defined 0.11 -0.72 0.94 0.42 0.80
19-25 years -1.14 -1.83 -0.45 0.35 0.001
26-35 years -2.16 -2.83 -1.49 0.34 3.01e-10
36-45 years -2.51 -3.19 -1.82 0.35 6.45e-13
46-55 years -2.46 -3.15 -1.78 0.35 1.45e-12
56-65 years -3.30 -4.01 -2.60 0.36 4.71e-20
66-70 years -3.99 -4.92 -3.06 0.47 5.06e-17
71-75 years -4.57 -5.74 -3.39 0.60 3.19e-14
76+ years -4.25 -6.36 -2.13 1.08 8.28e-05
Mixed or multiple ethnic origins -0.41 -1.16 0.34 0.38 0.28
Asian or Asian British -0.43 -1.62 0.76 0.61 0.48
African or African British -0.10 -1.95 1.74 0.94 0.91
Other ethnicity -0.20 -1.36 0.96 0.59 0.74
Key worker -0.25 -0.48 -0.01 0.12 0.04
Time difference: Lockdown to baseline -0.02 -0.09 0.04 0.03 0.48
n R2 adjust. R2 F p value df
9687 0.02 0.02 39.82 3.86e-48 6

OCI-R baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.34 11.53 13.16 0.41 2.57e-180
Anxiety disorders 2.05 0.59 3.52 0.75 0.006
Eating disorders 4.27 0.09 8.44 2.13 0.05
OCDs 10.43 7.72 13.15 1.38 5.70e-14
PTSD 6.78 3.74 9.83 1.55 1.30e-05
Depressive disorders 5.74 4.83 6.66 0.47 3.07e-34
Bipolar disorders 12.77 11.15 14.38 0.82 4.97e-53
n R2 adjust. R2 F p value df
5187 0.06 0.06 52.91 1.40e-63 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.33 12.63 14.03 0.36 1.93e-271
Depressive and anxiety disorder 2.50 1.63 3.36 0.44 1.64e-08
Only depressive disorder -0.78 -1.98 0.41 0.61 0.20
Only anxiety disorder 0.78 -0.45 2.01 0.63 0.21
Eating disorders 0.62 -0.45 1.68 0.54 0.26
OCDs 7.47 6.53 8.41 0.48 1.21e-53
Psychotic and bipolar disorder 7.02 4.50 9.54 1.29 5.11e-08
Only psychotic disorder 4.35 2.05 6.65 1.17 2.09e-04
Only bipolar disorder 3.31 1.66 4.97 0.84 8.90e-05
PTSD 1.96 1.03 2.89 0.47 3.42e-05
ASD 9.07 7.38 10.75 0.86 7.54e-26
ADHD 2.71 0.39 5.03 1.18 0.02
Personality disorder 3.43 2.16 4.71 0.65 1.23e-07
n R2 adjust. R2 F p value df
5187 0.06 0.06 52.91 1.40e-63 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 23.68 21.65 25.70 1.03 5.23e-111
Anxiety disorders 1.68 0.21 3.14 0.75 0.02
Eating disorders 3.33 -0.84 7.50 2.13 0.12
OCDs 8.67 5.98 11.37 1.38 3.16e-10
PTSD 6.50 3.46 9.54 1.55 2.80e-05
Depressive disorders 6.05 5.10 7.00 0.48 2.56e-35
Bipolar disorders 12.71 11.09 14.33 0.83 5.76e-52
Female -0.91 -1.87 0.05 0.49 0.06
Non-binary/Self-defined 1.83 -0.80 4.45 1.34 0.17
19-25 years -6.54 -8.29 -4.80 0.89 2.39e-13
26-35 years -8.25 -9.89 -6.60 0.84 1.47e-22
36-45 years -8.74 -10.44 -7.05 0.86 8.20e-24
46-55 years -8.90 -10.53 -7.28 0.83 1.22e-26
56-65 years -10.13 -11.74 -8.51 0.82 3.34e-34
66-70 years -10.77 -12.77 -8.77 1.02 8.84e-26
71-75 years -11.68 -13.98 -9.39 1.17 3.05e-23
76+ years -13.01 -16.85 -9.17 1.96 3.33e-11
Mixed or multiple ethnic origins 1.18 -1.15 3.50 1.19 0.32
Asian or Asian British 4.45 1.34 7.56 1.59 0.005
African or African British 3.11 -2.44 8.65 2.83 0.27
Other ethnicity 2.59 -0.83 6.02 1.75 0.14
Time difference: Lockdown to baseline -0.39 -0.56 -0.23 0.08 1.85e-06
n R2 adjust. R2 F p value df
5187 0.06 0.06 52.91 1.40e-63 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 23.74 21.90 25.58 0.94 5.46e-133
Depressive and anxiety disorder 3.34 2.45 4.24 0.46 3.28e-13
Only depressive disorder 0.35 -0.86 1.55 0.62 0.58
Only anxiety disorder 0.93 -0.31 2.16 0.63 0.14
Eating disorders 0.25 -0.81 1.31 0.54 0.64
OCDs 7.03 6.10 7.96 0.48 2.28e-48
Psychotic and bipolar disorder 6.97 4.48 9.46 1.27 4.18e-08
Only psychotic disorder 3.92 1.66 6.19 1.15 6.77e-04
Only bipolar disorder 3.29 1.64 4.94 0.84 9.04e-05
PTSD 2.30 1.38 3.23 0.47 1.14e-06
ASD 7.54 5.85 9.24 0.86 3.52e-18
ADHD 1.68 -0.61 3.98 1.17 0.15
Personality disorder 3.36 2.10 4.63 0.64 1.80e-07
Female -0.86 -1.77 0.05 0.47 0.06
Non-binary/Self-defined -1.12 -3.62 1.38 1.28 0.38
19-25 years -6.37 -7.97 -4.77 0.82 8.01e-15
26-35 years -8.06 -9.58 -6.53 0.78 7.44e-25
36-45 years -8.09 -9.67 -6.50 0.81 2.06e-23
46-55 years -7.92 -9.43 -6.41 0.77 1.96e-24
56-65 years -8.67 -10.16 -7.18 0.76 1.07e-29
66-70 years -8.88 -10.74 -7.02 0.95 1.20e-20
71-75 years -9.92 -12.07 -7.78 1.09 1.43e-19
76+ years -11.59 -15.22 -7.97 1.85 3.88e-10
Mixed or multiple ethnic origins 0.66 -1.55 2.87 1.13 0.56
Asian or Asian British 5.21 2.34 8.08 1.46 3.72e-04
African or African British 4.17 -0.97 9.30 2.62 0.11
Other ethnicity 1.40 -1.86 4.66 1.66 0.40
Key worker -1.05 -1.75 -0.35 0.36 0.003
Time difference: Lockdown to baseline -0.39 -0.54 -0.24 0.08 5.58e-07
n R2 adjust. R2 F p value df
5187 0.06 0.06 52.91 1.40e-63 6

OCIR prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.00 -10.15 14.15 6.18 0.75
Anxiety disorders -10.07 -23.37 3.24 6.77 0.14
Eating disorders -8.00 -27.20 11.20 9.77 0.41
OCDs -12.64 -26.34 1.07 6.97 0.07
PTSD -24.50 -43.70 -5.30 9.77 0.01
Depressive disorders -10.11 -22.30 2.09 6.20 0.10
Bipolar disorders -9.36 -21.92 3.19 6.39 0.14
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.97 -9.82 5.88 3.99 0.62
Depressive and anxiety disorder -4.69 -12.65 3.26 4.05 0.25
Only depressive disorder -4.49 -13.22 4.24 4.44 0.31
Only anxiety disorder -8.20 -16.94 0.54 4.45 0.07
Eating disorders -0.11 -2.79 2.58 1.37 0.94
OCDs -1.25 -3.47 0.98 1.13 0.27
Psychotic and bipolar disorder 12.95 5.33 20.57 3.88 9.07e-04
Only psychotic disorder -0.95 -6.48 4.59 2.82 0.74
Only bipolar disorder -1.15 -4.80 2.50 1.86 0.54
PTSD -3.79 -6.25 -1.33 1.25 0.003
ASD -0.45 -4.77 3.88 2.20 0.84
ADHD 6.08 -0.41 12.57 3.30 0.07
Personality disorder -1.65 -4.91 1.61 1.66 0.32
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -5.19 -19.61 9.24 7.34 0.48
Anxiety disorders -8.89 -22.30 4.52 6.82 0.19
Eating disorders -6.73 -25.88 12.42 9.74 0.49
OCDs -11.92 -25.71 1.86 7.01 0.09
PTSD -23.03 -42.29 -3.77 9.80 0.02
Depressive disorders -9.92 -22.25 2.40 6.27 0.11
Bipolar disorders -9.57 -22.24 3.09 6.44 0.14
Female -2.40 -5.48 0.68 1.57 0.13
Non-binary/Self-defined -2.97 -8.90 2.96 3.02 0.33
19-25 years 3.78 -3.29 10.86 3.60 0.29
26-35 years 7.23 0.30 14.16 3.52 0.04
36-45 years 6.97 -0.20 14.13 3.65 0.06
46-55 years 7.08 -0.01 14.17 3.61 0.05
56-65 years 4.47 -2.94 11.89 3.77 0.24
66-70 years 5.01 -4.17 14.20 4.67 0.28
71-75 years 7.74 -5.99 21.47 6.99 0.27
Mixed or multiple ethnic origins 2.32 -4.36 8.99 3.40 0.50
Asian or Asian British -25.07 -39.77 -10.37 7.48 8.73e-04
African or African British 17.03 -4.71 38.78 11.06 0.12
Other ethnicity -1.26 -9.90 7.39 4.40 0.77
Time difference: Lockdown to baseline 0.46 -0.30 1.22 0.39 0.23
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -10.12 -22.02 1.77 6.05 0.10
Depressive and anxiety disorder -4.23 -13.00 4.54 4.46 0.34
Only depressive disorder -4.32 -13.77 5.14 4.81 0.37
Only anxiety disorder -6.76 -16.24 2.72 4.82 0.16
Eating disorders 0.10 -2.63 2.83 1.39 0.94
OCDs -1.13 -3.38 1.11 1.14 0.32
Psychotic and bipolar disorder 11.21 3.49 18.93 3.93 0.005
Only psychotic disorder -1.54 -7.19 4.10 2.87 0.59
Only bipolar disorder -1.19 -4.91 2.53 1.89 0.53
PTSD -3.44 -5.97 -0.91 1.29 0.008
ASD -0.47 -4.83 3.90 2.22 0.83
ADHD 5.20 -1.33 11.72 3.32 0.12
Personality disorder -1.05 -4.32 2.23 1.67 0.53
Female -1.66 -4.79 1.48 1.59 0.30
Non-binary/Self-defined -1.50 -7.58 4.58 3.09 0.63
19-25 years 2.69 -4.26 9.64 3.53 0.45
26-35 years 6.20 -0.66 13.06 3.49 0.08
36-45 years 5.68 -1.38 12.75 3.59 0.11
46-55 years 6.10 -0.95 13.16 3.59 0.09
56-65 years 4.12 -3.25 11.49 3.75 0.27
66-70 years 3.84 -5.35 13.04 4.68 0.41
71-75 years 8.69 -3.67 21.06 6.29 0.17
Mixed or multiple ethnic origins 2.65 -4.05 9.34 3.41 0.44
Asian or Asian British -22.96 -37.78 -8.15 7.54 0.002
African or African British 17.05 -4.50 38.59 10.96 0.12
Other ethnicity -1.47 -10.07 7.14 4.38 0.74
Key worker 1.12 -1.09 3.33 1.12 0.32
Time difference: Lockdown to baseline 0.52 -0.23 1.27 0.38 0.17
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.60 -1.32 20.52 5.56 0.08
ocir.sum_score_prepan 0.65 0.58 0.71 0.03 3.49e-61
Anxiety disorders -11.49 -23.36 0.38 6.04 0.06
Eating disorders -9.29 -26.42 7.84 8.71 0.29
OCDs -9.11 -21.35 3.13 6.23 0.14
PTSD -20.88 -38.02 -3.73 8.72 0.02
Depressive disorders -8.32 -19.20 2.56 5.54 0.13
Bipolar disorders -5.59 -16.81 5.63 5.71 0.33
n R2 adjust. R2 F p value df
436 0.49 0.49 59.80 1.44e-59 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.70 -1.50 12.89 3.66 0.12
ocir.sum_score_prepan 0.64 0.57 0.71 0.04 1.22e-53
Depressive and anxiety disorder -4.17 -11.31 2.97 3.63 0.25
Only depressive disorder -5.37 -13.21 2.46 3.99 0.18
Only anxiety disorder -8.62 -16.46 -0.78 3.99 0.03
Eating disorders 0.48 -1.94 2.89 1.23 0.70
OCDs 2.28 0.17 4.39 1.07 0.03
Psychotic and bipolar disorder 11.83 4.99 18.67 3.48 7.37e-04
Only psychotic disorder 0.58 -4.40 5.55 2.53 0.82
Only bipolar disorder 0.87 -2.43 4.17 1.68 0.61
PTSD -2.65 -4.87 -0.43 1.13 0.02
ASD 0.22 -3.66 4.10 1.97 0.91
ADHD 4.02 -1.82 9.85 2.97 0.18
Personality disorder -0.69 -3.62 2.25 1.49 0.65
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.17 -7.12 23.45 7.78 0.29
ocir.sum_score_prepan 0.66 0.59 0.73 0.03 4.03e-59
Anxiety disorders -15.86 -30.44 -1.27 7.42 0.03
Eating disorders -13.66 -32.79 5.48 9.73 0.16
OCDs -14.11 -28.95 0.73 7.55 0.06
PTSD -25.47 -44.67 -6.27 9.77 0.009
Depressive disorders -13.35 -27.11 0.42 7.00 0.06
Bipolar disorders -10.79 -24.80 3.22 7.13 0.13
Female -1.78 -4.57 1.01 1.42 0.21
Non-binary/Self-defined -1.60 -6.96 3.77 2.73 0.56
19-25 years 4.74 -1.70 11.19 3.28 0.15
26-35 years 6.17 -0.15 12.49 3.21 0.06
36-45 years 6.33 -0.19 12.85 3.32 0.06
46-55 years 6.76 0.31 13.22 3.28 0.04
56-65 years 3.91 -2.85 10.68 3.44 0.26
66-70 years 3.06 -5.34 11.45 4.27 0.47
71-75 years 2.30 -10.22 14.81 6.37 0.72
Mixed or multiple ethnic origins 0.73 -5.31 6.77 3.07 0.81
Asian or Asian British -16.33 -29.77 -2.89 6.84 0.02
African or African British 21.98 2.34 41.61 9.99 0.03
Other ethnicity 1.08 -6.75 8.92 3.99 0.79
Key worker 0.18 -1.81 2.17 1.01 0.86
Time difference: Lockdown to baseline 0.29 -0.40 0.99 0.35 0.40
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.42 -11.36 10.52 5.56 0.94
ocir.sum_score_prepan 0.64 0.57 0.72 0.04 7.34e-51
Depressive and anxiety disorder -5.06 -12.99 2.87 4.03 0.21
Only depressive disorder -6.01 -14.57 2.55 4.35 0.17
Only anxiety disorder -8.84 -17.42 -0.25 4.37 0.04
Eating disorders 0.86 -1.61 3.33 1.26 0.49
OCDs 2.41 0.26 4.57 1.10 0.03
Psychotic and bipolar disorder 10.72 3.74 17.70 3.55 0.003
Only psychotic disorder 0.10 -5.02 5.21 2.60 0.97
Only bipolar disorder 0.61 -2.78 3.99 1.72 0.73
PTSD -2.34 -4.64 -0.04 1.17 0.05
ASD -0.19 -4.14 3.76 2.01 0.92
ADHD 3.54 -2.37 9.45 3.01 0.24
Personality disorder -0.21 -3.17 2.76 1.51 0.89
Female -1.56 -4.39 1.27 1.44 0.28
Non-binary/Self-defined -0.84 -6.34 4.66 2.80 0.77
19-25 years 3.71 -2.57 10.00 3.20 0.25
26-35 years 5.12 -1.09 11.32 3.16 0.11
36-45 years 4.99 -1.40 11.38 3.25 0.13
46-55 years 6.45 0.07 12.83 3.25 0.05
56-65 years 3.12 -3.54 9.79 3.39 0.36
66-70 years 2.25 -6.07 10.58 4.23 0.59
71-75 years 5.07 -6.14 16.27 5.70 0.37
Mixed or multiple ethnic origins -0.02 -6.10 6.06 3.09 1.00
Asian or Asian British -12.62 -26.19 0.94 6.90 0.07
African or African British 22.55 3.03 42.06 9.93 0.02
Other ethnicity 0.67 -7.12 8.47 3.97 0.87
Key worker 0.00 -2.01 2.01 1.02 1.00
Time difference: Lockdown to baseline 0.47 -0.21 1.15 0.35 0.17
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

OCIR retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.87 3.16 4.58 0.36 1.93e-26
Anxiety disorders -0.87 -2.14 0.41 0.65 0.18
Eating disorders -3.63 -7.18 -0.07 1.81 0.05
OCDs -1.87 -4.22 0.48 1.20 0.12
PTSD -0.55 -3.15 2.06 1.33 0.68
Depressive disorders -3.95 -4.74 -3.17 0.40 1.59e-22
Bipolar disorders -3.57 -4.89 -2.24 0.68 1.40e-07
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.83 3.19 4.47 0.33 4.16e-31
Depressive and anxiety disorder -4.38 -5.16 -3.60 0.40 6.38e-28
Only depressive disorder -2.11 -3.19 -1.03 0.55 1.37e-04
Only anxiety disorder -1.42 -2.54 -0.31 0.57 0.01
Eating disorders -0.25 -1.18 0.68 0.47 0.60
OCDs 0.30 -0.50 1.11 0.41 0.46
Psychotic and bipolar disorder 2.22 0.03 4.40 1.11 0.05
Only psychotic disorder 0.58 -1.38 2.53 1.00 0.56
Only bipolar disorder -0.55 -1.93 0.82 0.70 0.43
PTSD 0.21 -0.58 1.00 0.40 0.60
ASD 1.82 0.35 3.30 0.75 0.02
ADHD 2.21 0.12 4.29 1.06 0.04
Personality disorder -0.61 -1.69 0.47 0.55 0.27
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.47 13.75 17.19 0.88 3.11e-67
Anxiety disorders -0.24 -1.45 0.97 0.62 0.70
Eating disorders -2.11 -5.41 1.18 1.68 0.21
OCDs -0.31 -2.52 1.89 1.13 0.78
PTSD -0.45 -2.91 2.01 1.25 0.72
Depressive disorders -2.12 -2.90 -1.35 0.40 8.29e-08
Bipolar disorders -1.60 -2.87 -0.34 0.64 0.01
Female 0.19 -0.57 0.95 0.39 0.63
Non-binary/Self-defined -0.15 -2.21 1.91 1.05 0.89
19-25 years -4.69 -6.19 -3.19 0.77 9.96e-10
26-35 years -4.14 -5.56 -2.72 0.72 1.14e-08
36-45 years -3.90 -5.34 -2.45 0.74 1.42e-07
46-55 years -3.77 -5.18 -2.37 0.72 1.51e-07
56-65 years -2.18 -3.58 -0.77 0.72 0.002
66-70 years -2.05 -3.76 -0.35 0.87 0.02
71-75 years -1.38 -3.32 0.56 0.99 0.16
76+ years -4.17 -7.69 -0.65 1.80 0.02
Mixed or multiple ethnic origins 1.54 -0.25 3.33 0.91 0.09
Asian or Asian British 2.66 -0.05 5.36 1.38 0.05
African or African British 0.77 -3.58 5.12 2.22 0.73
Other ethnicity -0.64 -3.24 1.96 1.33 0.63
Time difference: Lockdown to baseline -1.65 -1.77 -1.52 0.06 6.80e-134
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.20 13.55 16.84 0.84 7.91e-71
Depressive and anxiety disorder -2.51 -3.28 -1.75 0.39 1.14e-10
Only depressive disorder -1.45 -2.48 -0.41 0.53 0.006
Only anxiety disorder -0.73 -1.79 0.33 0.54 0.18
Eating disorders -0.09 -0.96 0.78 0.44 0.83
OCDs 0.38 -0.38 1.13 0.38 0.32
Psychotic and bipolar disorder 2.27 0.23 4.31 1.04 0.03
Only psychotic disorder 0.30 -1.51 2.12 0.93 0.74
Only bipolar disorder -0.31 -1.60 0.98 0.66 0.64
PTSD 0.16 -0.59 0.91 0.38 0.68
ASD 1.01 -0.40 2.41 0.72 0.16
ADHD 1.67 -0.26 3.61 0.99 0.09
Personality disorder -0.24 -1.25 0.77 0.52 0.64
Female 0.30 -0.45 1.06 0.39 0.43
Non-binary/Self-defined -0.66 -2.72 1.39 1.05 0.53
19-25 years -4.49 -5.94 -3.05 0.74 1.06e-09
26-35 years -4.01 -5.39 -2.64 0.70 1.06e-08
36-45 years -3.80 -5.21 -2.40 0.72 1.20e-07
46-55 years -3.71 -5.07 -2.35 0.69 9.61e-08
56-65 years -2.15 -3.51 -0.80 0.69 0.002
66-70 years -1.87 -3.53 -0.21 0.84 0.03
71-75 years -1.83 -3.72 0.07 0.97 0.06
76+ years -3.99 -7.48 -0.51 1.78 0.02
Mixed or multiple ethnic origins 1.35 -0.44 3.14 0.91 0.14
Asian or Asian British 2.32 -0.28 4.92 1.33 0.08
African or African British 0.92 -3.41 5.24 2.21 0.68
Other ethnicity -0.67 -3.28 1.95 1.33 0.62
Key worker -0.08 -0.65 0.50 0.29 0.80
Time difference: Lockdown to baseline -1.61 -1.73 -1.48 0.06 8.91e-132
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.44 5.74 7.13 0.36 1.09e-70
ocir.sum_score_retro 0.73 0.71 0.75 0.01 0.00e+00
Anxiety disorders -0.10 -1.30 1.10 0.61 0.87
Eating disorders -1.54 -4.88 1.80 1.70 0.37
OCDs 1.47 -0.76 3.69 1.13 0.20
PTSD 1.43 -1.02 3.88 1.25 0.25
Depressive disorders -1.50 -2.27 -0.73 0.39 1.33e-04
Bipolar disorders 0.55 -0.74 1.84 0.66 0.40
n R2 adjust. R2 F p value df
4329 0.52 0.52 665.07 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.91 6.26 7.55 0.33 1.85e-93
ocir.sum_score_retro 0.70 0.68 0.73 0.01 0.00e+00
Depressive and anxiety disorder -2.55 -3.29 -1.81 0.38 1.67e-11
Only depressive disorder -1.71 -2.72 -0.69 0.52 9.57e-04
Only anxiety disorder -0.70 -1.74 0.35 0.53 0.19
Eating disorders -0.09 -0.95 0.78 0.44 0.84
OCDs 2.46 1.69 3.23 0.39 4.48e-10
Psychotic and bipolar disorder 3.47 1.43 5.51 1.04 8.69e-04
Only psychotic disorder 1.72 -0.11 3.55 0.93 0.07
Only bipolar disorder 0.59 -0.69 1.88 0.66 0.37
PTSD 0.78 0.04 1.52 0.38 0.04
ASD 3.70 2.31 5.08 0.71 1.73e-07
ADHD 2.01 0.06 3.95 0.99 0.04
Personality disorder 0.67 -0.34 1.69 0.52 0.19
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.68 16.03 19.33 0.84 2.62e-93
ocir.sum_score_retro 0.77 0.75 0.79 0.01 0.00e+00
Anxiety disorders 0.15 -1.00 1.31 0.59 0.79
Eating disorders -0.79 -3.91 2.34 1.60 0.62
OCDs 1.71 -0.40 3.83 1.08 0.11
PTSD 1.13 -1.23 3.49 1.20 0.35
Depressive disorders -0.45 -1.21 0.30 0.39 0.24
Bipolar disorders 1.41 0.17 2.65 0.63 0.03
Female 0.15 -0.58 0.87 0.37 0.69
Non-binary/Self-defined 0.56 -1.40 2.51 1.00 0.58
19-25 years -4.97 -6.40 -3.54 0.73 1.04e-11
26-35 years -4.78 -6.14 -3.42 0.69 6.30e-12
36-45 years -4.82 -6.21 -3.43 0.71 1.25e-11
46-55 years -4.68 -6.03 -3.33 0.69 1.19e-11
56-65 years -3.68 -5.02 -2.33 0.69 9.28e-08
66-70 years -3.76 -5.39 -2.13 0.83 6.40e-06
71-75 years -3.91 -5.76 -2.05 0.95 3.76e-05
76+ years -5.81 -9.21 -2.41 1.73 8.03e-04
Mixed or multiple ethnic origins 1.45 -0.26 3.17 0.87 0.10
Asian or Asian British 3.38 0.82 5.95 1.31 0.010
African or African British 1.02 -3.11 5.15 2.11 0.63
Other ethnicity 0.20 -2.30 2.69 1.27 0.88
Key worker -0.50 -1.05 0.05 0.28 0.07
Time difference: Lockdown to baseline -1.40 -1.52 -1.28 0.06 1.27e-105
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.79 16.22 19.37 0.80 2.58e-103
ocir.sum_score_retro 0.75 0.72 0.77 0.01 0.00e+00
Depressive and anxiety disorder -1.21 -1.94 -0.48 0.37 0.001
Only depressive disorder -1.01 -1.99 -0.03 0.50 0.04
Only anxiety disorder -0.29 -1.29 0.72 0.51 0.58
Eating disorders -0.05 -0.87 0.78 0.42 0.91
OCDs 2.11 1.38 2.84 0.37 1.55e-08
Psychotic and bipolar disorder 3.34 1.41 5.27 0.98 6.91e-04
Only psychotic disorder 1.23 -0.50 2.95 0.88 0.16
Only bipolar disorder 0.58 -0.64 1.81 0.63 0.35
PTSD 0.72 0.01 1.43 0.36 0.05
ASD 2.48 1.14 3.81 0.68 2.81e-04
ADHD 1.46 -0.37 3.29 0.93 0.12
Personality disorder 0.74 -0.22 1.70 0.49 0.13
Female 0.17 -0.55 0.88 0.37 0.65
Non-binary/Self-defined -0.52 -2.47 1.43 0.99 0.60
19-25 years -4.98 -6.35 -3.62 0.70 9.81e-13
26-35 years -5.02 -6.32 -3.72 0.66 4.99e-14
36-45 years -4.93 -6.26 -3.59 0.68 5.32e-13
46-55 years -4.75 -6.04 -3.46 0.66 6.48e-13
56-65 years -3.69 -4.98 -2.40 0.66 2.02e-08
66-70 years -3.51 -5.08 -1.93 0.80 1.29e-05
71-75 years -3.79 -5.59 -1.99 0.92 3.65e-05
76+ years -5.83 -9.13 -2.53 1.68 5.46e-04
Mixed or multiple ethnic origins 1.10 -0.60 2.79 0.86 0.20
Asian or Asian British 3.38 0.92 5.85 1.26 0.007
African or African British 1.35 -2.75 5.44 2.09 0.52
Other ethnicity -0.05 -2.53 2.42 1.26 0.97
Key worker -0.39 -0.94 0.15 0.28 0.16
Time difference: Lockdown to baseline -1.35 -1.47 -1.23 0.06 7.33e-102
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

OCIR retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.83 -6.91 1.24 2.08 0.17
Anxiety disorders -2.22 -6.61 2.17 2.24 0.32
Eating disorders -2.17 -8.88 4.55 3.42 0.53
OCDs -3.29 -8.28 1.70 2.55 0.20
PTSD -5.17 -11.06 0.73 3.01 0.09
Depressive disorders -2.57 -6.66 1.52 2.09 0.22
Bipolar disorders -2.70 -6.95 1.54 2.16 0.21
n R2 adjust. R2 F p value df
1746 0.00 0.00 0.58 0.75 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.69 -6.52 -0.87 1.44 0.01
Depressive and anxiety disorder -1.42 -4.27 1.44 1.46 0.33
Only depressive disorder -1.99 -5.10 1.12 1.59 0.21
Only anxiety disorder -2.05 -5.16 1.07 1.59 0.20
Eating disorders 0.14 -0.85 1.12 0.50 0.79
OCDs -0.26 -1.11 0.58 0.43 0.54
Psychotic and bipolar disorder 0.76 -1.82 3.33 1.31 0.56
Only psychotic disorder -0.04 -2.04 1.96 1.02 0.97
Only bipolar disorder -0.26 -1.65 1.13 0.71 0.71
PTSD -0.48 -1.31 0.36 0.43 0.26
ASD -0.16 -1.97 1.65 0.92 0.86
ADHD 1.24 -1.46 3.93 1.37 0.37
Personality disorder -0.75 -1.86 0.36 0.57 0.18
n R2 adjust. R2 F p value df
1746 0.00 0.00 0.58 0.75 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.89 -7.74 1.95 2.47 0.24
Anxiety disorders -2.23 -6.61 2.15 2.23 0.32
Eating disorders -2.00 -8.71 4.71 3.42 0.56
OCDs -3.21 -8.19 1.76 2.54 0.21
PTSD -5.21 -11.11 0.70 3.01 0.08
Depressive disorders -2.76 -6.86 1.35 2.09 0.19
Bipolar disorders -3.11 -7.36 1.14 2.17 0.15
Female -0.78 -1.77 0.22 0.51 0.13
Non-binary/Self-defined -0.68 -3.02 1.67 1.19 0.57
19-25 years -0.71 -3.25 1.83 1.29 0.58
26-35 years -0.28 -2.76 2.20 1.26 0.82
36-45 years 0.99 -1.51 3.48 1.27 0.44
46-55 years 0.68 -1.80 3.17 1.27 0.59
56-65 years 0.77 -1.78 3.31 1.30 0.56
66-70 years 2.07 -1.16 5.31 1.65 0.21
71-75 years 2.73 -1.30 6.76 2.05 0.18
76+ years 0.35 -8.12 8.81 4.32 0.94
Mixed or multiple ethnic origins 2.51 0.35 4.66 1.10 0.02
Asian or Asian British -1.11 -5.82 3.59 2.40 0.64
African or African British -0.56 -6.87 5.75 3.22 0.86
Other ethnicity 1.49 -1.41 4.39 1.48 0.31
Time difference: Lockdown to baseline 0.07 -0.14 0.27 0.11 0.54
n R2 adjust. R2 F p value df
1746 0.00 0.00 0.58 0.75 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.57 -7.51 0.38 2.01 0.08
Depressive and anxiety disorder -1.64 -4.57 1.28 1.49 0.27
Only depressive disorder -2.51 -5.69 0.66 1.62 0.12
Only anxiety disorder -2.13 -5.29 1.03 1.61 0.19
Eating disorders 0.38 -0.61 1.37 0.51 0.45
OCDs -0.16 -1.00 0.69 0.43 0.72
Psychotic and bipolar disorder 0.36 -2.21 2.94 1.31 0.78
Only psychotic disorder -0.37 -2.38 1.63 1.02 0.71
Only bipolar disorder -0.32 -1.73 1.08 0.72 0.65
PTSD -0.46 -1.31 0.39 0.43 0.29
ASD -0.06 -1.88 1.76 0.93 0.95
ADHD 1.36 -1.35 4.07 1.38 0.33
Personality disorder -0.74 -1.85 0.38 0.57 0.19
Female -0.77 -1.77 0.23 0.51 0.13
Non-binary/Self-defined -0.83 -3.22 1.56 1.22 0.49
19-25 years -0.99 -3.49 1.51 1.28 0.44
26-35 years -0.50 -2.95 1.95 1.25 0.69
36-45 years 0.75 -1.72 3.22 1.26 0.55
46-55 years 0.45 -2.01 2.91 1.26 0.72
56-65 years 0.59 -1.94 3.11 1.29 0.65
66-70 years 1.81 -1.38 5.00 1.63 0.27
71-75 years 2.39 -1.56 6.34 2.01 0.24
76+ years 0.41 -8.07 8.88 4.32 0.92
Mixed or multiple ethnic origins 2.46 0.28 4.64 1.11 0.03
Asian or Asian British -1.13 -5.84 3.58 2.40 0.64
African or African British -0.61 -6.92 5.69 3.21 0.85
Other ethnicity 1.78 -1.18 4.74 1.51 0.24
Key worker 0.11 -0.60 0.83 0.37 0.75
Time difference: Lockdown to baseline 0.07 -0.14 0.27 0.11 0.54
n R2 adjust. R2 F p value df
1746 0.00 0.00 0.58 0.75 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.61 -2.24 5.46 1.96 0.41
ocir.sum_score_retro 0.80 0.78 0.83 0.01 0.00e+00
Anxiety disorders -3.75 -7.86 0.35 2.09 0.07
Eating disorders -2.66 -8.93 3.62 3.20 0.41
OCDs -1.97 -6.64 2.69 2.38 0.41
PTSD -4.33 -9.84 1.18 2.81 0.12
Depressive disorders -2.63 -6.45 1.20 1.95 0.18
Bipolar disorders -1.69 -5.66 2.27 2.02 0.40
n R2 adjust. R2 F p value df
1746 0.71 0.71 615.64 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.14 -1.55 3.83 1.37 0.41
ocir.sum_score_retro 0.78 0.76 0.81 0.01 0.00e+00
Depressive and anxiety disorder -2.11 -4.77 0.55 1.35 0.12
Only depressive disorder -3.03 -5.93 -0.14 1.48 0.04
Only anxiety disorder -3.28 -6.18 -0.39 1.48 0.03
Eating disorders 0.29 -0.63 1.21 0.47 0.53
OCDs 1.45 0.63 2.26 0.41 5.00e-04
Psychotic and bipolar disorder 1.84 -0.56 4.24 1.22 0.13
Only psychotic disorder 0.37 -1.49 2.23 0.95 0.70
Only bipolar disorder 0.39 -0.91 1.68 0.66 0.56
PTSD 0.06 -0.72 0.84 0.40 0.87
ASD 1.15 -0.54 2.84 0.86 0.18
ADHD 1.06 -1.45 3.57 1.28 0.41
Personality disorder 0.25 -0.78 1.29 0.53 0.63
n R2 adjust. R2 F p value df
1750 0.03 0.03 9.60 2.04e-10 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.53 -2.17 7.24 2.40 0.29
ocir.sum_score_retro 0.80 0.78 0.83 0.01 0.00e+00
Anxiety disorders -4.58 -8.83 -0.32 2.17 0.04
Eating disorders -3.19 -9.57 3.19 3.25 0.33
OCDs -2.77 -7.56 2.02 2.44 0.26
PTSD -5.05 -10.68 0.59 2.87 0.08
Depressive disorders -3.55 -7.56 0.46 2.04 0.08
Bipolar disorders -2.64 -6.79 1.50 2.11 0.21
Female -0.61 -1.54 0.33 0.48 0.20
Non-binary/Self-defined -0.10 -2.30 2.09 1.12 0.93
19-25 years -1.07 -3.44 1.30 1.21 0.38
26-35 years -0.86 -3.18 1.46 1.18 0.47
36-45 years 0.00 -2.34 2.34 1.19 1.00
46-55 years 0.03 -2.30 2.36 1.19 0.98
56-65 years -0.32 -2.70 2.07 1.22 0.80
66-70 years 0.46 -2.58 3.49 1.55 0.77
71-75 years 0.00 -3.78 3.78 1.93 1.00
76+ years 0.33 -7.58 8.24 4.03 0.93
Mixed or multiple ethnic origins 2.17 0.11 4.24 1.05 0.04
Asian or Asian British 1.63 -2.78 6.04 2.25 0.47
African or African British 0.82 -5.08 6.72 3.01 0.78
Other ethnicity 1.83 -0.93 4.60 1.41 0.19
Key worker -0.39 -1.06 0.27 0.34 0.25
Time difference: Lockdown to baseline 0.13 -0.06 0.33 0.10 0.17
n R2 adjust. R2 F p value df
1750 0.03 0.03 9.60 2.04e-10 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.48 -2.24 5.20 1.90 0.44
ocir.sum_score_retro 0.78 0.76 0.81 0.01 0.00e+00
Depressive and anxiety disorder -2.31 -5.03 0.41 1.39 0.10
Only depressive disorder -3.37 -6.32 -0.41 1.51 0.03
Only anxiety disorder -3.39 -6.33 -0.44 1.50 0.02
Eating disorders 0.48 -0.45 1.40 0.47 0.31
OCDs 1.52 0.70 2.33 0.42 2.77e-04
Psychotic and bipolar disorder 1.50 -0.90 3.90 1.22 0.22
Only psychotic disorder 0.06 -1.80 1.93 0.95 0.95
Only bipolar disorder 0.36 -0.95 1.67 0.67 0.59
PTSD 0.05 -0.75 0.84 0.40 0.91
ASD 1.08 -0.63 2.78 0.87 0.22
ADHD 1.05 -1.47 3.58 1.29 0.41
Personality disorder 0.21 -0.83 1.25 0.53 0.70
Female -0.72 -1.65 0.21 0.48 0.13
Non-binary/Self-defined -0.41 -2.63 1.81 1.13 0.72
19-25 years -1.30 -3.63 1.03 1.19 0.27
26-35 years -1.14 -3.42 1.14 1.16 0.33
36-45 years -0.23 -2.53 2.07 1.17 0.84
46-55 years -0.11 -2.40 2.19 1.17 0.93
56-65 years -0.40 -2.75 1.95 1.20 0.74
66-70 years 0.47 -2.51 3.44 1.52 0.76
71-75 years 0.33 -3.36 4.01 1.88 0.86
76+ years -0.31 -8.21 7.58 4.02 0.94
Mixed or multiple ethnic origins 1.94 -0.09 3.97 1.04 0.06
Asian or Asian British 1.47 -2.93 5.87 2.24 0.51
African or African British 1.25 -4.63 7.12 2.99 0.68
Other ethnicity 1.75 -1.01 4.51 1.41 0.21
Key worker -0.24 -0.91 0.43 0.34 0.48
Time difference: Lockdown to baseline 0.14 -0.05 0.34 0.10 0.14
n R2 adjust. R2 F p value df
1750 0.03 0.03 9.60 2.04e-10 6

PCL baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.44 8.35 8.54 0.05 0.00e+00
Anxiety disorders 3.42 3.16 3.67 0.13 3.65e-153
Eating disorders 3.66 2.85 4.46 0.41 6.61e-19
OCDs 5.54 4.88 6.20 0.34 1.20e-60
PTSD 6.20 5.54 6.86 0.34 1.99e-75
Depressive disorders 6.48 6.36 6.60 0.06 0.00e+00
Bipolar disorders 8.99 8.67 9.31 0.16 0.00e+00
n R2 adjust. R2 F p value df
31227 0.28 0.28 1988.78 0.00e+00 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.65 8.57 8.74 0.04 0.00e+00
Depressive and anxiety disorder 6.11 5.98 6.24 0.07 0.00e+00
Only depressive disorder 2.78 2.61 2.95 0.09 1.85e-216
Only anxiety disorder 3.28 3.06 3.50 0.11 6.19e-185
Eating disorders 1.34 1.11 1.57 0.12 5.16e-30
OCDs 1.74 1.52 1.97 0.11 1.82e-53
Psychotic and bipolar disorder 1.21 0.59 1.84 0.32 1.50e-04
Only psychotic disorder 0.72 0.19 1.26 0.27 0.008
Only bipolar disorder 1.16 0.82 1.50 0.17 1.61e-11
PTSD 2.86 2.65 3.06 0.10 7.16e-163
ASD 1.99 1.59 2.39 0.20 2.03e-22
ADHD 1.21 0.67 1.74 0.27 9.18e-06
Personality disorder 2.82 2.52 3.11 0.15 4.00e-78
n R2 adjust. R2 F p value df
31227 0.28 0.28 1988.78 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.56 13.14 13.98 0.22 0.00e+00
Anxiety disorders 2.40 2.14 2.66 0.13 2.60e-72
Eating disorders 2.20 1.39 3.00 0.41 9.59e-08
OCDs 3.32 2.66 3.98 0.34 6.37e-23
PTSD 5.31 4.64 5.98 0.34 3.69e-54
Depressive disorders 5.42 5.28 5.56 0.07 0.00e+00
Bipolar disorders 7.79 7.47 8.11 0.16 0.00e+00
Female 0.77 0.63 0.91 0.07 7.32e-27
Non-binary/Self-defined 2.27 1.70 2.83 0.29 3.38e-15
19-25 years -1.80 -2.20 -1.39 0.21 2.43e-18
26-35 years -3.65 -4.02 -3.27 0.19 3.16e-80
36-45 years -4.44 -4.81 -4.06 0.19 2.47e-115
46-55 years -4.91 -5.28 -4.54 0.19 2.02e-147
56-65 years -5.84 -6.21 -5.47 0.19 2.24e-208
66-70 years -6.56 -6.96 -6.16 0.20 6.01e-223
71-75 years -6.68 -7.10 -6.25 0.22 1.29e-204
76+ years -6.54 -7.08 -5.99 0.28 7.01e-122
Mixed or multiple ethnic origins 0.56 0.11 1.01 0.23 0.01
Asian or Asian British 0.32 -0.23 0.87 0.28 0.25
African or African British 0.84 -0.09 1.77 0.47 0.08
Other ethnicity 0.99 0.16 1.83 0.42 0.02
Time difference: Lockdown to baseline -0.01 -0.04 0.02 0.02 0.34
n R2 adjust. R2 F p value df
31227 0.28 0.28 1988.78 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.73 13.34 14.12 0.20 0.00e+00
Depressive and anxiety disorder 5.23 5.09 5.38 0.07 0.00e+00
Only depressive disorder 2.64 2.46 2.83 0.09 5.39e-178
Only anxiety disorder 2.44 2.21 2.67 0.12 9.30e-96
Eating disorders 0.87 0.64 1.10 0.12 1.66e-13
OCDs 1.30 1.08 1.53 0.11 6.83e-31
Psychotic and bipolar disorder 1.44 0.82 2.06 0.32 5.08e-06
Only psychotic disorder 0.77 0.24 1.30 0.27 0.005
Only bipolar disorder 1.26 0.92 1.59 0.17 2.55e-13
PTSD 2.86 2.66 3.07 0.10 4.00e-163
ASD 1.07 0.67 1.48 0.21 1.69e-07
ADHD 0.60 0.07 1.13 0.27 0.03
Personality disorder 2.54 2.24 2.83 0.15 4.29e-64
Female 0.69 0.56 0.82 0.07 3.70e-24
Non-binary/Self-defined 1.20 0.67 1.74 0.27 1.01e-05
19-25 years -2.06 -2.43 -1.69 0.19 3.33e-27
26-35 years -3.78 -4.13 -3.43 0.18 7.88e-99
36-45 years -4.37 -4.73 -4.02 0.18 8.86e-129
46-55 years -4.64 -4.99 -4.30 0.18 1.29e-151
56-65 years -5.41 -5.75 -5.07 0.17 8.65e-209
66-70 years -6.15 -6.52 -5.78 0.19 2.61e-228
71-75 years -6.29 -6.69 -5.90 0.20 1.53e-210
76+ years -6.16 -6.67 -5.66 0.26 6.61e-125
Mixed or multiple ethnic origins 0.53 0.10 0.95 0.22 0.02
Asian or Asian British 0.77 0.26 1.28 0.26 0.003
African or African British 0.93 0.06 1.81 0.44 0.04
Other ethnicity 0.63 -0.15 1.41 0.40 0.11
Key worker -0.54 -0.66 -0.42 0.06 7.25e-18
Time difference: Lockdown to baseline -0.03 -0.05 0.00 0.01 0.06
n R2 adjust. R2 F p value df
31227 0.28 0.28 1988.78 0.00e+00 6

PCL prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.28 -0.70 1.26 0.50 0.58
Anxiety disorders -0.07 -1.15 1.01 0.55 0.89
Eating disorders -0.55 -2.63 1.53 1.06 0.61
OCDs -0.30 -1.76 1.15 0.74 0.68
PTSD -1.60 -3.30 0.10 0.86 0.06
Depressive disorders -0.04 -1.03 0.94 0.50 0.93
Bipolar disorders -0.27 -1.33 0.79 0.54 0.61
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.39 -0.31 1.09 0.36 0.27
Depressive and anxiety disorder 0.02 -0.68 0.73 0.36 0.95
Only depressive disorder -0.16 -0.92 0.61 0.39 0.69
Only anxiety disorder -0.21 -1.01 0.59 0.41 0.61
Eating disorders 0.13 -0.21 0.48 0.18 0.45
OCDs -0.08 -0.40 0.24 0.16 0.64
Psychotic and bipolar disorder -0.69 -1.63 0.24 0.48 0.15
Only psychotic disorder -0.03 -0.82 0.75 0.40 0.93
Only bipolar disorder 0.06 -0.41 0.53 0.24 0.79
PTSD -0.89 -1.20 -0.59 0.15 7.68e-09
ASD -0.12 -0.74 0.51 0.32 0.72
ADHD -0.23 -1.09 0.63 0.44 0.60
Personality disorder -0.29 -0.71 0.13 0.22 0.18
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.62 -1.90 0.67 0.66 0.35
Anxiety disorders -0.08 -1.16 1.00 0.55 0.88
Eating disorders -0.67 -2.74 1.41 1.06 0.53
OCDs -0.46 -1.92 0.99 0.74 0.53
PTSD -1.60 -3.30 0.11 0.87 0.07
Depressive disorders 0.01 -0.97 1.00 0.50 0.98
Bipolar disorders -0.12 -1.18 0.94 0.54 0.82
Female 0.62 0.33 0.91 0.15 2.26e-05
Non-binary/Self-defined -0.04 -0.85 0.78 0.42 0.93
19-25 years 0.46 -0.26 1.17 0.37 0.21
26-35 years 0.11 -0.57 0.80 0.35 0.74
36-45 years -0.36 -1.05 0.34 0.36 0.32
46-55 years -0.46 -1.15 0.24 0.35 0.20
56-65 years -0.17 -0.88 0.54 0.36 0.64
66-70 years -0.36 -1.24 0.52 0.45 0.42
71-75 years -0.37 -1.41 0.67 0.53 0.48
76+ years 0.44 -1.30 2.18 0.89 0.62
Mixed or multiple ethnic origins 0.37 -0.38 1.11 0.38 0.33
Asian or Asian British 0.12 -1.11 1.36 0.63 0.84
African or African British -0.37 -2.18 1.44 0.92 0.69
Other ethnicity -0.39 -1.55 0.77 0.59 0.51
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.53 -1.61 0.54 0.55 0.33
Depressive and anxiety disorder 0.08 -0.63 0.79 0.36 0.82
Only depressive disorder -0.03 -0.80 0.74 0.39 0.95
Only anxiety disorder -0.23 -1.03 0.58 0.41 0.58
Eating disorders 0.00 -0.35 0.35 0.18 1.00
OCDs -0.11 -0.43 0.21 0.16 0.50
Psychotic and bipolar disorder -0.59 -1.53 0.34 0.48 0.22
Only psychotic disorder 0.07 -0.72 0.86 0.40 0.86
Only bipolar disorder 0.20 -0.28 0.67 0.24 0.41
PTSD -0.87 -1.18 -0.57 0.16 1.96e-08
ASD -0.12 -0.75 0.52 0.32 0.72
ADHD -0.22 -1.08 0.64 0.44 0.62
Personality disorder -0.43 -0.86 -0.01 0.22 0.05
Female 0.68 0.39 0.97 0.15 3.68e-06
Non-binary/Self-defined 0.17 -0.64 0.99 0.42 0.68
19-25 years 0.47 -0.24 1.18 0.36 0.20
26-35 years 0.17 -0.51 0.85 0.35 0.63
36-45 years -0.28 -0.98 0.41 0.35 0.42
46-55 years -0.38 -1.07 0.31 0.35 0.28
56-65 years -0.15 -0.86 0.55 0.36 0.67
66-70 years -0.45 -1.32 0.42 0.44 0.31
71-75 years -0.47 -1.51 0.56 0.53 0.37
76+ years 0.28 -1.45 2.01 0.88 0.75
Mixed or multiple ethnic origins 0.45 -0.29 1.19 0.38 0.23
Asian or Asian British 0.23 -1.00 1.45 0.63 0.72
African or African British -0.41 -2.22 1.40 0.92 0.66
Other ethnicity -0.15 -1.29 0.99 0.58 0.80
Key worker -0.21 -0.44 0.01 0.11 0.06
Time difference: Lockdown to baseline 0.07 0.00 0.13 0.03 0.04
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.08 5.18 6.97 0.46 3.93e-40
pcl.sum_score_prepan 0.57 0.55 0.58 0.01 0.00e+00
Anxiety disorders -0.34 -1.30 0.62 0.49 0.49
Eating disorders 0.04 -1.81 1.89 0.94 0.97
OCDs 0.37 -0.92 1.66 0.66 0.57
PTSD 0.12 -1.39 1.62 0.77 0.88
Depressive disorders 0.94 0.06 1.82 0.45 0.04
Bipolar disorders 1.47 0.52 2.41 0.48 0.002
n R2 adjust. R2 F p value df
11019 0.33 0.33 764.66 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.83 6.17 7.48 0.33 7.35e-91
pcl.sum_score_prepan 0.53 0.52 0.55 0.01 0.00e+00
Depressive and anxiety disorder 0.51 -0.12 1.13 0.32 0.11
Only depressive disorder -0.51 -1.19 0.16 0.34 0.14
Only anxiety disorder -0.63 -1.34 0.08 0.36 0.08
Eating disorders 0.59 0.29 0.89 0.16 1.40e-04
OCDs 0.61 0.33 0.90 0.15 2.59e-05
Psychotic and bipolar disorder -0.40 -1.23 0.42 0.42 0.34
Only psychotic disorder -0.05 -0.74 0.65 0.35 0.89
Only bipolar disorder 0.35 -0.07 0.76 0.21 0.10
PTSD 0.73 0.46 1.01 0.14 1.43e-07
ASD 0.65 0.10 1.20 0.28 0.02
ADHD 0.24 -0.51 1.00 0.39 0.53
Personality disorder 1.08 0.71 1.46 0.19 1.71e-08
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.85 5.69 8.01 0.59 1.10e-30
pcl.sum_score_prepan 0.54 0.53 0.56 0.01 0.00e+00
Anxiety disorders -0.36 -1.31 0.59 0.49 0.46
Eating disorders -0.01 -1.84 1.82 0.93 0.99
OCDs 0.11 -1.17 1.39 0.65 0.87
PTSD 0.49 -1.01 1.99 0.77 0.52
Depressive disorders 1.14 0.27 2.01 0.44 0.01
Bipolar disorders 1.77 0.83 2.71 0.48 2.22e-04
Female 0.58 0.32 0.83 0.13 8.54e-06
Non-binary/Self-defined 0.77 0.05 1.49 0.37 0.04
19-25 years -0.16 -0.79 0.47 0.32 0.62
26-35 years -1.00 -1.62 -0.39 0.31 0.001
36-45 years -1.52 -2.14 -0.90 0.32 1.55e-06
46-55 years -1.65 -2.26 -1.03 0.31 1.56e-07
56-65 years -1.92 -2.55 -1.29 0.32 2.22e-09
66-70 years -3.07 -3.85 -2.30 0.40 1.04e-14
71-75 years -3.47 -4.39 -2.55 0.47 1.61e-13
76+ years -2.94 -4.48 -1.41 0.78 1.65e-04
Mixed or multiple ethnic origins 0.29 -0.37 0.95 0.34 0.39
Asian or Asian British 0.39 -0.70 1.48 0.55 0.48
African or African British 0.61 -0.98 2.21 0.81 0.45
Other ethnicity 0.14 -0.88 1.17 0.52 0.78
Key worker -0.69 -0.88 -0.49 0.10 8.77e-12
Time difference: Lockdown to baseline 0.08 0.03 0.14 0.03 0.004
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.64 6.66 8.62 0.50 1.82e-52
pcl.sum_score_prepan 0.51 0.50 0.53 0.01 0.00e+00
Depressive and anxiety disorder 0.70 0.08 1.33 0.32 0.03
Only depressive disorder -0.12 -0.79 0.55 0.34 0.73
Only anxiety disorder -0.64 -1.35 0.06 0.36 0.07
Eating disorders 0.42 0.12 0.73 0.15 0.006
OCDs 0.52 0.23 0.80 0.14 3.41e-04
Psychotic and bipolar disorder -0.20 -1.02 0.62 0.42 0.63
Only psychotic disorder 0.04 -0.65 0.72 0.35 0.92
Only bipolar disorder 0.51 0.10 0.92 0.21 0.02
PTSD 0.85 0.58 1.12 0.14 1.10e-09
ASD 0.37 -0.19 0.92 0.28 0.19
ADHD 0.16 -0.59 0.91 0.38 0.68
Personality disorder 0.93 0.55 1.30 0.19 1.31e-06
Female 0.46 0.21 0.72 0.13 3.36e-04
Non-binary/Self-defined 0.47 -0.25 1.18 0.36 0.20
19-25 years -0.32 -0.94 0.30 0.32 0.32
26-35 years -1.18 -1.78 -0.58 0.31 1.13e-04
36-45 years -1.66 -2.27 -1.05 0.31 8.51e-08
46-55 years -1.75 -2.36 -1.15 0.31 1.35e-08
56-65 years -1.96 -2.58 -1.34 0.32 5.58e-10
66-70 years -3.02 -3.78 -2.25 0.39 1.27e-14
71-75 years -3.39 -4.30 -2.49 0.46 2.42e-13
76+ years -2.95 -4.46 -1.43 0.77 1.43e-04
Mixed or multiple ethnic origins 0.24 -0.41 0.89 0.33 0.47
Asian or Asian British 0.52 -0.55 1.60 0.55 0.34
African or African British 0.75 -0.83 2.33 0.81 0.35
Other ethnicity 0.06 -0.94 1.06 0.51 0.91
Key worker -0.59 -0.79 -0.40 0.10 2.77e-09
Time difference: Lockdown to baseline 0.09 0.04 0.15 0.03 0.002
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

SENSITIVITY based on highest level of education

GAD prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.67 6.63 8.72 0.53 2.31e-46
highest_educationNVQ -0.27 -0.81 0.27 0.27 0.33
highest_educationA-levels -0.41 -0.84 0.02 0.22 0.06
highest_educationUniversity -1.78 -2.18 -1.39 0.20 6.22e-19
Anxiety disorders 1.06 -0.03 2.15 0.56 0.06
Eating disorders 2.69 0.56 4.82 1.09 0.01
OCDs 3.33 1.85 4.81 0.76 1.05e-05
PTSD 2.57 0.87 4.27 0.87 0.003
Depressive disorders 2.20 1.20 3.20 0.51 1.59e-05
Bipolar disorders 2.95 1.88 4.03 0.55 7.32e-08
n R2 adjust. R2 F p value df
10788 0.02 0.02 26.33 1.89e-45 9

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.20 7.44 8.96 0.39 3.66e-96
highest_educationNVQ -0.28 -0.80 0.24 0.26 0.29
highest_educationA-levels -0.53 -0.95 -0.12 0.21 0.01
highest_educationUniversity -1.64 -2.02 -1.26 0.19 2.33e-17
Depressive and anxiety disorder 1.22 0.53 1.92 0.36 5.98e-04
Only depressive disorder -1.50 -2.26 -0.75 0.39 9.72e-05
Only anxiety disorder 0.54 -0.25 1.33 0.40 0.18
Eating disorders 1.41 1.06 1.75 0.17 6.58e-16
OCDs 1.46 1.14 1.78 0.16 5.87e-19
Psychotic and bipolar disorder -0.47 -1.40 0.47 0.48 0.33
Only psychotic disorder -0.13 -0.92 0.65 0.40 0.74
Only bipolar disorder 0.11 -0.36 0.57 0.24 0.65
PTSD 1.27 0.97 1.57 0.15 1.32e-16
ASD 1.67 1.05 2.29 0.32 1.34e-07
ADHD 0.44 -0.40 1.29 0.43 0.30
Personality disorder 1.88 1.46 2.30 0.21 1.67e-18
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.04 8.74 11.33 0.66 2.80e-51
highest_educationNVQ -0.22 -0.75 0.31 0.27 0.41
highest_educationA-levels -1.09 -1.52 -0.67 0.22 5.02e-07
highest_educationUniversity -2.02 -2.42 -1.63 0.20 7.72e-24
Anxiety disorders 0.98 -0.08 2.04 0.54 0.07
Eating disorders 2.23 0.17 4.30 1.05 0.03
OCDs 2.80 1.36 4.24 0.73 1.39e-04
PTSD 3.06 1.40 4.72 0.85 3.00e-04
Depressive disorders 2.35 1.38 3.33 0.50 2.30e-06
Bipolar disorders 3.22 2.17 4.27 0.54 1.97e-09
Female 0.59 0.31 0.88 0.15 4.39e-05
Non-binary/Self-defined 1.20 0.39 2.01 0.41 0.004
19-25 years -0.19 -0.91 0.54 0.37 0.61
26-35 years -1.53 -2.24 -0.82 0.36 2.20e-05
36-45 years -2.25 -2.96 -1.53 0.36 7.09e-10
46-55 years -2.83 -3.53 -2.12 0.36 4.44e-15
56-65 years -4.17 -4.89 -3.44 0.37 1.54e-29
66-70 years -5.58 -6.47 -4.68 0.46 5.36e-34
71-75 years -6.32 -7.39 -5.25 0.54 6.11e-31
76+ years -5.96 -7.70 -4.22 0.89 2.15e-11
Mixed or multiple ethnic origins -0.09 -0.83 0.64 0.37 0.80
Asian or Asian British -0.12 -1.32 1.09 0.62 0.85
African or African British 0.29 -1.56 2.14 0.94 0.76
Other ethnicity 1.24 0.06 2.41 0.60 0.04
Key worker -0.73 -0.96 -0.51 0.11 7.88e-11
Time difference: Lockdown to baseline -0.01 -0.07 0.06 0.03 0.82
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.40 9.33 11.47 0.55 1.49e-79
highest_educationNVQ -0.21 -0.72 0.31 0.26 0.43
highest_educationA-levels -1.09 -1.50 -0.67 0.21 2.68e-07
highest_educationUniversity -1.83 -2.21 -1.45 0.20 9.68e-21
Depressive and anxiety disorder 1.38 0.70 2.07 0.35 8.33e-05
Only depressive disorder -0.88 -1.62 -0.13 0.38 0.02
Only anxiety disorder 0.46 -0.31 1.24 0.40 0.24
Eating disorders 1.15 0.82 1.49 0.17 1.57e-11
OCDs 1.22 0.90 1.53 0.16 3.34e-14
Psychotic and bipolar disorder -0.01 -0.92 0.91 0.47 0.99
Only psychotic disorder 0.06 -0.71 0.83 0.39 0.88
Only bipolar disorder 0.32 -0.14 0.78 0.23 0.17
PTSD 1.37 1.07 1.66 0.15 1.45e-19
ASD 1.18 0.56 1.79 0.31 1.69e-04
ADHD 0.20 -0.63 1.03 0.42 0.64
Personality disorder 1.56 1.15 1.97 0.21 1.38e-13
Female 0.37 0.09 0.65 0.14 0.009
Non-binary/Self-defined 0.40 -0.39 1.19 0.40 0.32
19-25 years -0.35 -1.04 0.35 0.36 0.33
26-35 years -1.70 -2.38 -1.02 0.35 1.01e-06
36-45 years -2.26 -2.94 -1.57 0.35 1.31e-10
46-55 years -2.73 -3.41 -2.05 0.35 3.99e-15
56-65 years -3.83 -4.53 -3.13 0.36 6.11e-27
66-70 years -5.02 -5.88 -4.15 0.44 1.16e-29
71-75 years -5.57 -6.60 -4.54 0.53 5.15e-26
76+ years -5.36 -7.05 -3.66 0.86 6.07e-10
Mixed or multiple ethnic origins -0.10 -0.81 0.61 0.36 0.78
Asian or Asian British 0.20 -0.97 1.37 0.60 0.74
African or African British 0.27 -1.53 2.07 0.92 0.77
Other ethnicity 1.05 -0.07 2.17 0.57 0.07
Key worker -0.48 -0.69 -0.26 0.11 1.45e-05
Time difference: Lockdown to baseline 0.01 -0.05 0.08 0.03 0.66
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

PHQ prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.96 8.78 11.14 0.60 6.67e-61
highest_educationNVQ -0.48 -1.09 0.13 0.31 0.12
highest_educationA-levels -0.57 -1.05 -0.08 0.25 0.02
highest_educationUniversity -2.59 -3.03 -2.15 0.23 2.29e-30
Anxiety disorders -0.85 -2.08 0.37 0.63 0.17
Eating disorders 0.97 -1.40 3.34 1.21 0.42
OCDs 2.17 0.50 3.84 0.85 0.01
PTSD 1.14 -0.78 3.06 0.98 0.25
Depressive disorders 2.82 1.69 3.94 0.57 9.02e-07
Bipolar disorders 4.26 3.05 5.47 0.62 5.21e-12
n R2 adjust. R2 F p value df
10783 0.05 0.05 61.56 1.25e-110 9

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.47 9.61 11.34 0.44 2.32e-121
highest_educationNVQ -0.51 -1.10 0.07 0.30 0.09
highest_educationA-levels -0.69 -1.16 -0.22 0.24 0.004
highest_educationUniversity -2.41 -2.84 -1.98 0.22 2.78e-28
Depressive and anxiety disorder 1.45 0.66 2.24 0.40 3.41e-04
Only depressive disorder 0.17 -0.69 1.03 0.44 0.70
Only anxiety disorder -1.38 -2.28 -0.49 0.46 0.002
Eating disorders 2.09 1.70 2.47 0.20 2.75e-26
OCDs 1.46 1.09 1.82 0.18 3.33e-15
Psychotic and bipolar disorder -0.58 -1.63 0.48 0.54 0.28
Only psychotic disorder 0.19 -0.70 1.07 0.45 0.68
Only bipolar disorder 0.75 0.23 1.28 0.27 0.005
PTSD 1.54 1.20 1.88 0.17 6.35e-19
ASD 2.02 1.32 2.72 0.36 1.46e-08
ADHD 0.78 -0.17 1.74 0.49 0.11
Personality disorder 2.87 2.40 3.35 0.24 2.34e-32
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.36 11.90 14.82 0.75 8.35e-71
highest_educationNVQ -0.24 -0.84 0.35 0.30 0.42
highest_educationA-levels -1.17 -1.65 -0.69 0.24 1.82e-06
highest_educationUniversity -2.56 -3.00 -2.12 0.23 9.78e-30
Anxiety disorders -0.93 -2.12 0.27 0.61 0.13
Eating disorders 0.67 -1.63 2.96 1.17 0.57
OCDs 1.57 -0.05 3.19 0.83 0.06
PTSD 1.59 -0.28 3.46 0.96 0.10
Depressive disorders 3.03 1.93 4.12 0.56 6.35e-08
Bipolar disorders 4.54 3.36 5.72 0.60 5.43e-14
Female 0.26 -0.06 0.58 0.16 0.11
Non-binary/Self-defined 1.76 0.85 2.67 0.46 1.54e-04
19-25 years -1.19 -2.00 -0.37 0.42 0.004
26-35 years -2.94 -3.73 -2.15 0.41 4.33e-13
36-45 years -3.57 -4.37 -2.77 0.41 3.08e-18
46-55 years -3.86 -4.66 -3.07 0.40 1.59e-21
56-65 years -5.33 -6.14 -4.52 0.41 1.10e-37
66-70 years -7.63 -8.64 -6.62 0.51 2.32e-49
71-75 years -8.35 -9.55 -7.16 0.61 3.72e-42
76+ years -7.89 -9.87 -5.92 1.01 5.67e-15
Mixed or multiple ethnic origins 0.34 -0.49 1.16 0.42 0.42
Asian or Asian British -0.14 -1.50 1.21 0.69 0.84
African or African British 0.57 -1.51 2.65 1.06 0.59
Other ethnicity 0.85 -0.47 2.17 0.67 0.21
Key worker -1.26 -1.51 -1.01 0.13 3.75e-23
Time difference: Lockdown to baseline 0.05 -0.02 0.12 0.04 0.19
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.96 12.76 15.17 0.62 2.16e-111
highest_educationNVQ -0.25 -0.83 0.33 0.30 0.40
highest_educationA-levels -1.17 -1.63 -0.70 0.24 9.04e-07
highest_educationUniversity -2.34 -2.77 -1.91 0.22 2.98e-26
Depressive and anxiety disorder 1.70 0.93 2.48 0.40 1.75e-05
Only depressive disorder 0.93 0.09 1.77 0.43 0.03
Only anxiety disorder -1.44 -2.31 -0.56 0.45 0.001
Eating disorders 1.83 1.45 2.21 0.19 2.46e-21
OCDs 1.17 0.82 1.52 0.18 9.50e-11
Psychotic and bipolar disorder -0.20 -1.23 0.83 0.53 0.71
Only psychotic disorder 0.37 -0.50 1.23 0.44 0.41
Only bipolar disorder 0.95 0.44 1.47 0.26 2.89e-04
PTSD 1.64 1.31 1.97 0.17 4.96e-22
ASD 1.23 0.54 1.92 0.35 4.99e-04
ADHD 0.43 -0.50 1.37 0.48 0.36
Personality disorder 2.54 2.08 3.01 0.24 1.19e-26
Female -0.07 -0.39 0.24 0.16 0.65
Non-binary/Self-defined 0.82 -0.07 1.71 0.45 0.07
19-25 years -1.44 -2.22 -0.65 0.40 3.48e-04
26-35 years -3.19 -3.96 -2.43 0.39 3.72e-16
36-45 years -3.71 -4.49 -2.94 0.40 7.27e-21
46-55 years -3.92 -4.68 -3.15 0.39 1.63e-23
56-65 years -5.20 -5.98 -4.41 0.40 2.83e-38
66-70 years -7.22 -8.19 -6.24 0.50 4.32e-47
71-75 years -7.82 -8.98 -6.66 0.59 1.78e-39
76+ years -7.43 -9.36 -5.50 0.98 4.48e-14
Mixed or multiple ethnic origins 0.24 -0.56 1.04 0.41 0.56
Asian or Asian British 0.14 -1.17 1.46 0.67 0.83
African or African British 0.84 -1.19 2.87 1.04 0.42
Other ethnicity 0.59 -0.67 1.85 0.64 0.36
Key worker -0.99 -1.23 -0.75 0.12 1.64e-15
Time difference: Lockdown to baseline 0.06 -0.01 0.14 0.04 0.08
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

OCIR prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 23.15 16.11 30.19 3.59 1.44e-10
highest_educationNVQ 0.91 -1.76 3.58 1.36 0.51
highest_educationA-levels -2.13 -4.23 -0.02 1.07 0.05
highest_educationUniversity -4.68 -6.60 -2.75 0.98 2.01e-06
Anxiety disorders -10.63 -17.95 -3.30 3.73 0.004
Eating disorders -4.65 -15.89 6.60 5.73 0.42
OCDs 3.63 -4.72 11.99 4.26 0.39
PTSD -1.74 -11.62 8.13 5.04 0.73
Depressive disorders -3.68 -10.54 3.17 3.49 0.29
Bipolar disorders 0.69 -6.43 7.82 3.63 0.85
n R2 adjust. R2 F p value df
1730 0.06 0.05 11.41 1.61e-17 9

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 21.37 16.67 26.06 2.39 1.11e-18
highest_educationNVQ 0.38 -2.15 2.91 1.29 0.77
highest_educationA-levels -2.67 -4.67 -0.68 1.02 0.009
highest_educationUniversity -4.30 -6.13 -2.48 0.93 4.21e-06
Depressive and anxiety disorder -4.48 -8.93 -0.02 2.27 0.05
Only depressive disorder -6.31 -11.16 -1.45 2.48 0.01
Only anxiety disorder -7.44 -12.29 -2.58 2.47 0.003
Eating disorders 1.28 -0.31 2.86 0.81 0.11
OCDs 7.90 6.53 9.27 0.70 9.89e-29
Psychotic and bipolar disorder 6.57 2.26 10.88 2.20 0.003
Only psychotic disorder 1.49 -1.71 4.69 1.63 0.36
Only bipolar disorder 1.79 -0.48 4.06 1.16 0.12
PTSD 1.49 0.14 2.83 0.69 0.03
ASD 5.61 2.65 8.57 1.51 2.11e-04
ADHD 1.00 -3.44 5.43 2.26 0.66
Personality disorder 3.07 1.27 4.87 0.92 8.15e-04
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 23.65 15.26 32.04 4.28 3.76e-08
highest_educationNVQ 1.08 -1.66 3.81 1.39 0.44
highest_educationA-levels -1.73 -3.89 0.44 1.10 0.12
highest_educationUniversity -4.12 -6.13 -2.10 1.03 6.29e-05
Anxiety disorders -11.23 -18.78 -3.69 3.85 0.004
Eating disorders -5.12 -16.46 6.22 5.78 0.38
OCDs 2.58 -5.93 11.09 4.34 0.55
PTSD -1.88 -11.91 8.15 5.11 0.71
Depressive disorders -4.28 -11.40 2.85 3.63 0.24
Bipolar disorders 0.36 -7.03 7.75 3.77 0.92
Female -0.20 -1.87 1.48 0.85 0.82
Non-binary/Self-defined 2.77 -1.13 6.68 1.99 0.16
19-25 years -0.72 -5.04 3.60 2.20 0.75
26-35 years -1.57 -5.81 2.68 2.16 0.47
36-45 years -2.32 -6.61 1.96 2.18 0.29
46-55 years -1.66 -5.88 2.56 2.15 0.44
56-65 years -3.96 -8.28 0.36 2.20 0.07
66-70 years -3.66 -9.20 1.88 2.83 0.20
71-75 years -7.95 -14.71 -1.20 3.45 0.02
76+ years -0.91 -13.30 11.47 6.32 0.88
Mixed or multiple ethnic origins 0.89 -2.77 4.56 1.87 0.63
Asian or Asian British 12.12 4.29 19.96 3.99 0.002
African or African British 7.27 -3.22 17.75 5.35 0.17
Other ethnicity 2.93 -2.00 7.86 2.51 0.24
Key worker -1.96 -3.15 -0.77 0.61 0.001
Time difference: Lockdown to baseline 0.34 -0.02 0.69 0.18 0.06
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 21.44 15.13 27.75 3.22 3.63e-11
highest_educationNVQ 0.54 -2.06 3.14 1.33 0.68
highest_educationA-levels -2.23 -4.28 -0.18 1.05 0.03
highest_educationUniversity -3.82 -5.74 -1.90 0.98 9.72e-05
Depressive and anxiety disorder -4.61 -9.16 -0.07 2.32 0.05
Only depressive disorder -5.93 -10.87 -0.99 2.52 0.02
Only anxiety disorder -7.55 -12.47 -2.64 2.51 0.003
Eating disorders 1.28 -0.31 2.87 0.81 0.11
OCDs 7.87 6.50 9.23 0.70 1.88e-28
Psychotic and bipolar disorder 6.39 2.09 10.69 2.19 0.004
Only psychotic disorder 1.43 -1.78 4.63 1.63 0.38
Only bipolar disorder 2.04 -0.25 4.34 1.17 0.08
PTSD 1.45 0.08 2.81 0.69 0.04
ASD 4.80 1.81 7.78 1.52 0.002
ADHD 0.37 -4.09 4.82 2.27 0.87
Personality disorder 2.93 1.14 4.72 0.91 0.001
Female -0.85 -2.46 0.75 0.82 0.30
Non-binary/Self-defined 1.63 -2.17 5.44 1.94 0.40
19-25 years -0.73 -4.79 3.33 2.07 0.72
26-35 years -1.71 -5.71 2.29 2.04 0.40
36-45 years -2.41 -6.44 1.63 2.06 0.24
46-55 years -1.13 -5.11 2.85 2.03 0.58
56-65 years -3.30 -7.38 0.77 2.08 0.11
66-70 years -2.38 -7.58 2.83 2.65 0.37
71-75 years -4.62 -10.92 1.68 3.21 0.15
76+ years -2.58 -14.42 9.26 6.04 0.67
Mixed or multiple ethnic origins 0.09 -3.37 3.55 1.76 0.96
Asian or Asian British 10.52 3.03 18.01 3.82 0.006
African or African British 8.81 -1.19 18.81 5.10 0.08
Other ethnicity 1.85 -2.86 6.56 2.40 0.44
Key worker -1.03 -2.17 0.12 0.58 0.08
Time difference: Lockdown to baseline 0.35 0.01 0.68 0.17 0.04
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

PCL prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.01 13.90 16.12 0.56 1.03e-150
highest_educationNVQ -0.28 -0.85 0.28 0.29 0.33
highest_educationA-levels -0.41 -0.86 0.05 0.23 0.08
highest_educationUniversity -1.94 -2.36 -1.53 0.21 2.70e-20
Anxiety disorders -0.63 -1.78 0.53 0.59 0.29
Eating disorders 1.07 -1.14 3.27 1.13 0.34
OCDs 1.43 -0.13 2.99 0.80 0.07
PTSD 2.39 0.60 4.18 0.91 0.009
Depressive disorders 2.19 1.14 3.25 0.54 4.67e-05
Bipolar disorders 3.57 2.43 4.71 0.58 7.75e-10
n R2 adjust. R2 F p value df
10703 0.03 0.03 42.74 6.65e-76 9

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.39 14.59 16.19 0.41 2.16e-289
highest_educationNVQ -0.29 -0.84 0.25 0.28 0.29
highest_educationA-levels -0.50 -0.93 -0.06 0.22 0.03
highest_educationUniversity -1.73 -2.12 -1.33 0.20 1.46e-17
Depressive and anxiety disorder 1.04 0.30 1.78 0.38 0.006
Only depressive disorder -0.88 -1.68 -0.08 0.41 0.03
Only anxiety disorder -1.02 -1.86 -0.19 0.42 0.02
Eating disorders 1.25 0.89 1.60 0.18 7.38e-12
OCDs 1.24 0.90 1.58 0.17 4.38e-13
Psychotic and bipolar disorder -0.12 -1.09 0.86 0.50 0.82
Only psychotic disorder -0.18 -1.00 0.64 0.42 0.67
Only bipolar disorder 0.61 0.12 1.10 0.25 0.01
PTSD 2.45 2.13 2.76 0.16 9.16e-52
ASD 1.48 0.83 2.12 0.33 8.16e-06
ADHD 0.73 -0.17 1.62 0.46 0.11
Personality disorder 2.52 2.08 2.96 0.22 5.83e-29
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 16.63 15.25 18.01 0.70 1.11e-120
highest_educationNVQ -0.09 -0.65 0.47 0.29 0.75
highest_educationA-levels -0.94 -1.39 -0.49 0.23 4.09e-05
highest_educationUniversity -1.99 -2.41 -1.58 0.21 5.96e-21
Anxiety disorders -0.70 -1.83 0.43 0.58 0.23
Eating disorders 0.79 -1.36 2.94 1.10 0.47
OCDs 0.93 -0.60 2.45 0.78 0.23
PTSD 2.86 1.10 4.62 0.90 0.001
Depressive disorders 2.35 1.31 3.38 0.53 9.49e-06
Bipolar disorders 3.78 2.66 4.90 0.57 3.51e-11
Female 0.48 0.17 0.78 0.15 0.002
Non-binary/Self-defined 1.68 0.83 2.53 0.43 1.11e-04
19-25 years -0.25 -1.01 0.52 0.39 0.53
26-35 years -1.59 -2.34 -0.85 0.38 2.80e-05
36-45 years -2.32 -3.07 -1.56 0.38 1.71e-09
46-55 years -2.60 -3.34 -1.85 0.38 8.79e-12
56-65 years -3.61 -4.37 -2.84 0.39 2.09e-20
66-70 years -5.45 -6.40 -4.50 0.48 3.66e-29
71-75 years -6.50 -7.63 -5.37 0.58 2.34e-29
76+ years -6.27 -8.10 -4.43 0.94 2.25e-11
Mixed or multiple ethnic origins 0.28 -0.50 1.06 0.40 0.48
Asian or Asian British 0.47 -0.81 1.76 0.66 0.47
African or African British 1.90 -0.05 3.85 0.99 0.06
Other ethnicity 0.50 -0.74 1.75 0.63 0.43
Key worker -1.13 -1.36 -0.89 0.12 4.16e-21
Time difference: Lockdown to baseline 0.09 0.02 0.16 0.04 0.008
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.04 15.92 18.17 0.58 1.66e-185
highest_educationNVQ -0.06 -0.60 0.48 0.28 0.82
highest_educationA-levels -0.92 -1.35 -0.48 0.22 3.72e-05
highest_educationUniversity -1.73 -2.13 -1.33 0.21 4.36e-17
Depressive and anxiety disorder 1.27 0.54 2.00 0.37 6.25e-04
Only depressive disorder -0.26 -1.04 0.53 0.40 0.52
Only anxiety disorder -1.04 -1.86 -0.21 0.42 0.01
Eating disorders 1.02 0.67 1.37 0.18 1.33e-08
OCDs 1.02 0.70 1.35 0.17 1.13e-09
Psychotic and bipolar disorder 0.21 -0.75 1.17 0.49 0.67
Only psychotic disorder -0.06 -0.87 0.74 0.41 0.87
Only bipolar disorder 0.79 0.31 1.27 0.25 0.001
PTSD 2.52 2.21 2.83 0.16 2.68e-56
ASD 0.88 0.24 1.53 0.33 0.007
ADHD 0.47 -0.41 1.34 0.45 0.29
Personality disorder 2.23 1.80 2.67 0.22 9.35e-24
Female 0.19 -0.10 0.49 0.15 0.20
Non-binary/Self-defined 0.77 -0.05 1.60 0.42 0.07
19-25 years -0.54 -1.27 0.20 0.37 0.15
26-35 years -1.92 -2.64 -1.21 0.37 1.41e-07
36-45 years -2.54 -3.26 -1.82 0.37 6.06e-12
46-55 years -2.74 -3.46 -2.03 0.37 6.38e-14
56-65 years -3.51 -4.24 -2.77 0.37 7.75e-21
66-70 years -5.06 -5.98 -4.15 0.47 2.77e-27
71-75 years -5.94 -7.02 -4.85 0.55 1.28e-26
76+ years -5.83 -7.61 -4.05 0.91 1.31e-10
Mixed or multiple ethnic origins 0.14 -0.61 0.89 0.38 0.71
Asian or Asian British 0.74 -0.50 1.98 0.63 0.24
African or African British 2.02 0.14 3.91 0.96 0.04
Other ethnicity 0.17 -1.02 1.35 0.60 0.78
Key worker -0.85 -1.07 -0.62 0.12 2.88e-13
Time difference: Lockdown to baseline 0.11 0.05 0.18 0.03 9.25e-04
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

SENSITIVITY based on employment status

GAD prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.35 5.37 7.33 0.50 9.56e-37
employment.unemployed_numeric 2.53 2.15 2.91 0.19 1.13e-38
Anxiety disorders 1.04 -0.04 2.12 0.55 0.06
Eating disorders 2.64 0.53 4.74 1.07 0.01
OCDs 3.14 1.67 4.60 0.75 2.75e-05
PTSD 2.57 0.87 4.26 0.87 0.003
Depressive disorders 2.12 1.13 3.10 0.50 2.64e-05
Bipolar disorders 2.79 1.73 3.85 0.54 2.63e-07
n R2 adjust. R2 F p value df
11153 0.02 0.02 33.96 3.77e-47 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.99 6.31 7.66 0.35 5.38e-89
employment.unemployedUnemployed 1.89 1.52 2.26 0.19 2.01e-23
Depressive and anxiety disorder 1.15 0.46 1.84 0.35 0.001
Only depressive disorder -1.56 -2.31 -0.82 0.38 3.74e-05
Only anxiety disorder 0.48 -0.30 1.26 0.40 0.23
Eating disorders 1.34 1.00 1.68 0.17 5.67e-15
OCDs 1.45 1.13 1.76 0.16 3.11e-19
Psychotic and bipolar disorder -0.69 -1.61 0.23 0.47 0.14
Only psychotic disorder -0.11 -0.88 0.66 0.39 0.79
Only bipolar disorder 0.07 -0.39 0.53 0.23 0.76
PTSD 1.35 1.05 1.64 0.15 4.53e-19
ASD 1.51 0.90 2.12 0.31 1.20e-06
ADHD 0.50 -0.34 1.33 0.43 0.24
Personality disorder 1.87 1.46 2.28 0.21 9.18e-19
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.99 7.73 10.25 0.64 5.34e-44
employment.unemployedUnemployed 1.99 1.61 2.38 0.20 4.80e-24
Anxiety disorders 1.00 -0.06 2.05 0.54 0.06
Eating disorders 2.30 0.26 4.35 1.04 0.03
OCDs 2.62 1.19 4.05 0.73 3.24e-04
PTSD 3.08 1.42 4.74 0.85 2.74e-04
Depressive disorders 2.36 1.40 3.33 0.49 1.69e-06
Bipolar disorders 3.20 2.16 4.24 0.53 1.75e-09
Female 0.64 0.36 0.92 0.14 9.22e-06
Non-binary/Self-defined 1.13 0.32 1.93 0.41 0.006
19-25 years -1.03 -1.73 -0.32 0.36 0.004
26-35 years -2.45 -3.13 -1.77 0.35 1.66e-12
36-45 years -3.01 -3.70 -2.32 0.35 1.23e-17
46-55 years -3.49 -4.18 -2.81 0.35 1.99e-23
56-65 years -4.67 -5.37 -3.98 0.36 5.82e-39
66-70 years -6.16 -7.02 -5.29 0.44 4.05e-44
71-75 years -6.77 -7.79 -5.75 0.52 1.34e-38
76+ years -6.37 -8.07 -4.68 0.87 2.08e-13
Mixed or multiple ethnic origins -0.17 -0.90 0.57 0.37 0.66
Asian or Asian British -0.16 -1.35 1.03 0.61 0.79
African or African British 0.31 -1.48 2.09 0.91 0.74
Other ethnicity 0.95 -0.20 2.09 0.58 0.10
Key worker -0.58 -0.81 -0.35 0.12 5.78e-07
Time difference: Lockdown to baseline 0.00 -0.07 0.06 0.03 0.90
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.51 8.48 10.53 0.52 9.63e-73
employment.unemployedUnemployed 1.56 1.19 1.94 0.19 4.85e-16
Depressive and anxiety disorder 1.38 0.70 2.06 0.35 7.25e-05
Only depressive disorder -0.91 -1.64 -0.17 0.37 0.02
Only anxiety disorder 0.43 -0.34 1.20 0.39 0.27
Eating disorders 1.07 0.74 1.40 0.17 2.56e-10
OCDs 1.25 0.94 1.56 0.16 3.01e-15
Psychotic and bipolar disorder -0.25 -1.15 0.66 0.46 0.60
Only psychotic disorder 0.05 -0.70 0.81 0.38 0.89
Only bipolar disorder 0.31 -0.14 0.76 0.23 0.17
PTSD 1.45 1.16 1.74 0.15 1.86e-22
ASD 1.03 0.43 1.64 0.31 8.53e-04
ADHD 0.26 -0.55 1.08 0.42 0.53
Personality disorder 1.61 1.21 2.02 0.21 8.10e-15
Female 0.40 0.13 0.68 0.14 0.004
Non-binary/Self-defined 0.35 -0.44 1.13 0.40 0.39
19-25 years -1.10 -1.78 -0.42 0.35 0.002
26-35 years -2.52 -3.18 -1.87 0.33 4.27e-14
36-45 years -2.94 -3.60 -2.28 0.34 3.86e-18
46-55 years -3.31 -3.97 -2.65 0.34 9.55e-23
56-65 years -4.28 -4.95 -3.60 0.34 2.76e-35
66-70 years -5.55 -6.39 -4.72 0.42 8.32e-39
71-75 years -6.01 -7.00 -5.03 0.50 6.79e-33
76+ years -5.70 -7.35 -4.04 0.84 1.45e-11
Mixed or multiple ethnic origins -0.19 -0.90 0.52 0.36 0.60
Asian or Asian British 0.12 -1.03 1.28 0.59 0.84
African or African British 0.34 -1.40 2.08 0.89 0.70
Other ethnicity 0.81 -0.28 1.91 0.56 0.14
Key worker -0.37 -0.59 -0.15 0.11 0.001
Time difference: Lockdown to baseline 0.01 -0.05 0.08 0.03 0.67
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

PHQ prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.15 7.05 9.25 0.56 3.10e-47
employment.unemployedUnemployed 4.07 3.64 4.49 0.22 2.00e-76
Anxiety disorders -0.99 -2.20 0.23 0.62 0.11
Eating disorders 0.67 -1.68 3.01 1.20 0.58
OCDs 1.80 0.15 3.45 0.84 0.03
PTSD 0.97 -0.95 2.89 0.98 0.32
Depressive disorders 2.54 1.43 3.64 0.57 7.56e-06
Bipolar disorders 3.85 2.66 5.05 0.61 2.71e-10
n R2 adjust. R2 F p value df
11150 0.05 0.05 88.98 1.13e-126 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.78 8.01 9.55 0.39 6.64e-109
employment.unemployedUnemployed 3.37 2.95 3.79 0.21 1.12e-55
Depressive and anxiety disorder 1.21 0.43 1.99 0.40 0.002
Only depressive disorder -0.11 -0.95 0.73 0.43 0.80
Only anxiety disorder -1.54 -2.43 -0.66 0.45 6.04e-04
Eating disorders 1.97 1.59 2.35 0.19 3.64e-24
OCDs 1.50 1.14 1.85 0.18 2.09e-16
Psychotic and bipolar disorder -0.91 -1.95 0.13 0.53 0.09
Only psychotic disorder 0.08 -0.79 0.95 0.44 0.85
Only bipolar disorder 0.69 0.17 1.21 0.26 0.009
PTSD 1.57 1.24 1.90 0.17 3.77e-20
ASD 1.70 1.01 2.39 0.35 1.40e-06
ADHD 0.97 0.03 1.91 0.48 0.04
Personality disorder 2.81 2.34 3.28 0.24 7.35e-32
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.11 10.69 13.52 0.72 3.40e-62
employment.unemployedUnemployed 3.23 2.80 3.67 0.22 3.97e-48
Anxiety disorders -0.99 -2.18 0.19 0.60 0.10
Eating disorders 0.50 -1.78 2.77 1.16 0.67
OCDs 1.22 -0.38 2.82 0.82 0.14
PTSD 1.48 -0.40 3.35 0.96 0.12
Depressive disorders 2.89 1.80 3.97 0.55 1.87e-07
Bipolar disorders 4.35 3.19 5.52 0.60 3.01e-13
Female 0.37 0.05 0.68 0.16 0.02
Non-binary/Self-defined 1.67 0.77 2.57 0.46 2.93e-04
19-25 years -2.28 -3.07 -1.48 0.40 1.85e-08
26-35 years -4.14 -4.91 -3.38 0.39 3.03e-26
36-45 years -4.63 -5.40 -3.86 0.39 1.25e-31
46-55 years -4.77 -5.54 -4.00 0.39 7.77e-34
56-65 years -6.04 -6.83 -5.26 0.40 6.30e-51
66-70 years -8.27 -9.23 -7.30 0.49 3.42e-62
71-75 years -9.02 -10.16 -7.88 0.58 1.45e-53
76+ years -8.67 -10.60 -6.75 0.98 1.15e-18
Mixed or multiple ethnic origins 0.28 -0.54 1.11 0.42 0.50
Asian or Asian British -0.25 -1.59 1.08 0.68 0.71
African or African British 0.37 -1.63 2.38 1.02 0.72
Other ethnicity 0.79 -0.50 2.07 0.66 0.23
Key worker -0.98 -1.23 -0.72 0.13 6.90e-14
Time difference: Lockdown to baseline 0.06 -0.02 0.13 0.04 0.12
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.85 11.70 14.01 0.59 2.02e-103
employment.unemployedUnemployed 2.76 2.34 3.19 0.22 4.96e-37
Depressive and anxiety disorder 1.59 0.82 2.35 0.39 4.67e-05
Only depressive disorder 0.72 -0.10 1.55 0.42 0.09
Only anxiety disorder -1.53 -2.39 -0.67 0.44 5.22e-04
Eating disorders 1.71 1.33 2.08 0.19 3.22e-19
OCDs 1.25 0.90 1.59 0.18 2.53e-12
Psychotic and bipolar disorder -0.50 -1.52 0.52 0.52 0.34
Only psychotic disorder 0.22 -0.63 1.06 0.43 0.62
Only bipolar disorder 0.94 0.43 1.44 0.26 2.86e-04
PTSD 1.67 1.34 1.99 0.17 2.57e-23
ASD 0.93 0.24 1.61 0.35 0.008
ADHD 0.65 -0.27 1.57 0.47 0.17
Personality disorder 2.58 2.12 3.04 0.23 3.16e-28
Female 0.02 -0.30 0.33 0.16 0.92
Non-binary/Self-defined 0.76 -0.12 1.64 0.45 0.09
19-25 years -2.44 -3.20 -1.68 0.39 3.79e-10
26-35 years -4.29 -5.03 -3.56 0.38 4.34e-30
36-45 years -4.69 -5.43 -3.94 0.38 1.06e-34
46-55 years -4.73 -5.47 -3.99 0.38 1.46e-35
56-65 years -5.84 -6.60 -5.08 0.39 5.56e-51
66-70 years -7.79 -8.73 -6.85 0.48 4.05e-59
71-75 years -8.48 -9.58 -7.37 0.56 1.31e-50
76+ years -8.14 -10.02 -6.27 0.96 1.90e-17
Mixed or multiple ethnic origins 0.16 -0.64 0.96 0.41 0.69
Asian or Asian British -0.01 -1.31 1.29 0.66 0.99
African or African British 0.63 -1.33 2.59 1.00 0.53
Other ethnicity 0.58 -0.65 1.81 0.63 0.35
Key worker -0.76 -1.01 -0.51 0.13 2.21e-09
Time difference: Lockdown to baseline 0.07 0.00 0.14 0.04 0.06
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

OCIR prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 19.50 12.61 26.39 3.51 3.24e-08
employment.unemployedUnemployed 5.47 3.72 7.21 0.89 9.29e-10
Anxiety disorders -10.52 -17.91 -3.12 3.77 0.005
Eating disorders -4.64 -15.99 6.70 5.79 0.42
OCDs 2.88 -5.56 11.31 4.30 0.50
PTSD -1.45 -11.41 8.51 5.08 0.78
Depressive disorders -3.66 -10.58 3.26 3.53 0.30
Bipolar disorders 1.15 -6.03 8.32 3.66 0.75
n R2 adjust. R2 F p value df
1783 0.05 0.05 14.21 4.64e-18 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.90 13.44 22.37 2.28 6.51e-15
employment.unemployedUnemployed 3.65 1.96 5.34 0.86 2.29e-05
Depressive and anxiety disorder -4.39 -8.90 0.12 2.30 0.06
Only depressive disorder -6.61 -11.51 -1.70 2.50 0.008
Only anxiety disorder -7.40 -12.32 -2.48 2.51 0.003
Eating disorders 0.96 -0.61 2.54 0.80 0.23
OCDs 7.50 6.14 8.86 0.69 2.22e-26
Psychotic and bipolar disorder 4.73 0.64 8.82 2.09 0.02
Only psychotic disorder 1.52 -1.67 4.71 1.63 0.35
Only bipolar disorder 2.71 0.47 4.95 1.14 0.02
PTSD 2.07 0.74 3.41 0.68 0.002
ASD 5.47 2.55 8.39 1.49 2.50e-04
ADHD 0.17 -4.09 4.44 2.17 0.94
Personality disorder 3.39 1.61 5.17 0.91 1.95e-04
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 20.79 12.40 29.18 4.28 1.28e-06
employment.unemployedUnemployed 4.43 2.61 6.26 0.93 1.98e-06
Anxiety disorders -10.83 -18.46 -3.21 3.89 0.005
Eating disorders -4.40 -15.86 7.06 5.84 0.45
OCDs 2.21 -6.39 10.82 4.39 0.61
PTSD -1.12 -11.24 9.01 5.16 0.83
Depressive disorders -3.75 -10.94 3.45 3.67 0.31
Bipolar disorders 1.32 -6.13 8.76 3.80 0.73
Female -0.06 -1.71 1.60 0.85 0.95
Non-binary/Self-defined 2.06 -1.87 5.99 2.00 0.30
19-25 years -2.97 -7.23 1.28 2.17 0.17
26-35 years -3.87 -8.03 0.29 2.12 0.07
36-45 years -4.28 -8.47 -0.08 2.14 0.05
46-55 years -3.47 -7.65 0.71 2.13 0.10
56-65 years -4.96 -9.23 -0.69 2.18 0.02
66-70 years -6.18 -11.57 -0.79 2.75 0.02
71-75 years -10.30 -16.96 -3.65 3.39 0.002
76+ years -3.26 -15.73 9.21 6.36 0.61
Mixed or multiple ethnic origins 1.04 -2.66 4.75 1.89 0.58
Asian or Asian British 11.95 4.04 19.86 4.03 0.003
African or African British 7.03 -3.57 17.63 5.40 0.19
Other ethnicity 3.21 -1.76 8.18 2.53 0.21
Key worker -1.65 -2.88 -0.42 0.63 0.009
Time difference: Lockdown to baseline 0.47 0.13 0.82 0.18 0.008
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 18.82 12.54 25.09 3.20 4.95e-09
employment.unemployedUnemployed 3.07 1.31 4.82 0.90 6.27e-04
Depressive and anxiety disorder -4.38 -8.98 0.22 2.35 0.06
Only depressive disorder -6.24 -11.23 -1.25 2.55 0.01
Only anxiety disorder -7.52 -12.50 -2.53 2.54 0.003
Eating disorders 0.98 -0.60 2.56 0.81 0.22
OCDs 7.54 6.18 8.90 0.69 1.01e-26
Psychotic and bipolar disorder 4.73 0.65 8.81 2.08 0.02
Only psychotic disorder 1.44 -1.75 4.63 1.63 0.38
Only bipolar disorder 2.89 0.64 5.15 1.15 0.01
PTSD 1.95 0.61 3.30 0.69 0.004
ASD 4.91 1.97 7.84 1.50 0.001
ADHD -0.27 -4.55 4.01 2.18 0.90
Personality disorder 3.24 1.47 5.02 0.91 3.52e-04
Female -0.63 -2.22 0.97 0.81 0.44
Non-binary/Self-defined 1.10 -2.73 4.93 1.95 0.57
19-25 years -2.69 -6.70 1.33 2.05 0.19
26-35 years -3.66 -7.59 0.28 2.01 0.07
36-45 years -4.05 -8.01 -0.08 2.02 0.05
46-55 years -2.67 -6.62 1.28 2.01 0.19
56-65 years -4.09 -8.13 -0.04 2.06 0.05
66-70 years -4.37 -9.45 0.71 2.59 0.09
71-75 years -6.60 -12.85 -0.36 3.18 0.04
76+ years -4.33 -16.28 7.63 6.10 0.48
Mixed or multiple ethnic origins 0.18 -3.32 3.69 1.79 0.92
Asian or Asian British 10.34 2.76 17.92 3.86 0.008
African or African British 8.39 -1.74 18.52 5.16 0.10
Other ethnicity 2.00 -2.76 6.76 2.43 0.41
Key worker -0.91 -2.09 0.28 0.60 0.13
Time difference: Lockdown to baseline 0.47 0.14 0.80 0.17 0.005
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

PCL prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.62 12.59 14.66 0.53 2.56e-142
employment.unemployedUnemployed 3.22 2.82 3.62 0.20 6.81e-56
Anxiety disorders -0.70 -1.85 0.44 0.58 0.23
Eating disorders 0.87 -1.31 3.06 1.11 0.43
OCDs 1.07 -0.47 2.62 0.79 0.17
PTSD 2.32 0.53 4.11 0.91 0.01
Depressive disorders 2.02 0.98 3.06 0.53 1.50e-04
Bipolar disorders 3.28 2.15 4.40 0.57 1.09e-08
n R2 adjust. R2 F p value df
11069 0.04 0.04 64.69 9.03e-92 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 14.08 13.37 14.79 0.36 5.81e-307
employment.unemployedUnemployed 2.49 2.11 2.88 0.20 3.44e-36
Depressive and anxiety disorder 0.97 0.24 1.69 0.37 0.009
Only depressive disorder -0.94 -1.72 -0.16 0.40 0.02
Only anxiety disorder -1.06 -1.88 -0.24 0.42 0.01
Eating disorders 1.12 0.77 1.48 0.18 3.74e-10
OCDs 1.29 0.96 1.62 0.17 2.39e-14
Psychotic and bipolar disorder -0.32 -1.28 0.64 0.49 0.52
Only psychotic disorder -0.16 -0.97 0.64 0.41 0.69
Only bipolar disorder 0.54 0.06 1.02 0.25 0.03
PTSD 2.50 2.19 2.81 0.16 1.06e-55
ASD 1.35 0.72 1.99 0.33 3.22e-05
ADHD 0.78 -0.10 1.66 0.45 0.08
Personality disorder 2.45 2.02 2.89 0.22 2.04e-28
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.53 14.19 16.86 0.68 4.84e-112
employment.unemployedUnemployed 2.52 2.11 2.92 0.21 1.21e-33
Anxiety disorders -0.71 -1.83 0.41 0.57 0.22
Eating disorders 0.73 -1.40 2.87 1.09 0.50
OCDs 0.61 -0.90 2.12 0.77 0.43
PTSD 2.84 1.08 4.60 0.90 0.002
Depressive disorders 2.29 1.26 3.32 0.52 1.27e-05
Bipolar disorders 3.68 2.57 4.78 0.56 7.75e-11
Female 0.55 0.26 0.85 0.15 2.64e-04
Non-binary/Self-defined 1.58 0.74 2.43 0.43 2.45e-04
19-25 years -1.04 -1.79 -0.30 0.38 0.006
26-35 years -2.46 -3.18 -1.75 0.37 1.84e-11
36-45 years -3.05 -3.78 -2.32 0.37 2.08e-16
46-55 years -3.25 -3.97 -2.53 0.37 1.43e-18
56-65 years -4.05 -4.79 -3.32 0.38 6.35e-27
66-70 years -5.96 -6.87 -5.05 0.47 2.61e-37
71-75 years -6.76 -7.84 -5.69 0.55 1.06e-34
76+ years -6.54 -8.33 -4.75 0.91 7.89e-13
Mixed or multiple ethnic origins 0.14 -0.64 0.91 0.40 0.73
Asian or Asian British 0.63 -0.64 1.90 0.65 0.33
African or African British 1.75 -0.13 3.63 0.96 0.07
Other ethnicity 0.52 -0.69 1.73 0.62 0.40
Key worker -0.92 -1.16 -0.68 0.12 6.15e-14
Time difference: Lockdown to baseline 0.10 0.04 0.17 0.03 0.003
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 16.02 14.94 17.10 0.55 2.24e-179
employment.unemployedUnemployed 2.00 1.61 2.40 0.20 4.57e-23
Depressive and anxiety disorder 1.29 0.57 2.01 0.37 4.26e-04
Only depressive disorder -0.26 -1.04 0.51 0.39 0.51
Only anxiety disorder -1.02 -1.83 -0.21 0.41 0.01
Eating disorders 0.89 0.54 1.23 0.18 6.05e-07
OCDs 1.10 0.77 1.42 0.17 3.51e-11
Psychotic and bipolar disorder 0.04 -0.91 0.98 0.48 0.94
Only psychotic disorder -0.07 -0.86 0.72 0.40 0.85
Only bipolar disorder 0.76 0.28 1.23 0.24 0.002
PTSD 2.58 2.27 2.88 0.16 1.38e-60
ASD 0.80 0.17 1.44 0.32 0.01
ADHD 0.55 -0.32 1.41 0.44 0.21
Personality disorder 2.23 1.80 2.66 0.22 2.07e-24
Female 0.27 -0.02 0.56 0.15 0.07
Non-binary/Self-defined 0.70 -0.12 1.52 0.42 0.09
19-25 years -1.21 -1.92 -0.50 0.36 8.64e-04
26-35 years -2.65 -3.33 -1.96 0.35 4.56e-14
36-45 years -3.16 -3.85 -2.46 0.35 7.14e-19
46-55 years -3.27 -3.96 -2.58 0.35 2.40e-20
56-65 years -3.86 -4.57 -3.15 0.36 1.72e-26
66-70 years -5.49 -6.36 -4.61 0.45 2.25e-34
71-75 years -6.17 -7.21 -5.14 0.53 1.97e-31
76+ years -6.00 -7.73 -4.27 0.88 1.13e-11
Mixed or multiple ethnic origins 0.00 -0.75 0.74 0.38 0.99
Asian or Asian British 0.86 -0.36 2.08 0.62 0.17
African or African British 1.91 0.09 3.73 0.93 0.04
Other ethnicity 0.23 -0.92 1.38 0.59 0.69
Key worker -0.69 -0.93 -0.46 0.12 5.30e-09
Time difference: Lockdown to baseline 0.12 0.05 0.18 0.03 4.73e-04
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

SENSITIVITY based on employment change

GAD prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.14 6.99 9.29 0.59 2.40e-43
employment_changeFurlough -1.22 -1.86 -0.59 0.32 1.66e-04
employment_changeKey Worker -2.01 -2.59 -1.44 0.29 8.26e-12
employment_changeRetired -3.87 -4.51 -3.24 0.32 6.74e-33
employment_changeStudent 0.45 -0.25 1.15 0.36 0.21
employment_changeUnemployed 0.81 0.16 1.47 0.33 0.02
employment_changeZero Hours Contract -1.22 -3.13 0.69 0.97 0.21
Anxiety disorders 1.06 -0.08 2.20 0.58 0.07
Eating disorders 2.85 0.57 5.12 1.16 0.01
OCDs 2.73 1.16 4.29 0.80 6.42e-04
PTSD 2.55 0.74 4.35 0.92 0.006
Depressive disorders 2.06 1.03 3.09 0.53 9.17e-05
Bipolar disorders 2.66 1.53 3.79 0.58 3.98e-06
n R2 adjust. R2 F p value df
8748 0.06 0.06 47.78 3.06e-111 12

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.68 7.78 9.57 0.46 2.68e-79
employment_changeFurlough -1.06 -1.68 -0.44 0.31 7.54e-04
employment_changeKey Worker -1.72 -2.28 -1.16 0.29 1.81e-09
employment_changeRetired -3.36 -3.97 -2.74 0.31 1.20e-26
employment_changeStudent 0.37 -0.30 1.05 0.34 0.28
employment_changeUnemployed 0.43 -0.21 1.06 0.32 0.19
employment_changeZero Hours Contract -1.35 -3.16 0.46 0.92 0.14
Depressive and anxiety disorder 1.01 0.27 1.75 0.38 0.007
Only depressive disorder -1.53 -2.33 -0.73 0.41 1.80e-04
Only anxiety disorder 0.36 -0.49 1.20 0.43 0.40
Eating disorders 1.51 1.14 1.89 0.19 4.41e-15
OCDs 1.14 0.78 1.50 0.18 3.45e-10
Psychotic and bipolar disorder -0.58 -1.62 0.47 0.53 0.28
Only psychotic disorder -0.13 -0.98 0.72 0.43 0.76
Only bipolar disorder 0.15 -0.38 0.68 0.27 0.58
PTSD 1.28 0.95 1.61 0.17 4.58e-14
ASD 1.36 0.67 2.05 0.35 1.19e-04
ADHD 0.46 -0.48 1.41 0.48 0.33
Personality disorder 1.61 1.13 2.09 0.25 6.15e-11
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.00 8.54 11.45 0.74 6.83e-41
employment_changeFurlough -1.35 -1.98 -0.72 0.32 2.95e-05
employment_changeKey Worker -1.93 -2.61 -1.24 0.35 3.54e-08
employment_changeRetired -1.13 -1.87 -0.39 0.38 0.003
employment_changeStudent -0.84 -1.57 -0.10 0.37 0.03
employment_changeUnemployed 1.07 0.39 1.74 0.34 0.002
employment_changeZero Hours Contract -1.25 -3.13 0.63 0.96 0.19
Anxiety disorders 1.05 -0.08 2.17 0.58 0.07
Eating disorders 2.68 0.44 4.91 1.14 0.02
OCDs 2.48 0.94 4.02 0.79 0.002
PTSD 2.92 1.13 4.71 0.91 0.001
Depressive disorders 2.21 1.19 3.24 0.52 2.28e-05
Bipolar disorders 2.88 1.76 4.00 0.57 4.49e-07
Female 0.55 0.23 0.86 0.16 6.92e-04
Non-binary/Self-defined 0.86 -0.05 1.77 0.46 0.06
19-25 years -0.90 -1.62 -0.18 0.37 0.01
26-35 years -2.29 -3.01 -1.57 0.37 5.90e-10
36-45 years -2.90 -3.64 -2.16 0.38 1.79e-14
46-55 years -3.58 -4.31 -2.84 0.38 2.09e-21
56-65 years -4.72 -5.50 -3.94 0.40 2.50e-32
66-70 years -5.98 -6.98 -4.97 0.51 2.29e-31
71-75 years -6.62 -7.77 -5.48 0.58 9.10e-30
76+ years -6.32 -8.10 -4.55 0.90 2.99e-12
Mixed or multiple ethnic origins 0.01 -0.81 0.84 0.42 0.97
Asian or Asian British -0.54 -1.85 0.78 0.67 0.42
African or African British 0.17 -1.89 2.23 1.05 0.87
Other ethnicity 0.83 -0.45 2.11 0.65 0.20
Key worker 0.30 -0.25 0.85 0.28 0.29
Time difference: Lockdown to baseline 0.01 -0.06 0.08 0.04 0.78
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.52 9.29 11.76 0.63 1.07e-61
employment_changeFurlough -1.15 -1.76 -0.53 0.31 2.76e-04
employment_changeKey Worker -1.63 -2.29 -0.96 0.34 1.88e-06
employment_changeRetired -1.14 -1.86 -0.42 0.37 0.002
employment_changeStudent -0.72 -1.43 -0.01 0.36 0.05
employment_changeUnemployed 0.72 0.06 1.38 0.34 0.03
employment_changeZero Hours Contract -1.40 -3.20 0.39 0.92 0.13
Depressive and anxiety disorder 1.16 0.42 1.89 0.38 0.002
Only depressive disorder -1.07 -1.87 -0.27 0.41 0.008
Only anxiety disorder 0.34 -0.50 1.18 0.43 0.43
Eating disorders 1.30 0.92 1.67 0.19 1.39e-11
OCDs 1.05 0.69 1.40 0.18 5.61e-09
Psychotic and bipolar disorder -0.30 -1.33 0.73 0.53 0.57
Only psychotic disorder -0.06 -0.90 0.78 0.43 0.89
Only bipolar disorder 0.26 -0.27 0.78 0.27 0.34
PTSD 1.34 1.01 1.67 0.17 1.56e-15
ASD 1.01 0.32 1.70 0.35 0.004
ADHD 0.30 -0.63 1.24 0.48 0.52
Personality disorder 1.42 0.95 1.90 0.24 4.68e-09
Female 0.34 0.03 0.65 0.16 0.03
Non-binary/Self-defined 0.19 -0.70 1.07 0.45 0.68
19-25 years -0.96 -1.66 -0.26 0.36 0.007
26-35 years -2.33 -3.03 -1.63 0.36 7.30e-11
36-45 years -2.77 -3.49 -2.05 0.37 3.76e-14
46-55 years -3.31 -4.02 -2.60 0.36 9.51e-20
56-65 years -4.21 -4.96 -3.45 0.39 1.41e-27
66-70 years -5.27 -6.24 -4.30 0.50 2.95e-26
71-75 years -5.75 -6.86 -4.64 0.57 3.85e-24
76+ years -5.53 -7.26 -3.80 0.88 3.81e-10
Mixed or multiple ethnic origins 0.01 -0.79 0.81 0.41 0.98
Asian or Asian British -0.33 -1.61 0.94 0.65 0.61
African or African British 0.12 -1.90 2.14 1.03 0.91
Other ethnicity 0.73 -0.49 1.95 0.62 0.24
Key worker 0.26 -0.28 0.80 0.27 0.34
Time difference: Lockdown to baseline 0.02 -0.05 0.09 0.04 0.57
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

PHQ prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.03 8.75 11.32 0.66 3.77e-52
employment_changeFurlough -1.53 -2.24 -0.82 0.36 2.52e-05
employment_changeKey Worker -2.61 -3.25 -1.96 0.33 2.85e-15
employment_changeRetired -4.23 -4.93 -3.52 0.36 2.39e-31
employment_changeStudent 0.94 0.16 1.72 0.40 0.02
employment_changeUnemployed 2.01 1.27 2.74 0.37 8.42e-08
employment_changeZero Hours Contract -1.60 -3.73 0.54 1.09 0.14
Anxiety disorders -0.59 -1.87 0.68 0.65 0.36
Eating disorders 1.03 -1.49 3.54 1.28 0.42
OCDs 1.84 0.09 3.60 0.89 0.04
PTSD 0.61 -1.42 2.64 1.04 0.55
Depressive disorders 2.72 1.57 3.88 0.59 3.87e-06
Bipolar disorders 3.89 2.63 5.15 0.64 1.69e-09
n R2 adjust. R2 F p value df
8745 0.10 0.10 79.95 2.72e-187 12

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.81 9.80 11.82 0.51 5.26e-96
employment_changeFurlough -1.36 -2.05 -0.66 0.35 1.29e-04
employment_changeKey Worker -2.34 -2.97 -1.71 0.32 3.61e-13
employment_changeRetired -3.78 -4.48 -3.09 0.35 1.39e-26
employment_changeStudent 0.83 0.07 1.59 0.39 0.03
employment_changeUnemployed 1.59 0.87 2.31 0.37 1.44e-05
employment_changeZero Hours Contract -1.25 -3.29 0.79 1.04 0.23
Depressive and anxiety disorder 1.15 0.32 1.99 0.43 0.007
Only depressive disorder 0.01 -0.89 0.91 0.46 0.98
Only anxiety disorder -1.55 -2.50 -0.60 0.49 0.001
Eating disorders 2.00 1.57 2.42 0.22 4.70e-20
OCDs 1.19 0.79 1.60 0.20 5.49e-09
Psychotic and bipolar disorder -1.03 -2.22 0.15 0.60 0.09
Only psychotic disorder 0.23 -0.73 1.19 0.49 0.63
Only bipolar disorder 0.86 0.27 1.46 0.31 0.005
PTSD 1.29 0.92 1.67 0.19 1.35e-11
ASD 1.53 0.75 2.31 0.40 1.29e-04
ADHD 0.97 -0.10 2.03 0.54 0.07
Personality disorder 2.31 1.77 2.86 0.28 6.87e-17
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.84 11.22 14.47 0.83 2.35e-53
employment_changeFurlough -1.62 -2.32 -0.91 0.36 7.40e-06
employment_changeKey Worker -2.35 -3.12 -1.59 0.39 1.73e-09
employment_changeRetired -1.09 -1.91 -0.26 0.42 0.010
employment_changeStudent -0.72 -1.54 0.10 0.42 0.08
employment_changeUnemployed 2.21 1.46 2.97 0.38 8.01e-09
employment_changeZero Hours Contract -1.64 -3.74 0.46 1.07 0.13
Anxiety disorders -0.54 -1.80 0.72 0.64 0.40
Eating disorders 1.04 -1.42 3.51 1.26 0.41
OCDs 1.55 -0.17 3.28 0.88 0.08
PTSD 0.94 -1.06 2.95 1.02 0.36
Depressive disorders 3.00 1.86 4.14 0.58 2.80e-07
Bipolar disorders 4.26 3.01 5.51 0.64 2.57e-11
Female 0.33 -0.02 0.68 0.18 0.07
Non-binary/Self-defined 1.25 0.23 2.26 0.52 0.02
19-25 years -2.08 -2.89 -1.27 0.41 4.55e-07
26-35 years -3.83 -4.64 -3.03 0.41 1.87e-20
36-45 years -4.46 -5.29 -3.64 0.42 5.85e-26
46-55 years -4.88 -5.70 -4.06 0.42 4.85e-31
56-65 years -6.18 -7.05 -5.31 0.44 1.18e-43
66-70 years -8.18 -9.30 -7.06 0.57 4.57e-46
71-75 years -8.92 -10.19 -7.64 0.65 2.11e-42
76+ years -8.65 -10.65 -6.66 1.02 2.31e-17
Mixed or multiple ethnic origins 0.37 -0.55 1.30 0.47 0.43
Asian or Asian British -0.53 -2.00 0.94 0.75 0.48
African or African British 0.43 -1.87 2.74 1.18 0.71
Other ethnicity 0.88 -0.55 2.31 0.73 0.23
Key worker 0.19 -0.43 0.81 0.31 0.54
Time difference: Lockdown to baseline 0.08 -0.01 0.16 0.04 0.07
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.84 12.46 15.23 0.71 2.07e-83
employment_changeFurlough -1.42 -2.11 -0.72 0.35 6.27e-05
employment_changeKey Worker -2.09 -2.84 -1.34 0.38 5.11e-08
employment_changeRetired -1.12 -1.93 -0.31 0.41 0.007
employment_changeStudent -0.67 -1.47 0.13 0.41 0.10
employment_changeUnemployed 1.84 1.10 2.58 0.38 1.07e-06
employment_changeZero Hours Contract -1.36 -3.38 0.66 1.03 0.19
Depressive and anxiety disorder 1.45 0.62 2.28 0.42 5.91e-04
Only depressive disorder 0.64 -0.25 1.54 0.46 0.16
Only anxiety disorder -1.50 -2.44 -0.56 0.48 0.002
Eating disorders 1.77 1.35 2.20 0.22 1.87e-16
OCDs 1.07 0.68 1.47 0.20 9.69e-08
Psychotic and bipolar disorder -0.79 -1.96 0.38 0.60 0.18
Only psychotic disorder 0.27 -0.67 1.22 0.48 0.57
Only bipolar disorder 1.01 0.42 1.59 0.30 8.29e-04
PTSD 1.36 0.99 1.73 0.19 5.28e-13
ASD 0.93 0.16 1.71 0.40 0.02
ADHD 0.71 -0.34 1.76 0.54 0.19
Personality disorder 2.17 1.64 2.71 0.27 1.87e-15
Female 0.03 -0.32 0.38 0.18 0.87
Non-binary/Self-defined 0.53 -0.47 1.52 0.51 0.30
19-25 years -2.23 -3.01 -1.45 0.40 2.48e-08
26-35 years -3.96 -4.74 -3.17 0.40 6.95e-23
36-45 years -4.47 -5.28 -3.67 0.41 1.91e-27
46-55 years -4.76 -5.56 -3.96 0.41 3.82e-31
56-65 years -5.88 -6.73 -5.03 0.43 1.35e-41
66-70 years -7.62 -8.71 -6.53 0.56 2.70e-42
71-75 years -8.32 -9.57 -7.08 0.63 6.82e-39
76+ years -8.08 -10.04 -6.12 1.00 7.03e-16
Mixed or multiple ethnic origins 0.28 -0.62 1.19 0.46 0.54
Asian or Asian British -0.41 -1.84 1.02 0.73 0.58
African or African British 0.64 -1.63 2.90 1.15 0.58
Other ethnicity 0.70 -0.67 2.07 0.70 0.32
Key worker 0.16 -0.44 0.77 0.31 0.59
Time difference: Lockdown to baseline 0.08 0.00 0.16 0.04 0.05
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

OCIR prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 19.56 11.28 27.84 4.22 3.96e-06
employment_changeFurlough -0.48 -3.62 2.65 1.60 0.76
employment_changeKey Worker -0.04 -2.86 2.79 1.44 0.98
employment_changeRetired 0.92 -2.27 4.12 1.63 0.57
employment_changeStudent 2.10 -1.42 5.63 1.80 0.24
employment_changeUnemployed 6.22 3.11 9.32 1.58 8.93e-05
employment_changeZero Hours Contract -8.98 -25.97 8.01 8.66 0.30
Anxiety disorders -10.68 -19.14 -2.22 4.31 0.01
Eating disorders -4.63 -17.15 7.88 6.38 0.47
OCDs 2.39 -7.07 11.85 4.82 0.62
PTSD -2.42 -13.34 8.50 5.57 0.66
Depressive disorders -4.59 -12.54 3.37 4.05 0.26
Bipolar disorders 0.88 -7.37 9.12 4.20 0.83
n R2 adjust. R2 F p value df
1374 0.07 0.06 8.57 6.99e-16 12

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 16.39 10.87 21.92 2.82 7.25e-09
employment_changeFurlough -0.42 -3.42 2.58 1.53 0.78
employment_changeKey Worker 0.32 -2.40 3.03 1.38 0.82
employment_changeRetired 1.44 -1.62 4.50 1.56 0.36
employment_changeStudent 1.77 -1.61 5.15 1.72 0.30
employment_changeUnemployed 4.34 1.35 7.33 1.52 0.004
employment_changeZero Hours Contract -7.65 -23.95 8.66 8.31 0.36
Depressive and anxiety disorder -3.71 -8.74 1.33 2.57 0.15
Only depressive disorder -5.73 -11.19 -0.28 2.78 0.04
Only anxiety disorder -6.18 -11.66 -0.71 2.79 0.03
Eating disorders 1.89 0.06 3.71 0.93 0.04
OCDs 6.60 5.03 8.17 0.80 3.44e-16
Psychotic and bipolar disorder 3.80 -0.78 8.39 2.34 0.10
Only psychotic disorder 0.83 -2.76 4.43 1.83 0.65
Only bipolar disorder 3.68 1.08 6.28 1.33 0.006
PTSD 1.92 0.38 3.47 0.79 0.01
ASD 6.43 2.97 9.88 1.76 2.73e-04
ADHD 0.26 -4.67 5.20 2.52 0.92
Personality disorder 3.96 1.81 6.11 1.10 3.13e-04
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 20.45 10.43 30.46 5.11 6.55e-05
employment_changeFurlough -0.31 -3.49 2.87 1.62 0.85
employment_changeKey Worker 0.40 -3.03 3.83 1.75 0.82
employment_changeRetired 3.22 -0.49 6.93 1.89 0.09
employment_changeStudent 1.14 -2.61 4.90 1.92 0.55
employment_changeUnemployed 6.34 3.03 9.64 1.68 1.75e-04
employment_changeZero Hours Contract -7.49 -24.33 9.36 8.59 0.38
Anxiety disorders -10.90 -19.74 -2.06 4.51 0.02
Eating disorders -3.88 -16.62 8.86 6.49 0.55
OCDs 2.01 -7.76 11.77 4.98 0.69
PTSD -2.03 -13.25 9.20 5.72 0.72
Depressive disorders -4.42 -12.83 3.99 4.29 0.30
Bipolar disorders 1.23 -7.46 9.91 4.43 0.78
Female -0.20 -2.06 1.66 0.95 0.83
Non-binary/Self-defined 2.20 -2.37 6.77 2.33 0.35
19-25 years -3.02 -7.39 1.34 2.23 0.17
26-35 years -4.00 -8.36 0.36 2.22 0.07
36-45 years -4.84 -9.25 -0.42 2.25 0.03
46-55 years -3.87 -8.28 0.54 2.25 0.09
56-65 years -5.86 -10.48 -1.24 2.35 0.01
66-70 years -7.64 -13.68 -1.61 3.08 0.01
71-75 years -11.69 -18.71 -4.66 3.58 0.001
76+ years -4.42 -17.03 8.19 6.43 0.49
Mixed or multiple ethnic origins 2.09 -2.02 6.19 2.09 0.32
Asian or Asian British 10.51 2.16 18.87 4.26 0.01
African or African British 20.44 3.76 37.13 8.51 0.02
Other ethnicity 2.80 -3.33 8.92 3.12 0.37
Key worker -0.03 -2.95 2.89 1.49 0.99
Time difference: Lockdown to baseline 0.40 -0.01 0.80 0.20 0.05
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.26 9.87 24.65 3.77 5.04e-06
employment_changeFurlough 0.05 -2.99 3.10 1.55 0.97
employment_changeKey Worker 0.64 -2.65 3.92 1.68 0.70
employment_changeRetired 2.94 -0.62 6.49 1.81 0.11
employment_changeStudent 1.50 -2.11 5.11 1.84 0.42
employment_changeUnemployed 4.79 1.61 7.98 1.62 0.003
employment_changeZero Hours Contract -6.29 -22.47 9.90 8.25 0.45
Depressive and anxiety disorder -3.58 -8.75 1.59 2.64 0.17
Only depressive disorder -5.29 -10.87 0.29 2.84 0.06
Only anxiety disorder -6.28 -11.84 -0.71 2.84 0.03
Eating disorders 2.06 0.23 3.89 0.93 0.03
OCDs 6.66 5.11 8.22 0.79 1.20e-16
Psychotic and bipolar disorder 3.62 -0.95 8.19 2.33 0.12
Only psychotic disorder 0.82 -2.78 4.41 1.83 0.66
Only bipolar disorder 3.76 1.15 6.36 1.33 0.005
PTSD 1.77 0.21 3.32 0.79 0.03
ASD 5.99 2.55 9.42 1.75 6.49e-04
ADHD -0.60 -5.59 4.40 2.55 0.81
Personality disorder 3.92 1.78 6.05 1.09 3.35e-04
Female -0.83 -2.63 0.97 0.92 0.37
Non-binary/Self-defined 1.30 -3.20 5.80 2.29 0.57
19-25 years -2.89 -7.03 1.26 2.11 0.17
26-35 years -3.80 -7.93 0.34 2.11 0.07
36-45 years -4.49 -8.69 -0.30 2.14 0.04
46-55 years -2.87 -7.08 1.34 2.14 0.18
56-65 years -4.70 -9.10 -0.29 2.25 0.04
66-70 years -5.48 -11.18 0.23 2.91 0.06
71-75 years -7.77 -14.42 -1.13 3.39 0.02
76+ years -4.92 -17.09 7.26 6.21 0.43
Mixed or multiple ethnic origins 1.20 -2.71 5.10 1.99 0.55
Asian or Asian British 8.25 0.18 16.32 4.11 0.05
African or African British 21.05 5.01 37.08 8.18 0.01
Other ethnicity 2.66 -3.24 8.57 3.01 0.38
Key worker 0.40 -2.41 3.20 1.43 0.78
Time difference: Lockdown to baseline 0.37 -0.02 0.75 0.20 0.06
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

PCL prepan

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.73 14.51 16.94 0.62 1.54e-137
employment_changeFurlough -1.82 -2.49 -1.15 0.34 8.63e-08
employment_changeKey Worker -2.88 -3.49 -2.28 0.31 1.11e-20
employment_changeRetired -4.16 -4.83 -3.50 0.34 1.71e-34
employment_changeStudent 0.02 -0.71 0.75 0.37 0.95
employment_changeUnemployed 0.89 0.20 1.57 0.35 0.01
employment_changeZero Hours Contract -1.09 -3.11 0.92 1.03 0.29
Anxiety disorders -0.45 -1.66 0.75 0.62 0.46
Eating disorders 1.51 -0.85 3.86 1.20 0.21
OCDs 1.00 -0.65 2.64 0.84 0.24
PTSD 2.24 0.33 4.14 0.97 0.02
Depressive disorders 2.28 1.18 3.37 0.56 4.46e-05
Bipolar disorders 3.37 2.17 4.56 0.61 3.30e-08
n R2 adjust. R2 F p value df
8682 0.08 0.08 63.61 6.28e-149 12

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 16.08 15.14 17.02 0.48 2.71e-232
employment_changeFurlough -1.65 -2.30 -1.01 0.33 5.46e-07
employment_changeKey Worker -2.59 -3.17 -2.00 0.30 6.21e-18
employment_changeRetired -3.68 -4.33 -3.04 0.33 5.69e-29
employment_changeStudent -0.04 -0.74 0.67 0.36 0.92
employment_changeUnemployed 0.43 -0.24 1.09 0.34 0.21
employment_changeZero Hours Contract -0.88 -2.79 1.04 0.98 0.37
Depressive and anxiety disorder 1.17 0.39 1.95 0.40 0.003
Only depressive disorder -0.56 -1.40 0.29 0.43 0.20
Only anxiety disorder -0.90 -1.79 -0.01 0.45 0.05
Eating disorders 1.22 0.83 1.62 0.20 1.36e-09
OCDs 1.01 0.63 1.38 0.19 1.17e-07
Psychotic and bipolar disorder -0.20 -1.29 0.89 0.56 0.72
Only psychotic disorder -0.06 -0.96 0.83 0.46 0.89
Only bipolar disorder 0.57 0.01 1.13 0.29 0.04
PTSD 2.34 1.99 2.69 0.18 2.29e-39
ASD 1.27 0.55 2.00 0.37 5.87e-04
ADHD 0.79 -0.21 1.78 0.51 0.12
Personality disorder 2.10 1.59 2.60 0.26 4.57e-16
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 16.58 15.04 18.12 0.79 1.58e-96
employment_changeFurlough -1.91 -2.57 -1.24 0.34 1.94e-08
employment_changeKey Worker -2.76 -3.48 -2.04 0.37 6.26e-14
employment_changeRetired -1.72 -2.49 -0.94 0.40 1.55e-05
employment_changeStudent -1.20 -1.97 -0.43 0.39 0.002
employment_changeUnemployed 1.07 0.37 1.78 0.36 0.003
employment_changeZero Hours Contract -1.13 -3.13 0.87 1.02 0.27
Anxiety disorders -0.41 -1.61 0.79 0.61 0.50
Eating disorders 1.52 -0.80 3.84 1.18 0.20
OCDs 0.78 -0.85 2.41 0.83 0.35
PTSD 2.55 0.66 4.45 0.97 0.008
Depressive disorders 2.47 1.38 3.55 0.56 9.00e-06
Bipolar disorders 3.65 2.46 4.83 0.61 1.88e-09
Female 0.50 0.17 0.84 0.17 0.003
Non-binary/Self-defined 1.49 0.54 2.45 0.49 0.002
19-25 years -0.86 -1.62 -0.10 0.39 0.03
26-35 years -2.15 -2.91 -1.39 0.39 3.19e-08
36-45 years -2.79 -3.57 -2.01 0.40 2.63e-12
46-55 years -3.22 -3.99 -2.45 0.39 4.02e-16
56-65 years -3.97 -4.79 -3.15 0.42 2.57e-21
66-70 years -5.55 -6.61 -4.50 0.54 8.99e-25
71-75 years -6.40 -7.61 -5.20 0.61 2.43e-25
76+ years -6.16 -8.02 -4.30 0.95 9.25e-11
Mixed or multiple ethnic origins 0.03 -0.85 0.90 0.44 0.95
Asian or Asian British 0.09 -1.31 1.49 0.71 0.90
African or African British 2.34 0.17 4.50 1.10 0.03
Other ethnicity 0.46 -0.89 1.81 0.69 0.51
Key worker 0.22 -0.36 0.80 0.30 0.46
Time difference: Lockdown to baseline 0.12 0.04 0.19 0.04 0.003
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.14 15.84 18.44 0.66 5.30e-142
employment_changeFurlough -1.70 -2.35 -1.05 0.33 2.75e-07
employment_changeKey Worker -2.42 -3.12 -1.72 0.36 1.41e-11
employment_changeRetired -1.76 -2.51 -1.00 0.39 5.32e-06
employment_changeStudent -1.13 -1.88 -0.38 0.38 0.003
employment_changeUnemployed 0.64 -0.05 1.33 0.35 0.07
employment_changeZero Hours Contract -0.99 -2.89 0.92 0.97 0.31
Depressive and anxiety disorder 1.36 0.58 2.14 0.40 6.18e-04
Only depressive disorder -0.13 -0.97 0.71 0.43 0.76
Only anxiety disorder -0.88 -1.77 0.00 0.45 0.05
Eating disorders 1.03 0.64 1.43 0.20 2.73e-07
OCDs 0.92 0.55 1.29 0.19 1.02e-06
Psychotic and bipolar disorder 0.00 -1.09 1.08 0.55 1.00
Only psychotic disorder -0.01 -0.89 0.87 0.45 0.98
Only bipolar disorder 0.72 0.16 1.27 0.28 0.01
PTSD 2.40 2.05 2.74 0.18 1.82e-41
ASD 0.86 0.13 1.58 0.37 0.02
ADHD 0.61 -0.38 1.59 0.50 0.23
Personality disorder 1.95 1.45 2.46 0.26 2.34e-14
Female 0.26 -0.06 0.59 0.17 0.11
Non-binary/Self-defined 0.76 -0.17 1.68 0.47 0.11
19-25 years -1.01 -1.74 -0.28 0.37 0.007
26-35 years -2.33 -3.06 -1.59 0.37 5.44e-10
36-45 years -2.86 -3.61 -2.11 0.38 1.06e-13
46-55 years -3.18 -3.93 -2.43 0.38 9.18e-17
56-65 years -3.66 -4.45 -2.86 0.40 1.96e-19
66-70 years -4.97 -5.99 -3.95 0.52 1.94e-21
71-75 years -5.70 -6.87 -4.54 0.59 1.12e-21
76+ years -5.54 -7.35 -3.73 0.92 2.14e-09
Mixed or multiple ethnic origins -0.08 -0.93 0.76 0.43 0.85
Asian or Asian British 0.17 -1.18 1.52 0.69 0.81
African or African British 2.39 0.28 4.50 1.08 0.03
Other ethnicity 0.22 -1.07 1.50 0.66 0.74
Key worker 0.16 -0.40 0.73 0.29 0.57
Time difference: Lockdown to baseline 0.13 0.05 0.20 0.04 0.001
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Sensitivity anlayses based on education and employment

FUNCTION CHANGE to include education as predictors

GAD prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.12 -2.12 -0.12 0.51 0.03
Anxiety disorders 0.20 -0.85 1.24 0.53 0.71
Eating disorders -0.36 -2.42 1.70 1.05 0.73
OCDs -0.18 -1.61 1.24 0.72 0.80
PTSD -0.08 -1.71 1.55 0.83 0.92
Depressive disorders 0.83 -0.13 1.78 0.49 0.09
Bipolar disorders 0.84 -0.19 1.86 0.52 0.11
Highest education NVQ -0.12 -0.64 0.39 0.26 0.64
Highest education A-Levels -0.41 -0.83 0.00 0.21 0.05
Highest education University 0.12 -0.25 0.50 0.19 0.52
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.70 -1.46 0.06 0.39 0.07
Depressive and anxiety disorder 0.32 -0.37 1.02 0.36 0.36
Only depressive disorder 0.88 0.12 1.63 0.38 0.02
Only anxiety disorder -0.34 -1.13 0.44 0.40 0.39
Eating disorders 0.15 -0.18 0.49 0.17 0.37
OCDs -0.20 -0.52 0.11 0.16 0.21
Psychotic and bipolar disorder -0.55 -1.47 0.38 0.47 0.25
Only psychotic disorder 0.88 0.11 1.66 0.40 0.03
Only bipolar disorder 0.26 -0.20 0.72 0.24 0.27
PTSD 0.08 -0.22 0.38 0.15 0.61
ASD 0.13 -0.48 0.74 0.31 0.68
ADHD -0.67 -1.50 0.17 0.43 0.12
Personality disorder -0.12 -0.53 0.30 0.21 0.58
Highest education NVQ -0.12 -0.64 0.39 0.26 0.64
Highest education A-Levels -0.40 -0.81 0.01 0.21 0.06
Highest education University 0.12 -0.25 0.50 0.19 0.52
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.70 -2.98 -0.42 0.65 0.009
Anxiety disorders 0.13 -0.91 1.18 0.53 0.80
Eating disorders -0.54 -2.60 1.52 1.05 0.61
OCDs -0.31 -1.74 1.11 0.73 0.67
PTSD -0.23 -1.88 1.41 0.84 0.78
Depressive disorders 0.73 -0.23 1.69 0.49 0.14
Bipolar disorders 0.80 -0.23 1.83 0.53 0.13
Female 0.48 0.20 0.76 0.14 7.82e-04
Non-binary/Self-defined 0.37 -0.43 1.17 0.41 0.36
19-25 years 0.42 -0.30 1.13 0.37 0.25
26-35 years 0.30 -0.39 1.00 0.35 0.40
36-45 years 0.44 -0.26 1.14 0.36 0.22
46-55 years 0.29 -0.41 0.98 0.35 0.42
56-65 years 0.40 -0.31 1.11 0.36 0.27
66-70 years 0.13 -0.76 1.02 0.45 0.77
71-75 years 0.07 -0.99 1.12 0.54 0.90
76+ years 0.61 -1.12 2.33 0.88 0.49
Mixed or multiple ethnic origins 0.35 -0.38 1.07 0.37 0.35
Asian or Asian British -0.36 -1.55 0.82 0.61 0.55
African or African British -1.71 -3.54 0.13 0.93 0.07
Other ethnicity 0.19 -0.96 1.35 0.59 0.74
Time difference: Lockdown to baseline 0.00 -0.07 0.06 0.03 0.94
Highest education NVQ -0.15 -0.67 0.37 0.27 0.57
Highest education A-Levels -0.46 -0.88 -0.04 0.21 0.03
Highest education University 0.06 -0.32 0.45 0.20 0.75
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.28 -2.37 -0.19 0.56 0.02
Depressive and anxiety disorder 0.29 -0.42 0.99 0.36 0.42
Only depressive disorder 0.85 0.09 1.61 0.39 0.03
Only anxiety disorder -0.38 -1.17 0.41 0.40 0.35
Eating disorders 0.11 -0.23 0.45 0.17 0.53
OCDs -0.22 -0.54 0.09 0.16 0.17
Psychotic and bipolar disorder -0.41 -1.34 0.52 0.47 0.39
Only psychotic disorder 0.90 0.12 1.68 0.40 0.02
Only bipolar disorder 0.35 -0.11 0.82 0.24 0.14
PTSD 0.05 -0.25 0.35 0.15 0.75
ASD 0.20 -0.42 0.82 0.32 0.53
ADHD -0.66 -1.50 0.18 0.43 0.13
Personality disorder -0.15 -0.57 0.27 0.21 0.47
Female 0.46 0.18 0.74 0.15 0.002
Non-binary/Self-defined 0.41 -0.40 1.21 0.41 0.32
19-25 years 0.42 -0.29 1.13 0.36 0.25
26-35 years 0.30 -0.39 0.99 0.35 0.39
36-45 years 0.41 -0.29 1.10 0.36 0.25
46-55 years 0.23 -0.47 0.92 0.35 0.52
56-65 years 0.32 -0.39 1.03 0.36 0.38
66-70 years 0.05 -0.84 0.93 0.45 0.92
71-75 years 0.05 -1.00 1.10 0.53 0.92
76+ years 0.52 -1.20 2.24 0.88 0.55
Mixed or multiple ethnic origins 0.37 -0.36 1.09 0.37 0.32
Asian or Asian British -0.30 -1.49 0.89 0.61 0.62
African or African British -1.62 -3.45 0.21 0.93 0.08
Other ethnicity 0.07 -1.07 1.20 0.58 0.91
Key worker 0.11 -0.11 0.33 0.11 0.32
Time difference: Lockdown to baseline -0.01 -0.07 0.06 0.03 0.87
Highest education NVQ -0.19 -0.71 0.34 0.27 0.48
Highest education A-Levels -0.49 -0.91 -0.07 0.21 0.02
Highest education University 0.03 -0.36 0.42 0.20 0.88
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.92 2.04 3.80 0.45 9.96e-11
gad.sum_score_prepan 0.54 0.53 0.56 0.01 0.00e+00
Anxiety disorders 0.58 -0.33 1.49 0.46 0.21
Eating disorders 0.93 -0.86 2.73 0.92 0.31
OCDs 1.44 0.20 2.69 0.63 0.02
PTSD 1.12 -0.30 2.55 0.73 0.12
Depressive disorders 1.46 0.62 2.29 0.42 6.08e-04
Bipolar disorders 1.81 0.91 2.70 0.46 8.01e-05
Highest education NVQ -0.19 -0.64 0.26 0.23 0.40
Highest education A-Levels -0.41 -0.77 -0.05 0.18 0.03
Highest education University -0.75 -1.08 -0.42 0.17 7.23e-06
n R2 adjust. R2 F p value df
11144 0.32 0.32 743.84 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.65 2.98 4.32 0.34 2.64e-26
gad.sum_score_prepan 0.51 0.49 0.53 0.01 0.00e+00
Depressive and anxiety disorder 0.78 0.18 1.38 0.31 0.01
Only depressive disorder -0.28 -0.93 0.37 0.33 0.40
Only anxiety disorder 0.10 -0.58 0.78 0.35 0.78
Eating disorders 0.76 0.47 1.05 0.15 3.50e-07
OCDs 0.61 0.34 0.89 0.14 1.41e-05
Psychotic and bipolar disorder -0.51 -1.31 0.29 0.41 0.21
Only psychotic disorder 0.38 -0.29 1.05 0.34 0.27
Only bipolar disorder 0.18 -0.22 0.58 0.20 0.37
PTSD 0.67 0.41 0.92 0.13 4.23e-07
ASD 0.88 0.35 1.41 0.27 0.001
ADHD -0.12 -0.85 0.60 0.37 0.74
Personality disorder 0.87 0.51 1.23 0.18 2.25e-06
Highest education NVQ -0.21 -0.65 0.24 0.23 0.36
Highest education A-Levels -0.47 -0.82 -0.11 0.18 0.01
Highest education University -0.74 -1.07 -0.42 0.17 7.80e-06
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.04 2.91 5.17 0.57 2.05e-12
gad.sum_score_prepan 0.51 0.49 0.52 0.01 0.00e+00
Anxiety disorders 0.55 -0.36 1.46 0.46 0.23
Eating disorders 0.74 -1.04 2.52 0.91 0.41
OCDs 1.24 0.01 2.48 0.63 0.05
PTSD 1.39 -0.03 2.82 0.73 0.06
Depressive disorders 1.55 0.72 2.39 0.42 2.56e-04
Bipolar disorders 2.03 1.13 2.92 0.46 9.80e-06
Female 0.53 0.28 0.77 0.12 2.23e-05
Non-binary/Self-defined 0.78 0.09 1.47 0.35 0.03
19-25 years 0.11 -0.51 0.73 0.32 0.73
26-35 years -0.63 -1.23 -0.02 0.31 0.04
36-45 years -0.90 -1.51 -0.29 0.31 0.004
46-55 years -1.27 -1.88 -0.67 0.31 3.67e-05
56-65 years -1.85 -2.47 -1.23 0.32 5.09e-09
66-70 years -2.70 -3.48 -1.93 0.39 7.05e-12
71-75 years -3.06 -3.98 -2.15 0.47 6.14e-11
76+ years -2.61 -4.11 -1.12 0.76 5.93e-04
Mixed or multiple ethnic origins 0.13 -0.50 0.75 0.32 0.69
Asian or Asian British -0.20 -1.23 0.83 0.53 0.71
African or African British -0.71 -2.29 0.87 0.81 0.38
Other ethnicity 0.71 -0.30 1.71 0.51 0.17
Key worker -0.29 -0.48 -0.10 0.10 0.003
Time difference: Lockdown to baseline 0.00 -0.06 0.05 0.03 0.87
Highest education NVQ -0.21 -0.66 0.25 0.23 0.37
Highest education A-Levels -0.79 -1.15 -0.42 0.19 2.29e-05
Highest education University -0.97 -1.31 -0.63 0.17 1.76e-08
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.74 3.79 5.69 0.49 2.19e-22
gad.sum_score_prepan 0.48 0.47 0.50 0.01 0.00e+00
Depressive and anxiety disorder 0.88 0.27 1.48 0.31 0.004
Only depressive disorder -0.02 -0.67 0.63 0.33 0.95
Only anxiety disorder 0.06 -0.62 0.74 0.35 0.86
Eating disorders 0.64 0.35 0.93 0.15 1.67e-05
OCDs 0.52 0.24 0.79 0.14 2.11e-04
Psychotic and bipolar disorder -0.20 -1.00 0.59 0.41 0.62
Only psychotic disorder 0.47 -0.20 1.13 0.34 0.17
Only bipolar disorder 0.33 -0.07 0.73 0.20 0.10
PTSD 0.73 0.48 0.99 0.13 2.59e-08
ASD 0.70 0.17 1.24 0.27 0.010
ADHD -0.22 -0.94 0.51 0.37 0.56
Personality disorder 0.74 0.38 1.10 0.18 6.11e-05
Female 0.41 0.17 0.65 0.12 9.57e-04
Non-binary/Self-defined 0.40 -0.28 1.09 0.35 0.25
19-25 years 0.02 -0.59 0.63 0.31 0.95
26-35 years -0.74 -1.33 -0.14 0.30 0.01
36-45 years -0.97 -1.57 -0.37 0.31 0.001
46-55 years -1.31 -1.90 -0.71 0.30 1.59e-05
56-65 years -1.82 -2.43 -1.21 0.31 4.83e-09
66-70 years -2.60 -3.36 -1.84 0.39 2.20e-11
71-75 years -2.85 -3.75 -1.95 0.46 6.39e-10
76+ years -2.51 -3.99 -1.03 0.75 8.65e-04
Mixed or multiple ethnic origins 0.12 -0.50 0.74 0.32 0.71
Asian or Asian British -0.04 -1.06 0.98 0.52 0.94
African or African British -0.64 -2.21 0.93 0.80 0.42
Other ethnicity 0.58 -0.40 1.55 0.50 0.25
Key worker -0.19 -0.37 0.00 0.10 0.05
Time difference: Lockdown to baseline 0.00 -0.05 0.06 0.03 0.90
Highest education NVQ -0.21 -0.65 0.24 0.23 0.37
Highest education A-Levels -0.80 -1.16 -0.44 0.18 1.28e-05
Highest education University -0.93 -1.26 -0.60 0.17 5.24e-08
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

GAD retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.63 2.38 2.87 0.13 9.34e-96
Anxiety disorders 0.84 0.52 1.15 0.16 1.60e-07
Eating disorders 0.46 -0.47 1.39 0.47 0.33
OCDs 1.18 0.39 1.97 0.40 0.003
PTSD 0.99 0.21 1.76 0.39 0.01
Depressive disorders 0.87 0.70 1.04 0.09 3.87e-23
Bipolar disorders 0.87 0.49 1.25 0.19 8.26e-06
Highest education NVQ -0.33 -0.71 0.05 0.19 0.09
Highest education A-Levels 0.06 -0.21 0.33 0.14 0.68
Highest education University -0.05 -0.28 0.19 0.12 0.70
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.63 2.39 2.87 0.12 9.98e-102
Depressive and anxiety disorder 0.85 0.67 1.03 0.09 4.00e-20
Only depressive disorder 0.27 0.03 0.51 0.12 0.03
Only anxiety disorder 0.89 0.60 1.17 0.15 1.44e-09
Eating disorders 0.47 0.19 0.75 0.14 8.97e-04
OCDs 0.10 -0.17 0.36 0.14 0.48
Psychotic and bipolar disorder -0.21 -0.99 0.56 0.40 0.59
Only psychotic disorder -0.33 -1.00 0.35 0.35 0.34
Only bipolar disorder -0.19 -0.60 0.23 0.21 0.38
PTSD 0.39 0.14 0.64 0.13 0.002
ASD 0.36 -0.12 0.84 0.25 0.15
ADHD 0.01 -0.63 0.66 0.33 0.97
Personality disorder 0.25 -0.11 0.61 0.18 0.17
Highest education NVQ -0.34 -0.71 0.04 0.19 0.08
Highest education A-Levels 0.04 -0.23 0.30 0.14 0.79
Highest education University -0.04 -0.27 0.19 0.12 0.73
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.94 3.41 4.46 0.27 7.75e-49
Anxiety disorders 0.60 0.27 0.92 0.17 3.78e-04
Eating disorders 0.09 -0.86 1.04 0.48 0.85
OCDs 0.62 -0.19 1.43 0.41 0.13
PTSD 0.78 -0.02 1.58 0.41 0.06
Depressive disorders 0.62 0.43 0.81 0.10 1.29e-10
Bipolar disorders 0.64 0.24 1.03 0.20 0.001
Female 0.77 0.57 0.97 0.10 6.86e-14
Non-binary/Self-defined -0.23 -0.90 0.44 0.34 0.50
19-25 years 1.21 0.73 1.69 0.25 9.19e-07
26-35 years 0.52 0.06 0.98 0.23 0.03
36-45 years 0.00 -0.47 0.46 0.24 0.99
46-55 years -0.22 -0.67 0.23 0.23 0.35
56-65 years -0.37 -0.82 0.08 0.23 0.11
66-70 years -0.69 -1.21 -0.17 0.27 0.010
71-75 years -1.03 -1.62 -0.44 0.30 6.45e-04
76+ years -1.42 -2.29 -0.54 0.45 0.001
Mixed or multiple ethnic origins -0.63 -1.18 -0.09 0.28 0.02
Asian or Asian British -0.42 -1.14 0.31 0.37 0.26
African or African British -0.53 -1.74 0.67 0.61 0.38
Other ethnicity 0.13 -0.85 1.12 0.50 0.79
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 1.57e-32
Highest education NVQ -0.20 -0.61 0.22 0.21 0.35
Highest education A-Levels -0.23 -0.51 0.06 0.15 0.12
Highest education University -0.34 -0.60 -0.08 0.13 0.01
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.84 3.33 4.35 0.26 2.84e-49
Depressive and anxiety disorder 0.64 0.44 0.84 0.10 2.35e-10
Only depressive disorder 0.28 0.02 0.54 0.13 0.03
Only anxiety disorder 0.66 0.36 0.96 0.15 1.68e-05
Eating disorders 0.28 0.00 0.56 0.14 0.05
OCDs -0.06 -0.33 0.21 0.14 0.65
Psychotic and bipolar disorder 0.10 -0.69 0.88 0.40 0.81
Only psychotic disorder -0.09 -0.78 0.59 0.35 0.79
Only bipolar disorder -0.09 -0.51 0.33 0.21 0.66
PTSD 0.39 0.13 0.64 0.13 0.003
ASD 0.37 -0.12 0.87 0.25 0.14
ADHD -0.06 -0.71 0.59 0.33 0.86
Personality disorder 0.12 -0.25 0.48 0.19 0.53
Female 0.73 0.53 0.93 0.10 8.80e-13
Non-binary/Self-defined -0.29 -0.96 0.37 0.34 0.39
19-25 years 1.12 0.65 1.59 0.24 2.85e-06
26-35 years 0.40 -0.05 0.85 0.23 0.08
36-45 years -0.12 -0.57 0.34 0.23 0.61
46-55 years -0.31 -0.75 0.13 0.22 0.16
56-65 years -0.37 -0.81 0.07 0.22 0.10
66-70 years -0.55 -1.06 -0.03 0.26 0.04
71-75 years -0.90 -1.48 -0.32 0.30 0.002
76+ years -1.28 -2.13 -0.42 0.44 0.004
Mixed or multiple ethnic origins -0.55 -1.09 -0.01 0.27 0.05
Asian or Asian British -0.20 -0.89 0.50 0.35 0.58
African or African British -0.61 -1.80 0.58 0.61 0.31
Other ethnicity 0.05 -0.91 1.01 0.49 0.92
Key worker 0.29 0.13 0.46 0.08 4.09e-04
Time difference: Lockdown to baseline -0.22 -0.26 -0.19 0.02 2.98e-32
Highest education NVQ -0.22 -0.63 0.19 0.21 0.29
Highest education A-Levels -0.24 -0.52 0.04 0.14 0.10
Highest education University -0.33 -0.59 -0.07 0.13 0.01
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.01 3.77 4.25 0.12 3.23e-231
gad.sum_score_retro 0.60 0.58 0.61 0.01 0.00e+00
Anxiety disorders 1.83 1.53 2.13 0.15 2.71e-33
Eating disorders 1.32 0.45 2.20 0.45 0.003
OCDs 2.81 2.06 3.55 0.38 1.80e-13
PTSD 2.20 1.47 2.92 0.37 3.36e-09
Depressive disorders 2.29 2.12 2.46 0.09 6.86e-148
Bipolar disorders 2.93 2.56 3.30 0.19 1.39e-54
Highest education NVQ -0.65 -1.01 -0.30 0.18 3.50e-04
Highest education A-Levels -0.16 -0.41 0.10 0.13 0.23
Highest education University -0.59 -0.81 -0.37 0.11 2.24e-07
n R2 adjust. R2 F p value df
18588 0.32 0.32 1276.84 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.26 4.03 4.49 0.12 6.71e-279
gad.sum_score_retro 0.55 0.53 0.56 0.01 0.00e+00
Depressive and anxiety disorder 2.33 2.15 2.51 0.09 1.30e-145
Only depressive disorder 0.71 0.48 0.93 0.11 7.44e-10
Only anxiety disorder 1.93 1.66 2.20 0.14 8.40e-45
Eating disorders 0.78 0.52 1.04 0.13 3.34e-09
OCDs 0.78 0.53 1.03 0.13 7.82e-10
Psychotic and bipolar disorder 0.04 -0.68 0.76 0.37 0.91
Only psychotic disorder -0.03 -0.66 0.60 0.32 0.93
Only bipolar disorder 0.19 -0.19 0.57 0.20 0.33
PTSD 0.81 0.58 1.04 0.12 7.03e-12
ASD 1.01 0.56 1.45 0.23 1.08e-05
ADHD 0.45 -0.15 1.05 0.31 0.14
Personality disorder 1.02 0.69 1.36 0.17 1.98e-09
Highest education NVQ -0.70 -1.05 -0.35 0.18 8.07e-05
Highest education A-Levels -0.26 -0.51 -0.01 0.13 0.04
Highest education University -0.62 -0.83 -0.40 0.11 2.45e-08
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.96 6.46 7.46 0.25 1.76e-161
gad.sum_score_retro 0.54 0.53 0.56 0.01 0.00e+00
Anxiety disorders 1.51 1.20 1.82 0.16 5.20e-22
Eating disorders 0.87 -0.01 1.75 0.45 0.05
OCDs 2.01 1.26 2.76 0.38 1.69e-07
PTSD 2.04 1.29 2.78 0.38 9.08e-08
Depressive disorders 2.07 1.88 2.25 0.09 7.84e-106
Bipolar disorders 2.73 2.36 3.11 0.19 1.73e-46
Female 0.77 0.59 0.96 0.10 4.62e-16
Non-binary/Self-defined 0.31 -0.31 0.94 0.32 0.32
19-25 years 0.41 -0.04 0.86 0.23 0.07
26-35 years -0.54 -0.97 -0.11 0.22 0.01
36-45 years -1.19 -1.62 -0.75 0.22 8.26e-08
46-55 years -1.60 -2.02 -1.18 0.22 1.25e-13
56-65 years -2.08 -2.50 -1.66 0.22 6.41e-22
66-70 years -2.60 -3.10 -2.11 0.25 2.53e-25
71-75 years -2.97 -3.52 -2.42 0.28 7.01e-26
76+ years -3.13 -3.94 -2.31 0.42 5.25e-14
Mixed or multiple ethnic origins -0.39 -0.89 0.12 0.26 0.13
Asian or Asian British -0.23 -0.90 0.43 0.34 0.49
African or African British -0.20 -1.31 0.91 0.57 0.72
Other ethnicity 0.44 -0.47 1.35 0.46 0.34
Key worker -0.02 -0.17 0.13 0.08 0.76
Time difference: Lockdown to baseline -0.23 -0.27 -0.20 0.02 8.36e-40
Highest education NVQ -0.37 -0.76 0.01 0.20 0.06
Highest education A-Levels -0.51 -0.78 -0.25 0.14 1.52e-04
Highest education University -0.90 -1.14 -0.66 0.12 3.25e-13
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.16 6.68 7.64 0.25 6.01e-183
gad.sum_score_retro 0.50 0.49 0.52 0.01 0.00e+00
Depressive and anxiety disorder 2.14 1.95 2.33 0.10 1.09e-108
Only depressive disorder 0.82 0.58 1.06 0.12 1.07e-11
Only anxiety disorder 1.66 1.38 1.94 0.14 2.34e-31
Eating disorders 0.53 0.27 0.79 0.13 5.38e-05
OCDs 0.59 0.34 0.84 0.13 4.44e-06
Psychotic and bipolar disorder 0.39 -0.33 1.11 0.37 0.28
Only psychotic disorder 0.23 -0.39 0.86 0.32 0.47
Only bipolar disorder 0.30 -0.09 0.69 0.20 0.13
PTSD 0.87 0.64 1.10 0.12 2.28e-13
ASD 0.81 0.36 1.27 0.23 4.60e-04
ADHD 0.24 -0.36 0.84 0.30 0.43
Personality disorder 0.90 0.57 1.24 0.17 1.26e-07
Female 0.72 0.54 0.91 0.09 1.51e-14
Non-binary/Self-defined -0.06 -0.67 0.55 0.31 0.85
19-25 years 0.15 -0.28 0.58 0.22 0.49
26-35 years -0.82 -1.23 -0.40 0.21 1.17e-04
36-45 years -1.40 -1.82 -0.98 0.21 6.23e-11
46-55 years -1.71 -2.11 -1.30 0.21 2.40e-16
56-65 years -2.07 -2.48 -1.67 0.21 2.11e-23
66-70 years -2.50 -2.98 -2.03 0.24 5.86e-25
71-75 years -2.81 -3.35 -2.28 0.27 8.65e-25
76+ years -2.99 -3.78 -2.20 0.40 1.10e-13
Mixed or multiple ethnic origins -0.28 -0.78 0.21 0.25 0.26
Asian or Asian British 0.11 -0.52 0.75 0.33 0.72
African or African British -0.18 -1.28 0.91 0.56 0.74
Other ethnicity 0.34 -0.54 1.21 0.45 0.45
Key worker 0.06 -0.09 0.21 0.08 0.44
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 1.77e-42
Highest education NVQ -0.34 -0.72 0.03 0.19 0.08
Highest education A-Levels -0.52 -0.78 -0.26 0.13 9.37e-05
Highest education University -0.82 -1.05 -0.58 0.12 1.75e-11
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

PHQ prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.81 -2.86 -0.76 0.54 7.37e-04
Anxiety disorders 1.89 0.79 2.98 0.56 7.51e-04
Eating disorders 0.06 -2.07 2.19 1.09 0.95
OCDs 1.87 0.39 3.36 0.76 0.01
PTSD 1.27 -0.45 2.99 0.88 0.15
Depressive disorders 1.19 0.19 2.19 0.51 0.02
Bipolar disorders 0.89 -0.19 1.97 0.55 0.10
Highest education NVQ -0.33 -0.87 0.21 0.28 0.24
Highest education A-Levels -0.26 -0.70 0.17 0.22 0.23
Highest education University 0.40 0.01 0.79 0.20 0.05
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.68 -2.48 -0.88 0.41 4.07e-05
Depressive and anxiety disorder 1.05 0.32 1.79 0.37 0.005
Only depressive disorder 0.92 0.12 1.71 0.40 0.02
Only anxiety disorder 1.72 0.89 2.54 0.42 4.76e-05
Eating disorders 0.33 -0.02 0.68 0.18 0.07
OCDs 0.07 -0.26 0.40 0.17 0.68
Psychotic and bipolar disorder -0.69 -1.67 0.29 0.50 0.17
Only psychotic disorder 0.19 -0.63 1.00 0.41 0.65
Only bipolar disorder -0.22 -0.70 0.27 0.25 0.38
PTSD -0.16 -0.47 0.15 0.16 0.31
ASD 0.40 -0.25 1.04 0.33 0.23
ADHD -0.01 -0.89 0.86 0.45 0.98
Personality disorder 0.00 -0.44 0.43 0.22 0.99
Highest education NVQ -0.34 -0.88 0.20 0.28 0.22
Highest education A-Levels -0.30 -0.74 0.13 0.22 0.17
Highest education University 0.38 -0.02 0.77 0.20 0.06
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.82 -3.16 -0.48 0.68 0.008
Anxiety disorders 1.81 0.71 2.90 0.56 0.001
Eating disorders -0.14 -2.27 1.99 1.09 0.90
OCDs 1.67 0.18 3.16 0.76 0.03
PTSD 1.03 -0.70 2.76 0.88 0.24
Depressive disorders 1.14 0.14 2.14 0.51 0.03
Bipolar disorders 0.91 -0.17 1.99 0.55 0.10
Female 0.29 0.00 0.58 0.15 0.05
Non-binary/Self-defined -0.17 -1.01 0.67 0.43 0.69
19-25 years -0.34 -1.09 0.41 0.38 0.37
26-35 years -0.50 -1.23 0.23 0.37 0.18
36-45 years -0.51 -1.25 0.22 0.37 0.17
46-55 years -0.73 -1.46 -0.01 0.37 0.05
56-65 years -0.83 -1.57 -0.08 0.38 0.03
66-70 years -0.62 -1.54 0.31 0.47 0.19
71-75 years -1.04 -2.15 0.06 0.57 0.06
76+ years -0.28 -2.10 1.54 0.93 0.77
Mixed or multiple ethnic origins -0.03 -0.79 0.73 0.39 0.94
Asian or Asian British -1.44 -2.69 -0.20 0.63 0.02
African or African British -1.28 -3.19 0.64 0.98 0.19
Other ethnicity 0.07 -1.14 1.28 0.62 0.91
Time difference: Lockdown to baseline 0.06 -0.01 0.13 0.03 0.07
Highest education NVQ -0.31 -0.85 0.24 0.28 0.27
Highest education A-Levels -0.34 -0.78 0.10 0.22 0.12
Highest education University 0.38 -0.03 0.78 0.21 0.07
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.81 -2.95 -0.67 0.58 0.002
Depressive and anxiety disorder 1.10 0.37 1.84 0.38 0.003
Only depressive disorder 1.01 0.21 1.81 0.41 0.01
Only anxiety disorder 1.71 0.88 2.54 0.42 5.67e-05
Eating disorders 0.28 -0.08 0.63 0.18 0.13
OCDs 0.04 -0.30 0.37 0.17 0.82
Psychotic and bipolar disorder -0.58 -1.57 0.40 0.50 0.25
Only psychotic disorder 0.20 -0.62 1.01 0.42 0.63
Only bipolar disorder -0.12 -0.61 0.36 0.25 0.62
PTSD -0.16 -0.47 0.15 0.16 0.32
ASD 0.37 -0.28 1.03 0.33 0.26
ADHD -0.02 -0.90 0.86 0.45 0.97
Personality disorder -0.03 -0.47 0.41 0.22 0.89
Female 0.26 -0.04 0.56 0.15 0.09
Non-binary/Self-defined -0.18 -1.02 0.66 0.43 0.68
19-25 years -0.37 -1.11 0.37 0.38 0.33
26-35 years -0.51 -1.23 0.22 0.37 0.17
36-45 years -0.50 -1.23 0.23 0.37 0.18
46-55 years -0.72 -1.45 0.00 0.37 0.05
56-65 years -0.81 -1.55 -0.07 0.38 0.03
66-70 years -0.56 -1.48 0.36 0.47 0.23
71-75 years -0.93 -2.03 0.18 0.56 0.10
76+ years -0.21 -2.03 1.61 0.93 0.82
Mixed or multiple ethnic origins 0.00 -0.76 0.76 0.39 1.00
Asian or Asian British -1.29 -2.54 -0.05 0.63 0.04
African or African British -1.26 -3.18 0.65 0.98 0.20
Other ethnicity -0.19 -1.39 1.01 0.61 0.76
Key worker 0.06 -0.17 0.29 0.12 0.62
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
Highest education NVQ -0.33 -0.88 0.22 0.28 0.24
Highest education A-Levels -0.38 -0.82 0.06 0.22 0.09
Highest education University 0.36 -0.05 0.77 0.21 0.08
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.88 1.93 3.83 0.48 2.77e-09
phq.sum_score_prepan 0.60 0.59 0.62 0.01 0.00e+00
Anxiety disorders 0.81 -0.17 1.78 0.50 0.10
Eating disorders 0.38 -1.51 2.28 0.97 0.69
OCDs 2.00 0.68 3.32 0.67 0.003
PTSD 1.15 -0.38 2.68 0.78 0.14
Depressive disorders 1.85 0.96 2.74 0.45 4.90e-05
Bipolar disorders 2.26 1.30 3.22 0.49 4.16e-06
Highest education NVQ -0.39 -0.87 0.09 0.24 0.11
Highest education A-Levels -0.38 -0.77 0.00 0.20 0.05
Highest education University -0.80 -1.15 -0.44 0.18 9.71e-06
n R2 adjust. R2 F p value df
11134 0.41 0.41 1107.68 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.48 2.75 4.21 0.37 8.25e-21
phq.sum_score_prepan 0.58 0.56 0.59 0.01 0.00e+00
Depressive and anxiety disorder 1.24 0.59 1.88 0.33 1.72e-04
Only depressive disorder 0.61 -0.08 1.31 0.36 0.08
Only anxiety disorder 0.42 -0.31 1.15 0.37 0.26
Eating disorders 1.07 0.76 1.38 0.16 2.05e-11
OCDs 0.66 0.36 0.95 0.15 1.11e-05
Psychotic and bipolar disorder -0.60 -1.46 0.26 0.44 0.17
Only psychotic disorder 0.19 -0.53 0.90 0.36 0.60
Only bipolar disorder 0.19 -0.23 0.62 0.22 0.37
PTSD 0.55 0.28 0.83 0.14 7.96e-05
ASD 1.09 0.52 1.65 0.29 1.72e-04
ADHD 0.32 -0.45 1.10 0.39 0.41
Personality disorder 1.22 0.83 1.61 0.20 5.82e-10
Highest education NVQ -0.42 -0.89 0.06 0.24 0.08
Highest education A-Levels -0.47 -0.85 -0.09 0.19 0.02
Highest education University -0.81 -1.16 -0.46 0.18 5.01e-06
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.59 3.38 5.80 0.62 9.43e-14
phq.sum_score_prepan 0.57 0.56 0.59 0.01 0.00e+00
Anxiety disorders 0.72 -0.25 1.69 0.50 0.15
Eating disorders 0.23 -1.64 2.11 0.96 0.81
OCDs 1.71 0.39 3.02 0.67 0.01
PTSD 1.27 -0.26 2.79 0.78 0.10
Depressive disorders 2.02 1.13 2.92 0.45 8.58e-06
Bipolar disorders 2.55 1.59 3.51 0.49 1.97e-07
Female 0.28 0.02 0.54 0.13 0.03
Non-binary/Self-defined 0.65 -0.09 1.39 0.38 0.08
19-25 years -0.72 -1.38 -0.06 0.34 0.03
26-35 years -1.57 -2.21 -0.92 0.33 1.91e-06
36-45 years -1.84 -2.49 -1.19 0.33 3.10e-08
46-55 years -2.10 -2.74 -1.45 0.33 1.84e-10
56-65 years -2.77 -3.43 -2.11 0.34 2.14e-16
66-70 years -3.61 -4.43 -2.79 0.42 9.12e-18
71-75 years -4.16 -5.14 -3.18 0.50 1.03e-16
76+ years -3.54 -5.14 -1.93 0.82 1.57e-05
Mixed or multiple ethnic origins 0.11 -0.56 0.78 0.34 0.76
Asian or Asian British -0.90 -2.00 0.19 0.56 0.11
African or African British -0.48 -2.16 1.21 0.86 0.58
Other ethnicity 0.40 -0.67 1.47 0.55 0.47
Key worker -0.51 -0.71 -0.30 0.10 9.74e-07
Time difference: Lockdown to baseline 0.06 0.00 0.12 0.03 0.06
Highest education NVQ -0.29 -0.77 0.20 0.25 0.24
Highest education A-Levels -0.70 -1.09 -0.31 0.20 4.13e-04
Highest education University -0.88 -1.24 -0.52 0.18 1.90e-06
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.25 4.23 6.27 0.52 1.13e-23
phq.sum_score_prepan 0.55 0.54 0.57 0.01 0.00e+00
Depressive and anxiety disorder 1.39 0.75 2.04 0.33 2.33e-05
Only depressive disorder 0.99 0.29 1.69 0.36 0.005
Only anxiety disorder 0.32 -0.40 1.05 0.37 0.38
Eating disorders 0.97 0.66 1.28 0.16 1.26e-09
OCDs 0.54 0.25 0.84 0.15 2.60e-04
Psychotic and bipolar disorder -0.39 -1.25 0.47 0.44 0.38
Only psychotic disorder 0.28 -0.43 0.99 0.36 0.44
Only bipolar disorder 0.36 -0.07 0.78 0.22 0.10
PTSD 0.64 0.37 0.92 0.14 5.01e-06
ASD 0.75 0.18 1.33 0.29 0.010
ADHD 0.19 -0.58 0.96 0.39 0.63
Personality disorder 1.13 0.74 1.51 0.20 1.07e-08
Female 0.11 -0.15 0.37 0.13 0.39
Non-binary/Self-defined 0.26 -0.47 0.99 0.37 0.49
19-25 years -0.85 -1.50 -0.20 0.33 0.010
26-35 years -1.71 -2.35 -1.08 0.32 1.15e-07
36-45 years -1.94 -2.58 -1.30 0.33 2.78e-09
46-55 years -2.16 -2.79 -1.52 0.32 2.53e-11
56-65 years -2.78 -3.43 -2.13 0.33 5.51e-17
66-70 years -3.54 -4.35 -2.73 0.41 1.37e-17
71-75 years -4.00 -4.97 -3.03 0.49 6.46e-16
76+ years -3.45 -5.04 -1.86 0.81 2.14e-05
Mixed or multiple ethnic origins 0.09 -0.57 0.75 0.34 0.79
Asian or Asian British -0.65 -1.73 0.44 0.55 0.24
African or African British -0.32 -1.99 1.35 0.85 0.71
Other ethnicity 0.19 -0.86 1.23 0.53 0.72
Key worker -0.41 -0.61 -0.21 0.10 6.44e-05
Time difference: Lockdown to baseline 0.06 0.00 0.12 0.03 0.04
Highest education NVQ -0.30 -0.77 0.18 0.24 0.23
Highest education A-Levels -0.73 -1.12 -0.35 0.20 1.85e-04
Highest education University -0.85 -1.21 -0.49 0.18 3.31e-06
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

PHQ retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.52 3.26 3.77 0.13 3.66e-158
Anxiety disorders 0.59 0.26 0.92 0.17 4.04e-04
Eating disorders 0.50 -0.49 1.49 0.50 0.32
OCDs 0.97 0.17 1.76 0.40 0.02
PTSD 1.06 0.25 1.86 0.41 0.010
Depressive disorders 0.92 0.75 1.09 0.09 5.78e-25
Bipolar disorders 0.93 0.53 1.32 0.20 3.82e-06
Highest education NVQ -0.97 -1.36 -0.59 0.20 9.08e-07
Highest education A-Levels -0.30 -0.58 -0.02 0.14 0.03
Highest education University -0.58 -0.82 -0.33 0.12 3.89e-06
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.59 3.34 3.84 0.13 4.57e-174
Depressive and anxiety disorder 0.76 0.57 0.94 0.09 8.77e-16
Only depressive disorder 0.43 0.18 0.67 0.12 6.51e-04
Only anxiety disorder 0.57 0.27 0.87 0.15 1.77e-04
Eating disorders 0.64 0.35 0.93 0.15 1.25e-05
OCDs 0.18 -0.09 0.46 0.14 0.19
Psychotic and bipolar disorder -0.85 -1.65 -0.05 0.41 0.04
Only psychotic disorder -0.61 -1.31 0.08 0.35 0.08
Only bipolar disorder -0.03 -0.46 0.40 0.22 0.89
PTSD 0.57 0.31 0.83 0.13 1.33e-05
ASD 0.50 0.01 0.99 0.25 0.05
ADHD 0.02 -0.64 0.68 0.34 0.95
Personality disorder 0.23 -0.14 0.60 0.19 0.22
Highest education NVQ -1.04 -1.42 -0.65 0.20 1.19e-07
Highest education A-Levels -0.35 -0.63 -0.08 0.14 0.01
Highest education University -0.61 -0.85 -0.37 0.12 7.75e-07
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.12 5.59 6.65 0.27 4.52e-111
Anxiety disorders 0.26 -0.09 0.60 0.18 0.14
Eating disorders 0.06 -0.95 1.08 0.52 0.91
OCDs 0.26 -0.55 1.07 0.42 0.53
PTSD 0.77 -0.06 1.60 0.43 0.07
Depressive disorders 0.70 0.50 0.89 0.10 2.21e-12
Bipolar disorders 0.73 0.33 1.14 0.21 4.22e-04
Female 0.72 0.52 0.93 0.10 3.03e-12
Non-binary/Self-defined 0.16 -0.52 0.84 0.35 0.65
19-25 years -0.31 -0.80 0.17 0.25 0.21
26-35 years -1.12 -1.59 -0.66 0.24 2.19e-06
36-45 years -1.57 -2.04 -1.10 0.24 6.46e-11
46-55 years -1.62 -2.07 -1.16 0.23 3.70e-12
56-65 years -1.81 -2.27 -1.36 0.23 8.57e-15
66-70 years -2.17 -2.71 -1.64 0.27 1.06e-15
71-75 years -2.16 -2.77 -1.56 0.31 2.66e-12
76+ years -2.43 -3.32 -1.54 0.45 8.93e-08
Mixed or multiple ethnic origins -0.19 -0.75 0.37 0.29 0.51
Asian or Asian British -0.27 -0.99 0.45 0.37 0.46
African or African British -0.29 -1.49 0.91 0.61 0.63
Other ethnicity -0.43 -1.44 0.57 0.51 0.40
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 2.88e-34
Highest education NVQ -0.56 -0.98 -0.13 0.22 0.010
Highest education A-Levels -0.41 -0.71 -0.12 0.15 0.006
Highest education University -0.56 -0.84 -0.29 0.14 4.51e-05
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.19 5.67 6.70 0.26 3.43e-120
Depressive and anxiety disorder 0.59 0.39 0.79 0.10 1.11e-08
Only depressive disorder 0.48 0.22 0.74 0.13 3.01e-04
Only anxiety disorder 0.27 -0.04 0.59 0.16 0.09
Eating disorders 0.43 0.13 0.72 0.15 0.004
OCDs 0.03 -0.25 0.31 0.14 0.85
Psychotic and bipolar disorder -0.59 -1.40 0.21 0.41 0.15
Only psychotic disorder -0.45 -1.15 0.26 0.36 0.21
Only bipolar disorder 0.08 -0.36 0.52 0.22 0.71
PTSD 0.59 0.32 0.85 0.13 1.26e-05
ASD 0.23 -0.28 0.74 0.26 0.37
ADHD -0.05 -0.72 0.63 0.34 0.89
Personality disorder 0.18 -0.20 0.55 0.19 0.36
Female 0.66 0.46 0.86 0.10 1.73e-10
Non-binary/Self-defined 0.04 -0.64 0.72 0.35 0.90
19-25 years -0.45 -0.93 0.02 0.24 0.06
26-35 years -1.29 -1.75 -0.84 0.23 2.86e-08
36-45 years -1.74 -2.20 -1.28 0.24 1.66e-13
46-55 years -1.77 -2.22 -1.32 0.23 9.51e-15
56-65 years -1.90 -2.35 -1.45 0.23 9.30e-17
66-70 years -2.12 -2.64 -1.60 0.27 1.35e-15
71-75 years -2.17 -2.76 -1.58 0.30 8.21e-13
76+ years -2.48 -3.35 -1.61 0.44 2.17e-08
Mixed or multiple ethnic origins -0.08 -0.64 0.47 0.28 0.77
Asian or Asian British -0.09 -0.79 0.61 0.36 0.80
African or African British -0.23 -1.40 0.95 0.60 0.71
Other ethnicity -0.57 -1.55 0.41 0.50 0.26
Key worker 0.24 0.08 0.41 0.09 0.004
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 7.33e-35
Highest education NVQ -0.59 -1.01 -0.17 0.21 0.006
Highest education A-Levels -0.44 -0.73 -0.14 0.15 0.004
Highest education University -0.57 -0.84 -0.30 0.14 3.73e-05
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.99 4.74 5.24 0.13 0.00e+00
phq.sum_score_retro 0.65 0.64 0.66 0.01 0.00e+00
Anxiety disorders 1.25 0.94 1.56 0.16 2.01e-15
Eating disorders 1.37 0.44 2.30 0.47 0.004
OCDs 2.22 1.47 2.97 0.38 5.82e-09
PTSD 2.13 1.37 2.89 0.39 3.49e-08
Depressive disorders 2.58 2.40 2.76 0.09 6.37e-176
Bipolar disorders 3.40 3.01 3.78 0.20 4.63e-67
Highest education NVQ -1.25 -1.62 -0.88 0.19 2.20e-11
Highest education A-Levels -0.48 -0.74 -0.22 0.13 3.30e-04
Highest education University -1.26 -1.49 -1.03 0.12 2.38e-26
n R2 adjust. R2 F p value df
19512 0.43 0.43 2104.41 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.31 5.07 5.55 0.12 0.00e+00
phq.sum_score_retro 0.61 0.60 0.63 0.01 0.00e+00
Depressive and anxiety disorder 2.41 2.22 2.59 0.09 1.07e-145
Only depressive disorder 1.25 1.02 1.48 0.12 1.46e-26
Only anxiety disorder 1.22 0.94 1.50 0.14 1.62e-17
Eating disorders 1.10 0.84 1.37 0.14 8.03e-16
OCDs 0.75 0.49 1.01 0.13 1.06e-08
Psychotic and bipolar disorder -0.61 -1.35 0.14 0.38 0.11
Only psychotic disorder -0.21 -0.86 0.44 0.33 0.52
Only bipolar disorder 0.52 0.12 0.92 0.20 0.01
PTSD 1.02 0.78 1.26 0.12 1.25e-16
ASD 1.26 0.80 1.72 0.24 7.62e-08
ADHD 0.71 0.09 1.32 0.31 0.02
Personality disorder 1.30 0.96 1.65 0.18 1.57e-13
Highest education NVQ -1.37 -1.72 -1.01 0.18 8.60e-14
Highest education A-Levels -0.61 -0.86 -0.35 0.13 3.70e-06
Highest education University -1.34 -1.56 -1.11 0.12 6.07e-31
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.04 8.53 9.54 0.26 1.15e-261
phq.sum_score_retro 0.60 0.59 0.62 0.01 0.00e+00
Anxiety disorders 0.80 0.48 1.12 0.16 9.94e-07
Eating disorders 0.85 -0.09 1.79 0.48 0.08
OCDs 1.19 0.44 1.95 0.39 0.002
PTSD 1.80 1.03 2.58 0.40 5.45e-06
Depressive disorders 2.40 2.21 2.59 0.10 2.07e-132
Bipolar disorders 3.29 2.90 3.68 0.20 7.04e-61
Female 0.76 0.57 0.95 0.10 3.82e-15
Non-binary/Self-defined 0.97 0.34 1.61 0.32 0.003
19-25 years -0.86 -1.32 -0.41 0.23 1.85e-04
26-35 years -2.08 -2.52 -1.65 0.22 7.67e-21
36-45 years -2.62 -3.06 -2.17 0.22 3.72e-31
46-55 years -2.81 -3.24 -2.39 0.22 7.76e-38
56-65 years -3.32 -3.74 -2.89 0.22 1.19e-51
66-70 years -3.98 -4.47 -3.48 0.25 3.87e-55
71-75 years -3.96 -4.53 -3.40 0.29 7.98e-43
76+ years -4.12 -4.95 -3.30 0.42 1.46e-22
Mixed or multiple ethnic origins 0.01 -0.50 0.53 0.26 0.96
Asian or Asian British -0.11 -0.78 0.56 0.34 0.75
African or African British -0.15 -1.26 0.96 0.57 0.79
Other ethnicity 0.02 -0.92 0.95 0.48 0.97
Key worker -0.14 -0.30 0.01 0.08 0.07
Time difference: Lockdown to baseline -0.23 -0.27 -0.20 0.02 2.89e-38
Highest education NVQ -0.66 -1.05 -0.27 0.20 9.99e-04
Highest education A-Levels -0.66 -0.94 -0.38 0.14 2.75e-06
Highest education University -1.27 -1.53 -1.02 0.13 7.07e-23
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.41 8.92 9.90 0.25 8.68e-303
phq.sum_score_retro 0.57 0.56 0.59 0.01 0.00e+00
Depressive and anxiety disorder 2.27 2.07 2.46 0.10 5.21e-114
Only depressive disorder 1.45 1.21 1.69 0.12 1.11e-31
Only anxiety disorder 0.82 0.53 1.11 0.15 3.69e-08
Eating disorders 0.84 0.57 1.11 0.14 8.53e-10
OCDs 0.54 0.28 0.80 0.13 4.73e-05
Psychotic and bipolar disorder -0.28 -1.02 0.46 0.38 0.45
Only psychotic disorder 0.00 -0.65 0.65 0.33 1.00
Only bipolar disorder 0.69 0.29 1.09 0.21 8.00e-04
PTSD 1.10 0.86 1.35 0.12 5.57e-19
ASD 0.79 0.32 1.25 0.24 9.51e-04
ADHD 0.51 -0.11 1.13 0.32 0.11
Personality disorder 1.28 0.93 1.62 0.18 6.26e-13
Female 0.65 0.47 0.84 0.09 6.73e-12
Non-binary/Self-defined 0.51 -0.11 1.13 0.32 0.11
19-25 years -1.19 -1.63 -0.76 0.22 8.54e-08
26-35 years -2.42 -2.84 -2.00 0.21 2.10e-29
36-45 years -2.92 -3.34 -2.49 0.22 9.46e-41
46-55 years -3.03 -3.45 -2.62 0.21 1.28e-46
56-65 years -3.44 -3.85 -3.02 0.21 3.87e-59
66-70 years -3.99 -4.47 -3.51 0.25 4.63e-59
71-75 years -3.97 -4.51 -3.42 0.28 2.60e-45
76+ years -4.17 -4.97 -3.37 0.41 1.82e-24
Mixed or multiple ethnic origins 0.10 -0.41 0.61 0.26 0.69
Asian or Asian British 0.18 -0.46 0.82 0.33 0.58
African or African British -0.02 -1.10 1.05 0.55 0.96
Other ethnicity -0.20 -1.10 0.71 0.46 0.67
Key worker -0.06 -0.21 0.10 0.08 0.47
Time difference: Lockdown to baseline -0.23 -0.27 -0.20 0.02 9.10e-40
Highest education NVQ -0.68 -1.07 -0.30 0.20 5.28e-04
Highest education A-Levels -0.69 -0.96 -0.42 0.14 6.74e-07
Highest education University -1.23 -1.48 -0.98 0.13 3.15e-22
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

OCIR prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.82 -11.14 14.77 6.59 0.78
Anxiety disorders -10.81 -24.23 2.62 6.83 0.11
Eating disorders -8.30 -27.62 11.02 9.83 0.40
OCDs -13.50 -27.33 0.33 7.03 0.06
PTSD -25.69 -45.07 -6.31 9.86 0.009
Depressive disorders -10.71 -23.01 1.59 6.26 0.09
Bipolar disorders -10.17 -22.88 2.54 6.47 0.12
Highest education NVQ -0.06 -5.59 5.47 2.81 0.98
Highest education A-Levels -0.41 -4.94 4.12 2.30 0.86
Highest education University 1.38 -2.94 5.69 2.19 0.53
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.80 -10.48 6.87 4.41 0.68
Depressive and anxiety disorder -5.01 -13.04 3.02 4.09 0.22
Only depressive disorder -4.66 -13.49 4.17 4.49 0.30
Only anxiety disorder -8.49 -17.34 0.36 4.50 0.06
Eating disorders -0.10 -2.84 2.65 1.40 0.94
OCDs -1.18 -3.49 1.13 1.17 0.32
Psychotic and bipolar disorder 15.79 6.85 24.74 4.55 5.75e-04
Only psychotic disorder -0.76 -6.35 4.84 2.84 0.79
Only bipolar disorder -1.72 -5.59 2.15 1.97 0.38
PTSD -3.70 -6.29 -1.11 1.32 0.005
ASD -0.89 -5.43 3.65 2.31 0.70
ADHD 4.56 -3.10 12.22 3.90 0.24
Personality disorder -1.28 -4.65 2.10 1.72 0.46
Highest education NVQ 0.63 -4.84 6.10 2.78 0.82
Highest education A-Levels -0.64 -5.04 3.76 2.24 0.78
Highest education University 0.25 -3.96 4.45 2.14 0.91
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -4.32 -19.47 10.83 7.70 0.58
Anxiety disorders -9.43 -23.05 4.18 6.93 0.17
Eating disorders -7.02 -26.37 12.34 9.85 0.48
OCDs -12.51 -26.51 1.49 7.12 0.08
PTSD -23.87 -43.40 -4.33 9.94 0.02
Depressive disorders -10.38 -22.91 2.14 6.37 0.10
Bipolar disorders -10.22 -23.15 2.70 6.58 0.12
Female -2.37 -5.59 0.85 1.64 0.15
Non-binary/Self-defined -2.65 -8.75 3.44 3.10 0.39
19-25 years 3.90 -3.76 11.55 3.89 0.32
26-35 years 7.22 -0.27 14.70 3.81 0.06
36-45 years 7.12 -0.62 14.87 3.94 0.07
46-55 years 6.86 -0.68 14.40 3.84 0.07
56-65 years 5.20 -2.73 13.12 4.03 0.20
66-70 years 4.56 -5.40 14.52 5.07 0.37
71-75 years 8.13 -8.45 24.70 8.43 0.34
Mixed or multiple ethnic origins 2.85 -3.95 9.65 3.46 0.41
Asian or Asian British -24.91 -39.75 -10.07 7.55 0.001
African or African British 17.29 -4.74 39.32 11.21 0.12
Other ethnicity -1.40 -10.18 7.38 4.47 0.75
Time difference: Lockdown to baseline 0.44 -0.35 1.22 0.40 0.28
Highest education NVQ -2.00 -7.78 3.78 2.94 0.50
Highest education A-Levels -0.97 -5.82 3.87 2.47 0.69
Highest education University -0.04 -4.73 4.64 2.38 0.99
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -9.79 -22.19 2.62 6.31 0.12
Depressive and anxiety disorder -4.12 -13.04 4.80 4.54 0.36
Only depressive disorder -4.04 -13.65 5.58 4.89 0.41
Only anxiety disorder -6.57 -16.23 3.09 4.91 0.18
Eating disorders 0.02 -2.77 2.81 1.42 0.99
OCDs -1.01 -3.35 1.33 1.19 0.40
Psychotic and bipolar disorder 13.94 4.87 23.01 4.61 0.003
Only psychotic disorder -1.56 -7.27 4.14 2.90 0.59
Only bipolar disorder -1.72 -5.65 2.22 2.00 0.39
PTSD -3.34 -5.99 -0.68 1.35 0.01
ASD -0.98 -5.57 3.60 2.33 0.67
ADHD 3.41 -4.31 11.13 3.93 0.39
Personality disorder -0.83 -4.21 2.56 1.72 0.63
Female -1.68 -4.94 1.57 1.66 0.31
Non-binary/Self-defined -1.02 -7.29 5.25 3.19 0.75
19-25 years 3.14 -4.35 10.64 3.81 0.41
26-35 years 6.60 -0.80 14.00 3.76 0.08
36-45 years 6.19 -1.45 13.83 3.89 0.11
46-55 years 6.09 -1.40 13.58 3.81 0.11
56-65 years 5.03 -2.82 12.89 3.99 0.21
66-70 years 4.37 -5.56 14.30 5.05 0.39
71-75 years 10.36 -3.69 24.41 7.15 0.15
Mixed or multiple ethnic origins 2.47 -4.39 9.32 3.49 0.48
Asian or Asian British -23.11 -38.10 -8.11 7.63 0.003
African or African British 17.06 -4.77 38.88 11.10 0.13
Other ethnicity -1.63 -10.38 7.12 4.45 0.71
Key worker 1.17 -1.09 3.42 1.15 0.31
Time difference: Lockdown to baseline 0.49 -0.29 1.27 0.40 0.21
Highest education NVQ -1.00 -6.74 4.74 2.92 0.73
Highest education A-Levels -0.82 -5.55 3.91 2.41 0.73
Highest education University -0.79 -5.38 3.80 2.34 0.74
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.19 -1.47 21.86 5.93 0.09
ocir.sum_score_prepan 0.64 0.58 0.71 0.03 1.40e-56
Anxiety disorders -11.71 -23.69 0.26 6.09 0.06
Eating disorders -9.34 -26.58 7.89 8.77 0.29
OCDs -9.15 -21.51 3.22 6.29 0.15
PTSD -20.95 -38.26 -3.64 8.81 0.02
Depressive disorders -8.56 -19.55 2.42 5.59 0.13
Bipolar disorders -6.31 -17.67 5.06 5.78 0.28
Highest education NVQ 1.15 -3.79 6.09 2.51 0.65
Highest education A-Levels -0.53 -4.57 3.51 2.06 0.80
Highest education University -0.32 -4.18 3.54 1.96 0.87
n R2 adjust. R2 F p value df
436 0.49 0.49 59.80 1.44e-59 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.93 -0.97 14.83 4.02 0.09
ocir.sum_score_prepan 0.62 0.55 0.69 0.04 1.24e-49
Depressive and anxiety disorder -4.18 -11.33 2.98 3.64 0.25
Only depressive disorder -5.19 -13.06 2.68 4.00 0.20
Only anxiety disorder -8.49 -16.37 -0.61 4.01 0.03
Eating disorders 0.52 -1.93 2.97 1.24 0.68
OCDs 2.48 0.31 4.65 1.10 0.03
Psychotic and bipolar disorder 15.89 7.92 23.86 4.05 1.04e-04
Only psychotic disorder 0.76 -4.23 5.75 2.54 0.77
Only bipolar disorder -0.17 -3.63 3.29 1.76 0.92
PTSD -3.00 -5.31 -0.69 1.17 0.01
ASD 0.20 -3.85 4.25 2.06 0.92
ADHD 3.07 -3.75 9.90 3.47 0.38
Personality disorder -0.45 -3.46 2.56 1.53 0.77
Highest education NVQ 1.45 -3.42 6.32 2.48 0.56
Highest education A-Levels -0.85 -4.77 3.07 1.99 0.67
Highest education University -1.29 -5.05 2.46 1.91 0.50
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.19 -5.82 26.20 8.14 0.21
ocir.sum_score_prepan 0.66 0.59 0.73 0.04 1.44e-54
Anxiety disorders -16.52 -31.31 -1.73 7.52 0.03
Eating disorders -14.54 -33.90 4.83 9.85 0.14
OCDs -14.69 -29.74 0.37 7.66 0.06
PTSD -26.16 -45.63 -6.69 9.90 0.009
Depressive disorders -14.19 -28.17 -0.21 7.11 0.05
Bipolar disorders -12.01 -26.30 2.28 7.27 0.10
Female -1.74 -4.65 1.17 1.48 0.24
Non-binary/Self-defined -1.26 -6.77 4.25 2.80 0.65
19-25 years 5.76 -1.22 12.75 3.55 0.11
26-35 years 7.07 0.23 13.91 3.48 0.04
36-45 years 7.39 0.32 14.45 3.59 0.04
46-55 years 7.10 0.23 13.98 3.50 0.04
56-65 years 5.08 -2.16 12.32 3.68 0.17
66-70 years 4.32 -4.80 13.44 4.64 0.35
71-75 years 4.87 -10.19 19.93 7.66 0.53
Mixed or multiple ethnic origins 0.52 -5.64 6.69 3.14 0.87
Asian or Asian British -16.23 -29.81 -2.64 6.91 0.02
African or African British 22.11 2.22 42.00 10.12 0.03
Other ethnicity 0.94 -7.02 8.90 4.05 0.82
Key worker 0.35 -1.68 2.39 1.03 0.73
Time difference: Lockdown to baseline 0.21 -0.51 0.93 0.36 0.57
Highest education NVQ -0.56 -5.79 4.68 2.66 0.83
Highest education A-Levels -1.40 -5.78 2.97 2.23 0.53
Highest education University -1.79 -6.04 2.46 2.16 0.41
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.82 -10.52 12.16 5.77 0.89
ocir.sum_score_prepan 0.63 0.55 0.70 0.04 1.28e-46
Depressive and anxiety disorder -4.83 -12.84 3.18 4.07 0.24
Only depressive disorder -5.55 -14.18 3.09 4.39 0.21
Only anxiety disorder -8.41 -17.09 0.27 4.42 0.06
Eating disorders 0.86 -1.65 3.37 1.28 0.50
OCDs 2.72 0.49 4.96 1.14 0.02
Psychotic and bipolar disorder 15.18 7.03 23.33 4.15 2.84e-04
Only psychotic disorder 0.12 -5.01 5.26 2.61 0.96
Only bipolar disorder -0.34 -3.88 3.21 1.80 0.85
PTSD -2.70 -5.09 -0.32 1.21 0.03
ASD -0.23 -4.35 3.89 2.10 0.91
ADHD 2.06 -4.88 9.00 3.53 0.56
Personality disorder -0.09 -3.13 2.96 1.55 0.95
Female -1.48 -4.41 1.44 1.49 0.32
Non-binary/Self-defined -0.20 -5.83 5.43 2.86 0.94
19-25 years 4.91 -1.83 11.65 3.43 0.15
26-35 years 6.21 -0.44 12.86 3.38 0.07
36-45 years 6.17 -0.69 13.04 3.49 0.08
46-55 years 7.01 0.28 13.73 3.42 0.04
56-65 years 4.36 -2.69 11.42 3.59 0.22
66-70 years 3.95 -4.97 12.86 4.54 0.38
71-75 years 8.04 -4.58 20.67 6.42 0.21
Mixed or multiple ethnic origins -1.14 -7.34 5.06 3.15 0.72
Asian or Asian British -11.82 -25.48 1.83 6.95 0.09
African or African British 22.72 3.09 42.35 9.99 0.02
Other ethnicity 0.39 -7.47 8.26 4.00 0.92
Key worker -0.01 -2.05 2.03 1.04 0.99
Time difference: Lockdown to baseline 0.40 -0.30 1.10 0.36 0.26
Highest education NVQ 0.37 -4.79 5.53 2.63 0.89
Highest education A-Levels -1.41 -5.66 2.84 2.16 0.51
Highest education University -2.28 -6.41 1.86 2.10 0.28
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

OCIR retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.67 4.67 6.66 0.51 2.31e-28
Anxiety disorders -0.88 -2.15 0.40 0.65 0.18
Eating disorders -3.91 -7.55 -0.27 1.86 0.04
OCDs -2.29 -4.65 0.07 1.20 0.06
PTSD -0.77 -3.35 1.81 1.31 0.56
Depressive disorders -3.85 -4.65 -3.06 0.40 2.38e-21
Bipolar disorders -3.09 -4.43 -1.75 0.69 6.69e-06
Highest education NVQ -7.35 -8.88 -5.82 0.78 6.76e-21
Highest education A-Levels -2.90 -3.87 -1.93 0.50 5.27e-09
Highest education University -1.52 -2.37 -0.67 0.43 4.73e-04
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.52 4.58 6.45 0.48 1.97e-30
Depressive and anxiety disorder -4.21 -4.99 -3.43 0.40 8.91e-26
Only depressive disorder -2.07 -3.16 -0.98 0.55 1.90e-04
Only anxiety disorder -1.50 -2.62 -0.38 0.57 0.009
Eating disorders -0.37 -1.31 0.56 0.48 0.43
OCDs 0.29 -0.52 1.10 0.41 0.48
Psychotic and bipolar disorder 3.26 1.00 5.53 1.16 0.005
Only psychotic disorder 0.72 -1.28 2.71 1.02 0.48
Only bipolar disorder -0.38 -1.77 1.00 0.71 0.59
PTSD 0.21 -0.58 1.01 0.41 0.60
ASD 1.66 0.16 3.15 0.76 0.03
ADHD 2.48 0.35 4.60 1.08 0.02
Personality disorder -0.53 -1.63 0.56 0.56 0.34
Highest education NVQ -7.22 -8.73 -5.71 0.77 1.26e-20
Highest education A-Levels -2.68 -3.63 -1.72 0.48 3.68e-08
Highest education University -1.49 -2.32 -0.65 0.43 4.88e-04
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 16.14 14.36 17.93 0.91 7.64e-68
Anxiety disorders -0.28 -1.50 0.93 0.62 0.65
Eating disorders -2.65 -6.04 0.75 1.73 0.13
OCDs -0.69 -2.92 1.53 1.14 0.54
PTSD -0.68 -3.12 1.77 1.25 0.59
Depressive disorders -2.13 -2.91 -1.35 0.40 1.01e-07
Bipolar disorders -1.39 -2.68 -0.11 0.66 0.03
Female 0.11 -0.66 0.88 0.39 0.77
Non-binary/Self-defined -0.21 -2.28 1.85 1.05 0.84
19-25 years -4.20 -5.79 -2.60 0.81 2.48e-07
26-35 years -3.87 -5.40 -2.33 0.78 7.94e-07
36-45 years -3.45 -5.01 -1.89 0.79 1.44e-05
46-55 years -3.39 -4.88 -1.90 0.76 8.92e-06
56-65 years -2.04 -3.53 -0.56 0.76 0.007
66-70 years -1.85 -3.64 -0.06 0.91 0.04
71-75 years -1.08 -3.14 0.98 1.05 0.30
76+ years -5.32 -9.10 -1.55 1.92 0.006
Mixed or multiple ethnic origins 1.62 -0.17 3.41 0.91 0.08
Asian or Asian British 2.91 0.23 5.60 1.37 0.03
African or African British 0.39 -3.94 4.72 2.21 0.86
Other ethnicity -0.67 -3.28 1.95 1.33 0.62
Time difference: Lockdown to baseline -1.61 -1.74 -1.48 0.07 3.13e-124
Highest education NVQ -4.53 -6.04 -3.02 0.77 4.77e-09
Highest education A-Levels -2.04 -2.98 -1.09 0.48 2.30e-05
Highest education University -0.73 -1.59 0.13 0.44 0.10
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.81 14.10 17.51 0.87 6.34e-71
Depressive and anxiety disorder -2.48 -3.25 -1.71 0.39 2.85e-10
Only depressive disorder -1.42 -2.46 -0.37 0.53 0.008
Only anxiety disorder -0.84 -1.91 0.23 0.55 0.12
Eating disorders -0.25 -1.13 0.63 0.45 0.57
OCDs 0.42 -0.35 1.18 0.39 0.28
Psychotic and bipolar disorder 3.24 1.12 5.36 1.08 0.003
Only psychotic disorder 0.54 -1.33 2.40 0.95 0.57
Only bipolar disorder -0.31 -1.62 1.00 0.67 0.64
PTSD 0.14 -0.62 0.89 0.39 0.73
ASD 0.97 -0.46 2.40 0.73 0.18
ADHD 1.85 -0.13 3.83 1.01 0.07
Personality disorder -0.19 -1.21 0.84 0.52 0.72
Female 0.22 -0.55 0.99 0.39 0.57
Non-binary/Self-defined -0.82 -2.89 1.25 1.06 0.44
19-25 years -4.09 -5.62 -2.56 0.78 1.80e-07
26-35 years -3.78 -5.27 -2.30 0.76 6.24e-07
36-45 years -3.39 -4.90 -1.88 0.77 1.15e-05
46-55 years -3.37 -4.81 -1.92 0.74 5.20e-06
56-65 years -2.05 -3.48 -0.62 0.73 0.005
66-70 years -1.70 -3.44 0.03 0.89 0.05
71-75 years -1.64 -3.65 0.37 1.02 0.11
76+ years -4.92 -8.65 -1.19 1.90 0.010
Mixed or multiple ethnic origins 1.37 -0.42 3.16 0.91 0.13
Asian or Asian British 2.57 -0.02 5.16 1.32 0.05
African or African British 0.57 -3.74 4.87 2.20 0.80
Other ethnicity -0.75 -3.38 1.88 1.34 0.58
Key worker -0.08 -0.66 0.49 0.30 0.77
Time difference: Lockdown to baseline -1.58 -1.70 -1.45 0.06 3.38e-122
Highest education NVQ -4.52 -6.02 -3.01 0.77 4.36e-09
Highest education A-Levels -1.76 -2.69 -0.83 0.47 2.01e-04
Highest education University -0.69 -1.55 0.17 0.44 0.11
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.85 7.87 9.82 0.50 2.17e-68
ocir.sum_score_retro 0.73 0.71 0.75 0.01 0.00e+00
Anxiety disorders -0.15 -1.36 1.05 0.61 0.80
Eating disorders -1.63 -5.05 1.79 1.75 0.35
OCDs 1.23 -1.01 3.46 1.14 0.28
PTSD 1.31 -1.12 3.74 1.24 0.29
Depressive disorders -1.45 -2.22 -0.68 0.39 2.32e-04
Bipolar disorders 0.74 -0.57 2.04 0.66 0.27
Highest education NVQ -6.37 -7.81 -4.93 0.73 5.50e-18
Highest education A-Levels -2.99 -3.90 -2.08 0.47 1.47e-10
Highest education University -2.55 -3.36 -1.75 0.41 5.59e-10
n R2 adjust. R2 F p value df
4329 0.52 0.52 665.07 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.16 8.24 10.07 0.47 1.62e-81
ocir.sum_score_retro 0.70 0.68 0.73 0.01 0.00e+00
Depressive and anxiety disorder -2.39 -3.13 -1.65 0.38 3.17e-10
Only depressive disorder -1.58 -2.60 -0.57 0.52 0.002
Only anxiety disorder -0.73 -1.78 0.31 0.53 0.17
Eating disorders -0.11 -0.98 0.76 0.44 0.81
OCDs 2.45 1.68 3.23 0.40 6.26e-10
Psychotic and bipolar disorder 4.31 2.20 6.43 1.08 6.52e-05
Only psychotic disorder 1.86 -0.01 3.72 0.95 0.05
Only bipolar disorder 0.56 -0.73 1.86 0.66 0.39
PTSD 0.70 -0.05 1.44 0.38 0.07
ASD 3.53 2.12 4.93 0.72 8.57e-07
ADHD 2.42 0.43 4.40 1.01 0.02
Personality disorder 0.58 -0.45 1.60 0.52 0.27
Highest education NVQ -6.14 -7.55 -4.72 0.72 2.36e-17
Highest education A-Levels -2.84 -3.73 -1.95 0.45 3.91e-10
Highest education University -2.44 -3.23 -1.66 0.40 1.01e-09
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 18.57 16.86 20.28 0.87 4.47e-95
ocir.sum_score_retro 0.77 0.75 0.79 0.01 0.00e+00
Anxiety disorders 0.05 -1.11 1.21 0.59 0.93
Eating disorders -1.15 -4.37 2.08 1.64 0.49
OCDs 1.46 -0.68 3.61 1.09 0.18
PTSD 0.95 -1.40 3.30 1.20 0.43
Depressive disorders -0.52 -1.29 0.24 0.39 0.18
Bipolar disorders 1.41 0.15 2.67 0.64 0.03
Female 0.10 -0.63 0.84 0.37 0.79
Non-binary/Self-defined 0.60 -1.37 2.56 1.00 0.55
19-25 years -4.05 -5.56 -2.53 0.77 1.66e-07
26-35 years -3.98 -5.45 -2.52 0.75 1.01e-07
36-45 years -3.94 -5.42 -2.45 0.76 2.29e-07
46-55 years -3.94 -5.37 -2.51 0.73 6.90e-08
56-65 years -3.22 -4.64 -1.80 0.72 9.00e-06
66-70 years -3.21 -4.92 -1.49 0.87 2.42e-04
71-75 years -3.26 -5.23 -1.29 1.00 0.001
76+ years -6.24 -9.89 -2.60 1.86 7.95e-04
Mixed or multiple ethnic origins 1.50 -0.22 3.21 0.87 0.09
Asian or Asian British 3.62 1.07 6.18 1.30 0.005
African or African British 0.75 -3.36 4.86 2.09 0.72
Other ethnicity 0.17 -2.34 2.68 1.28 0.90
Key worker -0.45 -1.00 0.11 0.28 0.11
Time difference: Lockdown to baseline -1.39 -1.51 -1.26 0.06 2.56e-100
Highest education NVQ -3.89 -5.34 -2.44 0.74 1.41e-07
Highest education A-Levels -2.11 -3.01 -1.21 0.46 4.13e-06
Highest education University -1.57 -2.40 -0.74 0.42 2.03e-04
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 18.69 17.05 20.32 0.83 5.66e-105
ocir.sum_score_retro 0.74 0.72 0.77 0.01 0.00e+00
Depressive and anxiety disorder -1.20 -1.94 -0.46 0.38 0.001
Only depressive disorder -0.92 -1.91 0.07 0.50 0.07
Only anxiety disorder -0.39 -1.40 0.62 0.52 0.45
Eating disorders -0.12 -0.96 0.71 0.42 0.77
OCDs 2.16 1.42 2.90 0.38 1.14e-08
Psychotic and bipolar disorder 4.16 2.16 6.17 1.02 4.92e-05
Only psychotic disorder 1.50 -0.26 3.27 0.90 0.10
Only bipolar disorder 0.45 -0.79 1.70 0.63 0.47
PTSD 0.63 -0.09 1.35 0.37 0.09
ASD 2.45 1.09 3.81 0.69 4.18e-04
ADHD 1.75 -0.12 3.63 0.96 0.07
Personality disorder 0.66 -0.32 1.63 0.50 0.18
Female 0.09 -0.64 0.82 0.37 0.81
Non-binary/Self-defined -0.60 -2.56 1.36 1.00 0.55
19-25 years -4.29 -5.74 -2.84 0.74 7.45e-09
26-35 years -4.42 -5.83 -3.01 0.72 8.17e-10
36-45 years -4.24 -5.67 -2.80 0.73 7.24e-09
46-55 years -4.18 -5.55 -2.81 0.70 2.40e-09
56-65 years -3.42 -4.78 -2.06 0.69 8.31e-07
66-70 years -3.15 -4.80 -1.51 0.84 1.78e-04
71-75 years -3.36 -5.27 -1.45 0.97 5.58e-04
76+ years -6.26 -9.79 -2.73 1.80 5.20e-04
Mixed or multiple ethnic origins 1.11 -0.58 2.81 0.86 0.20
Asian or Asian British 3.61 1.16 6.06 1.25 0.004
African or African British 1.11 -2.97 5.18 2.08 0.59
Other ethnicity -0.10 -2.59 2.40 1.27 0.94
Key worker -0.34 -0.89 0.21 0.28 0.22
Time difference: Lockdown to baseline -1.34 -1.46 -1.21 0.06 8.91e-97
Highest education NVQ -3.73 -5.16 -2.31 0.73 2.96e-07
Highest education A-Levels -1.91 -2.79 -1.03 0.45 2.02e-05
Highest education University -1.39 -2.20 -0.58 0.41 8.16e-04
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

PCL prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.27 -0.78 1.32 0.54 0.61
Anxiety disorders -0.12 -1.21 0.98 0.56 0.84
Eating disorders -0.60 -2.70 1.51 1.08 0.58
OCDs -0.33 -1.80 1.15 0.75 0.66
PTSD -1.67 -3.37 0.04 0.87 0.05
Depressive disorders -0.11 -1.11 0.89 0.51 0.82
Bipolar disorders -0.23 -1.31 0.84 0.55 0.67
Highest education NVQ -0.20 -0.73 0.34 0.27 0.47
Highest education A-Levels -0.23 -0.66 0.20 0.22 0.29
Highest education University 0.22 -0.17 0.61 0.20 0.28
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.42 -0.37 1.21 0.40 0.30
Depressive and anxiety disorder -0.05 -0.77 0.68 0.37 0.90
Only depressive disorder -0.24 -1.02 0.54 0.40 0.54
Only anxiety disorder -0.25 -1.06 0.57 0.42 0.55
Eating disorders 0.12 -0.23 0.47 0.18 0.50
OCDs -0.02 -0.35 0.31 0.17 0.91
Psychotic and bipolar disorder -0.72 -1.68 0.23 0.49 0.14
Only psychotic disorder 0.00 -0.80 0.81 0.41 0.99
Only bipolar disorder 0.19 -0.30 0.67 0.25 0.45
PTSD -0.91 -1.22 -0.61 0.16 6.82e-09
ASD -0.10 -0.74 0.54 0.33 0.76
ADHD -0.15 -1.03 0.73 0.45 0.74
Personality disorder -0.26 -0.69 0.17 0.22 0.24
Highest education NVQ -0.21 -0.75 0.32 0.27 0.44
Highest education A-Levels -0.25 -0.68 0.18 0.22 0.26
Highest education University 0.16 -0.23 0.55 0.20 0.43
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.19 -1.52 1.14 0.68 0.78
Anxiety disorders -0.12 -1.21 0.97 0.56 0.83
Eating disorders -0.74 -2.85 1.37 1.07 0.49
OCDs -0.51 -1.98 0.96 0.75 0.50
PTSD -1.64 -3.36 0.07 0.87 0.06
Depressive disorders -0.04 -1.04 0.96 0.51 0.93
Bipolar disorders -0.06 -1.14 1.02 0.55 0.91
Female 0.59 0.30 0.88 0.15 7.92e-05
Non-binary/Self-defined -0.09 -0.92 0.73 0.42 0.82
19-25 years 0.21 -0.53 0.95 0.38 0.58
26-35 years -0.22 -0.94 0.50 0.37 0.54
36-45 years -0.69 -1.41 0.04 0.37 0.07
46-55 years -0.78 -1.50 -0.06 0.37 0.03
56-65 years -0.53 -1.27 0.21 0.38 0.16
66-70 years -0.58 -1.50 0.34 0.47 0.21
71-75 years -0.73 -1.83 0.36 0.56 0.19
76+ years -0.19 -1.99 1.61 0.92 0.84
Mixed or multiple ethnic origins 0.44 -0.30 1.19 0.38 0.25
Asian or Asian British 0.11 -1.14 1.36 0.64 0.86
African or African British -0.65 -2.54 1.23 0.96 0.50
Other ethnicity -0.51 -1.71 0.69 0.61 0.40
Time difference: Lockdown to baseline 0.06 -0.01 0.13 0.03 0.08
Highest education NVQ -0.12 -0.66 0.43 0.28 0.67
Highest education A-Levels -0.39 -0.83 0.04 0.22 0.08
Highest education University 0.13 -0.27 0.54 0.20 0.51
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.14 -1.26 0.99 0.57 0.81
Depressive and anxiety disorder 0.04 -0.69 0.77 0.37 0.91
Only depressive disorder -0.09 -0.87 0.70 0.40 0.83
Only anxiety disorder -0.25 -1.06 0.57 0.42 0.56
Eating disorders 0.00 -0.36 0.35 0.18 0.99
OCDs -0.06 -0.39 0.27 0.17 0.71
Psychotic and bipolar disorder -0.61 -1.56 0.35 0.49 0.21
Only psychotic disorder 0.10 -0.70 0.91 0.41 0.80
Only bipolar disorder 0.32 -0.16 0.80 0.25 0.19
PTSD -0.89 -1.20 -0.58 0.16 1.75e-08
ASD -0.13 -0.77 0.52 0.33 0.70
ADHD -0.13 -1.01 0.75 0.45 0.78
Personality disorder -0.39 -0.82 0.05 0.22 0.08
Female 0.65 0.36 0.95 0.15 1.40e-05
Non-binary/Self-defined 0.10 -0.73 0.93 0.42 0.81
19-25 years 0.24 -0.49 0.97 0.37 0.52
26-35 years -0.15 -0.86 0.57 0.37 0.69
36-45 years -0.59 -1.31 0.13 0.37 0.11
46-55 years -0.66 -1.38 0.05 0.37 0.07
56-65 years -0.49 -1.22 0.25 0.37 0.19
66-70 years -0.65 -1.56 0.27 0.47 0.17
71-75 years -0.81 -1.90 0.28 0.56 0.15
76+ years -0.32 -2.11 1.47 0.91 0.73
Mixed or multiple ethnic origins 0.53 -0.22 1.28 0.38 0.17
Asian or Asian British 0.21 -1.04 1.46 0.64 0.74
African or African British -0.68 -2.57 1.20 0.96 0.48
Other ethnicity -0.24 -1.42 0.93 0.60 0.68
Key worker -0.23 -0.46 0.00 0.12 0.05
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.07
Highest education NVQ -0.07 -0.61 0.47 0.28 0.80
Highest education A-Levels -0.38 -0.81 0.06 0.22 0.09
Highest education University 0.12 -0.28 0.53 0.21 0.55
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.82 5.86 7.78 0.49 1.10e-43
pcl.sum_score_prepan 0.55 0.54 0.57 0.01 0.00e+00
Anxiety disorders -0.37 -1.34 0.60 0.49 0.45
Eating disorders 0.11 -1.76 1.98 0.95 0.91
OCDs 0.45 -0.86 1.75 0.67 0.50
PTSD 0.11 -1.40 1.62 0.77 0.89
Depressive disorders 0.90 0.01 1.79 0.45 0.05
Bipolar disorders 1.46 0.50 2.41 0.49 0.003
Highest education NVQ -0.21 -0.69 0.26 0.24 0.38
Highest education A-Levels -0.29 -0.67 0.09 0.19 0.14
Highest education University -0.72 -1.07 -0.37 0.18 4.87e-05
n R2 adjust. R2 F p value df
11019 0.33 0.33 764.66 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.57 6.83 8.31 0.38 4.17e-88
pcl.sum_score_prepan 0.52 0.51 0.54 0.01 0.00e+00
Depressive and anxiety disorder 0.47 -0.17 1.10 0.32 0.15
Only depressive disorder -0.55 -1.24 0.13 0.35 0.11
Only anxiety disorder -0.64 -1.36 0.08 0.37 0.08
Eating disorders 0.65 0.34 0.96 0.16 3.40e-05
OCDs 0.59 0.30 0.88 0.15 6.18e-05
Psychotic and bipolar disorder -0.42 -1.26 0.42 0.43 0.33
Only psychotic disorder -0.11 -0.82 0.60 0.36 0.77
Only bipolar disorder 0.40 -0.02 0.83 0.22 0.06
PTSD 0.70 0.42 0.98 0.14 8.70e-07
ASD 0.62 0.06 1.18 0.29 0.03
ADHD 0.25 -0.52 1.02 0.39 0.52
Personality disorder 1.05 0.67 1.44 0.20 7.75e-08
Highest education NVQ -0.24 -0.71 0.23 0.24 0.31
Highest education A-Levels -0.35 -0.73 0.02 0.19 0.07
Highest education University -0.73 -1.08 -0.39 0.18 3.33e-05
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.63 6.42 8.83 0.61 3.28e-35
pcl.sum_score_prepan 0.53 0.51 0.55 0.01 0.00e+00
Anxiety disorders -0.38 -1.35 0.58 0.49 0.43
Eating disorders 0.00 -1.85 1.85 0.94 1.00
OCDs 0.20 -1.09 1.49 0.66 0.76
PTSD 0.49 -1.01 1.99 0.77 0.52
Depressive disorders 1.10 0.22 1.98 0.45 0.01
Bipolar disorders 1.77 0.82 2.72 0.49 2.60e-04
Female 0.56 0.30 0.81 0.13 2.28e-05
Non-binary/Self-defined 0.75 0.02 1.47 0.37 0.04
19-25 years 0.04 -0.61 0.69 0.33 0.91
26-35 years -0.83 -1.47 -0.20 0.32 0.01
36-45 years -1.41 -2.05 -0.77 0.33 1.65e-05
46-55 years -1.58 -2.22 -0.95 0.32 1.07e-06
56-65 years -1.93 -2.59 -1.28 0.33 5.92e-09
66-70 years -2.86 -3.67 -2.04 0.41 5.67e-12
71-75 years -3.42 -4.39 -2.45 0.49 4.51e-12
76+ years -3.10 -4.67 -1.52 0.80 1.19e-04
Mixed or multiple ethnic origins 0.38 -0.28 1.04 0.34 0.26
Asian or Asian British 0.33 -0.78 1.43 0.56 0.56
African or African British 0.54 -1.11 2.20 0.84 0.52
Other ethnicity 0.07 -0.99 1.13 0.54 0.90
Key worker -0.62 -0.82 -0.42 0.10 1.35e-09
Time difference: Lockdown to baseline 0.08 0.02 0.14 0.03 0.01
Highest education NVQ -0.06 -0.53 0.42 0.24 0.82
Highest education A-Levels -0.62 -1.01 -0.24 0.20 0.001
Highest education University -0.82 -1.18 -0.47 0.18 5.82e-06
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.39 7.36 9.41 0.52 2.65e-57
pcl.sum_score_prepan 0.50 0.49 0.52 0.01 0.00e+00
Depressive and anxiety disorder 0.65 0.02 1.28 0.32 0.04
Only depressive disorder -0.17 -0.86 0.51 0.35 0.62
Only anxiety disorder -0.66 -1.37 0.06 0.36 0.07
Eating disorders 0.50 0.19 0.81 0.16 0.001
OCDs 0.49 0.20 0.78 0.15 8.84e-04
Psychotic and bipolar disorder -0.19 -1.02 0.65 0.43 0.66
Only psychotic disorder 0.00 -0.70 0.71 0.36 0.99
Only bipolar disorder 0.57 0.15 0.99 0.21 0.008
PTSD 0.82 0.54 1.09 0.14 7.89e-09
ASD 0.34 -0.22 0.91 0.29 0.23
ADHD 0.16 -0.61 0.93 0.39 0.68
Personality disorder 0.90 0.52 1.28 0.19 4.10e-06
Female 0.44 0.18 0.69 0.13 8.55e-04
Non-binary/Self-defined 0.45 -0.27 1.17 0.37 0.22
19-25 years -0.13 -0.77 0.51 0.33 0.70
26-35 years -1.02 -1.65 -0.40 0.32 0.001
36-45 years -1.56 -2.19 -0.93 0.32 1.33e-06
46-55 years -1.69 -2.32 -1.07 0.32 1.17e-07
56-65 years -1.98 -2.62 -1.34 0.33 1.53e-09
66-70 years -2.83 -3.63 -2.03 0.41 4.40e-12
71-75 years -3.34 -4.29 -2.38 0.49 7.28e-12
76+ years -3.12 -4.68 -1.56 0.80 9.18e-05
Mixed or multiple ethnic origins 0.34 -0.31 0.99 0.33 0.31
Asian or Asian British 0.47 -0.62 1.56 0.56 0.40
African or African British 0.67 -0.97 2.31 0.84 0.42
Other ethnicity -0.04 -1.06 0.99 0.52 0.94
Key worker -0.53 -0.73 -0.33 0.10 1.47e-07
Time difference: Lockdown to baseline 0.09 0.03 0.15 0.03 0.003
Highest education NVQ -0.06 -0.53 0.41 0.24 0.80
Highest education A-Levels -0.64 -1.02 -0.26 0.19 9.46e-04
Highest education University -0.79 -1.14 -0.44 0.18 1.19e-05
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

FUNCTION CHANGE to include employment status as predictors

GAD prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.15 -2.09 -0.22 0.48 0.02
Anxiety disorders 0.20 -0.83 1.23 0.53 0.71
Eating disorders -0.56 -2.59 1.47 1.04 0.59
OCDs -0.12 -1.52 1.28 0.72 0.87
PTSD -0.04 -1.67 1.58 0.83 0.96
Depressive disorders 0.87 -0.07 1.82 0.48 0.07
Bipolar disorders 0.85 -0.16 1.87 0.52 0.10
Unemployed -0.36 -0.72 0.01 0.19 0.05
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.82 -1.49 -0.14 0.34 0.02
Depressive and anxiety disorder 0.45 -0.23 1.14 0.35 0.19
Only depressive disorder 0.98 0.24 1.72 0.38 0.009
Only anxiety disorder -0.24 -1.02 0.53 0.40 0.54
Eating disorders 0.19 -0.14 0.52 0.17 0.27
OCDs -0.25 -0.56 0.06 0.16 0.12
Psychotic and bipolar disorder -0.48 -1.39 0.43 0.46 0.30
Only psychotic disorder 0.78 0.02 1.54 0.39 0.04
Only bipolar disorder 0.21 -0.24 0.66 0.23 0.36
PTSD 0.14 -0.15 0.43 0.15 0.35
ASD 0.19 -0.41 0.79 0.31 0.53
ADHD -0.73 -1.55 0.10 0.42 0.08
Personality disorder -0.14 -0.55 0.27 0.21 0.50
Unemployed -0.33 -0.69 0.04 0.19 0.08
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.94 -3.17 -0.70 0.63 0.002
Anxiety disorders 0.14 -0.89 1.17 0.53 0.79
Eating disorders -0.70 -2.74 1.33 1.04 0.50
OCDs -0.22 -1.63 1.19 0.72 0.76
PTSD -0.19 -1.83 1.45 0.84 0.82
Depressive disorders 0.78 -0.17 1.72 0.48 0.11
Bipolar disorders 0.81 -0.21 1.83 0.52 0.12
Female 0.48 0.20 0.75 0.14 7.55e-04
Non-binary/Self-defined 0.45 -0.35 1.24 0.40 0.27
19-25 years 0.53 -0.17 1.22 0.35 0.14
26-35 years 0.48 -0.18 1.15 0.34 0.15
36-45 years 0.64 -0.03 1.31 0.34 0.06
46-55 years 0.46 -0.21 1.13 0.34 0.18
56-65 years 0.63 -0.05 1.32 0.35 0.07
66-70 years 0.21 -0.64 1.06 0.43 0.63
71-75 years 0.14 -0.86 1.14 0.51 0.79
76+ years 0.89 -0.79 2.56 0.85 0.30
Mixed or multiple ethnic origins 0.27 -0.45 1.00 0.37 0.46
Asian or Asian British -0.16 -1.34 1.02 0.60 0.79
African or African British -1.24 -3.00 0.52 0.90 0.17
Other ethnicity 0.04 -1.09 1.17 0.58 0.94
Time difference: Lockdown to baseline 0.00 -0.07 0.06 0.03 0.90
Unemployed -0.33 -0.70 0.03 0.19 0.08
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.64 -2.68 -0.60 0.53 0.002
Depressive and anxiety disorder 0.39 -0.30 1.08 0.35 0.27
Only depressive disorder 0.92 0.18 1.67 0.38 0.02
Only anxiety disorder -0.29 -1.07 0.49 0.40 0.46
Eating disorders 0.14 -0.20 0.47 0.17 0.42
OCDs -0.26 -0.57 0.06 0.16 0.11
Psychotic and bipolar disorder -0.38 -1.29 0.53 0.47 0.41
Only psychotic disorder 0.80 0.04 1.56 0.39 0.04
Only bipolar disorder 0.29 -0.16 0.75 0.23 0.21
PTSD 0.12 -0.18 0.41 0.15 0.44
ASD 0.27 -0.34 0.88 0.31 0.39
ADHD -0.72 -1.55 0.11 0.42 0.09
Personality disorder -0.17 -0.58 0.24 0.21 0.41
Female 0.45 0.17 0.73 0.14 0.001
Non-binary/Self-defined 0.46 -0.33 1.26 0.40 0.25
19-25 years 0.54 -0.15 1.22 0.35 0.12
26-35 years 0.49 -0.17 1.15 0.34 0.14
36-45 years 0.61 -0.06 1.28 0.34 0.07
46-55 years 0.40 -0.26 1.07 0.34 0.24
56-65 years 0.57 -0.11 1.26 0.35 0.10
66-70 years 0.13 -0.71 0.97 0.43 0.76
71-75 years 0.16 -0.84 1.15 0.51 0.76
76+ years 0.84 -0.83 2.51 0.85 0.32
Mixed or multiple ethnic origins 0.32 -0.40 1.04 0.37 0.39
Asian or Asian British -0.18 -1.35 0.98 0.60 0.76
African or African British -1.17 -2.93 0.59 0.90 0.19
Other ethnicity -0.06 -1.16 1.05 0.56 0.92
Key worker 0.13 -0.09 0.36 0.11 0.25
Time difference: Lockdown to baseline -0.01 -0.07 0.06 0.03 0.86
Unemployed -0.24 -0.62 0.14 0.19 0.22
n R2 adjust. R2 F p value df
11144 0.00 0.00 2.98 0.007 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.28 1.46 3.11 0.42 5.69e-08
gad.sum_score_prepan 0.54 0.53 0.56 0.01 0.00e+00
Anxiety disorders 0.57 -0.33 1.47 0.46 0.22
Eating disorders 0.80 -0.97 2.57 0.90 0.38
OCDs 1.39 0.16 2.61 0.63 0.03
PTSD 1.14 -0.28 2.56 0.72 0.12
Depressive disorders 1.44 0.62 2.27 0.42 5.77e-04
Bipolar disorders 1.74 0.85 2.62 0.45 1.19e-04
Unemployed 0.96 0.64 1.28 0.16 3.78e-09
n R2 adjust. R2 F p value df
11144 0.32 0.32 743.84 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.98 2.38 3.57 0.30 1.27e-22
gad.sum_score_prepan 0.51 0.50 0.53 0.01 0.00e+00
Depressive and anxiety disorder 0.81 0.22 1.40 0.30 0.007
Only depressive disorder -0.25 -0.89 0.39 0.33 0.44
Only anxiety disorder 0.12 -0.55 0.79 0.34 0.73
Eating disorders 0.74 0.46 1.03 0.15 4.05e-07
OCDs 0.58 0.31 0.85 0.14 2.85e-05
Psychotic and bipolar disorder -0.59 -1.37 0.20 0.40 0.14
Only psychotic disorder 0.35 -0.31 1.00 0.33 0.30
Only bipolar disorder 0.14 -0.25 0.53 0.20 0.48
PTSD 0.73 0.48 0.99 0.13 1.40e-08
ASD 0.84 0.32 1.36 0.27 0.002
ADHD -0.13 -0.84 0.58 0.36 0.72
Personality disorder 0.85 0.49 1.20 0.18 2.88e-06
Unemployed 0.75 0.43 1.07 0.16 3.86e-06
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.35 2.26 4.43 0.55 1.64e-09
gad.sum_score_prepan 0.51 0.50 0.53 0.01 0.00e+00
Anxiety disorders 0.56 -0.34 1.46 0.46 0.22
Eating disorders 0.68 -1.08 2.44 0.90 0.45
OCDs 1.19 -0.03 2.41 0.62 0.06
PTSD 1.41 -0.01 2.83 0.72 0.05
Depressive disorders 1.57 0.75 2.39 0.42 1.81e-04
Bipolar disorders 2.00 1.12 2.89 0.45 9.38e-06
Female 0.55 0.31 0.79 0.12 8.23e-06
Non-binary/Self-defined 0.78 0.09 1.46 0.35 0.03
19-25 years -0.24 -0.85 0.36 0.31 0.43
26-35 years -0.98 -1.56 -0.40 0.30 9.85e-04
36-45 years -1.16 -1.75 -0.57 0.30 1.09e-04
46-55 years -1.50 -2.08 -0.91 0.30 5.54e-07
56-65 years -1.96 -2.56 -1.36 0.31 1.81e-10
66-70 years -2.91 -3.65 -2.17 0.38 1.54e-14
71-75 years -3.21 -4.08 -2.34 0.45 5.80e-13
76+ years -2.64 -4.09 -1.19 0.74 3.67e-04
Mixed or multiple ethnic origins 0.07 -0.55 0.70 0.32 0.82
Asian or Asian British -0.16 -1.17 0.86 0.52 0.76
African or African British -0.47 -1.99 1.05 0.78 0.54
Other ethnicity 0.49 -0.49 1.46 0.50 0.33
Key worker -0.20 -0.40 -0.01 0.10 0.04
Time difference: Lockdown to baseline 0.00 -0.06 0.05 0.03 0.89
Unemployed 0.83 0.50 1.16 0.17 7.71e-07
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.06 3.15 4.97 0.46 2.38e-18
gad.sum_score_prepan 0.49 0.47 0.50 0.01 0.00e+00
Depressive and anxiety disorder 0.92 0.32 1.51 0.30 0.002
Only depressive disorder 0.01 -0.63 0.65 0.33 0.99
Only anxiety disorder 0.09 -0.58 0.76 0.34 0.80
Eating disorders 0.61 0.32 0.90 0.15 3.43e-05
OCDs 0.51 0.24 0.78 0.14 1.94e-04
Psychotic and bipolar disorder -0.31 -1.09 0.47 0.40 0.44
Only psychotic disorder 0.41 -0.24 1.07 0.33 0.21
Only bipolar disorder 0.30 -0.09 0.69 0.20 0.13
PTSD 0.80 0.55 1.06 0.13 5.13e-10
ASD 0.66 0.13 1.19 0.27 0.01
ADHD -0.22 -0.93 0.49 0.36 0.55
Personality disorder 0.75 0.40 1.10 0.18 3.40e-05
Female 0.42 0.18 0.66 0.12 5.30e-04
Non-binary/Self-defined 0.40 -0.28 1.08 0.35 0.25
19-25 years -0.30 -0.89 0.29 0.30 0.31
26-35 years -1.06 -1.63 -0.49 0.29 2.75e-04
36-45 years -1.21 -1.79 -0.63 0.29 3.94e-05
46-55 years -1.50 -2.08 -0.93 0.29 2.99e-07
56-65 years -1.91 -2.50 -1.32 0.30 2.28e-10
66-70 years -2.81 -3.54 -2.08 0.37 4.48e-14
71-75 years -3.00 -3.86 -2.14 0.44 7.63e-12
76+ years -2.51 -3.94 -1.07 0.73 6.25e-04
Mixed or multiple ethnic origins 0.05 -0.57 0.67 0.32 0.87
Asian or Asian British -0.03 -1.03 0.98 0.51 0.96
African or African British -0.39 -1.90 1.11 0.77 0.61
Other ethnicity 0.39 -0.56 1.34 0.48 0.42
Key worker -0.12 -0.31 0.07 0.10 0.23
Time difference: Lockdown to baseline 0.00 -0.05 0.06 0.03 0.92
Unemployed 0.68 0.35 1.01 0.17 5.17e-05
n R2 adjust. R2 F p value df
11165 0.01 0.01 11.04 2.61e-12 6

GAD retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.59 2.44 2.73 0.07 7.42e-272
Anxiety disorders 0.82 0.51 1.13 0.16 2.17e-07
Eating disorders 0.41 -0.51 1.33 0.47 0.38
OCDs 1.10 0.32 1.88 0.40 0.006
PTSD 1.00 0.22 1.77 0.39 0.01
Depressive disorders 0.88 0.71 1.05 0.09 2.20e-24
Bipolar disorders 0.90 0.52 1.27 0.19 2.95e-06
Unemployed -0.23 -0.53 0.08 0.15 0.14
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.59 2.46 2.73 0.07 3.08e-304
Depressive and anxiety disorder 0.87 0.69 1.04 0.09 1.98e-21
Only depressive disorder 0.25 0.01 0.49 0.12 0.04
Only anxiety disorder 0.86 0.57 1.14 0.14 3.55e-09
Eating disorders 0.50 0.23 0.77 0.14 3.34e-04
OCDs 0.06 -0.21 0.32 0.13 0.68
Psychotic and bipolar disorder -0.16 -0.92 0.60 0.39 0.68
Only psychotic disorder -0.25 -0.91 0.41 0.34 0.46
Only bipolar disorder -0.20 -0.60 0.21 0.21 0.34
PTSD 0.43 0.19 0.68 0.12 4.69e-04
ASD 0.39 -0.08 0.86 0.24 0.11
ADHD 0.00 -0.63 0.64 0.32 1.00
Personality disorder 0.32 -0.03 0.67 0.18 0.07
Unemployed -0.39 -0.70 -0.09 0.15 0.01
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.86 3.36 4.36 0.26 1.79e-51
Anxiety disorders 0.57 0.24 0.89 0.17 6.28e-04
Eating disorders 0.03 -0.91 0.96 0.48 0.96
OCDs 0.54 -0.26 1.34 0.41 0.18
PTSD 0.77 -0.03 1.57 0.41 0.06
Depressive disorders 0.65 0.46 0.83 0.10 1.43e-11
Bipolar disorders 0.68 0.30 1.07 0.20 5.42e-04
Female 0.76 0.57 0.96 0.10 3.89e-14
Non-binary/Self-defined -0.21 -0.88 0.45 0.34 0.53
19-25 years 1.01 0.55 1.46 0.23 1.39e-05
26-35 years 0.30 -0.13 0.72 0.22 0.17
36-45 years -0.20 -0.63 0.23 0.22 0.37
46-55 years -0.38 -0.81 0.04 0.22 0.08
56-65 years -0.55 -0.97 -0.12 0.22 0.01
66-70 years -0.86 -1.35 -0.36 0.25 7.38e-04
71-75 years -1.23 -1.78 -0.67 0.29 1.81e-05
76+ years -1.55 -2.39 -0.72 0.43 2.65e-04
Mixed or multiple ethnic origins -0.65 -1.18 -0.11 0.28 0.02
Asian or Asian British -0.44 -1.16 0.27 0.36 0.22
African or African British -0.54 -1.72 0.63 0.60 0.36
Other ethnicity -0.03 -0.99 0.94 0.49 0.96
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 8.51e-34
Unemployed -0.26 -0.57 0.05 0.16 0.11
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.76 3.28 4.25 0.25 9.12e-52
Depressive and anxiety disorder 0.66 0.47 0.86 0.10 2.62e-11
Only depressive disorder 0.26 0.00 0.51 0.13 0.05
Only anxiety disorder 0.64 0.34 0.93 0.15 2.87e-05
Eating disorders 0.29 0.01 0.56 0.14 0.04
OCDs -0.09 -0.35 0.18 0.14 0.52
Psychotic and bipolar disorder 0.11 -0.65 0.88 0.39 0.77
Only psychotic disorder -0.03 -0.70 0.63 0.34 0.92
Only bipolar disorder -0.11 -0.52 0.30 0.21 0.61
PTSD 0.44 0.19 0.68 0.13 5.89e-04
ASD 0.37 -0.11 0.86 0.25 0.13
ADHD -0.07 -0.71 0.57 0.33 0.84
Personality disorder 0.20 -0.16 0.56 0.18 0.27
Female 0.73 0.53 0.92 0.10 5.44e-13
Non-binary/Self-defined -0.31 -0.97 0.35 0.34 0.36
19-25 years 0.94 0.49 1.38 0.23 3.39e-05
26-35 years 0.19 -0.23 0.61 0.21 0.37
36-45 years -0.30 -0.73 0.12 0.22 0.16
46-55 years -0.46 -0.88 -0.05 0.21 0.03
56-65 years -0.52 -0.94 -0.11 0.21 0.01
66-70 years -0.70 -1.19 -0.21 0.25 0.005
71-75 years -1.08 -1.63 -0.53 0.28 1.16e-04
76+ years -1.39 -2.21 -0.57 0.42 8.64e-04
Mixed or multiple ethnic origins -0.56 -1.10 -0.03 0.27 0.04
Asian or Asian British -0.22 -0.90 0.47 0.35 0.54
African or African British -0.62 -1.79 0.54 0.59 0.30
Other ethnicity -0.10 -1.04 0.84 0.48 0.83
Key worker 0.29 0.13 0.45 0.08 5.51e-04
Time difference: Lockdown to baseline -0.22 -0.26 -0.19 0.02 6.42e-34
Unemployed -0.22 -0.54 0.09 0.16 0.17
n R2 adjust. R2 F p value df
18588 0.01 0.01 18.23 3.23e-21 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.54 3.40 3.67 0.07 0.00e+00
gad.sum_score_retro 0.60 0.58 0.61 0.01 0.00e+00
Anxiety disorders 1.82 1.53 2.11 0.15 1.21e-33
Eating disorders 1.27 0.41 2.14 0.44 0.004
OCDs 2.71 1.97 3.45 0.38 6.08e-13
PTSD 2.18 1.45 2.91 0.37 4.67e-09
Depressive disorders 2.26 2.09 2.43 0.09 2.00e-148
Bipolar disorders 2.88 2.52 3.24 0.18 1.78e-54
Unemployed 0.82 0.53 1.10 0.15 3.06e-08
n R2 adjust. R2 F p value df
18588 0.32 0.32 1276.84 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.75 3.62 3.88 0.07 0.00e+00
gad.sum_score_retro 0.55 0.53 0.57 0.01 0.00e+00
Depressive and anxiety disorder 2.30 2.13 2.47 0.09 4.45e-146
Only depressive disorder 0.67 0.45 0.89 0.11 2.73e-09
Only anxiety disorder 1.90 1.63 2.16 0.14 5.42e-44
Eating disorders 0.79 0.53 1.04 0.13 1.22e-09
OCDs 0.73 0.48 0.97 0.13 6.32e-09
Psychotic and bipolar disorder 0.06 -0.64 0.77 0.36 0.86
Only psychotic disorder 0.00 -0.61 0.62 0.31 0.99
Only bipolar disorder 0.17 -0.21 0.54 0.19 0.39
PTSD 0.84 0.61 1.07 0.12 4.41e-13
ASD 0.98 0.54 1.43 0.23 1.24e-05
ADHD 0.46 -0.13 1.05 0.30 0.13
Personality disorder 1.04 0.71 1.37 0.17 5.72e-10
Unemployed 0.50 0.21 0.78 0.14 6.06e-04
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.56 6.09 7.04 0.24 2.15e-158
gad.sum_score_retro 0.55 0.53 0.57 0.01 0.00e+00
Anxiety disorders 1.49 1.18 1.79 0.15 8.01e-22
Eating disorders 0.79 -0.08 1.66 0.44 0.07
OCDs 1.91 1.17 2.65 0.38 4.15e-07
PTSD 2.00 1.25 2.74 0.38 1.49e-07
Depressive disorders 2.05 1.87 2.23 0.09 1.74e-107
Bipolar disorders 2.72 2.35 3.09 0.19 1.60e-47
Female 0.77 0.59 0.95 0.09 2.51e-16
Non-binary/Self-defined 0.23 -0.39 0.85 0.31 0.46
19-25 years -0.06 -0.48 0.36 0.22 0.78
26-35 years -1.06 -1.46 -0.65 0.20 2.68e-07
36-45 years -1.65 -2.06 -1.24 0.21 2.30e-15
46-55 years -1.99 -2.39 -1.59 0.20 2.63e-22
56-65 years -2.42 -2.82 -2.02 0.20 4.77e-32
66-70 years -2.89 -3.36 -2.42 0.24 1.29e-33
71-75 years -3.30 -3.82 -2.77 0.27 1.08e-34
76+ years -3.35 -4.13 -2.57 0.40 2.95e-17
Mixed or multiple ethnic origins -0.41 -0.91 0.09 0.26 0.11
Asian or Asian British -0.28 -0.94 0.38 0.34 0.40
African or African British -0.21 -1.30 0.87 0.56 0.70
Other ethnicity 0.27 -0.63 1.16 0.46 0.56
Key worker 0.05 -0.10 0.20 0.08 0.52
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 9.47e-40
Unemployed 0.81 0.51 1.10 0.15 9.96e-08
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.79 6.34 7.25 0.23 8.25e-182
gad.sum_score_retro 0.51 0.49 0.53 0.01 0.00e+00
Depressive and anxiety disorder 2.14 1.95 2.32 0.09 2.45e-111
Only depressive disorder 0.78 0.55 1.02 0.12 4.18e-11
Only anxiety disorder 1.62 1.34 1.89 0.14 1.40e-30
Eating disorders 0.52 0.26 0.77 0.13 6.81e-05
OCDs 0.56 0.31 0.81 0.13 7.87e-06
Psychotic and bipolar disorder 0.38 -0.32 1.08 0.36 0.29
Only psychotic disorder 0.23 -0.38 0.84 0.31 0.46
Only bipolar disorder 0.29 -0.09 0.67 0.19 0.13
PTSD 0.91 0.68 1.14 0.12 6.78e-15
ASD 0.75 0.30 1.20 0.23 0.001
ADHD 0.26 -0.33 0.85 0.30 0.39
Personality disorder 0.95 0.62 1.28 0.17 1.61e-08
Female 0.71 0.53 0.89 0.09 1.23e-14
Non-binary/Self-defined -0.13 -0.73 0.48 0.31 0.68
19-25 years -0.27 -0.68 0.14 0.21 0.20
26-35 years -1.27 -1.66 -0.89 0.20 1.11e-10
36-45 years -1.81 -2.20 -1.42 0.20 1.81e-19
46-55 years -2.05 -2.44 -1.66 0.20 2.89e-25
56-65 years -2.37 -2.76 -1.98 0.20 3.11e-33
66-70 years -2.76 -3.21 -2.31 0.23 8.41e-33
71-75 years -3.13 -3.64 -2.62 0.26 2.52e-33
76+ years -3.20 -3.95 -2.44 0.38 9.54e-17
Mixed or multiple ethnic origins -0.31 -0.80 0.18 0.25 0.22
Asian or Asian British 0.07 -0.55 0.70 0.32 0.82
African or African British -0.19 -1.26 0.88 0.55 0.73
Other ethnicity 0.19 -0.68 1.05 0.44 0.67
Key worker 0.11 -0.04 0.26 0.08 0.16
Time difference: Lockdown to baseline -0.23 -0.27 -0.20 0.02 8.45e-43
Unemployed 0.56 0.27 0.86 0.15 1.56e-04
n R2 adjust. R2 F p value df
23100 0.15 0.15 660.52 0.00e+00 6

PHQ prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.64 -2.62 -0.66 0.50 0.001
Anxiety disorders 1.91 0.83 2.99 0.55 5.32e-04
Eating disorders 0.03 -2.07 2.13 1.07 0.98
OCDs 1.85 0.39 3.32 0.75 0.01
PTSD 1.29 -0.41 3.00 0.87 0.14
Depressive disorders 1.22 0.24 2.21 0.50 0.02
Bipolar disorders 0.86 -0.20 1.93 0.54 0.11
Unemployed -0.54 -0.91 -0.16 0.19 0.006
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.53 -2.23 -0.82 0.36 2.28e-05
Depressive and anxiety disorder 1.09 0.37 1.81 0.37 0.003
Only depressive disorder 0.94 0.16 1.71 0.39 0.02
Only anxiety disorder 1.75 0.94 2.56 0.41 2.39e-05
Eating disorders 0.37 0.02 0.72 0.18 0.04
OCDs 0.03 -0.30 0.35 0.17 0.87
Psychotic and bipolar disorder -0.74 -1.69 0.22 0.49 0.13
Only psychotic disorder 0.17 -0.63 0.96 0.40 0.68
Only bipolar disorder -0.30 -0.77 0.17 0.24 0.22
PTSD -0.16 -0.46 0.15 0.16 0.31
ASD 0.40 -0.23 1.03 0.32 0.21
ADHD 0.08 -0.78 0.94 0.44 0.85
Personality disorder 0.03 -0.40 0.45 0.22 0.90
Unemployed -0.54 -0.92 -0.15 0.19 0.006
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.04 -3.33 -0.75 0.66 0.002
Anxiety disorders 1.83 0.75 2.91 0.55 8.94e-04
Eating disorders -0.12 -2.22 1.98 1.07 0.91
OCDs 1.68 0.21 3.14 0.75 0.02
PTSD 1.05 -0.67 2.77 0.88 0.23
Depressive disorders 1.17 0.18 2.16 0.50 0.02
Bipolar disorders 0.87 -0.20 1.93 0.54 0.11
Female 0.27 -0.02 0.56 0.15 0.07
Non-binary/Self-defined -0.08 -0.90 0.75 0.42 0.86
19-25 years 0.02 -0.70 0.74 0.37 0.96
26-35 years -0.05 -0.75 0.64 0.35 0.88
36-45 years -0.09 -0.79 0.61 0.36 0.81
46-55 years -0.39 -1.09 0.30 0.36 0.27
56-65 years -0.43 -1.14 0.29 0.37 0.24
66-70 years -0.41 -1.29 0.47 0.45 0.36
71-75 years -0.77 -1.82 0.28 0.53 0.15
76+ years 0.09 -1.67 1.85 0.90 0.92
Mixed or multiple ethnic origins -0.02 -0.78 0.73 0.38 0.95
Asian or Asian British -1.37 -2.60 -0.15 0.62 0.03
African or African British -1.10 -2.94 0.73 0.94 0.24
Other ethnicity -0.05 -1.22 1.13 0.60 0.94
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
Unemployed -0.54 -0.92 -0.16 0.19 0.006
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.03 -3.12 -0.95 0.55 2.44e-04
Depressive and anxiety disorder 1.10 0.38 1.82 0.37 0.003
Only depressive disorder 1.00 0.22 1.78 0.40 0.01
Only anxiety disorder 1.72 0.90 2.53 0.42 3.68e-05
Eating disorders 0.32 -0.03 0.67 0.18 0.07
OCDs 0.00 -0.33 0.32 0.17 0.98
Psychotic and bipolar disorder -0.65 -1.62 0.31 0.49 0.18
Only psychotic disorder 0.17 -0.62 0.97 0.41 0.67
Only bipolar disorder -0.21 -0.69 0.27 0.24 0.39
PTSD -0.16 -0.47 0.15 0.16 0.31
ASD 0.38 -0.26 1.02 0.33 0.24
ADHD 0.05 -0.81 0.92 0.44 0.90
Personality disorder -0.02 -0.45 0.41 0.22 0.94
Female 0.24 -0.05 0.53 0.15 0.11
Non-binary/Self-defined -0.10 -0.93 0.73 0.42 0.81
19-25 years 0.00 -0.72 0.72 0.37 1.00
26-35 years -0.04 -0.73 0.65 0.35 0.91
36-45 years -0.05 -0.75 0.64 0.36 0.88
46-55 years -0.35 -1.05 0.34 0.36 0.32
56-65 years -0.38 -1.09 0.33 0.36 0.29
66-70 years -0.31 -1.19 0.57 0.45 0.49
71-75 years -0.65 -1.69 0.40 0.53 0.22
76+ years 0.18 -1.57 1.94 0.90 0.84
Mixed or multiple ethnic origins 0.02 -0.73 0.77 0.38 0.96
Asian or Asian British -1.19 -2.41 0.03 0.62 0.06
African or African British -1.08 -2.92 0.76 0.94 0.25
Other ethnicity -0.27 -1.42 0.89 0.59 0.65
Key worker 0.05 -0.19 0.28 0.12 0.71
Time difference: Lockdown to baseline 0.07 0.00 0.13 0.03 0.05
Unemployed -0.50 -0.90 -0.10 0.20 0.01
n R2 adjust. R2 F p value df
11134 0.00 0.00 3.57 0.002 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.24 1.36 3.12 0.45 6.46e-07
phq.sum_score_prepan 0.60 0.59 0.62 0.01 0.00e+00
Anxiety disorders 0.77 -0.19 1.73 0.49 0.12
Eating disorders 0.24 -1.62 2.11 0.95 0.80
OCDs 1.84 0.54 3.14 0.66 0.006
PTSD 1.10 -0.42 2.62 0.77 0.16
Depressive disorders 1.75 0.87 2.63 0.45 9.26e-05
Bipolar disorders 2.06 1.12 3.01 0.48 1.89e-05
Unemployed 1.29 0.95 1.63 0.18 1.81e-13
n R2 adjust. R2 F p value df
11134 0.41 0.41 1107.68 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.80 2.16 3.44 0.33 1.12e-17
phq.sum_score_prepan 0.58 0.56 0.59 0.01 0.00e+00
Depressive and anxiety disorder 1.15 0.52 1.78 0.32 3.40e-04
Only depressive disorder 0.51 -0.17 1.19 0.35 0.14
Only anxiety disorder 0.38 -0.34 1.09 0.37 0.30
Eating disorders 1.04 0.73 1.34 0.16 3.62e-11
OCDs 0.65 0.36 0.93 0.15 1.09e-05
Psychotic and bipolar disorder -0.78 -1.63 0.06 0.43 0.07
Only psychotic disorder 0.13 -0.56 0.83 0.36 0.71
Only bipolar disorder 0.12 -0.30 0.53 0.21 0.58
PTSD 0.56 0.29 0.83 0.14 4.57e-05
ASD 0.94 0.39 1.50 0.28 8.65e-04
ADHD 0.46 -0.30 1.21 0.39 0.24
Personality disorder 1.20 0.82 1.58 0.19 5.40e-10
Unemployed 1.11 0.77 1.45 0.17 1.94e-10
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.86 2.70 5.02 0.59 7.63e-11
phq.sum_score_prepan 0.58 0.56 0.59 0.01 0.00e+00
Anxiety disorders 0.71 -0.25 1.67 0.49 0.15
Eating disorders 0.16 -1.69 2.02 0.94 0.86
OCDs 1.55 0.26 2.85 0.66 0.02
PTSD 1.23 -0.29 2.75 0.77 0.11
Depressive disorders 1.96 1.09 2.84 0.45 1.15e-05
Bipolar disorders 2.42 1.48 3.37 0.48 5.26e-07
Female 0.32 0.06 0.57 0.13 0.02
Non-binary/Self-defined 0.66 -0.07 1.39 0.37 0.08
19-25 years -0.96 -1.60 -0.32 0.33 0.003
26-35 years -1.80 -2.41 -1.18 0.32 1.25e-08
36-45 years -2.02 -2.65 -1.40 0.32 2.53e-10
46-55 years -2.26 -2.88 -1.63 0.32 1.27e-12
56-65 years -2.81 -3.45 -2.17 0.33 6.67e-18
66-70 years -3.71 -4.50 -2.93 0.40 2.80e-20
71-75 years -4.25 -5.18 -3.32 0.47 4.31e-19
76+ years -3.61 -5.16 -2.05 0.79 5.37e-06
Mixed or multiple ethnic origins 0.10 -0.56 0.77 0.34 0.76
Asian or Asian British -0.89 -1.97 0.18 0.55 0.10
African or African British -0.47 -2.09 1.14 0.82 0.57
Other ethnicity 0.31 -0.72 1.34 0.53 0.56
Key worker -0.39 -0.59 -0.18 0.11 2.38e-04
Time difference: Lockdown to baseline 0.06 0.00 0.12 0.03 0.04
Unemployed 1.07 0.72 1.43 0.18 2.60e-09
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.55 3.57 5.52 0.50 5.87e-20
phq.sum_score_prepan 0.56 0.54 0.57 0.01 0.00e+00
Depressive and anxiety disorder 1.34 0.70 1.97 0.32 3.34e-05
Only depressive disorder 0.90 0.21 1.58 0.35 0.010
Only anxiety disorder 0.30 -0.41 1.01 0.36 0.41
Eating disorders 0.93 0.62 1.24 0.16 2.66e-09
OCDs 0.55 0.26 0.84 0.15 1.62e-04
Psychotic and bipolar disorder -0.57 -1.41 0.27 0.43 0.19
Only psychotic disorder 0.20 -0.50 0.89 0.35 0.58
Only bipolar disorder 0.29 -0.12 0.71 0.21 0.16
PTSD 0.64 0.37 0.91 0.14 3.03e-06
ASD 0.62 0.06 1.18 0.29 0.03
ADHD 0.32 -0.44 1.07 0.38 0.41
Personality disorder 1.14 0.76 1.51 0.19 3.63e-09
Female 0.14 -0.11 0.40 0.13 0.27
Non-binary/Self-defined 0.27 -0.45 1.00 0.37 0.46
19-25 years -1.08 -1.71 -0.46 0.32 6.91e-04
26-35 years -1.93 -2.53 -1.32 0.31 4.84e-10
36-45 years -2.11 -2.73 -1.50 0.31 1.66e-11
46-55 years -2.29 -2.90 -1.68 0.31 2.08e-13
56-65 years -2.80 -3.43 -2.18 0.32 2.00e-18
66-70 years -3.62 -4.39 -2.84 0.40 7.01e-20
71-75 years -4.10 -5.02 -3.19 0.47 2.16e-18
76+ years -3.50 -5.04 -1.96 0.79 8.27e-06
Mixed or multiple ethnic origins 0.07 -0.59 0.73 0.34 0.83
Asian or Asian British -0.67 -1.73 0.40 0.54 0.22
African or African British -0.32 -1.93 1.28 0.82 0.69
Other ethnicity 0.13 -0.88 1.14 0.52 0.81
Key worker -0.31 -0.51 -0.10 0.10 0.003
Time difference: Lockdown to baseline 0.07 0.01 0.12 0.03 0.03
Unemployed 0.95 0.60 1.30 0.18 1.17e-07
n R2 adjust. R2 F p value df
11162 0.02 0.02 44.52 4.15e-54 6

PHQ retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.05 2.91 3.20 0.07 0.00e+00
Anxiety disorders 0.61 0.29 0.93 0.17 2.25e-04
Eating disorders 0.58 -0.39 1.55 0.50 0.24
OCDs 1.07 0.29 1.86 0.40 0.007
PTSD 1.04 0.23 1.85 0.41 0.01
Depressive disorders 0.94 0.77 1.12 0.09 1.07e-26
Bipolar disorders 0.95 0.56 1.34 0.20 1.70e-06
Unemployed -0.49 -0.80 -0.18 0.16 0.002
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.10 2.96 3.23 0.07 0.00e+00
Depressive and anxiety disorder 0.77 0.59 0.95 0.09 1.36e-16
Only depressive disorder 0.42 0.18 0.66 0.12 6.70e-04
Only anxiety disorder 0.59 0.29 0.89 0.15 9.61e-05
Eating disorders 0.67 0.38 0.95 0.14 4.09e-06
OCDs 0.21 -0.06 0.48 0.14 0.13
Psychotic and bipolar disorder -0.87 -1.65 -0.09 0.40 0.03
Only psychotic disorder -0.54 -1.22 0.14 0.35 0.12
Only bipolar disorder -0.08 -0.50 0.35 0.22 0.72
PTSD 0.58 0.33 0.84 0.13 6.37e-06
ASD 0.55 0.07 1.04 0.25 0.03
ADHD 0.08 -0.57 0.73 0.33 0.82
Personality disorder 0.39 0.02 0.75 0.19 0.04
Unemployed -0.63 -0.94 -0.32 0.16 6.37e-05
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.93 5.43 6.44 0.26 2.40e-115
Anxiety disorders 0.24 -0.10 0.58 0.17 0.17
Eating disorders 0.04 -0.96 1.04 0.51 0.94
OCDs 0.34 -0.46 1.15 0.41 0.40
PTSD 0.73 -0.11 1.57 0.43 0.09
Depressive disorders 0.72 0.53 0.92 0.10 1.53e-13
Bipolar disorders 0.77 0.37 1.18 0.20 1.57e-04
Female 0.73 0.53 0.93 0.10 6.65e-13
Non-binary/Self-defined 0.22 -0.46 0.90 0.35 0.52
19-25 years -0.60 -1.06 -0.14 0.23 0.01
26-35 years -1.44 -1.87 -1.01 0.22 5.83e-11
36-45 years -1.86 -2.30 -1.42 0.22 1.18e-16
46-55 years -1.85 -2.28 -1.42 0.22 3.07e-17
56-65 years -2.03 -2.46 -1.60 0.22 3.43e-20
66-70 years -2.42 -2.92 -1.91 0.26 7.84e-21
71-75 years -2.48 -3.06 -1.91 0.29 2.11e-17
76+ years -2.73 -3.58 -1.88 0.43 3.51e-10
Mixed or multiple ethnic origins -0.21 -0.76 0.35 0.28 0.46
Asian or Asian British -0.19 -0.90 0.52 0.36 0.59
African or African British -0.25 -1.43 0.94 0.60 0.68
Other ethnicity -0.35 -1.34 0.64 0.51 0.49
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 8.25e-36
Unemployed -0.61 -0.93 -0.29 0.16 1.63e-04
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.00 5.51 6.49 0.25 4.67e-125
Depressive and anxiety disorder 0.61 0.41 0.81 0.10 1.94e-09
Only depressive disorder 0.46 0.21 0.72 0.13 3.98e-04
Only anxiety disorder 0.26 -0.05 0.57 0.16 0.10
Eating disorders 0.44 0.15 0.73 0.15 0.003
OCDs 0.06 -0.22 0.34 0.14 0.67
Psychotic and bipolar disorder -0.64 -1.42 0.15 0.40 0.11
Only psychotic disorder -0.40 -1.09 0.29 0.35 0.25
Only bipolar disorder 0.06 -0.37 0.49 0.22 0.79
PTSD 0.59 0.33 0.85 0.13 8.52e-06
ASD 0.23 -0.27 0.73 0.26 0.37
ADHD -0.01 -0.68 0.65 0.34 0.97
Personality disorder 0.31 -0.06 0.68 0.19 0.10
Female 0.67 0.47 0.87 0.10 4.30e-11
Non-binary/Self-defined 0.05 -0.62 0.73 0.34 0.87
19-25 years -0.75 -1.20 -0.30 0.23 0.001
26-35 years -1.60 -2.03 -1.18 0.22 9.76e-14
36-45 years -2.02 -2.45 -1.59 0.22 4.51e-20
46-55 years -1.99 -2.42 -1.57 0.22 2.30e-20
56-65 years -2.11 -2.53 -1.68 0.21 1.20e-22
66-70 years -2.39 -2.89 -1.90 0.25 2.06e-21
71-75 years -2.49 -3.05 -1.93 0.29 3.54e-18
76+ years -2.77 -3.60 -1.94 0.42 6.77e-11
Mixed or multiple ethnic origins -0.10 -0.65 0.45 0.28 0.71
Asian or Asian British 0.00 -0.69 0.69 0.35 1.00
African or African British -0.16 -1.32 1.00 0.59 0.78
Other ethnicity -0.53 -1.49 0.44 0.49 0.28
Key worker 0.19 0.02 0.36 0.09 0.03
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 1.98e-36
Unemployed -0.60 -0.93 -0.28 0.17 2.77e-04
n R2 adjust. R2 F p value df
19512 0.01 0.01 18.92 4.40e-22 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.99 3.85 4.13 0.07 0.00e+00
phq.sum_score_retro 0.66 0.64 0.67 0.01 0.00e+00
Anxiety disorders 1.28 0.97 1.59 0.16 3.86e-16
Eating disorders 1.45 0.53 2.36 0.47 0.002
OCDs 2.27 1.53 3.01 0.38 1.94e-09
PTSD 2.04 1.28 2.81 0.39 1.59e-07
Depressive disorders 2.51 2.34 2.69 0.09 2.48e-171
Bipolar disorders 3.26 2.88 3.64 0.19 2.53e-63
Unemployed 0.97 0.67 1.27 0.15 1.95e-10
n R2 adjust. R2 F p value df
19512 0.43 0.43 2104.41 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.22 4.09 4.36 0.07 0.00e+00
phq.sum_score_retro 0.62 0.61 0.63 0.01 0.00e+00
Depressive and anxiety disorder 2.32 2.14 2.50 0.09 1.15e-139
Only depressive disorder 1.20 0.97 1.43 0.12 5.95e-25
Only anxiety disorder 1.23 0.95 1.51 0.14 5.30e-18
Eating disorders 1.08 0.82 1.35 0.14 1.39e-15
OCDs 0.76 0.50 1.01 0.13 6.81e-09
Psychotic and bipolar disorder -0.66 -1.40 0.07 0.37 0.08
Only psychotic disorder -0.19 -0.83 0.45 0.32 0.56
Only bipolar disorder 0.43 0.04 0.83 0.20 0.03
PTSD 1.00 0.77 1.24 0.12 1.39e-16
ASD 1.27 0.81 1.72 0.23 5.30e-08
ADHD 0.75 0.14 1.36 0.31 0.02
Personality disorder 1.36 1.02 1.70 0.17 5.75e-15
Unemployed 0.68 0.39 0.98 0.15 4.82e-06
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.52 8.04 9.00 0.24 2.87e-257
phq.sum_score_retro 0.61 0.60 0.62 0.01 0.00e+00
Anxiety disorders 0.78 0.46 1.10 0.16 1.43e-06
Eating disorders 0.81 -0.12 1.74 0.48 0.09
OCDs 1.24 0.49 1.99 0.38 0.001
PTSD 1.72 0.94 2.50 0.40 1.49e-05
Depressive disorders 2.36 2.17 2.55 0.10 1.46e-131
Bipolar disorders 3.22 2.83 3.60 0.20 5.34e-60
Female 0.78 0.59 0.96 0.10 3.09e-16
Non-binary/Self-defined 0.92 0.29 1.55 0.32 0.004
19-25 years -1.55 -1.98 -1.12 0.22 1.66e-12
26-35 years -2.83 -3.23 -2.42 0.21 6.79e-42
36-45 years -3.31 -3.72 -2.89 0.21 1.19e-54
46-55 years -3.39 -3.80 -2.98 0.21 2.78e-59
56-65 years -3.81 -4.22 -3.41 0.21 1.63e-74
66-70 years -4.45 -4.93 -3.98 0.24 1.24e-74
71-75 years -4.51 -5.05 -3.97 0.27 3.33e-60
76+ years -4.58 -5.38 -3.79 0.40 1.41e-29
Mixed or multiple ethnic origins -0.03 -0.54 0.49 0.26 0.92
Asian or Asian British -0.09 -0.75 0.57 0.34 0.80
African or African British -0.19 -1.29 0.91 0.56 0.74
Other ethnicity 0.06 -0.86 0.98 0.47 0.89
Key worker -0.07 -0.23 0.09 0.08 0.38
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 1.10e-37
Unemployed 0.89 0.58 1.20 0.16 1.36e-08
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.91 8.45 9.38 0.24 1.29e-300
phq.sum_score_retro 0.58 0.57 0.59 0.01 0.00e+00
Depressive and anxiety disorder 2.24 2.05 2.43 0.10 5.83e-114
Only depressive disorder 1.39 1.15 1.63 0.12 3.32e-30
Only anxiety disorder 0.80 0.51 1.08 0.15 6.32e-08
Eating disorders 0.81 0.54 1.08 0.14 2.75e-09
OCDs 0.57 0.31 0.82 0.13 1.26e-05
Psychotic and bipolar disorder -0.35 -1.08 0.37 0.37 0.34
Only psychotic disorder -0.02 -0.65 0.62 0.32 0.96
Only bipolar disorder 0.65 0.25 1.05 0.20 0.001
PTSD 1.09 0.85 1.32 0.12 6.58e-19
ASD 0.71 0.25 1.17 0.24 0.003
ADHD 0.55 -0.06 1.16 0.31 0.08
Personality disorder 1.36 1.02 1.70 0.17 7.73e-15
Female 0.67 0.49 0.85 0.09 9.00e-13
Non-binary/Self-defined 0.47 -0.15 1.08 0.32 0.14
19-25 years -1.86 -2.27 -1.44 0.21 1.50e-18
26-35 years -3.14 -3.53 -2.75 0.20 4.12e-55
36-45 years -3.58 -3.98 -3.18 0.20 1.73e-68
46-55 years -3.58 -3.97 -3.19 0.20 8.04e-71
56-65 years -3.92 -4.31 -3.53 0.20 2.27e-84
66-70 years -4.47 -4.93 -4.01 0.23 4.31e-80
71-75 years -4.51 -5.03 -3.99 0.27 6.50e-64
76+ years -4.62 -5.39 -3.85 0.39 5.47e-32
Mixed or multiple ethnic origins 0.06 -0.44 0.57 0.26 0.80
Asian or Asian British 0.19 -0.45 0.82 0.32 0.56
African or African British -0.05 -1.12 1.01 0.54 0.92
Other ethnicity -0.13 -1.02 0.76 0.45 0.78
Key worker -0.01 -0.16 0.15 0.08 0.93
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 2.52e-39
Unemployed 0.68 0.37 0.98 0.15 1.16e-05
n R2 adjust. R2 F p value df
23090 0.18 0.18 844.05 0.00e+00 6

OCIR prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.00 -10.16 14.16 6.18 0.75
Anxiety disorders -10.07 -23.38 3.25 6.78 0.14
Eating disorders -8.00 -27.22 11.22 9.78 0.41
OCDs -12.64 -26.35 1.08 6.98 0.07
PTSD -24.50 -43.72 -5.28 9.78 0.01
Depressive disorders -10.01 -22.23 2.20 6.21 0.11
Bipolar disorders -9.20 -21.78 3.39 6.40 0.15
Unemployed -0.73 -3.80 2.33 1.56 0.64
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.97 -9.82 5.89 4.00 0.62
Depressive and anxiety disorder -4.66 -12.63 3.31 4.05 0.25
Only depressive disorder -4.48 -13.22 4.26 4.45 0.31
Only anxiety disorder -8.22 -16.97 0.53 4.45 0.07
Eating disorders -0.11 -2.80 2.58 1.37 0.93
OCDs -1.22 -3.46 1.01 1.14 0.28
Psychotic and bipolar disorder 12.98 5.35 20.61 3.88 9.03e-04
Only psychotic disorder -0.90 -6.45 4.65 2.83 0.75
Only bipolar disorder -1.12 -4.78 2.55 1.87 0.55
PTSD -3.79 -6.26 -1.33 1.25 0.003
ASD -0.39 -4.74 3.96 2.21 0.86
ADHD 6.10 -0.40 12.60 3.31 0.07
Personality disorder -1.59 -4.89 1.70 1.68 0.34
Unemployed -0.41 -3.50 2.69 1.58 0.80
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -5.30 -19.74 9.14 7.35 0.47
Anxiety disorders -8.87 -22.29 4.55 6.83 0.19
Eating disorders -6.72 -25.89 12.44 9.75 0.49
OCDs -11.95 -25.75 1.85 7.02 0.09
PTSD -23.04 -42.31 -3.77 9.80 0.02
Depressive disorders -9.82 -22.16 2.52 6.28 0.12
Bipolar disorders -9.38 -22.08 3.31 6.46 0.15
Female -2.47 -5.57 0.62 1.57 0.12
Non-binary/Self-defined -3.02 -8.96 2.92 3.02 0.32
19-25 years 3.90 -3.19 11.00 3.61 0.28
26-35 years 7.30 0.37 14.24 3.53 0.04
36-45 years 7.09 -0.10 14.27 3.66 0.05
46-55 years 7.17 0.07 14.28 3.62 0.05
56-65 years 4.48 -2.95 11.90 3.78 0.24
66-70 years 5.07 -4.12 14.27 4.68 0.28
71-75 years 7.70 -6.04 21.45 6.99 0.27
Mixed or multiple ethnic origins 2.38 -4.31 9.06 3.40 0.48
Asian or Asian British -24.75 -39.50 -9.99 7.51 0.001
African or African British 16.89 -4.88 38.66 11.08 0.13
Other ethnicity -1.34 -10.00 7.32 4.40 0.76
Time difference: Lockdown to baseline 0.47 -0.29 1.24 0.39 0.22
Unemployed -0.86 -3.93 2.20 1.56 0.58
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -10.12 -22.03 1.79 6.06 0.10
Depressive and anxiety disorder -4.23 -13.01 4.55 4.47 0.34
Only depressive disorder -4.31 -13.78 5.16 4.82 0.37
Only anxiety disorder -6.76 -16.26 2.73 4.83 0.16
Eating disorders 0.10 -2.63 2.83 1.39 0.94
OCDs -1.13 -3.38 1.12 1.15 0.33
Psychotic and bipolar disorder 11.21 3.48 18.94 3.93 0.005
Only psychotic disorder -1.54 -7.20 4.12 2.88 0.59
Only bipolar disorder -1.18 -4.91 2.54 1.90 0.53
PTSD -3.44 -5.98 -0.91 1.29 0.008
ASD -0.46 -4.84 3.92 2.23 0.84
ADHD 5.20 -1.34 11.73 3.32 0.12
Personality disorder -1.04 -4.35 2.27 1.68 0.54
Female -1.66 -4.81 1.49 1.60 0.30
Non-binary/Self-defined -1.50 -7.60 4.60 3.10 0.63
19-25 years 2.70 -4.27 9.66 3.54 0.45
26-35 years 6.21 -0.67 13.08 3.50 0.08
36-45 years 5.69 -1.39 12.77 3.60 0.12
46-55 years 6.11 -0.96 13.18 3.60 0.09
56-65 years 4.12 -3.26 11.50 3.75 0.27
66-70 years 3.84 -5.36 13.05 4.68 0.41
71-75 years 8.69 -3.70 21.07 6.30 0.17
Mixed or multiple ethnic origins 2.65 -4.05 9.35 3.41 0.44
Asian or Asian British -22.94 -37.85 -8.02 7.59 0.003
African or African British 17.04 -4.54 38.62 10.98 0.12
Other ethnicity -1.47 -10.10 7.15 4.39 0.74
Key worker 1.11 -1.19 3.40 1.17 0.34
Time difference: Lockdown to baseline 0.52 -0.23 1.28 0.38 0.18
Unemployed -0.05 -3.29 3.19 1.65 0.98
n R2 adjust. R2 F p value df
436 0.02 0.00 1.20 0.31 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.69 -1.24 20.62 5.56 0.08
ocir.sum_score_prepan 0.65 0.58 0.71 0.03 9.29e-60
Anxiety disorders -11.51 -23.38 0.36 6.04 0.06
Eating disorders -9.30 -26.43 7.83 8.72 0.29
OCDs -9.07 -21.31 3.18 6.23 0.15
PTSD -20.83 -37.98 -3.69 8.72 0.02
Depressive disorders -8.46 -19.35 2.43 5.54 0.13
Bipolar disorders -5.83 -17.07 5.40 5.71 0.31
Unemployed 1.28 -1.48 4.04 1.40 0.36
n R2 adjust. R2 F p value df
436 0.49 0.49 59.80 1.44e-59 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.73 -1.47 12.94 3.66 0.12
ocir.sum_score_prepan 0.64 0.56 0.71 0.04 4.91e-53
Depressive and anxiety disorder -4.24 -11.39 2.91 3.64 0.24
Only depressive disorder -5.41 -13.25 2.44 3.99 0.18
Only anxiety disorder -8.59 -16.44 -0.74 3.99 0.03
Eating disorders 0.49 -1.93 2.90 1.23 0.69
OCDs 2.25 0.14 4.37 1.07 0.04
Psychotic and bipolar disorder 11.78 4.93 18.63 3.48 7.89e-04
Only psychotic disorder 0.49 -4.50 5.48 2.54 0.85
Only bipolar disorder 0.81 -2.50 4.12 1.68 0.63
PTSD -2.63 -4.85 -0.41 1.13 0.02
ASD 0.11 -3.79 4.01 1.98 0.95
ADHD 3.97 -1.88 9.81 2.97 0.18
Personality disorder -0.80 -3.76 2.16 1.51 0.60
Unemployed 0.83 -1.96 3.62 1.42 0.56
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.25 -7.04 23.55 7.78 0.29
ocir.sum_score_prepan 0.66 0.59 0.73 0.03 2.43e-58
Anxiety disorders -15.89 -30.48 -1.30 7.42 0.03
Eating disorders -13.72 -32.86 5.43 9.74 0.16
OCDs -14.07 -28.92 0.78 7.55 0.06
PTSD -25.47 -44.68 -6.25 9.77 0.010
Depressive disorders -13.48 -27.26 0.29 7.01 0.06
Bipolar disorders -11.00 -25.03 3.03 7.14 0.12
Female -1.68 -4.48 1.12 1.42 0.24
Non-binary/Self-defined -1.48 -6.86 3.89 2.73 0.59
19-25 years 4.63 -1.82 11.08 3.28 0.16
26-35 years 6.06 -0.27 12.39 3.22 0.06
36-45 years 6.17 -0.37 12.71 3.33 0.06
46-55 years 6.66 0.19 13.12 3.29 0.04
56-65 years 3.95 -2.81 10.72 3.44 0.25
66-70 years 3.06 -5.34 11.46 4.27 0.47
71-75 years 2.40 -10.12 14.93 6.37 0.71
Mixed or multiple ethnic origins 0.68 -5.37 6.72 3.07 0.83
Asian or Asian British -16.81 -30.31 -3.31 6.87 0.01
African or African British 22.20 2.54 41.85 10.00 0.03
Other ethnicity 1.28 -6.57 9.14 4.00 0.75
Key worker 0.40 -1.67 2.46 1.05 0.71
Time difference: Lockdown to baseline 0.28 -0.41 0.97 0.35 0.42
Unemployed 1.13 -1.77 4.03 1.47 0.44
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.40 -11.35 10.55 5.57 0.94
ocir.sum_score_prepan 0.64 0.57 0.72 0.04 1.31e-50
Depressive and anxiety disorder -5.09 -13.03 2.85 4.04 0.21
Only depressive disorder -6.04 -14.61 2.53 4.36 0.17
Only anxiety disorder -8.80 -17.40 -0.21 4.37 0.04
Eating disorders 0.86 -1.61 3.33 1.26 0.49
OCDs 2.39 0.23 4.55 1.10 0.03
Psychotic and bipolar disorder 10.69 3.70 17.68 3.56 0.003
Only psychotic disorder 0.04 -5.08 5.17 2.61 0.99
Only bipolar disorder 0.58 -2.81 3.97 1.72 0.74
PTSD -2.33 -4.63 -0.03 1.17 0.05
ASD -0.24 -4.20 3.72 2.01 0.91
ADHD 3.51 -2.41 9.43 3.01 0.24
Personality disorder -0.28 -3.28 2.71 1.52 0.85
Female -1.51 -4.36 1.33 1.45 0.30
Non-binary/Self-defined -0.77 -6.28 4.75 2.81 0.78
19-25 years 3.66 -2.64 9.96 3.20 0.25
26-35 years 5.07 -1.15 11.29 3.16 0.11
36-45 years 4.92 -1.48 11.33 3.26 0.13
46-55 years 6.39 -0.01 12.78 3.25 0.05
56-65 years 3.15 -3.53 9.82 3.40 0.35
66-70 years 2.25 -6.08 10.58 4.24 0.60
71-75 years 5.12 -6.11 16.34 5.71 0.37
Mixed or multiple ethnic origins -0.03 -6.12 6.05 3.10 0.99
Asian or Asian British -12.88 -26.52 0.76 6.94 0.06
African or African British 22.64 3.10 42.18 9.94 0.02
Other ethnicity 0.75 -7.06 8.57 3.98 0.85
Key worker 0.11 -1.98 2.19 1.06 0.92
Time difference: Lockdown to baseline 0.46 -0.22 1.15 0.35 0.18
Unemployed 0.58 -2.35 3.50 1.49 0.70
n R2 adjust. R2 F p value df
1786 0.03 0.03 10.03 6.36e-11 6

OCIR retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.87 3.16 4.58 0.36 2.28e-26
Anxiety disorders -0.86 -2.13 0.42 0.65 0.19
Eating disorders -3.63 -7.18 -0.08 1.81 0.05
OCDs -1.93 -4.30 0.44 1.21 0.11
PTSD -0.63 -3.25 2.00 1.34 0.64
Depressive disorders -3.92 -4.71 -3.12 0.41 7.23e-22
Bipolar disorders -3.50 -4.84 -2.16 0.68 2.98e-07
Unemployed -0.37 -1.38 0.64 0.52 0.48
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.83 3.18 4.47 0.33 7.02e-31
Depressive and anxiety disorder -4.35 -5.14 -3.57 0.40 2.07e-27
Only depressive disorder -2.09 -3.17 -1.00 0.55 1.67e-04
Only anxiety disorder -1.44 -2.56 -0.32 0.57 0.01
Eating disorders -0.24 -1.17 0.69 0.47 0.61
OCDs 0.27 -0.54 1.08 0.41 0.51
Psychotic and bipolar disorder 2.24 0.05 4.43 1.12 0.04
Only psychotic disorder 0.59 -1.37 2.55 1.00 0.56
Only bipolar disorder -0.55 -1.93 0.83 0.70 0.44
PTSD 0.23 -0.56 1.02 0.40 0.57
ASD 1.85 0.37 3.33 0.75 0.01
ADHD 2.21 0.12 4.29 1.06 0.04
Personality disorder -0.58 -1.67 0.51 0.56 0.30
Unemployed -0.22 -1.23 0.80 0.52 0.68
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.42 13.70 17.14 0.88 1.44e-66
Anxiety disorders -0.23 -1.45 0.98 0.62 0.70
Eating disorders -2.09 -5.39 1.21 1.68 0.21
OCDs -0.39 -2.61 1.83 1.13 0.73
PTSD -0.45 -2.93 2.03 1.27 0.72
Depressive disorders -2.13 -2.91 -1.36 0.40 8.10e-08
Bipolar disorders -1.65 -2.92 -0.38 0.65 0.01
Female 0.21 -0.55 0.97 0.39 0.58
Non-binary/Self-defined -0.14 -2.20 1.92 1.05 0.89
19-25 years -4.69 -6.19 -3.19 0.77 9.70e-10
26-35 years -4.14 -5.56 -2.72 0.72 1.18e-08
36-45 years -3.89 -5.34 -2.44 0.74 1.46e-07
46-55 years -3.78 -5.19 -2.38 0.72 1.43e-07
56-65 years -2.16 -3.57 -0.75 0.72 0.003
66-70 years -1.97 -3.68 -0.26 0.87 0.02
71-75 years -1.35 -3.29 0.60 0.99 0.17
76+ years -3.97 -7.55 -0.40 1.82 0.03
Mixed or multiple ethnic origins 1.55 -0.25 3.35 0.92 0.09
Asian or Asian British 2.67 -0.03 5.37 1.38 0.05
African or African British 0.74 -3.62 5.09 2.22 0.74
Other ethnicity -0.52 -3.15 2.11 1.34 0.70
Time difference: Lockdown to baseline -1.65 -1.77 -1.52 0.06 2.41e-133
Unemployed 0.37 -0.58 1.32 0.48 0.44
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.17 13.52 16.81 0.84 2.03e-70
Depressive and anxiety disorder -2.53 -3.30 -1.77 0.39 8.80e-11
Only depressive disorder -1.46 -2.49 -0.42 0.53 0.006
Only anxiety disorder -0.73 -1.79 0.33 0.54 0.18
Eating disorders -0.09 -0.96 0.78 0.44 0.83
OCDs 0.37 -0.39 1.12 0.38 0.34
Psychotic and bipolar disorder 2.21 0.17 4.25 1.04 0.03
Only psychotic disorder 0.28 -1.54 2.10 0.93 0.76
Only bipolar disorder -0.31 -1.61 0.98 0.66 0.64
PTSD 0.16 -0.59 0.90 0.38 0.68
ASD 0.97 -0.43 2.38 0.72 0.18
ADHD 1.68 -0.25 3.62 0.99 0.09
Personality disorder -0.29 -1.30 0.73 0.52 0.58
Female 0.31 -0.44 1.07 0.39 0.42
Non-binary/Self-defined -0.65 -2.71 1.41 1.05 0.53
19-25 years -4.51 -5.95 -3.07 0.74 9.62e-10
26-35 years -4.02 -5.40 -2.65 0.70 9.97e-09
36-45 years -3.81 -5.22 -2.41 0.72 1.11e-07
46-55 years -3.73 -5.10 -2.37 0.69 8.22e-08
56-65 years -2.15 -3.50 -0.79 0.69 0.002
66-70 years -1.83 -3.49 -0.17 0.85 0.03
71-75 years -1.79 -3.68 0.11 0.97 0.06
76+ years -3.95 -7.44 -0.46 1.78 0.03
Mixed or multiple ethnic origins 1.35 -0.44 3.14 0.91 0.14
Asian or Asian British 2.34 -0.26 4.94 1.33 0.08
African or African British 0.88 -3.44 5.21 2.21 0.69
Other ethnicity -0.66 -3.28 1.96 1.33 0.62
Key worker -0.01 -0.60 0.58 0.30 0.97
Time difference: Lockdown to baseline -1.61 -1.74 -1.49 0.06 6.67e-132
Unemployed 0.43 -0.55 1.41 0.50 0.39
n R2 adjust. R2 F p value df
4329 0.03 0.03 19.83 5.68e-23 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.45 5.75 7.15 0.36 6.95e-71
ocir.sum_score_retro 0.72 0.70 0.75 0.01 0.00e+00
Anxiety disorders -0.11 -1.31 1.09 0.61 0.86
Eating disorders -1.47 -4.81 1.87 1.70 0.39
OCDs 1.43 -0.80 3.67 1.14 0.21
PTSD 1.33 -1.14 3.79 1.26 0.29
Depressive disorders -1.55 -2.32 -0.78 0.39 7.83e-05
Bipolar disorders 0.43 -0.87 1.72 0.66 0.52
Unemployed 1.22 0.26 2.18 0.49 0.01
n R2 adjust. R2 F p value df
4329 0.52 0.52 665.07 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.91 6.26 7.55 0.33 3.96e-93
ocir.sum_score_retro 0.70 0.68 0.72 0.01 0.00e+00
Depressive and anxiety disorder -2.58 -3.32 -1.84 0.38 1.01e-11
Only depressive disorder -1.69 -2.70 -0.67 0.52 0.001
Only anxiety disorder -0.71 -1.75 0.34 0.53 0.19
Eating disorders -0.08 -0.94 0.79 0.44 0.86
OCDs 2.39 1.62 3.17 0.39 1.28e-09
Psychotic and bipolar disorder 3.36 1.32 5.41 1.04 0.001
Only psychotic disorder 1.67 -0.16 3.50 0.93 0.07
Only bipolar disorder 0.60 -0.69 1.89 0.66 0.36
PTSD 0.80 0.06 1.54 0.38 0.04
ASD 3.65 2.26 5.03 0.71 2.65e-07
ADHD 2.03 0.09 3.98 0.99 0.04
Personality disorder 0.58 -0.44 1.60 0.52 0.26
Unemployed 0.87 -0.09 1.82 0.49 0.08
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.60 15.95 19.25 0.84 1.23e-92
ocir.sum_score_retro 0.77 0.75 0.79 0.01 0.00e+00
Anxiety disorders 0.14 -1.01 1.29 0.59 0.81
Eating disorders -0.72 -3.85 2.41 1.59 0.65
OCDs 1.72 -0.40 3.84 1.08 0.11
PTSD 1.09 -1.27 3.45 1.20 0.36
Depressive disorders -0.51 -1.27 0.25 0.39 0.19
Bipolar disorders 1.29 0.05 2.53 0.63 0.04
Female 0.17 -0.55 0.90 0.37 0.64
Non-binary/Self-defined 0.56 -1.39 2.51 1.00 0.57
19-25 years -5.02 -6.45 -3.59 0.73 6.09e-12
26-35 years -4.84 -6.20 -3.48 0.69 3.64e-12
36-45 years -4.88 -6.27 -3.49 0.71 6.83e-12
46-55 years -4.77 -6.13 -3.42 0.69 4.87e-12
56-65 years -3.67 -5.01 -2.32 0.69 9.79e-08
66-70 years -3.64 -5.27 -2.00 0.83 1.30e-05
71-75 years -3.79 -5.64 -1.93 0.95 6.37e-05
76+ years -5.69 -9.09 -2.30 1.73 0.001
Mixed or multiple ethnic origins 1.44 -0.27 3.16 0.87 0.10
Asian or Asian British 3.43 0.87 5.99 1.31 0.009
African or African British 0.92 -3.20 5.05 2.10 0.66
Other ethnicity 0.23 -2.26 2.72 1.27 0.86
Key worker -0.29 -0.86 0.28 0.29 0.32
Time difference: Lockdown to baseline -1.41 -1.53 -1.28 0.06 3.08e-106
Unemployed 1.36 0.43 2.30 0.48 0.004
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 17.73 16.16 19.30 0.80 1.32e-102
ocir.sum_score_retro 0.74 0.72 0.77 0.01 0.00e+00
Depressive and anxiety disorder -1.25 -1.98 -0.52 0.37 8.16e-04
Only depressive disorder -1.03 -2.01 -0.05 0.50 0.04
Only anxiety disorder -0.29 -1.29 0.72 0.51 0.57
Eating disorders -0.05 -0.87 0.78 0.42 0.91
OCDs 2.09 1.36 2.82 0.37 1.97e-08
Psychotic and bipolar disorder 3.20 1.27 5.13 0.99 0.001
Only psychotic disorder 1.18 -0.54 2.90 0.88 0.18
Only bipolar disorder 0.59 -0.64 1.81 0.62 0.35
PTSD 0.71 0.01 1.42 0.36 0.05
ASD 2.40 1.06 3.73 0.68 4.45e-04
ADHD 1.49 -0.34 3.32 0.93 0.11
Personality disorder 0.63 -0.33 1.60 0.49 0.20
Female 0.19 -0.53 0.91 0.37 0.60
Non-binary/Self-defined -0.49 -2.44 1.46 0.99 0.62
19-25 years -5.02 -6.38 -3.65 0.70 6.72e-13
26-35 years -5.05 -6.35 -3.75 0.66 3.56e-14
36-45 years -4.96 -6.30 -3.63 0.68 3.55e-13
46-55 years -4.82 -6.11 -3.53 0.66 3.22e-13
56-65 years -3.68 -4.97 -2.39 0.66 2.20e-08
66-70 years -3.41 -4.98 -1.83 0.80 2.26e-05
71-75 years -3.70 -5.50 -1.90 0.92 5.56e-05
76+ years -5.74 -9.04 -2.43 1.68 6.66e-04
Mixed or multiple ethnic origins 1.09 -0.60 2.79 0.86 0.20
Asian or Asian British 3.42 0.96 5.89 1.26 0.006
African or African British 1.27 -2.83 5.36 2.09 0.54
Other ethnicity -0.03 -2.51 2.45 1.26 0.98
Key worker -0.23 -0.79 0.33 0.29 0.42
Time difference: Lockdown to baseline -1.35 -1.47 -1.23 0.06 2.07e-102
Unemployed 1.10 0.17 2.04 0.47 0.02
n R2 adjust. R2 F p value df
5094 0.06 0.06 51.24 1.63e-61 6

PCL prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.28 -0.70 1.26 0.50 0.58
Anxiety disorders -0.07 -1.15 1.01 0.55 0.90
Eating disorders -0.55 -2.63 1.53 1.06 0.61
OCDs -0.30 -1.75 1.15 0.74 0.69
PTSD -1.60 -3.29 0.10 0.86 0.06
Depressive disorders -0.04 -1.02 0.95 0.50 0.94
Bipolar disorders -0.26 -1.32 0.80 0.54 0.63
Unemployed -0.07 -0.45 0.31 0.19 0.72
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.39 -0.31 1.09 0.36 0.28
Depressive and anxiety disorder 0.02 -0.68 0.73 0.36 0.95
Only depressive disorder -0.16 -0.92 0.61 0.39 0.69
Only anxiety disorder -0.21 -1.01 0.59 0.41 0.61
Eating disorders 0.13 -0.21 0.47 0.18 0.46
OCDs -0.06 -0.39 0.26 0.16 0.70
Psychotic and bipolar disorder -0.70 -1.64 0.24 0.48 0.14
Only psychotic disorder -0.04 -0.82 0.75 0.40 0.93
Only bipolar disorder 0.06 -0.41 0.53 0.24 0.80
PTSD -0.90 -1.20 -0.60 0.15 5.62e-09
ASD -0.12 -0.75 0.50 0.32 0.70
ADHD -0.23 -1.10 0.63 0.44 0.59
Personality disorder -0.29 -0.72 0.13 0.22 0.18
Unemployed 0.03 -0.35 0.41 0.19 0.88
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.62 -1.91 0.66 0.66 0.34
Anxiety disorders -0.08 -1.16 1.00 0.55 0.88
Eating disorders -0.66 -2.74 1.41 1.06 0.53
OCDs -0.46 -1.91 0.99 0.74 0.53
PTSD -1.59 -3.30 0.11 0.87 0.07
Depressive disorders 0.02 -0.97 1.00 0.50 0.98
Bipolar disorders -0.12 -1.18 0.95 0.54 0.83
Female 0.63 0.34 0.91 0.15 2.04e-05
Non-binary/Self-defined -0.03 -0.85 0.79 0.42 0.94
19-25 years 0.45 -0.26 1.17 0.37 0.21
26-35 years 0.11 -0.58 0.80 0.35 0.75
36-45 years -0.36 -1.05 0.34 0.36 0.32
46-55 years -0.45 -1.14 0.24 0.35 0.20
56-65 years -0.17 -0.88 0.54 0.36 0.64
66-70 years -0.36 -1.24 0.52 0.45 0.42
71-75 years -0.37 -1.41 0.67 0.53 0.48
76+ years 0.44 -1.30 2.18 0.89 0.62
Mixed or multiple ethnic origins 0.39 -0.35 1.13 0.38 0.30
Asian or Asian British 0.17 -1.07 1.41 0.63 0.79
African or African British -0.37 -2.18 1.44 0.92 0.69
Other ethnicity -0.21 -1.37 0.96 0.59 0.73
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
Unemployed -0.04 -0.42 0.34 0.19 0.83
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.53 -1.60 0.54 0.55 0.33
Depressive and anxiety disorder 0.08 -0.63 0.80 0.36 0.82
Only depressive disorder -0.03 -0.80 0.74 0.39 0.95
Only anxiety disorder -0.23 -1.03 0.58 0.41 0.58
Eating disorders 0.00 -0.35 0.35 0.18 1.00
OCDs -0.11 -0.43 0.21 0.16 0.50
Psychotic and bipolar disorder -0.59 -1.53 0.35 0.48 0.22
Only psychotic disorder 0.07 -0.72 0.86 0.40 0.86
Only bipolar disorder 0.20 -0.27 0.67 0.24 0.41
PTSD -0.87 -1.18 -0.57 0.16 2.03e-08
ASD -0.12 -0.75 0.52 0.32 0.72
ADHD -0.22 -1.08 0.65 0.44 0.62
Personality disorder -0.43 -0.86 -0.01 0.22 0.05
Female 0.68 0.39 0.97 0.15 3.85e-06
Non-binary/Self-defined 0.17 -0.64 0.99 0.42 0.68
19-25 years 0.47 -0.24 1.18 0.36 0.20
26-35 years 0.17 -0.51 0.85 0.35 0.63
36-45 years -0.28 -0.98 0.41 0.35 0.42
46-55 years -0.38 -1.06 0.31 0.35 0.29
56-65 years -0.15 -0.86 0.55 0.36 0.67
66-70 years -0.45 -1.32 0.42 0.44 0.31
71-75 years -0.48 -1.51 0.55 0.53 0.36
76+ years 0.28 -1.45 2.01 0.88 0.75
Mixed or multiple ethnic origins 0.45 -0.29 1.19 0.38 0.23
Asian or Asian British 0.22 -1.00 1.45 0.63 0.72
African or African British -0.41 -2.22 1.40 0.92 0.66
Other ethnicity -0.15 -1.29 0.99 0.58 0.80
Key worker -0.22 -0.45 0.01 0.12 0.07
Time difference: Lockdown to baseline 0.07 0.00 0.13 0.03 0.04
Unemployed -0.02 -0.42 0.37 0.20 0.90
n R2 adjust. R2 F p value df
11019 0.00 0.00 1.05 0.39 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.18 5.29 7.08 0.46 1.06e-41
pcl.sum_score_prepan 0.56 0.54 0.57 0.01 0.00e+00
Anxiety disorders -0.38 -1.34 0.57 0.49 0.43
Eating disorders 0.04 -1.81 1.88 0.94 0.97
OCDs 0.31 -0.98 1.59 0.66 0.64
PTSD 0.11 -1.39 1.62 0.77 0.88
Depressive disorders 0.86 -0.01 1.74 0.45 0.05
Bipolar disorders 1.31 0.37 2.25 0.48 0.006
Unemployed 1.38 1.04 1.72 0.17 1.38e-15
n R2 adjust. R2 F p value df
11019 0.33 0.33 764.66 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.88 6.22 7.53 0.33 2.19e-92
pcl.sum_score_prepan 0.53 0.51 0.54 0.01 0.00e+00
Depressive and anxiety disorder 0.48 -0.14 1.10 0.32 0.13
Only depressive disorder -0.52 -1.19 0.15 0.34 0.13
Only anxiety disorder -0.63 -1.34 0.08 0.36 0.08
Eating disorders 0.60 0.29 0.90 0.15 1.21e-04
OCDs 0.59 0.30 0.87 0.15 5.29e-05
Psychotic and bipolar disorder -0.51 -1.33 0.32 0.42 0.23
Only psychotic disorder -0.13 -0.82 0.57 0.35 0.72
Only bipolar disorder 0.31 -0.11 0.72 0.21 0.15
PTSD 0.72 0.45 0.99 0.14 2.16e-07
ASD 0.55 0.00 1.10 0.28 0.05
ADHD 0.23 -0.53 0.98 0.39 0.56
Personality disorder 1.00 0.62 1.38 0.19 1.91e-07
Unemployed 1.19 0.86 1.53 0.17 4.09e-12
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.83 5.67 7.99 0.59 1.42e-30
pcl.sum_score_prepan 0.54 0.52 0.55 0.01 0.00e+00
Anxiety disorders -0.38 -1.33 0.57 0.48 0.43
Eating disorders -0.01 -1.83 1.82 0.93 0.99
OCDs 0.07 -1.21 1.35 0.65 0.91
PTSD 0.49 -1.01 1.99 0.76 0.52
Depressive disorders 1.10 0.23 1.96 0.44 0.01
Bipolar disorders 1.68 0.74 2.62 0.48 4.52e-04
Female 0.61 0.35 0.86 0.13 2.66e-06
Non-binary/Self-defined 0.73 0.01 1.45 0.37 0.05
19-25 years -0.19 -0.82 0.45 0.32 0.56
26-35 years -1.04 -1.65 -0.43 0.31 8.78e-04
36-45 years -1.55 -2.17 -0.94 0.32 8.21e-07
46-55 years -1.70 -2.31 -1.08 0.31 6.47e-08
56-65 years -1.92 -2.55 -1.30 0.32 2.04e-09
66-70 years -2.95 -3.73 -2.18 0.40 1.01e-13
71-75 years -3.35 -4.27 -2.43 0.47 1.03e-12
76+ years -2.85 -4.38 -1.32 0.78 2.63e-04
Mixed or multiple ethnic origins 0.28 -0.38 0.93 0.33 0.41
Asian or Asian British 0.41 -0.68 1.49 0.55 0.46
African or African British 0.61 -0.97 2.20 0.81 0.45
Other ethnicity 0.13 -0.89 1.16 0.52 0.80
Key worker -0.51 -0.72 -0.31 0.10 7.51e-07
Time difference: Lockdown to baseline 0.08 0.03 0.14 0.03 0.005
Unemployed 1.10 0.75 1.45 0.18 5.51e-10
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.59 6.62 8.57 0.50 5.80e-52
pcl.sum_score_prepan 0.51 0.49 0.52 0.01 0.00e+00
Depressive and anxiety disorder 0.69 0.06 1.31 0.32 0.03
Only depressive disorder -0.13 -0.80 0.54 0.34 0.71
Only anxiety disorder -0.63 -1.34 0.07 0.36 0.08
Eating disorders 0.43 0.12 0.73 0.15 0.006
OCDs 0.49 0.21 0.78 0.14 6.02e-04
Psychotic and bipolar disorder -0.27 -1.09 0.55 0.42 0.52
Only psychotic disorder -0.02 -0.70 0.67 0.35 0.96
Only bipolar disorder 0.49 0.08 0.90 0.21 0.02
PTSD 0.84 0.57 1.11 0.14 1.36e-09
ASD 0.31 -0.25 0.86 0.28 0.28
ADHD 0.15 -0.60 0.90 0.38 0.70
Personality disorder 0.87 0.49 1.24 0.19 5.81e-06
Female 0.49 0.24 0.75 0.13 1.42e-04
Non-binary/Self-defined 0.45 -0.26 1.17 0.36 0.21
19-25 years -0.34 -0.96 0.28 0.32 0.28
26-35 years -1.21 -1.81 -0.61 0.31 7.61e-05
36-45 years -1.69 -2.30 -1.09 0.31 4.49e-08
46-55 years -1.80 -2.40 -1.19 0.31 5.43e-09
56-65 years -1.97 -2.59 -1.35 0.32 4.73e-10
66-70 years -2.92 -3.68 -2.15 0.39 8.48e-14
71-75 years -3.29 -4.20 -2.39 0.46 1.15e-12
76+ years -2.87 -4.38 -1.35 0.77 2.13e-04
Mixed or multiple ethnic origins 0.23 -0.42 0.88 0.33 0.49
Asian or Asian British 0.54 -0.53 1.61 0.55 0.32
African or African British 0.74 -0.84 2.32 0.81 0.36
Other ethnicity 0.05 -0.95 1.04 0.51 0.93
Key worker -0.45 -0.65 -0.24 0.10 1.53e-05
Time difference: Lockdown to baseline 0.09 0.03 0.15 0.03 0.002
Unemployed 0.97 0.63 1.32 0.18 3.85e-08
n R2 adjust. R2 F p value df
11081 0.02 0.02 32.92 1.45e-39 6